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Found 483 with Last Name = 'andrésson' and Initial = 't'
TargetProstaglandin E2 receptor EP3 subtype(Homo sapiens (Human))
Decode Chemistry

Curated by ChEMBL
LigandPNGBDBM50254766(2-(3-(2,4-dichlorophenylthio)-1H-indol-4-yloxy)-N-...)
Affinity DataIC50:  0.200nMAssay Description:Displacement of [3H]PGE2 from human EP3 receptor in presence of 10% human serumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP3 subtype(Homo sapiens (Human))
Decode Chemistry

Curated by ChEMBL
LigandPNGBDBM50254687(CHEMBL464032 | N-(4,5-dichlorothiophen-2-ylsulfony...)
Affinity DataIC50:  0.300nMAssay Description:Displacement of [3H]PGE2 from human EP3 receptor in presence of 10% human serumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP3 subtype(Homo sapiens (Human))
Decode Chemistry

Curated by ChEMBL
LigandPNGBDBM50254841(2-(3-(3,4-dichlorophenylthio)-1H-indol-4-yloxy)-N-...)
Affinity DataIC50:  0.300nMAssay Description:Antagonist activity at human EP3 receptor assessed as cAMP production by cell-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP3 subtype(Homo sapiens (Human))
Decode Chemistry

Curated by ChEMBL
LigandPNGBDBM50254883(CHEMBL479434 | N-(4,5-dichlorothiophen-2-ylsulfony...)
Affinity DataIC50:  0.5nMAssay Description:Displacement of [3H]PGE2 from human EP3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP3 subtype(Homo sapiens (Human))
Decode Chemistry

Curated by ChEMBL
LigandPNGBDBM50254520(CHEMBL466184 | N-(3,4-difluorophenylsulfonyl)-2-(3...)
Affinity DataIC50:  0.700nMAssay Description:Displacement of [3H]PGE2 from human EP3 receptor in presence of 10% human serumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP3 subtype(Homo sapiens (Human))
Decode Chemistry

Curated by ChEMBL
LigandPNGBDBM50254728(CHEMBL465947 | N-(4-methoxyphenylsulfonyl)-2-(3-(n...)
Affinity DataIC50:  0.700nMAssay Description:Displacement of [3H]PGE2 from human EP3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP3 subtype(Homo sapiens (Human))
Decode Chemistry

Curated by ChEMBL
LigandPNGBDBM50311624(3,4-difluoro-N-(5-(5-fluoro-3-methyl-1-(naphthalen...)
Affinity DataIC50:  1nMAssay Description:Displacement of [3H]PGE2 from human EP3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP3 subtype(Homo sapiens (Human))
Decode Chemistry

Curated by ChEMBL
LigandPNGBDBM50303711(3,4-Difluoro-N-{(E)-3-[5-fluoro-1-(3-methoxybenzyl...)
Affinity DataIC50:  1nMAssay Description:Displacement of [3H]PGE2 from human EP3 receptor after 1 hr by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP3 subtype(Homo sapiens (Human))
Decode Chemistry

Curated by ChEMBL
LigandPNGBDBM50254647(2-(3-(3,4-dichlorophenylsulfonyl)-1H-indol-4-yloxy...)
Affinity DataIC50:  1nMAssay Description:Antagonist activity at human EP3 receptor assessed as cAMP production by cell-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Decode Chemistry

Curated by ChEMBL
LigandPNGBDBM50317487((S)-2-((4-(4-(thiophen-3-yl)phenoxy)phenoxy)methyl...)
Affinity DataIC50:  1nMAssay Description:Inhibition of human LTA4H hydrolysis assessed as inhibition of Ca2+ ionophore-stimulated LTB4 formation in human whole blood by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP3 subtype(Homo sapiens (Human))
Decode Chemistry

Curated by ChEMBL
LigandPNGBDBM50311615(4,5-dichloro-N-(5-(5-fluoro-3-methyl-1-(naphthalen...)
Affinity DataIC50:  1nMAssay Description:Displacement of [3H]PGE2 from human EP3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP3 subtype(Homo sapiens (Human))
Decode Chemistry

Curated by ChEMBL
LigandPNGBDBM50311621(3,4-dichloro-N-(5-(1-(2,4-dichlorobenzyl)-5-fluoro...)
Affinity DataIC50:  1nMAssay Description:Displacement of [3H]PGE2 from human EP3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP3 subtype(Homo sapiens (Human))
Decode Chemistry

Curated by ChEMBL
LigandPNGBDBM50311623(CHEMBL1081186 | N-(5-(1-(2,4-dichlorobenzyl)-5-flu...)
Affinity DataIC50:  1nMAssay Description:Displacement of [3H]PGE2 from human EP3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP3 subtype(Homo sapiens (Human))
Decode Chemistry

Curated by ChEMBL
LigandPNGBDBM50303675(2-(1-(2,4-dichlorobenzyl)-1H-benzo[d]imidazol-7-yl...)
Affinity DataIC50:  1.10nMAssay Description:Displacement of [3H]PGE2 from human EP3 receptor after 1 hr by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP3 subtype(Homo sapiens (Human))
Decode Chemistry

Curated by ChEMBL
LigandPNGBDBM50303675(2-(1-(2,4-dichlorobenzyl)-1H-benzo[d]imidazol-7-yl...)
Affinity DataIC50:  1.10nMAssay Description:Displacement of [3H]PGE2 from human EP3 receptor after 60 mins repeated washing by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP3 subtype(Homo sapiens (Human))
Decode Chemistry

Curated by ChEMBL
LigandPNGBDBM50254841(2-(3-(3,4-dichlorophenylthio)-1H-indol-4-yloxy)-N-...)
Affinity DataIC50:  1.10nMAssay Description:Displacement of [3H]PGE2 from human EP3 receptor in presence of 10% human serumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP3 subtype(Homo sapiens (Human))
Decode Chemistry

Curated by ChEMBL
LigandPNGBDBM50254640(CHEMBL482379 | N-(2,5-dimethoxyphenylsulfonyl)-2-(...)
Affinity DataIC50:  1.20nMAssay Description:Displacement of [3H]PGE2 from human EP3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP3 subtype(Homo sapiens (Human))
Decode Chemistry

Curated by ChEMBL
LigandPNGBDBM50254768(CHEMBL518396 | N-(4,5-dichlorothiophen-2-ylsulfony...)
Affinity DataIC50:  1.30nMAssay Description:Displacement of [3H]PGE2 from human EP3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP3 subtype(Homo sapiens (Human))
Decode Chemistry

Curated by ChEMBL
LigandPNGBDBM50303663(4,5-Dichlorothiophene-2-sulfonic Acid[(E)-3-(5-Flu...)
Affinity DataIC50:  1.30nMAssay Description:Displacement of [3H]PGE2 from human EP3 receptor after 1 hr by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP3 subtype(Homo sapiens (Human))
Decode Chemistry

Curated by ChEMBL
LigandPNGBDBM50254841(2-(3-(3,4-dichlorophenylthio)-1H-indol-4-yloxy)-N-...)
Affinity DataIC50:  1.30nMAssay Description:Displacement of [3H]PGE2 from human EP3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP3 subtype(Homo sapiens (Human))
Decode Chemistry

Curated by ChEMBL
LigandPNGBDBM50254641(CHEMBL482380 | N-(2-chlorophenylsulfonyl)-2-(3-(na...)
Affinity DataIC50:  1.40nMAssay Description:Displacement of [3H]PGE2 from human EP3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP3 subtype(Homo sapiens (Human))
Decode Chemistry

Curated by ChEMBL
LigandPNGBDBM50254880(CHEMBL520741 | N-(4,5-dichlorothiophen-2-ylsulfony...)
Affinity DataIC50:  1.60nMAssay Description:Displacement of [3H]PGE2 from human EP3 receptor in presence of 10% human serumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP3 subtype(Homo sapiens (Human))
Decode Chemistry

Curated by ChEMBL
LigandPNGBDBM50255058(CHEMBL479427 | N-(4,5-dichlorothiophen-2-ylsulfony...)
Affinity DataIC50:  1.70nMAssay Description:Displacement of [3H]PGE2 from human EP3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP3 subtype(Homo sapiens (Human))
Decode Chemistry

Curated by ChEMBL
LigandPNGBDBM50255778(3-(1-(2,3-dichlorobenzyl)-3a-methyl-2-oxo-2,3,3a,4...)
Affinity DataIC50:  1.70nMAssay Description:Antagonist activity at human EP3 receptor expressed in CHO-K1 cells assessed as reversal of inhibition of forskolin-induced cAMP productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP3 subtype(Homo sapiens (Human))
Decode Chemistry

Curated by ChEMBL
LigandPNGBDBM50255343(3-(1-(3,4-difluorobenzyl)-3a-methyl-2-oxo-2,3,3a,4...)
Affinity DataIC50:  1.80nMAssay Description:Displacement of [3H]PGE2 from human EP3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP3 subtype(Homo sapiens (Human))
Decode Chemistry

Curated by ChEMBL
LigandPNGBDBM50254797(2-(3-(2-chloro-4-fluorophenylthio)-1H-indol-4-ylox...)
Affinity DataIC50:  1.80nMAssay Description:Displacement of [3H]PGE2 from human EP3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP3 subtype(Homo sapiens (Human))
Decode Chemistry

Curated by ChEMBL
LigandPNGBDBM50248275(CHEMBL474751 | N-(3,4-difluorophenylsulfonyl)-3-(1...)
Affinity DataIC50:  1.90nMAssay Description:Displacement of [3H]PGE2 from human EP3 receptor at 20 uM in presence of normal bufferMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP3 subtype(Homo sapiens (Human))
Decode Chemistry

Curated by ChEMBL
LigandPNGBDBM50254767(CHEMBL464271 | N-(4,5-dichlorothiophen-2-ylsulfony...)
Affinity DataIC50:  1.90nMAssay Description:Displacement of [3H]PGE2 from human EP3 receptor in presence of 10% human serumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP3 subtype(Homo sapiens (Human))
Decode Chemistry

Curated by ChEMBL
LigandPNGBDBM50311610(4,5-dichloro-N-(5-(1-(2,4-dichlorobenzyl)-5-fluoro...)
Affinity DataIC50:  2nMAssay Description:Displacement of [3H]PGE2 from human EP3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP3 subtype(Mus musculus (Mouse))
Decode Chemistry

Curated by ChEMBL
LigandPNGBDBM50254647(2-(3-(3,4-dichlorophenylsulfonyl)-1H-indol-4-yloxy...)
Affinity DataIC50:  2nMAssay Description:Displacement of [3H]PGE2 from mouse EP3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP3 subtype(Homo sapiens (Human))
Decode Chemistry

Curated by ChEMBL
LigandPNGBDBM50254686(CHEMBL464031 | N-(3-chlorophenylsulfonyl)-2-(3-(na...)
Affinity DataIC50:  2nMAssay Description:Displacement of [3H]PGE2 from human EP3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP3 subtype(Homo sapiens (Human))
Decode Chemistry

Curated by ChEMBL
LigandPNGBDBM50254520(CHEMBL466184 | N-(3,4-difluorophenylsulfonyl)-2-(3...)
Affinity DataIC50:  2nMAssay Description:Displacement of [3H]PGE2 from human EP3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP3 subtype(Homo sapiens (Human))
Decode Chemistry

Curated by ChEMBL
LigandPNGBDBM50303660(CHEMBL566005 | N-{(E)-3-[1-(2,4-Dichlorobenzyl)-5-...)
Affinity DataIC50:  2nMAssay Description:Displacement of [3H]PGE2 from human EP3 receptor after 1 hr by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP3 subtype(Homo sapiens (Human))
Decode Chemistry

Curated by ChEMBL
LigandPNGBDBM50303695(CHEMBL585581 | Thiophene-2-sulfonic Acid{(E)-3-[1-...)
Affinity DataIC50:  2nMAssay Description:Displacement of [3H]PGE2 from human EP3 receptor after 1 hr by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP3 subtype(Homo sapiens (Human))
Decode Chemistry

Curated by ChEMBL
LigandPNGBDBM50303695(CHEMBL585581 | Thiophene-2-sulfonic Acid{(E)-3-[1-...)
Affinity DataIC50:  2nMAssay Description:Displacement of [3H]PGE2 from human EP3 receptor after 60 mins repeated washing by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP3 subtype(Homo sapiens (Human))
Decode Chemistry

Curated by ChEMBL
LigandPNGBDBM50311619(CHEMBL1080106 | N-(5-(1-(2,4-dichlorobenzyl)-5-flu...)
Affinity DataIC50:  2nMAssay Description:Displacement of [3H]PGE2 from human EP3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP3 subtype(Homo sapiens (Human))
Decode Chemistry

Curated by ChEMBL
LigandPNGBDBM50254730(2-(3-(naphthalen-2-ylthio)-1H-indol-4-yloxy)-N-(ph...)
Affinity DataIC50:  2.20nMAssay Description:Displacement of [3H]PGE2 from human EP3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP3 subtype(Homo sapiens (Human))
Decode Chemistry

Curated by ChEMBL
LigandPNGBDBM50255780(3-(1-(3-chlorobenzyl)-3a-methyl-2-oxo-2,3,3a,4,5,6...)
Affinity DataIC50:  2.20nMAssay Description:Displacement of [3H]PGE2 from human EP3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP3 subtype(Homo sapiens (Human))
Decode Chemistry

Curated by ChEMBL
LigandPNGBDBM50254686(CHEMBL464031 | N-(3-chlorophenylsulfonyl)-2-(3-(na...)
Affinity DataIC50:  2.20nMAssay Description:Displacement of [3H]PGE2 from human EP3 receptor in presence of 10% human serumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP3 subtype(Homo sapiens (Human))
Decode Chemistry

Curated by ChEMBL
LigandPNGBDBM50303677(CHEMBL566016 | N-(4,5-dichlorothiophen-2-ylsulfony...)
Affinity DataIC50:  2.20nMAssay Description:Displacement of [3H]PGE2 from human EP3 receptor after 1 hr by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP3 subtype(Homo sapiens (Human))
Decode Chemistry

Curated by ChEMBL
LigandPNGBDBM50255779(3-(1-(2,4-dichlorobenzyl)-3a-methyl-2-oxo-2,3,3a,4...)
Affinity DataIC50:  2.30nMAssay Description:Displacement of [3H]PGE2 from human EP3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP3 subtype(Homo sapiens (Human))
Decode Chemistry

Curated by ChEMBL
LigandPNGBDBM50303709(3,4-Difluoro-N-[(E)-3-(5-fluoro-1-imidazo[1,2-a]py...)
Affinity DataIC50:  2.30nMAssay Description:Displacement of [3H]PGE2 from human EP3 receptor after 1 hr by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP3 subtype(Homo sapiens (Human))
Decode Chemistry

Curated by ChEMBL
LigandPNGBDBM50254643(CHEMBL481589 | N-(3,5-dichlorophenylsulfonyl)-2-(3...)
Affinity DataIC50:  2.30nMAssay Description:Displacement of [3H]PGE2 from human EP3 receptor in presence of 10% human serumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP3 subtype(Homo sapiens (Human))
Decode Chemistry

Curated by ChEMBL
LigandPNGBDBM50303680(4,5-Dichlorothiophene-2-sulfonic Acid[3-(3-Naphtha...)
Affinity DataIC50:  2.40nMAssay Description:Displacement of [3H]PGE2 from human EP3 receptor after 1 hr by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP3 subtype(Homo sapiens (Human))
Decode Chemistry

Curated by ChEMBL
LigandPNGBDBM50255125(CHEMBL481823 | N-(3,4-difluorophenylsulfonyl)-3-(1...)
Affinity DataIC50:  2.5nMAssay Description:Displacement of [3H]PGE2 from human EP3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP3 subtype(Homo sapiens (Human))
Decode Chemistry

Curated by ChEMBL
LigandPNGBDBM50303682(4,5-Dichloro-thiophene-2-sulfonic acid{3-[5-fluoro...)
Affinity DataIC50:  2.5nMAssay Description:Displacement of [3H]PGE2 from human EP3 receptor after 1 hr by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP3 subtype(Homo sapiens (Human))
Decode Chemistry

Curated by ChEMBL
LigandPNGBDBM50254924(CHEMBL465923 | N-(4,5-dichlorothiophen-2-ylsulfony...)
Affinity DataIC50:  2.5nMAssay Description:Displacement of [3H]PGE2 from human EP3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP3 subtype(Homo sapiens (Human))
Decode Chemistry

Curated by ChEMBL
LigandPNGBDBM50303679(4,5-Dichlorothiophene-2-sulfonic Acid[3-(1-Methyl-...)
Affinity DataIC50:  2.5nMAssay Description:Displacement of [3H]PGE2 from human EP3 receptor after 1 hr by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP3 subtype(Homo sapiens (Human))
Decode Chemistry

Curated by ChEMBL
LigandPNGBDBM50248277(3-(4-(3,4-dichlorophenoxy)-1-methyl-1H-indol-3-yl)...)
Affinity DataIC50:  2.60nMAssay Description:Displacement of [3H]PGE2 from human EP3 receptor at 20 uM in presence of normal bufferMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP3 subtype(Homo sapiens (Human))
Decode Chemistry

Curated by ChEMBL
LigandPNGBDBM50254797(2-(3-(2-chloro-4-fluorophenylthio)-1H-indol-4-ylox...)
Affinity DataIC50:  2.60nMAssay Description:Displacement of [3H]PGE2 from human EP3 receptor in presence of 10% human serumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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