TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Institute Of Science And Technology
Curated by ChEMBL
Institute Of Science And Technology
Curated by ChEMBL
Affinity DataKi: 3.40E+3nMAssay Description:Inhibition of interaction between fluorescein-labeled proline hydroxylated human HIFalpha (556 to 575) and human VHL-human elongin B-human elongin C ...More data for this Ligand-Target Pair
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Institute Of Science And Technology
Curated by ChEMBL
Institute Of Science And Technology
Curated by ChEMBL
Affinity DataKi: 3.70E+3nMAssay Description:Inhibition of interaction between fluorescein-labeled proline hydroxylated human HIFalpha (556 to 575) and human VHL-human elongin B-human elongin C ...More data for this Ligand-Target Pair
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Institute Of Science And Technology
Curated by ChEMBL
Institute Of Science And Technology
Curated by ChEMBL
Affinity DataKi: 5.80E+3nMAssay Description:Inhibition of interaction between fluorescein-labeled proline hydroxylated human HIFalpha (556 to 575) and human VHL-human elongin B-human elongin C ...More data for this Ligand-Target Pair
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Institute Of Science And Technology
Curated by ChEMBL
Institute Of Science And Technology
Curated by ChEMBL
Affinity DataKi: 1.30E+4nMAssay Description:Inhibition of interaction between fluorescein-labeled proline hydroxylated human HIFalpha (556 to 575) and human VHL-human elongin B-human elongin C ...More data for this Ligand-Target Pair
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Institute Of Science And Technology
Curated by ChEMBL
Institute Of Science And Technology
Curated by ChEMBL
Affinity DataKi: 1.50E+4nMAssay Description:Inhibition of interaction between fluorescein-labeled proline hydroxylated human HIFalpha (556 to 575) and human VHL-human elongin B-human elongin C ...More data for this Ligand-Target Pair
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Institute Of Science And Technology
Curated by ChEMBL
Institute Of Science And Technology
Curated by ChEMBL
Affinity DataKi: 1.60E+4nMAssay Description:Inhibition of interaction between fluorescein-labeled proline hydroxylated human HIFalpha (556 to 575) and human VHL-human elongin B-human elongin C ...More data for this Ligand-Target Pair
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Institute Of Science And Technology
Curated by ChEMBL
Institute Of Science And Technology
Curated by ChEMBL
Affinity DataKi: 1.80E+4nMAssay Description:Inhibition of interaction between fluorescein-labeled proline hydroxylated human HIFalpha (556 to 575) and human VHL-human elongin B-human elongin C ...More data for this Ligand-Target Pair
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Institute Of Science And Technology
Curated by ChEMBL
Institute Of Science And Technology
Curated by ChEMBL
Affinity DataKi: 5.00E+4nMAssay Description:Inhibition of interaction between fluorescein-labeled proline hydroxylated human HIFalpha (556 to 575) and human VHL-human elongin B-human elongin C ...More data for this Ligand-Target Pair
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Institute Of Science And Technology
Curated by ChEMBL
Institute Of Science And Technology
Curated by ChEMBL
Affinity DataKi: 5.80E+4nMAssay Description:Inhibition of interaction between fluorescein-labeled proline hydroxylated human HIFalpha (556 to 575) and human VHL-human elongin B-human elongin C ...More data for this Ligand-Target Pair
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Institute Of Science And Technology
Curated by ChEMBL
Institute Of Science And Technology
Curated by ChEMBL
Affinity DataKi: 7.70E+4nMAssay Description:Inhibition of interaction between fluorescein-labeled proline hydroxylated human HIFalpha (556 to 575) and human VHL-human elongin B-human elongin C ...More data for this Ligand-Target Pair
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Institute Of Science And Technology
Curated by ChEMBL
Institute Of Science And Technology
Curated by ChEMBL
Affinity DataKi: 1.09E+5nMAssay Description:Inhibition of interaction between fluorescein-labeled proline hydroxylated human HIFalpha (556 to 575) and human VHL-human elongin B-human elongin C ...More data for this Ligand-Target Pair
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Institute Of Science And Technology
Curated by ChEMBL
Institute Of Science And Technology
Curated by ChEMBL
Affinity DataKi: >5.00E+5nMAssay Description:Inhibition of interaction between fluorescein-labeled proline hydroxylated human HIFalpha (556 to 575) and human VHL-human elongin B-human elongin C ...More data for this Ligand-Target Pair
Affinity DataIC50: 0.00100nMAssay Description:This Example illustrates that exemplary compounds of the present invention inhibit the phosphorylation of ERK downstream of KRAS G12D. AGS cells (ATC...More data for this Ligand-Target Pair
Affinity DataIC50: <0.00200nMAssay Description:This Example illustrates that exemplary compounds of the present invention inhibit the phosphorylation of ERK downstream of KRAS G12D. AGS cells (ATC...More data for this Ligand-Target Pair
Affinity DataIC50: <0.00200nMAssay Description:This Example illustrates that exemplary compounds of the present invention inhibit the phosphorylation of ERK downstream of KRAS G12D. AGS cells (ATC...More data for this Ligand-Target Pair
Affinity DataIC50: <0.00200nMAssay Description:This Example illustrates that exemplary compounds of the present invention inhibit the phosphorylation of ERK downstream of KRAS G12D. AGS cells (ATC...More data for this Ligand-Target Pair
Affinity DataIC50: <0.00200nMAssay Description:This Example illustrates that exemplary compounds of the present invention inhibit the phosphorylation of ERK downstream of KRAS G12D. AGS cells (ATC...More data for this Ligand-Target Pair
Affinity DataIC50: <0.00200nMAssay Description:This Example illustrates that exemplary compounds of the present invention inhibit the phosphorylation of ERK downstream of KRAS G12D. AGS cells (ATC...More data for this Ligand-Target Pair
Affinity DataIC50: <0.00200nMAssay Description:This Example illustrates that exemplary compounds of the present invention inhibit the phosphorylation of ERK downstream of KRAS G12D. AGS cells (ATC...More data for this Ligand-Target Pair
Affinity DataIC50: 0.00600nMAssay Description:This Example illustrates that exemplary compounds of the present invention inhibit the phosphorylation of ERK downstream of KRAS G12D. AGS cells (ATC...More data for this Ligand-Target Pair
Affinity DataIC50: 0.00700nMAssay Description:This Example illustrates that exemplary compounds of the present invention inhibit the phosphorylation of ERK downstream of KRAS G12D. AGS cells (ATC...More data for this Ligand-Target Pair
Affinity DataIC50: 0.0120nMAssay Description:This Example illustrates that exemplary compounds of the present invention inhibit the phosphorylation of ERK downstream of KRAS G12D. AGS cells (ATC...More data for this Ligand-Target Pair
Affinity DataIC50: 0.0270nMAssay Description:This Example illustrates that exemplary compounds of the present invention inhibit the phosphorylation of ERK downstream of KRAS G12D. AGS cells (ATC...More data for this Ligand-Target Pair
Affinity DataIC50: 0.0620nMAssay Description:This Example illustrates that exemplary compounds of the present invention inhibit the phosphorylation of ERK downstream of KRAS G12D. AGS cells (ATC...More data for this Ligand-Target Pair
Affinity DataIC50: 0.100nMAssay Description:Table 2: The ability of a compound to bind to KRAS G12D was measured using a TR-FRET displacement assay. Biotinylated GDP-loaded recombinant human KR...More data for this Ligand-Target Pair
Affinity DataIC50: 0.100nMAssay Description:This Example illustrates that exemplary compounds of the present invention inhibit the phosphorylation of ERK downstream of KRAS G12D. AGS cells (ATC...More data for this Ligand-Target Pair
Affinity DataIC50: 0.200nMAssay Description:This Example illustrates that exemplary compounds of the present invention inhibit the phosphorylation of ERK downstream of KRAS G12D. AGS cells (ATC...More data for this Ligand-Target Pair
Affinity DataIC50: 0.200nMAssay Description:Table 2: The ability of a compound to bind to KRAS G12D was measured using a TR-FRET displacement assay. Biotinylated GDP-loaded recombinant human KR...More data for this Ligand-Target Pair
Affinity DataIC50: 0.300nMAssay Description:This Example illustrates that exemplary compounds of the present invention inhibit the phosphorylation of ERK downstream of KRAS G12D. AGS cells (ATC...More data for this Ligand-Target Pair
Affinity DataIC50: 0.300nMAssay Description:Table 2: The ability of a compound to bind to KRAS G12D was measured using a TR-FRET displacement assay. Biotinylated GDP-loaded recombinant human KR...More data for this Ligand-Target Pair
Affinity DataIC50: 0.340nMAssay Description:A competitive displacement assay was configured for B-Raf that monitors the amount of a fluorescently-tagged “tracer” bound to B-Raf via TR-FRET from...More data for this Ligand-Target Pair
Affinity DataIC50: 0.340nMAssay Description:A competitive displacement assay was configured for B-Raf that monitors the amount of a fluorescently-tagged “tracer” bound to B-Raf via TR-FRET from...More data for this Ligand-Target Pair
Affinity DataIC50: 0.400nMAssay Description:This Example illustrates that exemplary compounds of the present invention inhibit the phosphorylation of ERK downstream of KRAS G12D. AGS cells (ATC...More data for this Ligand-Target Pair
Affinity DataIC50: 0.400nMAssay Description:This Example illustrates that exemplary compounds of the present invention inhibit the phosphorylation of ERK downstream of KRAS G12D. AGS cells (ATC...More data for this Ligand-Target Pair
Affinity DataIC50: 0.400nMAssay Description:Table 2: The ability of a compound to bind to KRAS G12D was measured using a TR-FRET displacement assay. Biotinylated GDP-loaded recombinant human KR...More data for this Ligand-Target Pair
Affinity DataIC50: 0.400nMAssay Description:Table 2: The ability of a compound to bind to KRAS G12D was measured using a TR-FRET displacement assay. Biotinylated GDP-loaded recombinant human KR...More data for this Ligand-Target Pair
Affinity DataIC50: 0.400nMAssay Description:Table 2: The ability of a compound to bind to KRAS G12D was measured using a TR-FRET displacement assay. Biotinylated GDP-loaded recombinant human KR...More data for this Ligand-Target Pair
Affinity DataIC50: 0.400nMAssay Description:This Example illustrates that exemplary compounds of the present invention inhibit the phosphorylation of ERK downstream of KRAS G12D. AGS cells (ATC...More data for this Ligand-Target Pair
Affinity DataIC50: 0.400nMAssay Description:Table 2: The ability of a compound to bind to KRAS G12D was measured using a TR-FRET displacement assay. Biotinylated GDP-loaded recombinant human KR...More data for this Ligand-Target Pair
Affinity DataIC50: 0.400nMAssay Description:Table 2: The ability of a compound to bind to KRAS G12D was measured using a TR-FRET displacement assay. Biotinylated GDP-loaded recombinant human KR...More data for this Ligand-Target Pair
Affinity DataIC50: 0.400nMAssay Description:Table 2: The ability of a compound to bind to KRAS G12D was measured using a TR-FRET displacement assay. Biotinylated GDP-loaded recombinant human KR...More data for this Ligand-Target Pair
Affinity DataIC50: 0.400nMAssay Description:This Example illustrates that exemplary compounds of the present invention inhibit the phosphorylation of ERK downstream of KRAS G12D. AGS cells (ATC...More data for this Ligand-Target Pair
Affinity DataIC50: 0.400nMAssay Description:This Example illustrates that exemplary compounds of the present invention inhibit the phosphorylation of ERK downstream of KRAS G12D. AGS cells (ATC...More data for this Ligand-Target Pair
Affinity DataIC50: 0.400nMAssay Description:This Example illustrates that exemplary compounds of the present invention inhibit the phosphorylation of ERK downstream of KRAS G12D. AGS cells (ATC...More data for this Ligand-Target Pair
Affinity DataIC50: 0.460nMAssay Description:A competitive displacement assay was configured for B-Raf that monitors the amount of a fluorescently-tagged “tracer” bound to B-Raf via TR-FRET from...More data for this Ligand-Target Pair
Affinity DataIC50: 0.460nMAssay Description:A competitive displacement assay was configured for B-Raf that monitors the amount of a fluorescently-tagged “tracer” bound to B-Raf via TR-FRET from...More data for this Ligand-Target Pair
Affinity DataIC50: 0.5nMAssay Description:This Example illustrates that exemplary compounds of the present invention inhibit the phosphorylation of ERK downstream of KRAS G12D. AGS cells (ATC...More data for this Ligand-Target Pair
Affinity DataIC50: 0.5nMAssay Description:This Example illustrates that exemplary compounds of the present invention inhibit the phosphorylation of ERK downstream of KRAS G12D. AGS cells (ATC...More data for this Ligand-Target Pair
Affinity DataIC50: 0.5nMAssay Description:This Example illustrates that exemplary compounds of the present invention inhibit the phosphorylation of ERK downstream of KRAS G12D. AGS cells (ATC...More data for this Ligand-Target Pair
Affinity DataIC50: 0.5nMAssay Description:This Example illustrates that exemplary compounds of the present invention inhibit the phosphorylation of ERK downstream of KRAS G12D. AGS cells (ATC...More data for this Ligand-Target Pair