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• 1CU1: crystal structure of an enzyme complex from hepatitis c virus (10.1016/S0969-2126(00)80025-8 )
• 1DXP: inhibition of the hepatitis c virus ns3/4a protease. the crystal structures of two protease-inhibitor complexes (apo structure) (10.1074/JBC.275.10.7152 )
• 1DXW: structure of hetero complex of non structural protein (ns) of hepatitis c virus (hcv) and synthetic peptidic compound (10.1093/EMBOJ/19.6.1195 )
• 1DY8: inhibition of the hepatitis c virus ns3/4a protease. the crystal structures of two protease-inhibitor complexes (inhibitor ii) (10.1074/JBC.275.10.7152 )
• 1DY9: inhibition of the hepatitis c virus ns3/4a protease. the crystal structures of two protease-inhibitor complexes (inhibitor i) (10.1074/JBC.275.10.7152 )
• 1HEI: structure of the hepatitis c virus rna helicase domain (10.1038/NSB0697-463 )
• 1JXP: bk strain hepatitis c virus (hcv) ns3-ns4a
• 1N1L: crystal structure of hcv ns3 protease domain:ns4a peptide complex with covalently bound inhibitor (gw472467x) (10.1021/OL027014P )
• 1NS3: structure of hcv protease (bk strain)
• 1RGQ: m9a hcv protease complex with pentapeptide keto-amide inhibitor (10.1016/J.ABB.2003.11.013 )
• 1RTL: crystal structure of hcv ns3 protease domain: ns4a peptide complex with covalently bound pyrrolidine-5,5-translactam inhibitor (10.1021/OL035826V )
• 1W3C: crystal structure of the hepatitis c virus ns3 protease in complex with a peptidomimetic inhibitor (10.1021/JM049435D )
• 2A4G: hepatitis c protease ns3-4a serine protease with ketoamide inhibitor sch225724 bound (10.1016/J.BMCL.2005.06.091 )
• 2A4Q: hcv ns3 protease with ns4a peptide and a covalently bound macrocyclic ketoamide compound. (10.1016/J.BMCL.2005.07.033 )
• 2A4R: hcv ns3 protease domain with a ketoamide inhibitor covalently bound. (10.1016/J.BMCL.2005.07.009 )
• 2F55: two hepatitis c virus ns3 helicase domains complexed with the same strand of dna (10.1074/JBC.M512100200 )
• 2F9U: hcv ns3 protease domain with ns4a peptide and a ketoamide inhibitor with a p2 norborane (10.1016/J.BMCL.2005.12.046 )
• 2F9V: hcv ns3 protease domain with ns4a peptide and a ketoamide inhibitor with p1 and p2 cyclopropylalannines (10.1016/J.BMCL.2005.12.013 )
• 2FM2: hcv ns3-4a protease domain complexed with a ketoamide inhibitor, sch446211 (10.1074/JBC.M510246200 )
• 2GVF: hcv ns3-4a protease domain complexed with a macrocyclic ketoamide inhibitor, sch419021 (10.1016/J.BMCL.2006.05.022 )
• 2K1Q: nmr structure of hepatitis c virus ns3 serine protease complexed with the non-covalently bound phenethylamide inhibitor (10.1016/J.JMB.2008.11.017 )
• 2O8M: crystal structure of the s139a mutant of hepatitis c virus ns3/4a protease (10.1021/JM060173K )
• 2OBO: structure of hepatitis c viral ns3 protease domain complexed with ns4a peptide and ketoamide sch476776 2 1 source title (10.1021/JM060173K )
• 2OBQ: discovery of the hcv ns3/4a protease inhibitor sch503034. key steps in structure-based optimization (10.1021/JM060173K )
• 2OC0: structure of ns3 complexed with a ketoamide inhibitor sch491762 (10.1021/JM060173K )
• 2OC1: structure of the hcv ns3/4a protease inhibitor cvs4819 (10.1021/JM060173K )
• 2OC7: structure of hepatitis c viral ns3 protease domain complexed with ns4a peptide and ketoamide sch571696 (10.1021/JM060173K )
• 2OC8: structure of hepatitis c viral ns3 protease domain complexed with ns4a peptide and ketoamide sch503034 (10.1021/JM060173K )
• 2OIN: crystal structure of hcv ns3-4a r155k muntant (10.1074/JBC.M610207200 )
• 2P59: crystal structure of hepatitis c virus ns3.4a protease (10.1016/J.BMCL.2007.03.090 )
• 2QV1: crystal structure of hcv ns3-4a v36m mutant
• 2XCF: crystal structure of hcv ns3 protease with a boronate inhibitor (10.1016/J.BMCL.2010.04.129 )
• 2XCN: crystal structure of hcv ns3 protease with a boronate inhibitor (10.1016/J.BMCL.2010.04.129 )
• 2XNI: protein-ligand complex of a novel macrocyclic hcv ns3 protease inhibitor derived from amino cyclic boronates (10.1016/J.BMCL.2010.08.022 )
• 2ZJO: crystal structure of hepatitis c virus ns3 helicase with a novel inhibitor
• 3EYD: structure of hcv ns3-4a protease with an inhibitor derived from a boronic acid (10.1016/J.BMCL.2008.10.124 )
• 3KEE: hcv ns3/ns4a complexed with non-covalent macrocyclic compound tmc435 (10.1002/ANIE.200906696 )
• 3KF2: the hcv ns3/ns4a protease apo structure (10.1002/ANIE.200906696 )
• 3KN2: hcv ns3 protease domain with ketoamide inhibitor (10.1016/J.BMCL.2009.11.094 )
• 3KNX: hcv ns3 protease domain with p1-p3 macrocyclic ketoamide inhibitor (10.1021/JM800940U )
• 3KQH: three conformational snapshots of the hepatitis c virus ns3 helicase reveal a ratchet translocation mechanism (10.1073/PNAS.0913380107 )
• 3KQK: three conformational snapshots of the hepatitis c virus ns3 helicase reveal a ratchet translocation mechanism (10.1073/PNAS.0913380107 )
• 3KQL: three conformational snapshots of the hepatitis c virus ns3 helicase reveal a ratchet translocation mechanism (10.1073/PNAS.0913380107 )
• 3KQN: three conformational snapshots of the hepatitis c virus ns3 helicase reveal a ratchet translocation mechanism (10.1073/PNAS.0913380107 )
• 3KQU: three conformational snapshots of the hepatitis c virus ns3 helicase reveal a ratchet translocation mechanism (10.1073/PNAS.0913380107 )
• 3LON: hcv ns3-4a protease domain with ketoamide inhibitor narlaprevir
• 3LOX: hcv ns3-4a protease domain with a ketoamide inhibitor derivative of boceprevir bound (10.1016/J.BMCL.2010.02.063 )
• 3M5L: crystal structure of hcv ns3/4a protease in complex with itmn-191 (10.1073/PNAS.1006370107 )
• 3M5M: avoiding drug resistance against hcv ns3/4a protease inhibitors (10.1073/PNAS.1006370107 )
• 3M5N: crystal structure of hcv ns3/4a protease in complex with n-terminal product 4b5a (10.1073/PNAS.1006370107 )
• 3M5O: crystal structure of hcv ns3/4a protease in complex with n-terminal product 5a5b (10.1073/PNAS.1006370107 )
• 3O8B: visualizing atp-dependent rna translocation by the ns3 helicase from hcv (10.1016/J.JMB.2010.11.034 )
• 3O8C: visualizing atp-dependent rna translocation by the ns3 helicase from hcv (10.1016/J.JMB.2010.11.034 )
• 3O8D: visualizing atp-dependent rna translocation by the ns3 helicase from hcv (10.1016/J.JMB.2010.11.034 )
• 3O8R: visualizing atp-dependent rna translocation by the ns3 helicase from hcv (10.1016/J.JMB.2010.11.034 )
• 3OYP: hcv ns3/4a in complex with ligand 3 (10.1038/NCHEMBIO.492 )
• 3P8N: crystal structure of hcv ns3/ns4a protease complexed with bi 201335 (10.1074/JBC.M110.211417 )
• 3P8O: crystal structure of hcv ns3/ns4a protease complexed with des-bromine analogue of bi 201335 (10.1074/JBC.M110.211417 )
• 3RC4: molecular mechanisms of viral and host-cell substrate recognition by hcv ns3/4a protease (10.1128/JVI.00377-11 )
• 3RC5: molecular mechanisms of viral and host-cell substrate recognition by hcv ns3/4a protease (10.1128/JVI.00377-11 )
• 3RC6: molecular mechanisms of viral and host-cell substrate recognition by hcv ns3/4a protease (10.1128/JVI.00377-11 )
• 3RVB: the structure of hcv ns3 helicase (heli-80) bound with inhibitor itmn- 3479
• 3SU3: crystal structure of ns3/4a protease in complex with vaniprevir (10.1371/JOURNAL.PPAT.1002832 )
• 3SUD: crystal structure of ns3/4a protease in complex with mk-5172 (10.1371/JOURNAL.PPAT.1002832 )
• 3SUE: crystal structure of ns3/4a protease variant r155k in complex with mk- 5172 (10.1371/JOURNAL.PPAT.1002832 )
• 3SUF: crystal structure of ns3/4a protease variant d168a in complex with mk- 5172 (10.1371/JOURNAL.PPAT.1002832 )
• 3SV6: crystal structure of ns3/4a protease in complex with telaprevir (10.1371/JOURNAL.PPAT.1002832 )
• 3SV7: crystal structure of ns3/4a protease variant r155k in complex with telaprevir (10.1371/JOURNAL.PPAT.1002832 )
• 3SV8: crystal structure of ns3/4a protease variant d168a in complex with telaprevir (10.1371/JOURNAL.PPAT.1002832 )
• 3SV9: crystal structure of ns3/4a protease variant a156t in complex with telaprevir (10.1371/JOURNAL.PPAT.1002832 )
• 4A1T: co-complex of the of ns3-4a protease with the inhibitory peptide cp5- 46-a (in-house data) (10.1074/JBC.M112.393843 )
• 4A1V: co-complex structure of ns3-4a protease with the optimized inhibitory peptide cp5-46a-4d5e (10.1074/JBC.M112.393843 )
• 4A1X: co-complex structure of ns3-4a protease with the inhibitory peptide cp5-46-a (synchrotron data) (10.1074/JBC.M112.393843 )
• 4A92: full-length hcv ns3-4a protease-helicase in complex with a macrocyclic protease inhibitor. (10.1073/PNAS.1110534108 )
• 4B6E: discovery of an allosteric mechanism for the regulation of hcv ns3 protein function (10.1038/NCHEMBIO.1081 )
• 4B6F: discovery of an allosteric mechanism for the regulation of hcv ns3 protein function (10.1038/NCHEMBIO.1081 )
• 4B71: discovery of an allosteric mechanism for the regulation of hcv ns3 protein function (10.1038/NCHEMBIO.1081 )
• 4B73: discovery of an allosteric mechanism for the regulation of hcv ns3 protein function (10.1038/NCHEMBIO.1081 )
• 4B74: discovery of an allosteric mechanism for the regulation of hcv ns3 protein function (10.1038/NCHEMBIO.1081 )
• 4B75: discovery of an allosteric mechanism for the regulation of hcv ns3 protein function (10.1038/NCHEMBIO.1081 )
• 4B76: discovery of an allosteric mechanism for the regulation of hcv ns3 protein function (10.1038/NCHEMBIO.1081 )
• 4I31: crystal structure of hcv ns3/ns4a protease complexed with compound 4 (10.1074/JBC.M112.439455 )
• 4I32: crystal structure of hcv ns3/4a d168v protease complexed with compound 4 (10.1074/JBC.M112.439455 )
• 4I33: crystal structure of hcv ns3/4a r155k protease complexed with compound 4 (10.1074/JBC.M112.439455 )
• 4JMY: crystal structure of hcv ns3/ns4a protease complexed with ddivpc peptide
• 4K8B: crystal structure of hcv ns3/4a protease complexed with inhibitor (10.1021/JM401338C )
• 4KTC: ns3/ns4a protease with inhibitor (10.1021/JM400164C )
• 4NWK: crystal structure of hepatis c virus protease (ns3) complexed with bms-605339 aka n-(tert-butoxycarbonyl)-3-me thyl-l-valyl-(4r)-n-((1r, 2s)-1-((cyclopropylsulfonyl)carba moyl)-2-vinylcyclopropyl)-4-((6- methoxy-1-isoquinolinyl)ox y)-l-prolinamide (10.1021/JM401840S )
• 4NWL: crystal structure of hepatis c virus protease (ns3) complexed with bms-650032 aka n-(tert-butoxycarbonyl)-3-me thyl-l-valyl-(4r)-4-((7- chloro-4-methoxy-1-isoquinolinyl)o xy)-n-((1r,2s)-1- ((cyclopropylsulfonyl)carbamoyl)-2-vinylc yclopropyl)-l-prolinamide (10.1021/JM401840S )
• 4OJQ: crystal structure of hepatitis c virus ns3 helicase inhibitor co- complex with fragment 1 [(5-bromo-1h-indol-3-yl)acetic acid] (10.1021/JM401432C )
• 4OK3: crystal structure of hepatitis c virus ns3 helicase inhibitor co- complex with compound 7 [[1-(3-chlorobenzyl)-1h-indol-3-yl]acetic acid] (10.1021/JM401432C )
• 4OK5: crystal structure of hepatitis c virus ns3 helicase inhibitor co- complex with compound 9 [1-(3-ethynylbenzyl)-1h-indol-3-yl]acetic acid] (10.1021/JM401432C )
• 4OK6: crystal structure of hepatitis c virus ns3 helicase inhibitor co- complex with compound 13 [[1-(2-methoxy-5-nitrobenzyl)-1h-indol-3- yl]acetic acid] (10.1021/JM401432C )
• 4OKS: crystal structure of hepatitis c virus ns3 helicase inhibitor co- complex with compound 19 [[6-(3,5-diaminophenyl)-1-(2-methoxy-5- nitrobenzyl)-1h-indol-3-yl]acetic acid] (10.1021/JM401432C )
• 4TYD: structure-based design of a novel series of azetidine inhibitors of the hepatitis c virus ns3/4a serine protease (10.1016/J.BMCL.2014.08.002 )
• 4U01: hcv ns3/4a serine protease in complex with 6570 (10.1016/J.BMCL.2015.09.009 )
• 4WF8: crystal structure of ns3/4a protease in complex with asunaprevir (10.1021/CB5006118 )
• 4WH6: crystal structure of hcv ns3/4a protease variant r155k in complex with asunaprevir (10.1021/CB5006118 )
• 4WH8: crystal structure of hcv ns3/4a protease in complex with an asunaprevir p1-p3 macrocyclic analog. (10.1021/CB5006118 )
• 4WXP: x-ray crystal structure of ns3 helicase from hcv with a bound fragment inhibitor at 2.08 a resolution
• 4WXR: x-ray crystal structure of ns3 helicase from hcv with a bound inhibitor at 2.42 a resolution
• 5E4F: the spring alpha-helix coordinates multiple modes of hcv ns3 helicase action (10.1074/JBC.M115.704379 )
• 5EPN: crystal structure of hcv ns3/4a protease in complex with 5172-mcp1p3 (mk-5172 p1-p3 macrocyclic analogue) (10.1021/ACSCHEMBIO.5B00647 )
• 5EQQ: crystal structure of hcv ns3/4a wt protease in complex with 5172- linear (mk-5172 linear analogue) (10.1021/ACSCHEMBIO.5B00647 )
• 5EQS: crystal structure of a genotype 1a/3a chimeric hcv ns3/4a protease in complex with asunaprevir (10.1021/JACS.6B06454 )
• 5ETX: crystal structure of hcv ns3/4a protease a156t variant in complex with 5172-linear (mk-5172 linear analogue) (10.1021/ACSCHEMBIO.5B00647 )
• 5FPS: structure of hepatitis c virus (hcv) full-length ns3 complex with small-molecule ligand 3-aminobenzene-1,2-dicarboxylic acid (at1246) in an alternate binding site. (10.1073/PNAS.1518946112 )
• 5FPT: structure of hepatitis c virus (hcv) full-length ns3 complex with small-molecule ligand 2-(1-methyl-1h-indol-3- yl)acetic acid (at3437) in an alternate binding site. (10.1073/PNAS.1518946112 )
• 5FPY: structure of hepatitis c virus (hcv) full-length ns3 complex with small-molecule ligand 5-bromo-1-methyl-1h-indole-2- carboxylic acid (at21457) in an alternate binding site. (10.1073/PNAS.1518946112 )
• 5VOJ: crystal structure of hcv ns3/4a protease in complex with jz01-15, an analogue of 5172-mcp1p3 (10.1021/ACS.JMEDCHEM.7B00426 )
• 5VP9: crystal structure of hcv ns3/4a protease in complex with am-07, an analogue of 5172-mcp1p3 (10.1021/ACS.JMEDCHEM.7B00426 )
• 6BQJ: crystal structure of hepatis c virus protease (ns3) complexed with tripeptidic acyl sulfonamide inhibitor (compound 16) (10.1021/ACSMEDCHEMLETT.7B00503 )
• 6BQK: crystal structure of hepatis c virus protease (ns3) complexed with tripeptidic acyl sulfonamide inhibitor (compound 18) (10.1021/ACSMEDCHEMLETT.7B00503 )
• 6C2M: crystal structure of hcv ns3/4a protease variant y56h in complex with mk-5172
• 6C2O: crystal structure of hcv ns3/4a protease variant y56h in complex with danoprevir
• 6CVW: crystal structure of hcv ns3/4a wt protease in complex with aj-52 (mk- 5172 linear analogue) (10.1021/ACSMEDCHEMLETT.8B00150 )
• 6CVX: crystal structure of hcv ns3/4a wt protease in complex with aj-50 (mk- 5172 linear analogue) (10.1021/ACSMEDCHEMLETT.8B00150 )
• 6CVY: crystal structure of hcv ns3/4a wt protease in complex with aj-21 (mk- 5172 linear analogue) (10.1021/ACSMEDCHEMLETT.8B00150 )
• 6DIQ: crystal structure of hcv ns3/4a protease in complex with p4-p5-1 (wk- 23)
• 6DIR: crystal structure of hcv ns3/4a protease in complex with p4-p5-2 (aj- 67)
• 6DIS: crystal structure of hcv ns3/4a protease in complex with p4-1 (aj-71)
• 6DIT: crystal structure of hcv ns3/4a protease in complex with p4-2 (jz01- 19)
• 6DIU: crystal structure of hcv ns3/4a protease in complex with p4-3(aj-74)
• 6DIV: crystal structure of hcv ns3/4a d168a protease in complex with p4-p5-2 (aj-67)
• 6DIW: crystal structure of hcv ns3/4a d168a protease in complex with p4-1 (aj-71)
• 6FE6: solution structure of a last generation p2-p4 macrocyclic inhibitor
• 6N4N: crystal structure of the designed protein dncr2/danoprevir/ns3a complex (10.1038/S41587-019-0242-8 )
• 6NZT: crystal structure of hcv ns3/4a protease in complex with voxilaprevir (10.1016/J.BMCL.2019.03.037 )
• 6NZV: crystal structure of hcv ns3/4a protease in complex with compound 12 (10.1016/J.BMCL.2019.03.037 )
• 6P6L: hcv ns3/4a protease domain of genotype 1a in complex with glecaprevir
• 6P6M: hcv ns3/4a protease domain of genotype 1a c159 in complex with glecaprevir
• 6P6O: hcv ns3/4a protease domain of genotype 1a d168e in complex with glecaprevir
• 6PIU: crystal structure of hcv ns3/4a d168a protease in complex with p4-p5-6 (nr03-68) (10.1128/MBIO.00172-20 )
• 6PIV: crystal structure of hcv ns3/4a d168a protease in complex with p4-7 (nr03-77) (10.1128/MBIO.00172-20 )
• 6PIW: crystal structure of hcv ns3/4a d168a protease in complex with p4-6 (nr03-67) (10.1128/MBIO.00172-20 )
• 6PIX: crystal structure of hcv ns3/4a d168a protease in complex with p4-p5-5 (wk-25) (10.1128/MBIO.00172-20 )
• 6PIY: crystal structure of hcv ns3/4a d168a protease in complex with p4-2 (nr02-61) (10.1128/MBIO.00172-20 )
• 6PIZ: crystal structure of hcv ns3/4a d168a protease in complex with p4-1 (nr02-24) (10.1128/MBIO.00172-20 )
• 6PJ0: crystal structure of hcv ns3/4a d168a protease in complex with p4-5 (nr01-97) (10.1128/MBIO.00172-20 )
• 6PJ1: crystal structure of hcv ns3/4a d168a protease in complex with p4- 4(aj-74) (10.1128/MBIO.00172-20 )
• 6PJ2: crystal structure of hcv ns3/4a d168a protease in complex with p4-p5-4 (aj-65) (10.1128/MBIO.00172-20 )
• 6UE3: crystal structure of hcv ns3/4a d168a protease in complex with pc (jz01-15) (10.1128/MBIO.00172-20 )
• 6VDL: hcv ns3/4a protease a156t mutant in complex with glecaprevir
• 6VDM: hcv ns3/4a protease a156t, d168e double mutant in complex with glecaprevir
• 6VDN: hcv ns3/4a protease a156t mutant
• 6VDO: hcv ns3/4a protease a156t, d168e double mutant
• 7D5L: discovery of bms-986144, a third generation, pan genotype ns3/4a protease inhibitor for the treatment of hepatitis c virus infection (10.1021/ACS.JMEDCHEM.0C01296 )
• 7L7L: crystal structure of hcv ns3/4a d168a protease in complex with nr01- 129 (10.1021/ACS.JMEDCHEM.1C00554 )
• 7L7N: crystal structure of hcv ns3/4a d168a protease in complex with nr02-59 (10.1021/ACS.JMEDCHEM.1C00554 )
• 7L7O: crystal structure of hcv ns3/4a d168a protease in complex with nr04-49 (10.1021/ACS.JMEDCHEM.1C00554 )
• 7L7P: crystal structure of hcv ns3/4a d168a protease in complex with ch-24 (10.1021/ACS.JMEDCHEM.1C00554 )
• 8OHM: crystal structure of rna helicase from genotype 1b hepatitis c virus: mechanism of unwinding duplex rna (10.1074/JBC.273.24.15045 )