Synthesis of a cyanopeptide-analogue with trypsin activating properties

G Radau; D Rauh

doi:10.1016/s0960-894x(00)00101-3

Synthesis of a cyanopeptide-analogue with trypsin activating properties

Bioorg Med Chem Lett. 2000 Apr 17;10(8):779-81. doi: 10.1016/s0960-894x(00)00101-3.

Authors

G Radau¹, D Rauh

Affiliation

¹ Institute of Pharmacy, Ernst-Moritz-Arndt-University, Pharmaceutical/Medicinal Chemistry, Greifswald, Germany. radau@pharmazie.uni-greifswald.de

PMID: 10782685
DOI: 10.1016/s0960-894x(00)00101-3

Abstract

An efficient synthesis of a peptidic analogue of cyanobacterial metabolites with proposed serine protease inhibitory activity has been developed. Surprisingly, one trypsin activating compound was obtained.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Cyanides / chemistry
Enzyme Activation
Peptides / chemical synthesis*
Peptides / chemistry
Serine Proteinase Inhibitors / chemical synthesis*
Serine Proteinase Inhibitors / chemistry
Trypsin / metabolism*

Substances

Cyanides
Peptides
Serine Proteinase Inhibitors
Trypsin