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1BOZSTRUCTURE-BASED DESIGN AND SYNTHESIS OF LIPOPHILIC 2,4- DIAMINO-6-SUBSTITUTED QUINAZOLINES AND THEIR EVALUATION AS INHIBITORS OF DIHYDROFOLATE REDUCTASE AND POTENTIAL ANTITUMOR AGENTS
1DHFCRYSTAL STRUCTURES OF RECOMBINANT HUMAN DIHYDROFOLATE REDUCTASE COMPLEXED WITH FOLATE AND 5-DEAZOFOLATE
1DLRMETHOTREXATE-RESISTANT VARIANTS OF HUMAN DIHYDROFOLATE REDUCTASE WITH SUBSTITUTION OF LEUCINE 22: KINETICS, CRYSTALLOGRAPHY AND POTENTIAL AS SELECTABLE MARKERS
1DLSMETHOTREXATE-RESISTANT VARIANTS OF HUMAN DIHYDROFOLATE REDUCTASE WITH SUBSTITUTION OF LEUCINE 22: KINETICS, CRYSTALLOGRAPHY AND POTENTIAL AS SELECTABLE MARKERS
1DRFCRYSTAL STRUCTURE OF HUMAN DIHYDROFOLATE REDUCTASE COMPLEXED WITH FOLATE
1HFPCOMPARISON OF TERNARY CRYSTAL COMPLEXES OF HUMAN DIHYDROFOLATE REDUCTASE WITH NADPH AND A CLASSICAL ANTITUMOR FUROPYRIMDINE
1HFQCOMPARISON OF TERNARY CRYSTAL COMPLEXES OF HUMAN DIHYDROFOLATE REDUCTASE WITH NADPH AND A CLASSICAL ANTITUMOR FUROPYRIMDINE
1HFRCOMPARISON OF TERNARY CRYSTAL COMPLEXES OF HUMAN DIHYDROFOLATE REDUCTASE WITH NADPH AND A CLASSICAL ANTITUMOR FUROPYRIMDINE
1KMSHUMAN DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADPH AND 6- ([5-QUINOLYLAMINO]METHYL)-2,4-DIAMINO-5-METHYLPYRIDO[2,3- D]PYRIMIDINE (SRI-9439), A LIPOPHILIC ANTIFOLATE
1KMVHUMAN DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADPH AND (Z)- 6-(2-[2,5-DIMETHOXYPHENYL]ETHEN-1-YL)-2,4-DIAMINO-5- METHYLPYRIDO[2,3-D]PYRIMIDINE (SRI-9662), A LIPOPHILIC ANTIFOLATE
1MVSANALYSIS OF TWO POLYMORPHIC FORMS OF A PYRIDO[2,3- D]PYRIMIDINE N9-C10 REVERSE-BRIDGE ANTIFOLATE BINARY COMPLEX WITH HUMAN DIHYDROFOLATE REDUCTASE
1MVTANALYSIS OF TWO POLYMORPHIC FORMS OF A PYRIDO[2,3- D]PYRIMIDINE N9-C10 REVERSE-BRIDGE ANTIFOLATE BINARY COMPLEX WITH HUMAN DIHYDROFOLATE REDUCTASE
1OHJHUMAN DIHYDROFOLATE REDUCTASE, MONOCLINIC (P21) CRYSTAL FORM
1OHKHUMAN DIHYDROFOLATE REDUCTASE, ORTHORHOMBIC (P21 21 21) CRYSTAL FORM
1PD8ANALYSIS OF THREE CRYSTAL STRUCTURE DETERMINATIONS OF A 5- METHYL-6-N-METHYLANILINO PYRIDOPYRIMIDINE ANTIFOLATE COMPLEX WITH HUMAN DIHYDROFOLATE REDUCTASE
1PD9ANALYSIS OF THREE CRYSTAL STRUCTURE DETERMINATIONS OF A 5- METHYL-6-N-METHYLANILINO PYRIDOPYRIMIDINE ANTIFOLATE COMPLEX WITH HUMAN DIHYDROFOLATE REDUCTASE
1S3USTRUCTURE DETERMINATION OF TETRAHYDROQUINAZOLINE ANTIFOLATES IN COMPLEX WITH HUMAN AND PNEUMOCYSTIS CARINII DIHYDROFOLATE REDUCTASE: CORRELATIONS OF ENZYME SELECTIVITY AND STEREOCHEMISTRY
1S3VSTRUCTURE DETERMINATION OF TETRAHYDROQUINAZOLINE ANTIFOLATES IN COMPLEX WITH HUMAN AND PNEUMOCYSTIS CARINII DIHYDROFOLATE REDUCTASE: CORRELATIONS OF ENZYME SELECTIVITY AND STEREOCHEMISTRY
1S3WSTRUCTURE DETERMINATION OF TETRAHYDROQUINAZOLINE ANTIFOALTES IN COMPLEX WITH HUMAN AND PNEUMOCYSTIS CARINII DIHYDROFOLATE REDUCTASE: CORRELATIONS OF ENZYME SELECTIVITY AND STEREOCHEMISTRY
1U70UNDERSTANDING THE ROLE OF LEU22 VARIANTS IN METHOTREXATE RESISTANCE: COMPARISON OF WILD-TYPE AND LEU22ARG VARIANT MOUSE AND HUMAN DIHYDROFOLATE REDUCTASE
1U71UNDERSTANDING THE ROLE OF LEU22 VARIANTS IN METHOTREXATE RESISTANCE: COMPARISON OF WILD-TYPE AND LEU22ARG VARIANT MOUSE AND HUMAN DIHYDROFOLATE REDUCTASE TERNARY CRYSTAL COMPLEXES WITH METHOTREXATE AND NADPH
1U72UNDERSTANDING THE ROLE OF LEU22 VARIANTS IN METHOTREXATE RESISTANCE: COMPARISON OF WILD-TYPE AND LEU22ARG VARIANT MOUSE AND HUMAN DIHYDRFOLATE REDUCTASE TERNARY CRYSTAL COMPLEXES WITH METHOTREXATE AND NADPH
2C2SHUMAN DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADPH AND 2,4- DIAMINO-5-(1-O-CARBORANYLMETHYL)-6-METHYLPYRIMIDINE, A NOVEL BORON CONTAINING, NONCLASSICAL ANTIFOLATE
2C2THUMAN DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADPH AND 2,4- DIAMINO-5-((7,8-DICARBAUNDECABORAN-7-YL)METHYL)-6- METHYLPYRIMIDINE, A NOVEL BORON CONTAINING, NONCLASSICAL ANTIFOLATE
2DHFCRYSTAL STRUCTURES OF RECOMBINANT HUMAN DIHYDROFOLATE REDUCTASE COMPLEXED WITH FOLATE AND 5-DEAZOFOLATE
2FZJNEW INSIGHTS INTO DHFR INTERACTIONS: ANALYSIS OF PNEUMOCYSTIS CARINII AND MOUSE DHFR COMPLEXES WITH NADPH AND TWO HIGHLY POTENT TRIMETHOPRIM DERIVATIVES