Homoisofagomines: chemical-enzymatic synthesis and evaluation as alpha- and beta-glucosidase inhibitors

Bioorg Med Chem Lett. 1999 Feb 22;9(4):615-8. doi: 10.1016/s0960-894x(99)00042-6.

Abstract

Methyl- and hydroxymethyl derivatives of the highly potent glycosidase inhibitor isofagomine are accessible via aldolase-catalyzed C-C bond formation and competitively inhibit beta-glucosidase at low micromolar concentrations.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Enzyme Inhibitors / chemical synthesis*
  • Enzyme Inhibitors / chemistry
  • Enzyme Inhibitors / pharmacology
  • Glycoside Hydrolase Inhibitors*
  • Molecular Structure
  • Piperidines / chemical synthesis*
  • Piperidines / chemistry
  • Piperidines / pharmacology*
  • beta-Glucosidase / antagonists & inhibitors*

Substances

  • Enzyme Inhibitors
  • Glycoside Hydrolase Inhibitors
  • Piperidines
  • beta-Glucosidase