Found 91 with Last Name = 'ambrus' and Initial = 'g' 
Affinity DataKi: 1nMAssay Description:Inhibition of catalytic activity of human cloned COMT expressed in Escherichia coli using [3H]-S-adenosylmethionine as substrate after 20 mins by liq...More data for this Ligand-Target Pair
Affinity DataKi: 1.20nMAssay Description:Compound was tested in vitro for binding affinity against Alpha-2A adrenergic receptor from cloned human C-10 receptor transfected into Chinese hamst...More data for this Ligand-Target Pair
Affinity DataKi: 1.5nMAssay Description:Inhibition of catalytic activity of rat COMT expressed in Escherichia coli using [3H]-S-adenosylmethionine as substrate after 20 mins by liquid scint...More data for this Ligand-Target Pair
3D Structure (crystal)Affinity DataKi: 1.5nMAssay Description:Inhibition of catalytic activity of mouse COMT expressed in Escherichia coli using [3H]-S-adenosylmethionine as substrate after 20 mins by liquid sci...More data for this Ligand-Target Pair
Affinity DataKi: 2nMAssay Description:Compound was tested in vitro for binding affinity against Alpha-2A adrenergic receptor from cloned human C-10 receptor transfected into Chinese hamst...More data for this Ligand-Target Pair
Affinity DataKi: 2.90nMAssay Description:Compound was tested in vitro for binding affinity against Alpha-2A adrenergic receptor from cloned human C-10 receptor transfected into Chinese hamst...More data for this Ligand-Target Pair
Affinity DataKi: 3.80nMAssay Description:Compound was tested in vitro for binding affinity against Alpha-2A adrenergic receptor from cloned human C-10 receptor transfected into Chinese hamst...More data for this Ligand-Target Pair
Affinity DataKi: 4.80nMAssay Description:Compound was tested in vitro for binding affinity against Alpha-2B adrenergic receptor from cloned rat RNG receptor transfected into Chinese hamster ...More data for this Ligand-Target Pair
Affinity DataKi: 8.30nMAssay Description:Compound was tested in vitro for binding affinity against Alpha-2B adrenergic receptor from cloned rat RNG receptor transfected into Chinese hamster ...More data for this Ligand-Target Pair
Affinity DataKi: 8.90nMAssay Description:Compound was tested in vitro for binding affinity against Alpha-2C adrenergic receptor from cloned human C-2 receptor transfected into Chinese hamste...More data for this Ligand-Target Pair
Affinity DataKi: 9.60nMAssay Description:Compound was tested in vitro for binding affinity against Alpha-2A adrenergic receptor from cloned human C-10 receptor transfected into Chinese hamst...More data for this Ligand-Target Pair
Affinity DataKi: 17nMAssay Description:Compound was tested in vitro for binding affinity against Alpha-2B adrenergic receptor from cloned rat RNG receptor transfected into Chinese hamster ...More data for this Ligand-Target Pair
Affinity DataKi: 27nMAssay Description:Compound was tested in vitro for binding affinity against Alpha-2C adrenergic receptor from cloned human C-2 receptor transfected into Chinese hamste...More data for this Ligand-Target Pair
Affinity DataKi: 30nMAssay Description:Compound was tested in vitro for binding affinity against Alpha-2C adrenergic receptor from cloned human C-2 receptor transfected into Chinese hamste...More data for this Ligand-Target Pair
Affinity DataKi: 30nMAssay Description:Compound was tested in vitro for binding affinity against Alpha-2C adrenergic receptor from cloned human C-2 receptor transfected into Chinese hamste...More data for this Ligand-Target Pair
Affinity DataKi: 30nMAssay Description:Compound was tested in vitro for binding affinity against Alpha-2B adrenergic receptor from cloned rat RNG receptor transfected into Chinese hamster ...More data for this Ligand-Target Pair
Affinity DataKi: 120nMAssay Description:Compound was tested in vitro for binding affinity against Alpha-2C adrenergic receptor from cloned human C-2 receptor transfected into Chinese hamste...More data for this Ligand-Target Pair
Affinity DataKi: 140nMAssay Description:Compound was tested in vitro for binding affinity against Alpha-2B adrenergic receptor from cloned rat RNG receptor transfected into Chinese hamster ...More data for this Ligand-Target Pair
Affinity DataKi: 6.30E+3nMAssay Description:Inhibition of catalytic activity of human cloned COMT expressed in Escherichia coli using [3H]-S-adenosylmethionine as substrate after 20 mins by liq...More data for this Ligand-Target Pair
Affinity DataKi: 7.90E+3nMAssay Description:Inhibition of catalytic activity of human cloned COMT expressed in Escherichia coli using [3H]-S-adenosylmethionine as substrate after 20 mins by liq...More data for this Ligand-Target Pair
Affinity DataKi: 2.50E+4nMAssay Description:Inhibition of catalytic activity of human cloned COMT expressed in Escherichia coli using [3H]-S-adenosylmethionine as substrate after 20 mins by liq...More data for this Ligand-Target Pair
Affinity DataKi: 6.30E+4nMAssay Description:Inhibition of catalytic activity of mouse COMT expressed in Escherichia coli using [3H]-S-adenosylmethionine as substrate after 20 mins by liquid sci...More data for this Ligand-Target Pair
Affinity DataKi: 1.58E+5nMAssay Description:Inhibition of catalytic activity of rat COMT expressed in Escherichia coli using [3H]-S-adenosylmethionine as substrate after 20 mins by liquid scint...More data for this Ligand-Target Pair
Affinity DataKi: 2.51E+5nMAssay Description:Inhibition of catalytic activity of human cloned COMT expressed in Escherichia coli using [3H]-S-adenosylmethionine as substrate after 20 mins by liq...More data for this Ligand-Target Pair
TargetNACHT, LRR and PYD domains-containing protein 3(Homo sapiens (Human))
Jecure Therapeutics
Curated by ChEMBL
Jecure Therapeutics
Curated by ChEMBL
Affinity DataIC50: 5.40nMAssay Description:Inhibition of NLRP3 inflammasome activation in LPS and nigericin-stimulated human PBMC cells assessed as reduction in IL-1beta release preincubated w...More data for this Ligand-Target Pair
TargetNACHT, LRR and PYD domains-containing protein 3(Homo sapiens (Human))
Jecure Therapeutics
Curated by ChEMBL
Jecure Therapeutics
Curated by ChEMBL
Affinity DataIC50: 12nMAssay Description:Inhibition of NLRP3 inflammasome activation in LPS and nigericin-stimulated human PBMC cells assessed as reduction in IL-1beta release preincubated w...More data for this Ligand-Target Pair
TargetNACHT, LRR and PYD domains-containing protein 3(Homo sapiens (Human))
Jecure Therapeutics
Curated by ChEMBL
Jecure Therapeutics
Curated by ChEMBL
Affinity DataIC50: 13nMAssay Description:Inhibition of NLRP3 inflammasome activation in LPS and nigericin-stimulated human PBMC cells assessed as reduction in IL-1beta release preincubated w...More data for this Ligand-Target Pair
TargetNACHT, LRR and PYD domains-containing protein 3(Homo sapiens (Human))
Jecure Therapeutics
Curated by ChEMBL
Jecure Therapeutics
Curated by ChEMBL
Affinity DataIC50: 16nMAssay Description:Inhibition of NLRP3 inflammasome activation in LPS-stimulated human monocyte-derived macrophage assessed as reduction in ILbeta secretion in presence...More data for this Ligand-Target Pair
TargetNACHT, LRR and PYD domains-containing protein 3(Homo sapiens (Human))
Jecure Therapeutics
Curated by ChEMBL
Jecure Therapeutics
Curated by ChEMBL
Affinity DataIC50: 17nMAssay Description:Inhibition of NLRP3 inflammasome activation in LPS-stimulated human monocyte-derived macrophage assessed as reduction in ILbeta secretion in presence...More data for this Ligand-Target Pair
TargetNACHT, LRR and PYD domains-containing protein 3(Homo sapiens (Human))
Jecure Therapeutics
Curated by ChEMBL
Jecure Therapeutics
Curated by ChEMBL
Affinity DataIC50: 17nMAssay Description:Inhibition of NLRP3 inflammasome activation in LPS-stimulated human monocyte-derived macrophage assessed as reduction in IL-18 secretion in presence ...More data for this Ligand-Target Pair
TargetNACHT, LRR and PYD domains-containing protein 3(Homo sapiens (Human))
Jecure Therapeutics
Curated by ChEMBL
Jecure Therapeutics
Curated by ChEMBL
Affinity DataIC50: 17nMAssay Description:Inhibition of NLRP3 inflammasome activation in LPS-stimulated human monocyte-derived macrophage assessed as reduction in IL-18 secretion in presence ...More data for this Ligand-Target Pair
TargetNACHT, LRR and PYD domains-containing protein 3(Homo sapiens (Human))
Jecure Therapeutics
Curated by ChEMBL
Jecure Therapeutics
Curated by ChEMBL
Affinity DataIC50: 29nMAssay Description:Inhibition of NLRP3 inflammasome activation in LPS and nigericin-stimulated human PBMC cells assessed as reduction in IL-1beta release preincubated w...More data for this Ligand-Target Pair
TargetNACHT, LRR and PYD domains-containing protein 3(Homo sapiens (Human))
Jecure Therapeutics
Curated by ChEMBL
Jecure Therapeutics
Curated by ChEMBL
Affinity DataIC50: 48nMAssay Description:Inhibition of NLRP3 inflammasome activation in LPS/nigericin stimulated human THP1-ASC-GFP cells assessed as decrease in ASC speck formation preincub...More data for this Ligand-Target Pair
TargetNACHT, LRR and PYD domains-containing protein 3(Homo sapiens (Human))
Jecure Therapeutics
Curated by ChEMBL
Jecure Therapeutics
Curated by ChEMBL
Affinity DataIC50: 51nMAssay Description:Inhibition of NLRP3 induced caspase 1 activity in LPS/nigericin-treated human THP-1 cells preincubated with LPS for 3 hrs followed by compound additi...More data for this Ligand-Target Pair
Affinity DataIC50: 62nMAssay Description:Inhibition of human N-terminal His6-tagged TEV protease site linked DHPS expressed in Escherichia coli BL21 (DE3) assessed as reduction in radiolabel...More data for this Ligand-Target Pair
TargetNACHT, LRR and PYD domains-containing protein 3(Mus musculus)
Jecure Therapeutics
Curated by ChEMBL
Jecure Therapeutics
Curated by ChEMBL
Affinity DataIC50: 63nMAssay Description:Inhibition of NLRP3 induced IL-1beta release in LPS/nigericin-treated mouse BMDM cells preincubated with LPS for 3 hrs followed by compound addition ...More data for this Ligand-Target Pair
TargetNACHT, LRR and PYD domains-containing protein 3(Homo sapiens (Human))
Jecure Therapeutics
Curated by ChEMBL
Jecure Therapeutics
Curated by ChEMBL
Affinity DataIC50: 63nMAssay Description:Inhibition of NLRP3 inflammasome activation in LPS and nigericin-stimulated human PBMC cells assessed as reduction in IL-1beta release preincubated w...More data for this Ligand-Target Pair
TargetNACHT, LRR and PYD domains-containing protein 3(Homo sapiens (Human))
Jecure Therapeutics
Curated by ChEMBL
Jecure Therapeutics
Curated by ChEMBL
Affinity DataIC50: 86nMAssay Description:Inhibition of NLRP3 inflammasome activation in LPS and nigericin-stimulated human PBMC cells assessed as reduction in IL-1beta release preincubated w...More data for this Ligand-Target Pair
Affinity DataIC50: 92nMAssay Description:Inhibition of human N-terminal His6-tagged TEV protease site linked DHPS expressed in Escherichia coli BL21 (DE3) assessed as reduction in radiolabel...More data for this Ligand-Target Pair
TargetNACHT, LRR and PYD domains-containing protein 3(Mus musculus)
Jecure Therapeutics
Curated by ChEMBL
Jecure Therapeutics
Curated by ChEMBL
Affinity DataIC50: 100nMAssay Description:Inhibition of NLRP3 inflammasome activation in LPS and ATP-stimulated mouse whole blood assessed as reduction in IL-1beta release preincubated for 3 ...More data for this Ligand-Target Pair
Affinity DataIC50: 120nMAssay Description:Inhibition of human N-terminal His6-tagged TEV protease site linked DHPS expressed in Escherichia coli BL21 (DE3) assessed as reduction in radiolabel...More data for this Ligand-Target Pair
Affinity DataIC50: 140nMAssay Description:Inhibition of human N-terminal His6-tagged TEV protease site linked DHPS expressed in Escherichia coli BL21 (DE3) assessed as reduction in radiolabel...More data for this Ligand-Target Pair
TargetNACHT, LRR and PYD domains-containing protein 3(Homo sapiens (Human))
Jecure Therapeutics
Curated by ChEMBL
Jecure Therapeutics
Curated by ChEMBL
Affinity DataIC50: 210nMAssay Description:Inhibition of NLRP3 inflammasome activation in LPS and nigericin-stimulated human PBMC cells assessed as reduction in IL-1beta release preincubated w...More data for this Ligand-Target Pair
TargetNACHT, LRR and PYD domains-containing protein 3(Homo sapiens (Human))
Jecure Therapeutics
Curated by ChEMBL
Jecure Therapeutics
Curated by ChEMBL
Affinity DataIC50: 290nMAssay Description:Inhibition of NLRP3 inflammasome activation in LPS-stimulated human whole blood assessed as reduction in ILbeta secretion in presence of calcium pyro...More data for this Ligand-Target Pair
TargetNACHT, LRR and PYD domains-containing protein 3(Homo sapiens (Human))
Jecure Therapeutics
Curated by ChEMBL
Jecure Therapeutics
Curated by ChEMBL
Affinity DataIC50: 340nMAssay Description:Inhibition of NLRP3 inflammasome activation in LPS and nigericin-stimulated human PBMC cells assessed as reduction in IL-1beta release preincubated w...More data for this Ligand-Target Pair
TargetNACHT, LRR and PYD domains-containing protein 3(Homo sapiens (Human))
Jecure Therapeutics
Curated by ChEMBL
Jecure Therapeutics
Curated by ChEMBL
Affinity DataIC50: 380nMAssay Description:Inhibition of NLRP3 inflammasome activation in LPS-stimulated human whole blood assessed as reduction in ILbeta secretion in presence of monosodium u...More data for this Ligand-Target Pair
TargetNACHT, LRR and PYD domains-containing protein 3(Homo sapiens (Human))
Jecure Therapeutics
Curated by ChEMBL
Jecure Therapeutics
Curated by ChEMBL
Affinity DataIC50: 400nMAssay Description:Inhibition of NLRP3 inflammasome activation in LPS and ATP-stimulated human whole blood assessed as reduction in IL-1beta release in plasma preincuba...More data for this Ligand-Target Pair
TargetNACHT, LRR and PYD domains-containing protein 3(Homo sapiens (Human))
Jecure Therapeutics
Curated by ChEMBL
Jecure Therapeutics
Curated by ChEMBL
Affinity DataIC50: 410nMAssay Description:Inhibition of NLRP3 inflammasome activation in LPS and nigericin-stimulated human PBMC cells assessed as reduction in IL-1beta release preincubated w...More data for this Ligand-Target Pair
Affinity DataIC50: 430nMAssay Description:Inhibition of human N-terminal His6-tagged TEV protease site linked DHPS expressed in Escherichia coli BL21 (DE3) assessed as reduction in radiolabel...More data for this Ligand-Target Pair
TargetNACHT, LRR and PYD domains-containing protein 3(Homo sapiens (Human))
Jecure Therapeutics
Curated by ChEMBL
Jecure Therapeutics
Curated by ChEMBL
Affinity DataIC50: 430nMAssay Description:Inhibition of NLRP3 inflammasome activation in LPS and nigericin-stimulated human PBMC cells assessed as reduction in IL-1beta release preincubated w...More data for this Ligand-Target Pair
