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Found 667 with Last Name = 'antoni' and Initial = 'l'
TargetAdenosine deaminase(Bos taurus (bovine))
Universita Di Pisa

LigandPNGBDBM28388(3-[4-({4-oxo-2H,4H,5H-pyrazolo[3,4-d]pyrimidin-2-y...)
Affinity DataKi:  160nM ΔG°:  -39.4kJ/molepH: 7.2 T: 2°CAssay Description:The activity of ADA was determined spectrophotometrically by monitoring the change in absorbance at 262 nm, due to the deamination of adenosine catal...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAminopeptidase N(Homo sapiens (Human))
Monash University

Curated by ChEMBL
LigandPNGBDBM50518449(CHEMBL4435950)
Affinity DataKi:  300nMAssay Description:Inhibition of human APN expressed in HEK293 cells preincubated for 20 mins followed by L-leucine-7-amido-4-methylcoumarin addition by fluorescence as...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAdenosine deaminase(Bos taurus (bovine))
Universita Di Pisa

LigandPNGBDBM28383(N-[4-({4-oxo-2H,4H,5H-pyrazolo[3,4-d]pyrimidin-2-y...)
Affinity DataKi:  510nM ΔG°:  -36.5kJ/molepH: 7.2 T: 2°CAssay Description:The activity of ADA was determined spectrophotometrically by monitoring the change in absorbance at 262 nm, due to the deamination of adenosine catal...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine deaminase(Bos taurus (bovine))
Universita Di Pisa

LigandPNGBDBM28382(4-fluoro-N-[4-({4-oxo-2H,4H,5H-pyrazolo[3,4-d]pyri...)
Affinity DataKi:  960nM ΔG°:  -34.9kJ/molepH: 7.2 T: 2°CAssay Description:The activity of ADA was determined spectrophotometrically by monitoring the change in absorbance at 262 nm, due to the deamination of adenosine catal...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine deaminase(Bos taurus (bovine))
Universita Di Pisa

LigandPNGBDBM28393((+)-EHNA | (2S,3R)-3-(6-amino-9H-purin-9-yl)nonan-...)
Affinity DataKi:  1.14E+3nM ΔG°:  -34.5kJ/molepH: 7.2 T: 2°CAssay Description:The activity of ADA was determined spectrophotometrically by monitoring the change in absorbance at 262 nm, due to the deamination of adenosine catal...More data for this Ligand-Target Pair
TargetAdenosine deaminase(Bos taurus (bovine))
Universita Di Pisa

LigandPNGBDBM28387(1-(4-fluorophenyl)-3-[4-({4-oxo-2H,4H,5H-pyrazolo[...)
Affinity DataKi:  1.15E+3nM ΔG°:  -34.5kJ/molepH: 7.2 T: 2°CAssay Description:The activity of ADA was determined spectrophotometrically by monitoring the change in absorbance at 262 nm, due to the deamination of adenosine catal...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine deaminase(Bos taurus (bovine))
Universita Di Pisa

LigandPNGBDBM28389(1-[4-(dimethylamino)phenyl]-3-[4-({4-oxo-2H,4H,5H-...)
Affinity DataKi:  2.01E+3nM ΔG°:  -33.1kJ/molepH: 7.2 T: 2°CAssay Description:The activity of ADA was determined spectrophotometrically by monitoring the change in absorbance at 262 nm, due to the deamination of adenosine catal...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine deaminase(Bos taurus (bovine))
Universita Di Pisa

LigandPNGBDBM28385(3-[4-({4-oxo-2H,4H,5H-pyrazolo[3,4-d]pyrimidin-2-y...)
Affinity DataKi:  2.42E+3nM ΔG°:  -32.6kJ/molepH: 7.2 T: 2°CAssay Description:The activity of ADA was determined spectrophotometrically by monitoring the change in absorbance at 262 nm, due to the deamination of adenosine catal...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine deaminase(Bos taurus (bovine))
Universita Di Pisa

LigandPNGBDBM28380(N-[4-({4-oxo-2H,4H,5H-pyrazolo[3,4-d]pyrimidin-2-y...)
Affinity DataKi:  1.27E+4nM ΔG°:  -28.4kJ/molepH: 7.2 T: 2°CAssay Description:The activity of ADA was determined spectrophotometrically by monitoring the change in absorbance at 262 nm, due to the deamination of adenosine catal...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine deaminase(Bos taurus (bovine))
Universita Di Pisa

LigandPNGBDBM28381(4-methoxy-N-[4-({4-oxo-2H,4H,5H-pyrazolo[3,4-d]pyr...)
Affinity DataKi:  1.56E+4nM ΔG°:  -27.9kJ/molepH: 7.2 T: 2°CAssay Description:The activity of ADA was determined spectrophotometrically by monitoring the change in absorbance at 262 nm, due to the deamination of adenosine catal...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine deaminase(Bos taurus (bovine))
Universita Di Pisa

LigandPNGBDBM28386(1-(4-methoxyphenyl)-3-[4-({4-oxo-2H,4H,5H-pyrazolo...)
Affinity DataKi:  2.83E+4nM ΔG°:  -26.4kJ/molepH: 7.2 T: 2°CAssay Description:The activity of ADA was determined spectrophotometrically by monitoring the change in absorbance at 262 nm, due to the deamination of adenosine catal...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine deaminase(Bos taurus (bovine))
Universita Di Pisa

LigandPNGBDBM28384(N-[4-({4-oxo-2H,4H,5H-pyrazolo[3,4-d]pyrimidin-2-y...)
Affinity DataKi:  4.79E+4nM ΔG°:  -25.1kJ/molepH: 7.2 T: 2°CAssay Description:The activity of ADA was determined spectrophotometrically by monitoring the change in absorbance at 262 nm, due to the deamination of adenosine catal...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine deaminase(Bos taurus (bovine))
Universita Di Pisa

LigandPNGBDBM28392(1-benzyl-3-[4-({4-oxo-2H,4H,5H-pyrazolo[3,4-d]pyri...)
Affinity DataKi:  8.57E+4nM ΔG°:  -23.6kJ/molepH: 7.2 T: 2°CAssay Description:The activity of ADA was determined spectrophotometrically by monitoring the change in absorbance at 262 nm, due to the deamination of adenosine catal...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine deaminase(Bos taurus (bovine))
Universita Di Pisa

LigandPNGBDBM28391(1-[4-(benzyloxy)phenyl]-3-[4-({4-oxo-2H,4H,5H-pyra...)
Affinity DataKi:  1.08E+5nM ΔG°:  -23.0kJ/molepH: 7.2 T: 2°CAssay Description:The activity of ADA was determined spectrophotometrically by monitoring the change in absorbance at 262 nm, due to the deamination of adenosine catal...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine deaminase(Bos taurus (bovine))
Universita Di Pisa

LigandPNGBDBM28390(1-(4-benzylphenyl)-3-[4-({4-oxo-2H,4H,5H-pyrazolo[...)
Affinity DataKi:  1.86E+5nM ΔG°:  -21.6kJ/molepH: 7.2 T: 2°CAssay Description:The activity of ADA was determined spectrophotometrically by monitoring the change in absorbance at 262 nm, due to the deamination of adenosine catal...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
University Of Kragujevac

Curated by ChEMBL
LigandPNGBDBM50593468(CHEMBL5199803)
Affinity DataIC50:  0.190nMAssay Description:Antagonist activity at ERalpha (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetEstrogen receptor(Homo sapiens (Human))
University Of Kragujevac

Curated by ChEMBL
LigandPNGBDBM50593464(CHEMBL5184399)
Affinity DataIC50:  0.260nMAssay Description:Antagonist activity at ERalpha (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetEstrogen receptor(Homo sapiens (Human))
University Of Kragujevac

Curated by ChEMBL
LigandPNGBDBM50593462(CHEMBL5178058)
Affinity DataIC50:  0.330nMAssay Description:Antagonist activity at ERalpha (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetEstrogen receptor(Homo sapiens (Human))
University Of Kragujevac

Curated by ChEMBL
LigandPNGBDBM50593471(CHEMBL5195371)
Affinity DataIC50:  0.390nMAssay Description:Antagonist activity at ERalpha (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Monash University

Curated by ChEMBL
LigandPNGBDBM50063917((2S,3R)-N(4)-[(2S)-3,3-dimethyl-1-(methylamino)-1-...)
Affinity DataIC50:  0.430nMAssay Description:Inhibition of MMP2 (unknown origin) preincubated for 1 hr followed by (QF)-24 substrate addition measured at 1 min time interval for 1 hr by fluoresc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetEstrogen receptor(Homo sapiens (Human))
University Of Kragujevac

Curated by ChEMBL
LigandPNGBDBM50593476(CHEMBL5191405)
Affinity DataIC50:  0.670nMAssay Description:Antagonist activity at ERalpha (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetEstrogen receptor(Homo sapiens (Human))
University Of Kragujevac

Curated by ChEMBL
LigandPNGBDBM50593472(CHEMBL5174813)
Affinity DataIC50:  0.710nMAssay Description:Antagonist activity at ERalpha (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetEstrogen receptor(Homo sapiens (Human))
University Of Kragujevac

Curated by ChEMBL
LigandPNGBDBM19441(2-(4-hydroxyphenyl)-3-({4-[2-(piperidin-1-yl)ethox...)
Affinity DataIC50:  0.740nMAssay Description:Antagonist activity at ERalpha (unknown origin)More data for this Ligand-Target Pair
TargetEstrogen receptor(Homo sapiens (Human))
University Of Kragujevac

Curated by ChEMBL
LigandPNGBDBM50593473(CHEMBL5207726)
Affinity DataIC50:  0.75nMAssay Description:Antagonist activity at ERalpha (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetEstrogen receptor(Homo sapiens (Human))
University Of Kragujevac

Curated by ChEMBL
LigandPNGBDBM50593466(CHEMBL5187253)
Affinity DataIC50:  0.760nMAssay Description:Antagonist activity at ERalpha (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetHistone acetyltransferase KAT6A [507-778](Homo sapiens)
The Broad Institute

WIPO
LigandPNGBDBM534094(WO2022081807, Example 201)
Affinity DataIC50:  0.810nMAssay Description:Kat6a inhibitory activities of the compounds described in the present invention were quantified using a Fluorescence Resonance Energy Transfer (TR-FR...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetEstrogen receptor beta(Homo sapiens (Human))
University Of Kragujevac

Curated by ChEMBL
LigandPNGBDBM17292((1S,10R,11S,14S,15S)-15-methyltetracyclo[8.7.0.0^{...)
Affinity DataIC50:  0.890nMAssay Description:Antagonist activity at ERbeta (unknown origin)More data for this Ligand-Target Pair
TargetEstrogen receptor(Homo sapiens (Human))
University Of Kragujevac

Curated by ChEMBL
LigandPNGBDBM17292((1S,10R,11S,14S,15S)-15-methyltetracyclo[8.7.0.0^{...)
Affinity DataIC50:  0.890nMAssay Description:Antagonist activity at ERalpha (unknown origin)More data for this Ligand-Target Pair
TargetEstrogen receptor(Homo sapiens (Human))
University Of Kragujevac

Curated by ChEMBL
LigandPNGBDBM50593475(CHEMBL5178110)
Affinity DataIC50:  1.10nMAssay Description:Antagonist activity at ERalpha (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetEstrogen receptor(Homo sapiens (Human))
University Of Kragujevac

Curated by ChEMBL
LigandPNGBDBM50593474(CHEMBL5203282)
Affinity DataIC50:  1.10nMAssay Description:Antagonist activity at ERalpha (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetEstrogen receptor(Homo sapiens (Human))
University Of Kragujevac

Curated by ChEMBL
LigandPNGBDBM50180684(4-OHT | Afimoxifene | TamoGel)
Affinity DataIC50:  1.10nMAssay Description:Antagonist activity at ERalpha (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetHistone acetyltransferase KAT6A [507-778](Homo sapiens)
The Broad Institute

WIPO
LigandPNGBDBM533971(WO2022081807, Example 78)
Affinity DataIC50:  1.41nMAssay Description:Kat6a inhibitory activities of the compounds described in the present invention were quantified using a Fluorescence Resonance Energy Transfer (TR-FR...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetHistone acetyltransferase KAT6A [507-778](Homo sapiens)
The Broad Institute

WIPO
LigandPNGBDBM533872(WO2022081807, Example 5)
Affinity DataIC50:  1.42nMAssay Description:Kat6a inhibitory activities of the compounds described in the present invention were quantified using a Fluorescence Resonance Energy Transfer (TR-FR...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetHistone acetyltransferase KAT6A [507-778](Homo sapiens)
The Broad Institute

WIPO
LigandPNGBDBM534119(WO2022081807, Example 226)
Affinity DataIC50:  1.79nMAssay Description:Kat6a inhibitory activities of the compounds described in the present invention were quantified using a Fluorescence Resonance Energy Transfer (TR-FR...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetHistone acetyltransferase KAT6A [507-778](Homo sapiens)
The Broad Institute

WIPO
LigandPNGBDBM534154(6-Cyclopropyl-N-(2-ethoxy-5-sec-butyl-phenyl)sulfo...)
Affinity DataIC50:  1.84nMAssay Description: Kat6a inhibitory activities of the compounds described in the present invention were quantified using a Fluorescence Resonance Energy Transfer (TR-F...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetHistone acetyltransferase KAT6A [507-778](Homo sapiens)
The Broad Institute

WIPO
LigandPNGBDBM534100(WO2022081807, Example 207)
Affinity DataIC50:  1.86nMAssay Description:Kat6a inhibitory activities of the compounds described in the present invention were quantified using a Fluorescence Resonance Energy Transfer (TR-FR...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetHistone acetyltransferase KAT6A [507-778](Homo sapiens)
The Broad Institute

WIPO
LigandPNGBDBM534192(N-[(2-Cyclobutoxy-5-isopropylphenyl)sulfonyl]-6-cy...)
Affinity DataIC50:  2.09nMAssay Description: Kat6a inhibitory activities of the compounds described in the present invention were quantified using a Fluorescence Resonance Energy Transfer (TR-F...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetHistone acetyltransferase KAT6A [507-778](Homo sapiens)
The Broad Institute

WIPO
LigandPNGBDBM534190(N-((5-(tert-Butyl)-2-cyclobutoxyphenyl)sulfonyl)-6...)
Affinity DataIC50:  2.46nMAssay Description: Kat6a inhibitory activities of the compounds described in the present invention were quantified using a Fluorescence Resonance Energy Transfer (TR-F...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetHistone acetyltransferase KAT6A [507-778](Homo sapiens)
The Broad Institute

WIPO
LigandPNGBDBM534121(WO2022081807, Example 228)
Affinity DataIC50:  2.57nMAssay Description:Kat6a inhibitory activities of the compounds described in the present invention were quantified using a Fluorescence Resonance Energy Transfer (TR-FR...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetHistone acetyltransferase KAT6A [507-778](Homo sapiens)
The Broad Institute

WIPO
LigandPNGBDBM534187(N-[(2-(Benzyloxy)-5-(tert-butyl)phenyl)sulfonyl]-6...)
Affinity DataIC50:  2.67nMAssay Description: Kat6a inhibitory activities of the compounds described in the present invention were quantified using a Fluorescence Resonance Energy Transfer (TR-F...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetHistone acetyltransferase KAT6A [507-778](Homo sapiens)
The Broad Institute

WIPO
LigandPNGBDBM534188(N-((5-(tert-butyl)-2-(cyclopropylmethoxy)phenyl)su...)
Affinity DataIC50:  2.92nMAssay Description: Kat6a inhibitory activities of the compounds described in the present invention were quantified using a Fluorescence Resonance Energy Transfer (TR-F...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetSerine/threonine-protein kinase Chk2(Homo sapiens (Human))
The Institute Of Cancer Research

Curated by ChEMBL
LigandPNGBDBM50335684(4-FLUORO-2-(4-{[(3S,4R)-4-(1-HYDROXY-1-METHYLETHYL...)
Affinity DataIC50:  3nMAssay Description:Inhibition of CHK2 by DELFIA assayMore data for this Ligand-Target Pair
TargetHistone acetyltransferase KAT6A [507-778](Homo sapiens)
The Broad Institute

WIPO
LigandPNGBDBM534161(6-Cyclopropyl-N-[2-(cyclopropylmethoxy)-5-isopropy...)
Affinity DataIC50:  3.01nMAssay Description: Kat6a inhibitory activities of the compounds described in the present invention were quantified using a Fluorescence Resonance Energy Transfer (TR-F...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Monash University

Curated by ChEMBL
LigandPNGBDBM50063917((2S,3R)-N(4)-[(2S)-3,3-dimethyl-1-(methylamino)-1-...)
Affinity DataIC50:  3.10nMAssay Description:Inhibition of MMP9 (unknown origin) preincubated for 1 hr followed by (QF)-24 substrate addition measured at 1 min time interval for 1 hr by fluoresc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetHistone acetyltransferase KAT6A [507-778](Homo sapiens)
The Broad Institute

WIPO
LigandPNGBDBM534193(N-((5-(tert-butyl)-2-methoxyphenyl)sulfonyl)-6-cyc...)
Affinity DataIC50:  3.31nMAssay Description: Kat6a inhibitory activities of the compounds described in the present invention were quantified using a Fluorescence Resonance Energy Transfer (TR-F...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetHistone acetyltransferase KAT6A [507-778](Homo sapiens)
The Broad Institute

WIPO
LigandPNGBDBM534186(N-((5-(tert-butyl)-2-cyclopropoxyphenyl)sulfonyl)-...)
Affinity DataIC50:  3.58nMAssay Description: Kat6a inhibitory activities of the compounds described in the present invention were quantified using a Fluorescence Resonance Energy Transfer (TR-F...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetEstrogen receptor beta(Homo sapiens (Human))
University Of Kragujevac

Curated by ChEMBL
LigandPNGBDBM50180684(4-OHT | Afimoxifene | TamoGel)
Affinity DataIC50:  3.60nMAssay Description:Antagonist activity at ERbeta (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetHistone acetyltransferase KAT6A [507-778](Homo sapiens)
The Broad Institute

WIPO
LigandPNGBDBM534118(6-(Azetidin-1-yl)-N-[(2-(benzyloxy)-5-(tert-butyl)...)
Affinity DataIC50:  3.72nMAssay Description:Kat6a inhibitory activities of the compounds described in the present invention were quantified using a Fluorescence Resonance Energy Transfer (TR-FR...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetHistone acetyltransferase KAT6A [507-778](Homo sapiens)
The Broad Institute

WIPO
LigandPNGBDBM534117(WO2022081807, Example 224)
Affinity DataIC50:  3.72nMAssay Description:Kat6a inhibitory activities of the compounds described in the present invention were quantified using a Fluorescence Resonance Energy Transfer (TR-FR...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetHistone acetyltransferase KAT6A [507-778](Homo sapiens)
The Broad Institute

WIPO
LigandPNGBDBM534107(6-(azetidin-1-yl)-N-[2-(cyclopropylmethoxy)-5-isop...)
Affinity DataIC50:  3.91nMAssay Description:Kat6a inhibitory activities of the compounds described in the present invention were quantified using a Fluorescence Resonance Energy Transfer (TR-FR...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
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