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Found 262 with Last Name = 'ahlfors' and Initial = 'j'
TargetCaspase-3(Homo sapiens (Human))
Genesis Technologies

US Patent
LigandPNGBDBM160788(US10167313, Compound 55 | US9045524, 55)
Affinity DataIC50:  10nMAssay Description:Selectivity of compound 55, compound 63, compound 48, compound 57, compound 88 toward caspase-1 (pro-inflammatory group), caspase-5 (group I), caspas...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCaspase-3(Homo sapiens (Human))
Genesis Technologies

US Patent
LigandPNGBDBM160781(US10167313, Compound 48 | US9045524, 48)
Affinity DataIC50:  10nMAssay Description:Selectivity of compound 55, compound 63, compound 48, compound 57, compound 88 toward caspase-1 (pro-inflammatory group), caspase-5 (group I), caspas...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCaspase-3(Homo sapiens (Human))
Genesis Technologies

US Patent
LigandPNGBDBM160798(US10167313, Compound 65 | US9045524, 65)
Affinity DataIC50:  10nMAssay Description:Selectivity of compound 55, compound 63, compound 48, compound 57, compound 88 toward caspase-1 (pro-inflammatory group), caspase-5 (group I), caspas...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCaspase-3(Homo sapiens (Human))
Genesis Technologies

US Patent
LigandPNGBDBM160781(US10167313, Compound 48 | US9045524, 48)
Affinity DataIC50:  10nMAssay Description:Selectivity of compound 55, compound 63, compound 48, compound 57, compound 88 toward caspase-1 (pro-inflammatory group), caspase-5 (group I), caspas...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCaspase-3(Homo sapiens (Human))
Genesis Technologies

US Patent
LigandPNGBDBM160798(US10167313, Compound 65 | US9045524, 65)
Affinity DataIC50:  10nMAssay Description:To test the efficacy of caspase-3 inhibitors at the cellular level, the ability of selected compounds to inhibit the proteolytic cleavage of PARP (po...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCaspase-3(Homo sapiens (Human))
Genesis Technologies

US Patent
LigandPNGBDBM160788(US10167313, Compound 55 | US9045524, 55)
Affinity DataIC50:  10nMAssay Description:To test the efficacy of caspase-3 inhibitors at the cellular level, the ability of selected compounds to inhibit the proteolytic cleavage of PARP (po...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCaspase-3(Homo sapiens (Human))
Genesis Technologies

US Patent
LigandPNGBDBM160781(US10167313, Compound 48 | US9045524, 48)
Affinity DataIC50:  10nMAssay Description:To test the efficacy of caspase-3 inhibitors at the cellular level, the ability of selected compounds to inhibit the proteolytic cleavage of PARP (po...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCaspase-3(Homo sapiens (Human))
Genesis Technologies

US Patent
LigandPNGBDBM160792(US10167313, Compound 59 | US9045524, 59)
Affinity DataIC50:  20nMAssay Description:To test the efficacy of caspase-3 inhibitors at the cellular level, the ability of selected compounds to inhibit the proteolytic cleavage of PARP (po...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCaspase-3(Homo sapiens (Human))
Genesis Technologies

US Patent
LigandPNGBDBM160792(US10167313, Compound 59 | US9045524, 59)
Affinity DataIC50:  20nMAssay Description:Selectivity of compound 55, compound 63, compound 48, compound 57, compound 88 toward caspase-1 (pro-inflammatory group), caspase-5 (group I), caspas...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCaspase-3(Homo sapiens (Human))
Genesis Technologies

US Patent
LigandPNGBDBM160790(US10167313, Compound 57 | US9045524, 57)
Affinity DataIC50:  30nMAssay Description:Selectivity of compound 55, compound 63, compound 48, compound 57, compound 88 toward caspase-1 (pro-inflammatory group), caspase-5 (group I), caspas...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCaspase-3(Homo sapiens (Human))
Genesis Technologies

US Patent
LigandPNGBDBM160816(US10167313, Compound 85 | US9045524, 85)
Affinity DataIC50:  30nMAssay Description:To test the efficacy of caspase-3 inhibitors at the cellular level, the ability of selected compounds to inhibit the proteolytic cleavage of PARP (po...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCaspase-3(Homo sapiens (Human))
Genesis Technologies

US Patent
LigandPNGBDBM160790(US10167313, Compound 57 | US9045524, 57)
Affinity DataIC50:  30nMAssay Description:To test the efficacy of caspase-3 inhibitors at the cellular level, the ability of selected compounds to inhibit the proteolytic cleavage of PARP (po...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCaspase-3(Homo sapiens (Human))
Genesis Technologies

US Patent
LigandPNGBDBM160816(US10167313, Compound 85 | US9045524, 85)
Affinity DataIC50:  30nMAssay Description:Selectivity of compound 55, compound 63, compound 48, compound 57, compound 88 toward caspase-1 (pro-inflammatory group), caspase-5 (group I), caspas...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCaspase-3(Homo sapiens (Human))
Genesis Technologies

US Patent
LigandPNGBDBM160808(US10167313, Compound 76 | US9045524, 76)
Affinity DataIC50:  30nMAssay Description:To test the efficacy of caspase-3 inhibitors at the cellular level, the ability of selected compounds to inhibit the proteolytic cleavage of PARP (po...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCaspase-3(Homo sapiens (Human))
Genesis Technologies

US Patent
LigandPNGBDBM160808(US10167313, Compound 76 | US9045524, 76)
Affinity DataIC50:  30nMAssay Description:Selectivity of compound 55, compound 63, compound 48, compound 57, compound 88 toward caspase-1 (pro-inflammatory group), caspase-5 (group I), caspas...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCaspase-3(Homo sapiens (Human))
Genesis Technologies

US Patent
LigandPNGBDBM160796(US10167313, Compound 63 | US9045524, 63)
Affinity DataIC50:  40nMAssay Description:To test the efficacy of caspase-3 inhibitors at the cellular level, the ability of selected compounds to inhibit the proteolytic cleavage of PARP (po...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCaspase-7(Homo sapiens (Human))
Novagenesis Foundation

US Patent
LigandPNGBDBM160792(US10167313, Compound 59 | US9045524, 59)
Affinity DataIC50:  40nMT: 2°CAssay Description:Selectivity of compound 55, compound 63, compound 48, compound 57, compound 88 toward caspase-1 (pro-inflammatory group), caspase-5 (group I), caspas...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCaspase-3(Homo sapiens (Human))
Genesis Technologies

US Patent
LigandPNGBDBM160819(US10167313, Compound 88 | US9045524, 88)
Affinity DataIC50:  40nMAssay Description:To test the efficacy of caspase-3 inhibitors at the cellular level, the ability of selected compounds to inhibit the proteolytic cleavage of PARP (po...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCaspase-7(Homo sapiens (Human))
Novagenesis Foundation

US Patent
LigandPNGBDBM160792(US10167313, Compound 59 | US9045524, 59)
Affinity DataIC50:  40nMAssay Description:Selectivity of compound 55, compound 63, compound 48, compound 57, compound 88 toward caspase-1 (pro-inflammatory group), caspase-5 (group I), caspas...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCaspase-3(Homo sapiens (Human))
Genesis Technologies

US Patent
LigandPNGBDBM160819(US10167313, Compound 88 | US9045524, 88)
Affinity DataIC50:  40nMAssay Description:Selectivity of compound 55, compound 63, compound 48, compound 57, compound 88 toward caspase-1 (pro-inflammatory group), caspase-5 (group I), caspas...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCaspase-3(Homo sapiens (Human))
Genesis Technologies

US Patent
LigandPNGBDBM160796(US10167313, Compound 63 | US9045524, 63)
Affinity DataIC50:  40nMAssay Description:Selectivity of compound 55, compound 63, compound 48, compound 57, compound 88 toward caspase-1 (pro-inflammatory group), caspase-5 (group I), caspas...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCaspase-3(Homo sapiens (Human))
Genesis Technologies

US Patent
LigandPNGBDBM160849(US9045524, 123)
Affinity DataIC50:  60nMAssay Description:The inhibition of the activity of Caspase-1 to -10 by four different compounds (#53, #111, #123 & Z-DEVD-FMK used as a prodrug: z-D(OMe)E(OMe)VD(OMe)...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCaspase-3(Homo sapiens (Human))
Genesis Technologies

US Patent
LigandPNGBDBM160786(US10167313, Compound 53 | US9045524, 53)
Affinity DataIC50:  60nMAssay Description:To test the efficacy of caspase-3 inhibitors at the cellular level, the ability of selected compounds to inhibit the proteolytic cleavage of PARP (po...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCaspase-3(Homo sapiens (Human))
Genesis Technologies

US Patent
LigandPNGBDBM160786(US10167313, Compound 53 | US9045524, 53)
Affinity DataIC50:  60nMAssay Description:Selectivity of compound 55, compound 63, compound 48, compound 57, compound 88 toward caspase-1 (pro-inflammatory group), caspase-5 (group I), caspas...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCaspase-3(Homo sapiens (Human))
Genesis Technologies

US Patent
LigandPNGBDBM160841(US9045524, 111)
Affinity DataIC50:  80nMAssay Description:The inhibition of the activity of Caspase-1 to -10 by four different compounds (#53, #111, #123 & Z-DEVD-FMK used as a prodrug: z-D(OMe)E(OMe)VD(OMe)...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCaspase-3(Homo sapiens (Human))
Genesis Technologies

US Patent
LigandPNGBDBM160786(US10167313, Compound 53 | US9045524, 53)
Affinity DataIC50:  90nMAssay Description:The inhibition of the activity of Caspase-1 to -10 by four different compounds (#53, #111, #123 & Z-DEVD-FMK used as a prodrug: z-D(OMe)E(OMe)VD(OMe)...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCaspase-3(Homo sapiens (Human))
Genesis Technologies

US Patent
LigandPNGBDBM160804(US9045524, 71)
Affinity DataIC50:  100nMAssay Description:To test the efficacy of caspase-3 inhibitors at the cellular level, the ability of selected compounds to inhibit the proteolytic cleavage of PARP (po...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCaspase-3(Homo sapiens (Human))
Genesis Technologies

US Patent
LigandPNGBDBM160802(US10167313, Compound 69 | US9045524, 69)
Affinity DataIC50:  100nMAssay Description:To test the efficacy of caspase-3 inhibitors at the cellular level, the ability of selected compounds to inhibit the proteolytic cleavage of PARP (po...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCaspase-3(Homo sapiens (Human))
Genesis Technologies

US Patent
LigandPNGBDBM160802(US10167313, Compound 69 | US9045524, 69)
Affinity DataIC50:  100nMAssay Description:Selectivity of compound 55, compound 63, compound 48, compound 57, compound 88 toward caspase-1 (pro-inflammatory group), caspase-5 (group I), caspas...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCaspase-3(Homo sapiens (Human))
Genesis Technologies

US Patent
LigandPNGBDBM314073(US10167313, Compound 71 | Z-Asp-(D,L Ala(2'-quinol...)
Affinity DataIC50:  100nMAssay Description:Selectivity of compound 55, compound 63, compound 48, compound 57, compound 88 toward caspase-1 (pro-inflammatory group), caspase-5 (group I), caspas...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCaspase-3(Homo sapiens (Human))
Genesis Technologies

US Patent
LigandPNGBDBM160801(US10167313, Compound 68 | US9045524, 68)
Affinity DataIC50:  200nMAssay Description:To test the efficacy of caspase-3 inhibitors at the cellular level, the ability of selected compounds to inhibit the proteolytic cleavage of PARP (po...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCaspase-3(Homo sapiens (Human))
Genesis Technologies

US Patent
LigandPNGBDBM160801(US10167313, Compound 68 | US9045524, 68)
Affinity DataIC50:  200nMAssay Description:Selectivity of compound 55, compound 63, compound 48, compound 57, compound 88 toward caspase-1 (pro-inflammatory group), caspase-5 (group I), caspas...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCaspase-7(Homo sapiens (Human))
Novagenesis Foundation

US Patent
LigandPNGBDBM160790(US10167313, Compound 57 | US9045524, 57)
Affinity DataIC50:  200nMAssay Description:Selectivity of compound 55, compound 63, compound 48, compound 57, compound 88 toward caspase-1 (pro-inflammatory group), caspase-5 (group I), caspas...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCaspase-3(Homo sapiens (Human))
Genesis Technologies

US Patent
LigandPNGBDBM160799(US10167313, Compound 66 | US9045524, 66)
Affinity DataIC50:  200nMAssay Description:Selectivity of compound 55, compound 63, compound 48, compound 57, compound 88 toward caspase-1 (pro-inflammatory group), caspase-5 (group I), caspas...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCaspase-7(Homo sapiens (Human))
Novagenesis Foundation

US Patent
LigandPNGBDBM160790(US10167313, Compound 57 | US9045524, 57)
Affinity DataIC50:  200nMT: 2°CAssay Description:Selectivity of compound 55, compound 63, compound 48, compound 57, compound 88 toward caspase-1 (pro-inflammatory group), caspase-5 (group I), caspas...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCaspase-3(Homo sapiens (Human))
Genesis Technologies

US Patent
LigandPNGBDBM160799(US10167313, Compound 66 | US9045524, 66)
Affinity DataIC50:  200nMAssay Description:To test the efficacy of caspase-3 inhibitors at the cellular level, the ability of selected compounds to inhibit the proteolytic cleavage of PARP (po...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCaspase-9(Homo sapiens (Human))
Genesis Technologies

US Patent
LigandPNGBDBM160798(US10167313, Compound 65 | US9045524, 65)
Affinity DataIC50:  300nMAssay Description:Selectivity of compound 55, compound 63, compound 48, compound 57, compound 88 toward caspase-1 (pro-inflammatory group), caspase-5 (group I), caspas...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCaspase-3(Homo sapiens (Human))
Genesis Technologies

US Patent
LigandPNGBDBM314076(US10167313, Compound 70 | Z-Asp-(D,L Ala(2'-quinol...)
Affinity DataIC50:  300nMAssay Description:Selectivity of compound 55, compound 63, compound 48, compound 57, compound 88 toward caspase-1 (pro-inflammatory group), caspase-5 (group I), caspas...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCaspase-9(Homo sapiens (Human))
Genesis Technologies

US Patent
LigandPNGBDBM160798(US10167313, Compound 65 | US9045524, 65)
Affinity DataIC50:  300nMT: 2°CAssay Description:Selectivity of compound 55, compound 63, compound 48, compound 57, compound 88 toward caspase-1 (pro-inflammatory group), caspase-5 (group I), caspas...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCaspase-3(Homo sapiens (Human))
Genesis Technologies

US Patent
LigandPNGBDBM160803(US9045524, 70)
Affinity DataIC50:  300nMAssay Description:To test the efficacy of caspase-3 inhibitors at the cellular level, the ability of selected compounds to inhibit the proteolytic cleavage of PARP (po...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCaspase-3(Homo sapiens (Human))
Genesis Technologies

US Patent
LigandPNGBDBM160813(US10167313, Compound 82 | US9045524, 82)
Affinity DataIC50:  300nMAssay Description:To test the efficacy of caspase-3 inhibitors at the cellular level, the ability of selected compounds to inhibit the proteolytic cleavage of PARP (po...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCaspase-3(Homo sapiens (Human))
Genesis Technologies

US Patent
LigandPNGBDBM160813(US10167313, Compound 82 | US9045524, 82)
Affinity DataIC50:  300nMAssay Description:Selectivity of compound 55, compound 63, compound 48, compound 57, compound 88 toward caspase-1 (pro-inflammatory group), caspase-5 (group I), caspas...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCaspase-7(Homo sapiens (Human))
Novagenesis Foundation

US Patent
LigandPNGBDBM160781(US10167313, Compound 48 | US9045524, 48)
Affinity DataIC50:  400nMAssay Description:Selectivity of compound 55, compound 63, compound 48, compound 57, compound 88 toward caspase-1 (pro-inflammatory group), caspase-5 (group I), caspas...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCaspase-1(Homo sapiens (Human))
Genesis Technologies

US Patent
LigandPNGBDBM160781(US10167313, Compound 48 | US9045524, 48)
Affinity DataIC50:  400nMAssay Description:Selectivity of compound 55, compound 63, compound 48, compound 57, compound 88 toward caspase-1 (pro-inflammatory group), caspase-5 (group I), caspas...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCaspase-7(Homo sapiens (Human))
Novagenesis Foundation

US Patent
LigandPNGBDBM160781(US10167313, Compound 48 | US9045524, 48)
Affinity DataIC50:  400nMT: 2°CAssay Description:Selectivity of compound 55, compound 63, compound 48, compound 57, compound 88 toward caspase-1 (pro-inflammatory group), caspase-5 (group I), caspas...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCaspase-7(Homo sapiens (Human))
Novagenesis Foundation

US Patent
LigandPNGBDBM160798(US10167313, Compound 65 | US9045524, 65)
Affinity DataIC50:  400nMAssay Description:Selectivity of compound 55, compound 63, compound 48, compound 57, compound 88 toward caspase-1 (pro-inflammatory group), caspase-5 (group I), caspas...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCaspase-7(Homo sapiens (Human))
Novagenesis Foundation

US Patent
LigandPNGBDBM160781(US10167313, Compound 48 | US9045524, 48)
Affinity DataIC50:  400nMAssay Description:Selectivity of compound 55, compound 63, compound 48, compound 57, compound 88 toward caspase-1 (pro-inflammatory group), caspase-5 (group I), caspas...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCaspase-7(Homo sapiens (Human))
Novagenesis Foundation

US Patent
LigandPNGBDBM160798(US10167313, Compound 65 | US9045524, 65)
Affinity DataIC50:  400nMT: 2°CAssay Description:Selectivity of compound 55, compound 63, compound 48, compound 57, compound 88 toward caspase-1 (pro-inflammatory group), caspase-5 (group I), caspas...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCaspase-9(Homo sapiens (Human))
Genesis Technologies

US Patent
LigandPNGBDBM160781(US10167313, Compound 48 | US9045524, 48)
Affinity DataIC50:  500nMAssay Description:Selectivity of compound 55, compound 63, compound 48, compound 57, compound 88 toward caspase-1 (pro-inflammatory group), caspase-5 (group I), caspas...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCaspase-9(Homo sapiens (Human))
Genesis Technologies

US Patent
LigandPNGBDBM160792(US10167313, Compound 59 | US9045524, 59)
Affinity DataIC50:  500nMAssay Description:Selectivity of compound 55, compound 63, compound 48, compound 57, compound 88 toward caspase-1 (pro-inflammatory group), caspase-5 (group I), caspas...More data for this Ligand-Target Pair
In DepthDetails US Patent
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