General synthesis of alpha-substituted 3-bisaryloxy propionic acid derivatives as specific MMP inhibitors

Bioorg Med Chem Lett. 2001 Feb 12;11(3):295-9. doi: 10.1016/s0960-894x(00)00646-6.

Abstract

Modulations of alpha and aryl substitutions on 3-aryloxy propionic acid hydroxamates led to novel and potent inhibitors of MMP-2,3,9 and 13, and selectivity versus MMP-1.

MeSH terms

  • Animals
  • Antineoplastic Agents / chemical synthesis
  • Antineoplastic Agents / pharmacokinetics
  • Antineoplastic Agents / pharmacology
  • Antirheumatic Agents / chemical synthesis
  • Antirheumatic Agents / pharmacokinetics
  • Antirheumatic Agents / pharmacology
  • Biological Availability
  • Cartilage / drug effects
  • Combinatorial Chemistry Techniques
  • Drug Stability
  • Humans
  • Matrix Metalloproteinase Inhibitors*
  • Mice
  • Microsomes, Liver
  • Neoplasm Metastasis / drug therapy
  • Neoplasms, Experimental / drug therapy
  • Propionates / chemical synthesis
  • Propionates / pharmacokinetics
  • Propionates / pharmacology*
  • Proteoglycans / drug effects
  • Proteoglycans / metabolism
  • Structure-Activity Relationship
  • Substrate Specificity
  • Tumor Cells, Cultured

Substances

  • Antineoplastic Agents
  • Antirheumatic Agents
  • Matrix Metalloproteinase Inhibitors
  • Propionates
  • Proteoglycans