Bruton's tyrosine kinase inhibitors: approaches to potent and selective inhibition, preclinical and clinical evaluation for inflammatory diseases and B cell malignancies

J Med Chem. 2012 May 24;55(10):4539-50. doi: 10.1021/jm300035p. Epub 2012 Mar 21.
No abstract available

Publication types

  • Review

MeSH terms

  • Agammaglobulinaemia Tyrosine Kinase
  • Animals
  • Anti-Inflammatory Agents / chemistry*
  • Anti-Inflammatory Agents / pharmacology
  • Antineoplastic Agents / chemistry*
  • Antineoplastic Agents / pharmacology
  • Catalytic Domain
  • Clinical Trials as Topic
  • Drug Evaluation, Preclinical
  • Drug Industry
  • Humans
  • Inflammation / drug therapy*
  • Inflammation / enzymology
  • Leukemia, B-Cell / drug therapy*
  • Leukemia, B-Cell / enzymology
  • Models, Molecular
  • Protein Conformation
  • Protein-Tyrosine Kinases / antagonists & inhibitors*
  • Protein-Tyrosine Kinases / chemistry
  • Structure-Activity Relationship

Substances

  • Anti-Inflammatory Agents
  • Antineoplastic Agents
  • Protein-Tyrosine Kinases
  • Agammaglobulinaemia Tyrosine Kinase