BindingDB is a public, web-accessible database of measured binding affinities, focusing chiefly on the interactions of protein considered to be drug-targets with small, drug-like molecules.
On-line virtual screening tools allow you to upload a set of active compounds or build one on BindingDB, and then upload your own compound catalog and rank the compounds by likelihood of activity.
What's new: data entered within the last 30 days
BindingDB Affinity Statistics
Monthly Growth of Data Holdings
References
- Liu,T., Lin,Y., Wen,X., Jorrisen, R.N. and Gilson,M.K. BindingDB: a web-accessible database of experimentally determined protein-ligand binding affinities Nucleic Acids Research 35:D198-D201 (2007). [pdf]
- Chen,X., Lin,Y. and Gilson,M.K. The Binding Database: Overview and User's Guide Biopolymers Nucleic Acid Sci. 61:127-141 (2002).
- Chen,X., Lin,Y., Liu,M. and Gilson,M.K. The Binding Database: Data Management and Interface Design Bioinformatics 18:130-139(2002).
- Chen,X., Liu,M., and Gilson,M.K. Binding DB: A web-accessible molecular recognition database J. Combi. Chem. High-Throughput Screen 4:719-725 (2001).
July, 2007. SDFile of all BindingDB compounds, with target and affinity data, made available for download. The SDfile format is documented here.
May, 2007. BindingDB Structure Search enhanced.
December, 2006. BindingDB paper published in database issue of Nucleic Acids Research.
May, 2006. Capability to search PDB for molecules in BindingDB introduced.
May, 2006. BindingDB appears in Drug Discovery News.
April, 2006. User forum for BindingDB opens.
March, 2006. BindingDB presented in Science magazine's Netwatch.
December, 2005. On-line virtual screening tools go live.
May, 2005. Start of service for downloading SDfiles from BindingDB queries.