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Choose a Target 11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1) 11-beta-Hydroxysteroid Dehydrogenase 2 (11-beta-HSD2) 15-Lipoxygenase 17-beta-Hydroxysteroid Dehydrogenase 1 (17-beta-HSD1) 17-beta-Hydroxysteroid Dehydrogenase 2 (17-beta-HSD2) 17-beta-Hydroxysteroid Dehydrogenase 5 (17-beta-HSD5, AKR1C3) 20-alpha-Hydroxysteroid Dehydrogenase (AKR1C1) 3-alpha-Hydroxysteroid Dehydrogenase Type 1 (AKR1C4) 3-alpha-Hydroxysteroid Dehydrogenase Type 3 (AKR1C2) 3-Phosphoinositide-Dependent Protein Kinase 1 (PDK1) 5-Lipoxygenase Ab N1G9 Abhydrolase Domain-Containing Protein 6 ABL Acetate Operon Repressor (C-IclR) Acetate Operon Repressor (IclR) Acetylcholinesterase (AChE) Activated Protein C (APC) Acyl Cholesterol Acyltransferase 1 (ACAT-1) ADAMTS-4 (Aggrecanase-1) ADAMTS-5 (Aggrecanase-2) Adenosine A3 Receptor Adenosine Deaminase Adenosine Kinase (AK) Adenosine Phosphosulfate Reductase (APSR) Adenosine Receptor A1 Adenosine Receptor A2A AICAR Tfase Aldehyde Reductase (ALR1) Aldose Reductase (ALR2) Aldosterone Synthase (CYP11B2) Alpha-1 Adrenergic Receptor alpha-Amylase alpha-Glucosidase (alpha-Glu) alpha-Methylacyl-CoA Racemase Alpha2 Adrenoreceptor Aminopeptidase M Androgen Receptor (AR) Angiotensin-Converting Enzyme Angiotensin-Converting Enzyme 2 Anthrax Lethal Factor (LF) apocytochrome b562 Apoptosis Regulator Bcl-2 Apoptosis Regulator Bcl-xL Apurinic-Apyrimidinic Endonuclease 1 (APE1) Aromatase (CYP19) Aryl Hydrocarbon Receptor (AhR) Asparaginyl Endopeptidase (AE) ATP Phosphoribosyltransferase Aurora Kinase A (Aurora-A) Aurora Kinase B (Aurora-B) Aurora Kinase C (Aurora-C) B-Raf Protein Kinase Bacterial Leucyl Aminopeptidase Bacteriophage T4 DNA Ligase Beta-1 Adrenergic Receptor Beta-2 Adrenergic Receptor Beta-3 Adrenergic Receptor beta-Ketoacyl-ACP Synthase III (FabH) beta-Secretase (BACE-1) beta-Secretase (BACE-2) BirA Bifunctional Protein Botulinum Neurotoxin Type A Butyrylcholinesterase (BuChE) C-Raf Protein Kinase Calcium-Sensing Receptor (CaSR) Calpain-1 Calpain-2 CaM Kinase II cAMP-Dependent Protein Kinase (PKA) Cannabinoid Receptor 1 Cannabinoid Receptor 2 Carbonic Anhydrase (hpCA) Carbonic Anhydrase (mtCA 1) Carbonic Anhydrase (mtCA 3) Carbonic Anhydrase I Carbonic Anhydrase II Carbonic Anhydrase III Carbonic Anhydrase IV Carbonic Anhydrase IX Carbonic Anhydrase VA Carbonic Anhydrase VB Carbonic Anhydrase VI Carbonic Anhydrase VII Carbonic Anhydrase XII Carbonic Anhydrase XIII Carbonic Anhydrase XIV Carbonic Anhydrase XV Carboxylesterase 1 Carboxylesterase 2 (intestine, liver) Carboxypeptidase A (CPA) Casein Kinase I Casein Kinase II Caspase-1 Caspase-2 Caspase-3 Caspase-3|IST-1 Complex Caspase-4 Caspase-5 Caspase-6 Caspase-7 Caspase-8 Caspase-9 Cathepsin B Cathepsin B-Like Cysteine Protease (TbcatB) Cathepsin D Cathepsin K Cathepsin L Cathepsin S Cathepsin V Cdc7 Kinase cGMP-Dependent Protein Kinase Checkpoint Kinase (Chk1) Chicken erythrocyte chromatin Chitinase Cholecystokinin-1 Receptor Cholecystokinin-2 Receptor Chymase Chymotrypsin cIAP-1 BIR3 cIAP-2 BIR3 cIAP1-BIR3 cIAP2-BIR3 Collagenase (ChC) Conantokin-G Conantokin-T Corticotropin-releasing Factor Receptor 1 cPLA2 C2 Cyclin-Dependent Kinase 1 (CDK1) Cyclin-Dependent Kinase 2 (CDK2) Cyclin-Dependent Kinase 4 (CDK4) Cyclin-Dependent Kinase 5 (CDK5) Cyclin-Dependent Kinase 6 (CDK6) Cyclin-Dependent Kinase 7 (CDK7) Cyclin-Dependent Kinase 9 (CDK9) Cyclooxygenase-1 Cyclooxygenase-2 Cytochrome P450 1A2 Cytochrome P450 2A6 Cytochrome P450 2B4 Cytochrome P450 2C19 Cytochrome P450 2C9 Cytochrome P450 2D6 Cytochrome P450 3A4 Cytochrome P450 51(CYP51) Cytochrome P450 Reductase (CPR) D-Amino Acid Oxidase (DAAO) Delta Opioid Receptor Diacyl Glycerolacyltransferase 1 (DGAT-1) Diacyl Glycerolacyltransferase 2 (DGAT-2) Dihydrofolate Reductase (DHFR) Dihydrofolate Reductase-Thymidylate Synthase (DHFR-TS) Dihydroorotate Dehydrogenase (DHODH) Dipeptidyl Peptidase II (DPP-II) (QPP) Dipeptidyl Peptidase IV (DPP-IV) Dipeptidyl Peptidase VII (DPP-VII) (QPP) DNA Gyrase DNA Ligase (MtuLigA) DNA Ligase I DNA Polymerase alpha DNA Polymerase gamma DNA polymerase IIIC DNA polymerase IIIE DNA Topoisomerase IV DNA(calf thymus) Dopamine Receptor D2 Dopamine Transporter (DAT) DPP8 DPP9 DYRK1A EGF-R Tyrosine Kinase Endothelin-Converting Enzyme 1 Enoyl-ACP Reductase (FabI) Enoyl-ACP Reductase (FabK) Enoyl-ACP Reductase (InhA) Enoyl-ACP Reductase (PfENR) Epoxide Hydrolase B (EHB) Equilibrative Nucleoside Transporter 1 (ENT1) ErbB-2 (HER2) Tyrosine Kinase ErbB-4 (HER4) Tyrosine Kinase ERK-2 Estrogen Receptor (ER-alpha) Estrogen Receptor (ER-beta) Estrogen-Related Receptor, alpha Estrogen-Related Receptor, gamma Factor IXa (fIXa) Factor VIIa (fVIIa) Factor Xa (fXa) Factor XIa (fXIa) Factor XIIa (fXIIa) FAD-Binding Domain Falcipain-2 Farnesoid X-Activated Receptor Farnesyl Diphosphate Synthase (FPPS) Fatty Acid Amide Hydrolase Fatty Acid Synthase FGFR-1 Tyrosine Kinase FGFR-2 Tyrosine Kinase Fibroblast Activation Protein (FAP) Formyl Peptide Receptor-Like 1 G-protein Coupled Receptor 40 G-protein Coupled Receptor 54 GABAA Receptor, alpha-1, beta-2, gamma-2 GABAA Receptor, alpha-1, beta-3, gamma-2 GABAA Receptor, alpha-2, beta-2, gamma-2 GABAA Receptor, alpha-2, beta-3, gamma-2 GABAA Receptor, alpha-3, beta-2, gamma-2 GABAA Receptor, alpha-3, beta-3, gamma-2 GABAA Receptor, alpha-4, beta-2, gamma-2 GABAA Receptor, alpha-4, beta-3, gamma-2 GABAA Receptor, alpha-5, beta-2, gamma-2 GABAA Receptor, alpha-5, beta-3, gamma-2 GABAA Receptor, alpha-6, beta-2, gamma-2 GABAA Receptor, alpha-6, beta-3, gamma-2 Galectin-1 Galectin-3 Galectin-7 Galectin-8 Galectin-9 gamma-Aminobutyric Acid Type B Receptor Gamma-Secretase GAR Tfase Gastric Inhibitory Polypeptide Receptor (GIPR) Geranylgeranyl Diphosphate Synthase (GGPPS) Geranylgeranyl Transferase (GGTase-I) Ghrelin Receptor (Growth Hormone Secretagogue Receptor Type 1) Glucagon Receptor Glucocerebrosidase (Acid beta-Glucosidase) Glucocorticoid Receptor (GR) Glutamate Carboxypeptidase II (GCPII) Glutaminyl Cyclase Glycogen Phosphorylase A Glycogen Synthase Kinase-3, alpha Glycogen Synthase Kinase-3, beta Glyoxylate Regulatory Protein (C-AllR) GRB2 H1/H5-depleted chromatin HCV NS3 Helicase HCV NS3-NS4A Serine Proteinase Heat Shock Protein 90 (Hsp90) Hepsin hERG Potassium Channel 1 Histamine H1 Receptor Histamine H2 Receptor Histamine H3 Receptor Histamine H4 Receptor Histone Deacetylase (pfHDAC-1) Histone Deacetylase 1 (HDAC1) Histone Deacetylase 10 (HDAC10) Histone Deacetylase 11 (HDAC11) Histone Deacetylase 2 (HDAC2) Histone Deacetylase 3 (HDAC3) Histone Deacetylase 4 (HDAC4) Histone Deacetylase 5 (HDAC5) Histone Deacetylase 6 (HDAC6) Histone Deacetylase 7 (HDAC7) Histone Deacetylase 8 (HDAC8) Histone Lysine Demethylase Histone-Arginine Methyltransferase CARM1 HIV-1 Integrase HIV-1 Nef HIV-1 Protease HIV-1 Protease AE HIV-1 Protease AE-P HIV-1 Reverse Transcriptase HIV-2 Protease HIV-2 Reverse Transcriptase HMG-CoA Reductase Homoisocitrate Dehydrogenase (HICDH) I-kappa-B Kinase 1 (IKK-alpha) I-kappa-B Kinase 2 (IKK-beta) I-kappa-B Kinase 3 (IKK-epsilon) Immunophilin FKBP12 IMP Cyclohydrolase (IMPCH) Indoleamine 2,3-Dioxygenase Inosine Monophosphate Dehydrogenase Type 1 (IMPDH1) Inosine Monophosphate Dehydrogenase Type 2 (IMPDH2) Insulin Receptor Tyrosine Kinase (IRK) Insulin-like Growth Factor 1 Receptor (IGF-1R) Integrin alpha1beta1 Integrin alpha2beta1 Integrin alpha4beta1 (VLA-4) Integrin alpha4beta7 Integrin alpha5beta1 Kallikrein Kappa Opioid Receptor KIAA1363 Kinesin Spindle Protein Eg5 Lactate Dehydrogenase Lck Leucine Aminopeptidase Leukotriene A4 Hydrolase Lipoxygenase-1 Liver Receptor Homolog 1 Liver X Receptor alpha (LXR-alpha) Liver X Receptor beta (LXR-beta) Major Urinary Protein (MUP-1) Malate Dehydrogenase (pfMDH) Malate Dehydrogenase, cytoplasmic Malate Dehydrogenase, mitochondrial Mammalian Target of Rapamycin (mTOR) MAP Kinase Kinase 1 (MEK1) MAP Kinase p38 alpha MAP Kinase p38 beta MAP-Microtubule Affinity-Regulating Kinase 3 (MARK3) MAP4K4 (HGK) Matriptase Matrix Metalloproteinase-1 (MMP-1) Matrix Metalloproteinase-10 (MMP-10) Matrix Metalloproteinase-12 (MMP-12) Matrix Metalloproteinase-13 (MMP-13) Matrix Metalloproteinase-14 (MMP-14) Matrix Metalloproteinase-2 (MMP-2) Matrix Metalloproteinase-3 (MMP-3) Matrix Metalloproteinase-7 (MMP-7) Matrix Metalloproteinase-8 (MMP-8) Matrix Metalloproteinase-9 (MMP-9) Methionine Aminopeptidase (MAP) Methionine Aminopeptidase Type 1 (MetAP1) Methionine Aminopeptidase Type 2 (MetAP2) Methylthioadenosine Nucleosidase(MTAN) Methylthioadenosine Phosphorylase (MTAP) Mineralocorticoid Receptor (MR) Mitogen- and Stress-Activated Protein Kinase 1 (MSK1) Mitogen-Activated Protein Kinase 1 Mitogen-Activated Protein Kinase 10 (JNK3) Mitogen-Activated Protein Kinase 8 (JNK1) Mitogen-Activated Protein Kinase 9 (JNK2) Mixed Lineage Kinase 1 (MLK1) Mixed Lineage Kinase 2 (MLK2) Mixed Lineage Kinase 3 (MLK3) ML-IAP-BIR Monoamine Oxidase Type A (MAO-A) Monoamine Oxidase Type B (MAO-B) Monocarboxylate Transporter 1 Monoglyceride Lipase (MGL) MRCK alpha Mu Opioid Receptor MurD Myosin Light-Chain Kinase NAD-Dependent Deacetylase Sirtuin-1 NAD-Dependent Deacetylase Sirtuin-2 Neuraminidase A Neuraminidase B Neutral Endopeptidase Neutrophil Elastase (NE) Niacin Receptor GPR109A Nitric Oxide Synthase, brain Nitric Oxide Synthase, endothelial Nitric Oxide Synthase, inducible NK1 Receptor Nociceptin Receptor (ORL1 Receptor) Norepinephrine Transporter (NET) Orotidine Monophosphate Decarboxylase (ODCase) Outer Membrane Phospholipase A Papain PDGFR-beta Pepsin Peptide Deformylase Peripheral-Type Benzodiazepine Receptor Peroxisome Proliferator-Activated Receptor alpha Peroxisome Proliferator-Activated Receptor delta Peroxisome Proliferator-Activated Receptor gamma Phenylethanolamine N-Methyltransferase (PNMT) Phosphodiesterase Type 1 (PDE1B) Phosphodiesterase Type 10 (PDE10A) Phosphodiesterase Type 11 (PDE11A) Phosphodiesterase Type 2 (PDE2A) Phosphodiesterase Type 3 (PDE3A) Phosphodiesterase Type 3 (PDE3B) Phosphodiesterase Type 4 (PDE4A) Phosphodiesterase Type 4 (PDE4B) Phosphodiesterase Type 4 (PDE4C) Phosphodiesterase Type 4 (PDE4D) Phosphodiesterase Type 5 (PDE5) Phosphodiesterase Type 5 (PDE5A) Phosphodiesterase Type 6 (PDE6) Phosphodiesterase Type 7 (PDE7B) Phosphodiesterase Type 8 (PDE8A) Phosphodiesterase Type 9 (PDE9A) Phosphoinositide 3-Kinase (PI3K), alpha Phosphoinositide 3-Kinase (PI3K), beta Phosphoinositide 3-Kinase (PI3K), C2beta Phosphoinositide 3-Kinase (PI3K), delta Phosphoinositide 3-Kinase (PI3K), gamma Phosphoinositide 3-Kinase (PI3K), Vps34 Phospholipase A2, major isoenzyme Phospholipase A2, membrane associated Phosphorylase Kinase PIM-1 Kinase PIM-2 Kinase Plasma Kallikrein Plasmepsin I Plasmepsin II Plasmin PLD alpha C2 PLD beta C2 Polo-Like Kinase 1 Polo-Like Kinase 2 Polo-Like Kinase 3 Polo-Like Kinase 4 Poly (ADP-ribose) Polymerase-1 (PARP-1) Poly (ADP-ribose) Polymerase-2 (PARP-2) Pregnane X Receptor Progesterone Receptor (PR) Prokineticin Receptor 1 (PKR1) Prokineticin Receptor 2 (PKR2) Prostacyclin (IP) Receptor Prostaglandin D Synthase Prostaglandin D2 Receptor CRTH2 Protein Farnesyltransferase (PFT) Protein kinase B (Akt 1) Protein kinase B (Akt 2) Protein kinase B (Akt 3) Protein Kinase C Protein Kinase C, alpha Protein Kinase C, beta I Protein Kinase C, beta II Protein Kinase C, delta Protein Kinase C, epsilon Protein Kinase C, eta Protein Kinase C, gamma Protein Kinase C, theta Protein Kinase C, zeta Protein Kinase YpkA Protein Tyrosine Phosphatase CD45 Protein Tyrosine Phosphatase LAR Protein Tyrosine Phosphatase PTPA Protein Tyrosine Phosphatase PTPB Protein Tyrosine Phosphatase TC-PTP Protein Tyrosine Phosphatase VHR Protein-Tyrosine Phosphatase 1B (PTP1B) Protein-Tyrosine Phosphatase SHP-1 Protein-Tyrosine Phosphatase SHP-2 Purine Nucleoside Phosphorylase (PNP) Quinone Reductase 2 (QR2) RAF-1 Receptor Tyrosine Kinase TrkA Receptor Tyrosine Kinase TrkB Renin Rho Transcription Termination Factor Rho-kinase (ROCK I) Rho-kinase (ROCK II) Ribosomal S6 Kinase 1 (RSK-1) Ribosomal S6 Kinase 2 (RSK-2) Ribosomal S6 Kinase 3 (RSK-3) Ribosomal S6 Kinase 4 (RSK-4) RNA(23-mer) Runt-Related Transcription Factor 1 Isoform AML1C S-Adenosylmethionine Decarboxylase (AdoMetDC) SARS Coronavirus 3C-like Protease Serine Hydroxymethyltransferase Serotonin Receptor 1A Serotonin Receptor 1B Serotonin Receptor 1D Serotonin Receptor 2A Serotonin Receptor 2B Serotonin Receptor 2C Serotonin Receptor 4 Serotonin Receptor 6 Serotonin Receptor 7 Serotonin Transporter (SERT) Sodium-Dependent Glucose Cotransporter 1 (SGLT1) Sodium-Dependent Glucose Cotransporter 2 (SGLT2) Sphingosine 1-Phosphate Receptor 1 Sphingosine 1-Phosphate Receptor 2 Sphingosine 1-Phosphate Receptor 3 Sphingosine 1-Phosphate Receptor 4 Sphingosine 1-Phosphate Receptor 5 Src STE20-Like Kinase MST2 Steroid 11-beta-Hydroxylase (CYP11B1) Steroid 17-alpha-Monooxygenase (CYP17) Steroid Sulfatase (STS) Steroidogenic Factor 1 Streptavadin(N23A) Streptavadin(N23E) Streptavadin(S27A) Streptavadin(W108F) Streptavadin(W120F) Streptavadin(W79F) Streptavadin(Y43A) Streptavidin Streptavidin (Y43F) T-Cell Protein-Tyrosine Phosphatase (TCPTP) t-Plasminogen Activator (tPA) Tankyrase-1 TGF-beta Receptor Type-1 TGR5 Thrombin Thromboxane A2 Synthase (P450 TxA2) Thymidine Kinase Thymidine Kinase (TK.dT) Thymidine Phosphorylase (TP) Thymidylate Synthase (TS) Thyroid Hormone Receptor (TR-alpha) Thyroid Hormone Receptor (TR-beta) Tie-2 TNF-alpha-Converting Enzyme Transcription Factor STAT1 Transcription Factor STAT1:STAT3 Dimer Transcription Factor STAT3 Transcriptional Regulator TtgR Transcriptional Regulator TtgR-DNA Triacylglycerol Hydrolase tRNA synthetase (AspRS) tRNA synthetase (GlnRS) tRNA synthetase (GluRS) tRNA synthetase (GlyRS) tRNA synthetase (IleRS) tRNA synthetase (PheRS) tRNA synthetase (TyrRS) Trypanothione Reductase (TryR) Trypsin Tryptase Tumor Progression Loci-2 Kinase (COT) Tyrosine Kinase ACK1 Tyrosine Kinase Axl Tyrosine Kinase BMX Tyrosine Kinase BRK Tyrosine Kinase BTK Tyrosine Kinase c-Kit Tyrosine Kinase c-Met Tyrosine Kinase c-Ret Tyrosine Kinase CSF1-R Tyrosine Kinase CSK Tyrosine Kinase EphB4 Tyrosine Kinase FAK Tyrosine Kinase FLT3 Tyrosine Kinase FRK Tyrosine Kinase FYN Tyrosine Kinase JAK2 Tyrosine Kinase JAK3 Tyrosine Kinase Syk Tyrosine Kinase TrkA Tyrosine Kinase ZAP-70 Tyrosine-protein kinase ITK Tyrosine-Specific Protein Kinase Ubiquitin C-terminal Hydrolase L3 (UCH-L3) UDP-3-O-Acyl-GlcNAc Deacetylase (LpxC) Urea Amidohydrolase Urokinase (uPA) v-Src SH2 Domain Vanilloid Receptor 1 (TRPV1, VR1) VEGFR-1 (Flt-1) VEGFR-2 (KDR) VEGFR-3 (FLT4) West Nile Virus (WNV) NS2B-NS3 Protease XIAP-BIR3 Protein/small molecule only

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BindingDB is beginning to incorporate quantatitive binding data from PubChem assays. See http://www.bindingdb.org/bind/ByPCBioAssay.jsp

BindingDB is a public, web-accessible database of measured binding affinities, focusing chiefly on the interactions of protein considered to be drug-targets with small, drug-like molecules.

What's new: data entered within the last 30 days

BindingDB Affinity Statistics

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References

1. Liu,T., Lin,Y., Wen,X., Jorrisen, R.N. and Gilson,M.K. BindingDB: a web-accessible database of experimentally determined protein-ligand binding affinities Nucleic Acids Research 35:D198-D201 (2007).    [pdf]
2. Chen,X., Lin,Y. and Gilson,M.K. The Binding Database: Overview and User's Guide Biopolymers Nucleic Acid Sci. 61:127-141 (2002).
3. Chen,X., Lin,Y., Liu,M. and Gilson,M.K. The Binding Database: Data Management and Interface Design Bioinformatics 18:130-139(2002).
4. Chen,X., Liu,M., and Gilson,M.K. Binding DB: A web-accessible molecular recognition database J. Combi. Chem. High-Throughput Screen 4:719-725 (2001).