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Found 192 with Last Name = 'abou-zeid' and Initial = 'la'
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Mansoura University

Curated by ChEMBL
LigandPNGBDBM50531540(CHEBI:75998 | GSK-1120212 | GSK1120212 | JTP 74057...)
Affinity DataIC50:  0.700nMAssay Description:Inhibition of MEK1 (unknown origin)More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Mansoura University

Curated by ChEMBL
LigandPNGBDBM50363397(CHEMBL1946170 | REGORAFENIB | US10183928, Regorafe...)
Affinity DataIC50:  4.20nMAssay Description:Inhibition of VEGFR2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetDual specificity mitogen-activated protein kinase kinase 2(Homo sapiens (Human))
Mansoura University

Curated by ChEMBL
LigandPNGBDBM50531540(CHEBI:75998 | GSK-1120212 | GSK1120212 | JTP 74057...)
Affinity DataIC50:  15nMAssay Description:Inhibition of MEK2 (unknown origin)More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Mansoura University

Curated by ChEMBL
LigandPNGBDBM5447(CHEMBL939 | GEFITINIB | Iressa | N-(3-Chloro-4-flu...)
Affinity DataIC50:  18nMAssay Description:Inhibition of EGFR in human RPMI-8226 cells incubated for 2 hrs by ELISAMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Mansoura University

Curated by ChEMBL
LigandPNGBDBM50535309(CHEMBL4582195)
Affinity DataIC50:  27nMAssay Description:Inhibition of human VEGFR2 in human A549 cells incubated for over night by ELISA methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Mansoura University

Curated by ChEMBL
LigandPNGBDBM26474(5-({4-[(2,3-dimethyl-2H-indazol-6-yl)(methyl)amino...)
Affinity DataIC50:  30nMAssay Description:Inhibition of VEGFR2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetEpidermal growth factor receptor(Homo sapiens (Human))
Mansoura University

Curated by ChEMBL
LigandPNGBDBM50551188(CHEMBL4778826)
Affinity DataIC50:  36nMAssay Description:Inhibition of EGFR in human RPMI-8226 cells incubated for 2 hrs by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Mansoura University

Curated by ChEMBL
LigandPNGBDBM21(CHEMBL24828 | N-(4-bromo-2-fluorophenyl)-6-methoxy...)
Affinity DataIC50:  40nMAssay Description:Inhibition of VEGFR2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 8(Homo sapiens (Human))
Mansoura University

Curated by ChEMBL
LigandPNGBDBM50551188(CHEMBL4778826)
Affinity DataIC50:  47nMAssay Description:Inhibition of HDAC8 in human RPMI-8226 cells incubated for 2 hrs by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Mansoura University

Curated by ChEMBL
LigandPNGBDBM50535325(CHEMBL4437943)
Affinity DataIC50:  54nMAssay Description:Inhibition of human HER2 in human A549 cells by ELISA methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTranscription factor p65(Homo sapiens (Human))
Mansoura University

Curated by ChEMBL
LigandPNGBDBM5447(CHEMBL939 | GEFITINIB | Iressa | N-(3-Chloro-4-flu...)
Affinity DataIC50:  55nMAssay Description:Inhibition of NFkappaB p65 in human RPMI-8226 cells incubated for 2 hrs by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Mansoura University

Curated by ChEMBL
LigandPNGBDBM16673(4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamo...)
Affinity DataIC50:  57nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged EGFR (695 to end) expressed in baculovirus infected Sf9 cells using ATP as substrate after 40 m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Mansoura University

Curated by ChEMBL
LigandPNGBDBM50535314(CHEMBL4437803)
Affinity DataIC50:  64nMAssay Description:Inhibition of human HER2 in human A549 cells by ELISA methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Mansoura University

Curated by ChEMBL
LigandPNGBDBM5446(CHEMBL553 | ERLOTINIB HYDROCHLORIDE | Erlotinib | ...)
Affinity DataIC50:  64nMAssay Description:Inhibition of human HER2 in human A549 cells by ELISA methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Mansoura University

Curated by ChEMBL
LigandPNGBDBM50535325(CHEMBL4437943)
Affinity DataIC50:  70nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged EGFR (695 to end) expressed in baculovirus infected Sf9 cells using ATP as substrate after 40 m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 8(Homo sapiens (Human))
Mansoura University

Curated by ChEMBL
LigandPNGBDBM50069989((R)-3-methyl-1-((S)-3-phenyl-2-(pyrazine-2-carboxa...)
Affinity DataIC50:  72nMAssay Description:Inhibition of HDAC8 in human RPMI-8226 cells incubated for 2 hrs by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
King Saud University

Curated by ChEMBL
LigandPNGBDBM18050(2-[(4-{[(2,4-diaminopteridin-6-yl)methyl](methyl)a...)
Affinity DataIC50:  80nMAssay Description:Inhibition of human DHFR after 2 minsMore data for this Ligand-Target Pair
TargetDihydrofolate reductase(Bos taurus (Cattle))
King Saud University

Curated by ChEMBL
LigandPNGBDBM18050(2-[(4-{[(2,4-diaminopteridin-6-yl)methyl](methyl)a...)
Affinity DataIC50:  80nMAssay Description:Inhibition of bovine DHFR after 2 minsMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Mansoura University

Curated by ChEMBL
LigandPNGBDBM4814(CHEMBL535 | N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fl...)
Affinity DataIC50:  80nMAssay Description:Inhibition of VEGFR2 (unknown origin)More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Mansoura University

Curated by ChEMBL
LigandPNGBDBM50535309(CHEMBL4582195)
Affinity DataIC50:  84nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged EGFR (695 to end) expressed in baculovirus infected Sf9 cells using ATP as substrate after 40 m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Mansoura University

Curated by ChEMBL
LigandPNGBDBM50535314(CHEMBL4437803)
Affinity DataIC50:  87nMAssay Description:Inhibition of human VEGFR2 in human A549 cells incubated for over night by ELISA methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Mansoura University

Curated by ChEMBL
LigandPNGBDBM16673(4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamo...)
Affinity DataIC50:  90nMAssay Description:Inhibition of VEGFR2 (unknown origin)More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Mansoura University

Curated by ChEMBL
LigandPNGBDBM50535325(CHEMBL4437943)
Affinity DataIC50:  94nMAssay Description:Inhibition of human VEGFR2 in human A549 cells incubated for over night by ELISA methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Mansoura University

Curated by ChEMBL
LigandPNGBDBM50535330(CHEMBL4466088)
Affinity DataIC50:  96nMAssay Description:Inhibition of human VEGFR2 in human A549 cells incubated for over night by ELISA methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Mansoura University

Curated by ChEMBL
LigandPNGBDBM50535323(CHEMBL4543044)
Affinity DataIC50:  96nMAssay Description:Inhibition of human VEGFR2 in human A549 cells incubated for over night by ELISA methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Mansoura University

Curated by ChEMBL
LigandPNGBDBM50535318(CHEMBL4584717)
Affinity DataIC50:  100nMAssay Description:Inhibition of human VEGFR2 in human A549 cells incubated for over night by ELISA methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Mansoura University

Curated by ChEMBL
LigandPNGBDBM50535309(CHEMBL4582195)
Affinity DataIC50:  104nMAssay Description:Inhibition of human HER2 in human A549 cells by ELISA methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Mansoura University

Curated by ChEMBL
LigandPNGBDBM16673(4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamo...)
Affinity DataIC50:  105nMAssay Description:Inhibition of VEGFR2 in human RPMI-8226 cells incubated for 2 hrs by ELISAMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Mansoura University

Curated by ChEMBL
LigandPNGBDBM50535324(CHEMBL4443510)
Affinity DataIC50:  113nMAssay Description:Inhibition of human VEGFR2 in human A549 cells incubated for over night by ELISA methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Mansoura University

Curated by ChEMBL
LigandPNGBDBM50535327(CHEMBL4521454)
Affinity DataIC50:  115nMAssay Description:Inhibition of human VEGFR2 in human A549 cells incubated for over night by ELISA methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Mansoura University

Curated by ChEMBL
LigandPNGBDBM50535313(CHEMBL4536372)
Affinity DataIC50:  120nMAssay Description:Inhibition of human VEGFR2 in human A549 cells incubated for over night by ELISA methodMore data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetTranscription factor p65(Homo sapiens (Human))
Mansoura University

Curated by ChEMBL
LigandPNGBDBM50551188(CHEMBL4778826)
Affinity DataIC50:  134nMAssay Description:Inhibition of NFkappaB p65 in human RPMI-8226 cells incubated for 2 hrs by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Mansoura University

Curated by ChEMBL
LigandPNGBDBM50535314(CHEMBL4437803)
Affinity DataIC50:  147nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged EGFR (695 to end) expressed in baculovirus infected Sf9 cells using ATP as substrate after 40 m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Mansoura University

Curated by ChEMBL
LigandPNGBDBM50535316(CHEMBL4558158)
Affinity DataIC50:  160nMAssay Description:Inhibition of human VEGFR2 in human A549 cells incubated for over night by ELISA methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Mansoura University

Curated by ChEMBL
LigandPNGBDBM50535321(CHEMBL4513911)
Affinity DataIC50:  160nMAssay Description:Inhibition of human VEGFR2 in human A549 cells incubated for over night by ELISA methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Mansoura University

Curated by ChEMBL
LigandPNGBDBM16673(4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamo...)
Affinity DataIC50:  180nMAssay Description:Inhibition of human VEGFR2 in human A549 cells incubated for over night by ELISA methodMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Mansoura University

Curated by ChEMBL
LigandPNGBDBM50535319(CHEMBL4449758)
Affinity DataIC50:  200nMAssay Description:Inhibition of human VEGFR2 in human A549 cells incubated for over night by ELISA methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Mansoura University

Curated by ChEMBL
LigandPNGBDBM50535326(CHEMBL4529255)
Affinity DataIC50:  200nMAssay Description:Inhibition of human VEGFR2 in human A549 cells incubated for over night by ELISA methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Mansoura University

Curated by ChEMBL
LigandPNGBDBM50535320(CHEMBL4467322)
Affinity DataIC50:  221nMAssay Description:Inhibition of human VEGFR2 in human A549 cells incubated for over night by ELISA methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Mansoura University

Curated by ChEMBL
LigandPNGBDBM50535322(CHEMBL4570460)
Affinity DataIC50:  286nMAssay Description:Inhibition of human VEGFR2 in human A549 cells incubated for over night by ELISA methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Ovis aries (Sheep))
King Saud University

Curated by ChEMBL
LigandPNGBDBM11639(4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyraz...)
Affinity DataIC50:  300nMAssay Description:Inhibition of ovine COX2 using arachidonic acid as substrate preincubated for 5 mins followed by substrate addition by ELISAMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Ovis aries (Sheep))
King Saud University

Curated by ChEMBL
LigandPNGBDBM11639(4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyraz...)
Affinity DataIC50:  300nMAssay Description:Inhibition of ovine COX2 assessed as reduction in PGH2-dervied PGF2alpha production preincubated for 5 mins followed by addition of arachidonic acid ...More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Mansoura University

Curated by ChEMBL
LigandPNGBDBM50535331(CHEMBL4465496)
Affinity DataIC50:  302nMAssay Description:Inhibition of human VEGFR2 in human A549 cells incubated for over night by ELISA methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Mansoura University

Curated by ChEMBL
LigandPNGBDBM50535310(CHEMBL4436488)
Affinity DataIC50:  319nMAssay Description:Inhibition of human VEGFR2 in human A549 cells incubated for over night by ELISA methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Ovis aries (Sheep))
King Saud University

Curated by ChEMBL
LigandPNGBDBM11639(4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyraz...)
Affinity DataIC50:  330nMAssay Description:Inhibition of ovine COX2 assessed as reduction in PGF2alpha production using arachidonic acid as substrate preincubated with enzyme for 5 mins follow...More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Ovis aries (Sheep))
King Saud University

Curated by ChEMBL
LigandPNGBDBM50180630(CHEMBL3814616)
Affinity DataIC50:  330nMAssay Description:Inhibition of ovine COX2 using arachidonic acid as substrate preincubated for 5 mins followed by substrate addition by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Mansoura University

Curated by ChEMBL
LigandPNGBDBM50551188(CHEMBL4778826)
Affinity DataIC50:  388nMAssay Description:Inhibition of VEGFR2 in human RPMI-8226 cells incubated for 2 hrs by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Mansoura University

Curated by ChEMBL
LigandPNGBDBM50535312(CHEMBL4469407)
Affinity DataIC50:  396nMAssay Description:Inhibition of human VEGFR2 in human A549 cells incubated for over night by ELISA methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Bos taurus (Cattle))
King Saud University

Curated by ChEMBL
LigandPNGBDBM50316117(2-Allylthio-3-benzyl-6-diallylamino-quinazolin-4(3...)
Affinity DataIC50:  400nMAssay Description:Inhibition of bovine DHFR after 2 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Ovis aries (Sheep))
King Saud University

Curated by ChEMBL
LigandPNGBDBM50180632(CHEMBL3813998)
Affinity DataIC50:  400nMAssay Description:Inhibition of ovine COX2 using arachidonic acid as substrate preincubated for 5 mins followed by substrate addition by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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