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Target
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Ki
IC50
Kd
EC50
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ΔG°
ΔH°
-TΔS°
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rcsb
for Cytochrome P450 3A
1TQN
: crystal structure of human microsomal p450 3a4 (
10.1074/JBC.C400293200
)
1W0E
: crystal structure of human cytochrome p450 3a4 (
10.1126/SCIENCE.1099736
)
1W0F
: crystal structure of human cytochrome p450 3a4 (
10.1126/SCIENCE.1099736
)
1W0G
: crystal structure of human cytochrome p450 3a4 (
10.1126/SCIENCE.1099736
)
2J0D
: crystal structure of human p450 3a4 in complex with erythromycin (
10.1073/PNAS.0603236103
)
2V0M
: crystal structure of human p450 3a4 in complex with ketoconazole (
10.1073/PNAS.0603236103
)
3NXU
: crystal structure of human cytochrome p4503a4 bound to an inhibitor ritonavir (
10.1073/PNAS.1010693107
)
3TJS
: crystal structure of the complex between human cytochrome p450 3a4 and desthiazolylmethyloxycarbonyl ritonavir (
10.1016/J.ABB.2012.02.018
)
3UA1
: crystal structure of the cytochrome p4503a4-bromoergocryptine complex (
10.1074/JBC.M111.317081
)
4D6Z
: cytochrome p450 3a4 bound to imidazole and an inhibitor (
10.1021/ACS.JMEDCHEM.5B01146
)
4D75
: cytochrome p450 3a4 bound to an inhibitor (
10.1021/ACS.JMEDCHEM.5B01146
)
4D78
: cytochrome p450 3a4 bound to an inhibitor (
10.1021/ACS.JMEDCHEM.5B01146
)
4D7D
: cytochrome p450 3a4 bound to an inhibitor (
10.1021/ACS.JMEDCHEM.5B01146
)
4I3Q
: crystal structure of human cyp3a4 coordinated to a water molecule (
10.1021/JM400288Z
)
4I4G
: crystal structure of cyp3a4 ligated to oxazole-substituted desoxyritonavir (
10.1021/JM400288Z
)
4I4H
: crystal structure of cyp3a4 ligated to pyridine-substituted desoxyritonavir (
10.1021/JM400288Z
)
4K9T
: complex of cyp3a4 with a desoxyritonavir analog (
10.1021/BI4005396
)
4K9U
: complex of human cyp3a4 with a desoxyritonavir analog (
10.1021/BI4005396
)
4K9V
: complex of cyp3a4 with a desoxyritonavir analog (
10.1021/BI4005396
)
4K9W
: complex of human cyp3a4 with a desoxyritonavir analog (
10.1021/BI4005396
)
4K9X
: complex of human cyp3a4 with a desoxyritonavir analog (
10.1021/BI4005396
)
4NY4
: crystal structure of cyp3a4 in complex with an inhibitor (
10.1016/J.DRUDIS.2014.03.012
)
5A1P
: crystal structure of cytochrome p450 3a4 bound to progesterone and citrate (
10.1021/ACS.BIOCHEM.5B00510
)
5A1R
: crystal structure of cytochrome p450 3a4 bound to progesterone (
10.1021/ACS.BIOCHEM.5B00510
)
5G5J
: crystal structure of human cyp3a4 bound to metformin (
10.1016/J.CHEMBIOL.2017.08.009
)
5TE8
: crystal structure of the midazolam-bound human cyp3a4 (
10.1073/PNAS.1616198114
)
5VC0
: crystal structure of human cyp3a4 bound to ritonavir (
10.1021/ACS.BIOCHEM.7B00334
)
5VCC
: crystal structure of human cyp3a4 bound to glycerol (
10.1021/ACS.BIOCHEM.7B00334
)
5VCD
: crystal structure of the cysteine depleted cyp3a4 bound to glycerol (
10.1021/ACS.BIOCHEM.7B00334
)
5VCE
: crystal structure of the cysteine depleted cyp3a4 bound to ritonavir (
10.1021/ACS.BIOCHEM.7B00334
)
5VCG
: crystal structure of the cysteine depleted cyp3a4 bound to bromoergocryptine (
10.1021/ACS.BIOCHEM.7B00334
)
6BCZ
: crystal structure of human cyp3a4 bound to an inhibitor (
10.1021/ACS.MOLPHARMACEUT.7B00957
)
6BD5
: crystal structure of human cyp3a4 bound to an inhibitor (
10.1021/ACS.MOLPHARMACEUT.7B00957
)
6BD6
: crystal structure of human cyp3a4 bound to an inhibitor (
10.1021/ACS.MOLPHARMACEUT.7B00957
)
6BD7
: crystal structure of human cyp3a4 bound to an inhibitor
6BD8
: crystal structure of human cyp3a4 bound to an inhibitor
6BDH
: crystal structure of human cyp3a4 bound to an inhibitor
6BDI
: crystal structure of human cyp3a4 bound to an inhibitor
6BDK
: crystal structure of human cyp3a4 bound to an inhibitor (
10.1021/ACS.MOLPHARMACEUT.7B00957
)
6BDM
: crystal structure of human cyp3a4 bound to an inhibitor
6DA2
: human cyp3a4 bound to an inhibitor (
10.1021/ACS.BIOCHEM.9B00156
)
6DA3
: human cyp3a4 bound to an inhibitor (
10.1021/ACS.BIOCHEM.9B00156
)
6DA5
: human cyp3a4 bound to an inhibitor (
10.1021/ACS.BIOCHEM.9B00156
)
6DA8
: human cyp3a4 bound to an inhibitor (
10.1021/ACS.BIOCHEM.9B00156
)
6DAA
: human cyp3a4 bound to an inhibitor (
10.1021/ACS.BIOCHEM.9B00156
)
6DAB
: human cyp3a4 bound to an inhibitor (
10.1021/ACS.BIOCHEM.9B00156
)
6DAC
: human cyp3a4 bound to an inhibitor (
10.1021/ACS.BIOCHEM.9B00156
)
6DAG
: human cyp3a4 bound to an inhibitor (
10.1021/ACS.BIOCHEM.9B00156
)
6DAJ
: human cyp3a4 bound to an inhibitor (
10.1021/ACS.BIOCHEM.9B00156
)
6DAL
: human cyp3a4 bound to an inhibitor (
10.1021/ACS.BIOCHEM.9B00156
)
6MA6
: human cyp3a4 bound to an inhibitor metyrapone (
10.1021/ACS.BIOCHEM.8B01221
)
6MA7
: human cyp3a4 bound to an inhibitor fluconazole (
10.1021/ACS.BIOCHEM.8B01221
)
6MA8
: human cyp3a4 bound to pmsf (
10.1021/ACS.BIOCHEM.8B01221
)
6OO9
: human cyp3a4 bound to a drug mibefradil (
10.3390/IJMS20174245
)
6OOA
: human cyp3a4 bound to a drug substrate (
10.3390/IJMS20174245
)
6OOB
: human cyp3a4 bound to a suicide substrate (
10.3390/IJMS20174245
)
6UNE
: human cyp3a4 bound to an inhibitor (
10.1016/J.BMC.2020.115349
)
6UNG
: human cyp3a4 bound to an inhibitor (
10.1016/J.BMC.2020.115349
)
6UNH
: human cyp3a4 bound to an inhibitor (
10.1016/J.BMC.2020.115349
)
6UNI
: human cyp3a4 bound to an inhibitor (
10.1016/J.BMC.2020.115349
)
6UNJ
: human cyp3a4 bound to an inhibitor (
10.1016/J.BMC.2020.115349
)
6UNK
: human cyp3a4 bound to an inhibitor (
10.1016/J.BMC.2020.115349
)
6UNL
: cyp3a4 bound to an inhibitor (
10.1016/J.BMC.2020.115349
)
6UNM
: cyp3a4 bound to an inhibitor (
10.1016/J.BMC.2020.115349
)
7KS8
: crystal structure of human cyp3a4 with the caged inhibitor
7KSA
: crystal structure of human cyp3a4 with the caged inhibitor
7KVH
: human cyp3a4 bound to an inhibitor (
10.3390/IJMS22020852
)
7KVI
: human cyp3a4 bound to an inhibitor (
10.3390/IJMS22020852
)
7KVJ
: human cyp3a4 bound to an inhibitor (
10.3390/IJMS22020852
)
7KVK
: human cyp3a4 bound to an inhibitor (
10.3390/IJMS22020852
)
7KVM
: human cyp3a4 bound to an inhibitor (
10.3390/IJMS22020852
)
7KVN
: human cyp3a4 bound to an inhibitor (
10.3390/IJMS22020852
)
7KVO
: human cyp3a4 bound to an inhibitor (
10.3390/IJMS22020852
)
7KVP
: human cyp3a4 bound to an inhibitor (
10.3390/IJMS22020852
)
7KVQ
: human cyp3a4 bound to an inhibitor (
10.3390/IJMS22020852
)
7KVS
: human cyp3a4 bound to an inhibitor (
10.3390/IJMS22020852
)
7LXL
: crystal structure of human cyp3a4 bound to the testosterone dimer
7MK8
: crystal structure of a surface mutant of human fetal-specific cyp3a7 bound to dithiothreitol