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Found 60 with Last Name = 'arai' and Initial = 'j'
TargetProstaglandin G/H synthase 2(Ovis aries (Sheep))
Tohoku Medical And Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50182889(CHEMBL3818849)
Affinity DataIC50:  470nMAssay Description:Inhibition of heme catalyzed hydroperoxidase activity of ovine COX-2 using arachidonic acid as substrate preincubated for 5 mins followed by substrat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Ovis aries (Sheep))
Tohoku Medical And Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM11639(4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyraz...)
Affinity DataIC50:  560nMAssay Description:Inhibition of ovine COX-2 using arachidonic acid after 5 mins by colorimetric methodMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
Tohoku Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM17638(2-{1-[(4-chlorophenyl)carbonyl]-5-methoxy-2-methyl...)
Affinity DataIC50:  790nMAssay Description:Inhibition of ovine COX-1 using arachidonic acid after 5 mins by colorimetric methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransthyretin(Homo sapiens (Human))
Universidade De Coimbra

Curated by ChEMBL
LigandPNGBDBM50410534(CHEMBL83116)
Affinity DataIC50:  1.59E+3nMAssay Description:Stabilization of recombinant human wild type TTR expressed in Escherichia coli BL21 (DE3) assessed as inhibition of amyloid beta formation by measuri...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransthyretin(Homo sapiens (Human))
Universidade De Coimbra

Curated by ChEMBL
LigandPNGBDBM50410534(CHEMBL83116)
Affinity DataIC50:  1.59E+3nMAssay Description:Stabilization of recombinant human wild type TTR expressed in Escherichia coli BL21 (DE3) assessed as inhibition of amyloid beta formation by measuri...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Ovis aries (Sheep))
Tohoku Medical And Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50056999(CHEMBL56367 | nimesulide)
Affinity DataIC50:  1.92E+3nMAssay Description:Inhibition of ovine COX-2 using arachidonic acid after 5 mins by colorimetric methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransthyretin(Homo sapiens (Human))
Universidade De Coimbra

Curated by ChEMBL
LigandPNGBDBM50197882(CHEMBL3959466)
Affinity DataIC50:  2.02E+3nMAssay Description:Stabilization of recombinant human wild type TTR expressed in Escherichia coli BL21 (DE3) assessed as inhibition of amyloid beta formation by measuri...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransthyretin(Homo sapiens (Human))
Universidade De Coimbra

Curated by ChEMBL
LigandPNGBDBM50197882(CHEMBL3959466)
Affinity DataIC50:  2.04E+3nMAssay Description:Stabilization of recombinant human wild type TTR expressed in Escherichia coli BL21 (DE3) assessed as inhibition of amyloid beta formation by measuri...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransthyretin(Homo sapiens (Human))
Universidade De Coimbra

Curated by ChEMBL
LigandPNGBDBM50301375(3,3',5,5'-tetraiodo-L-thyronine | 3,5,3',5'-tetrai...)
Affinity DataIC50:  2.19E+3nMAssay Description:Stabilization of recombinant human wild type TTR expressed in Escherichia coli BL21 (DE3) assessed as inhibition of amyloid beta formation by measuri...More data for this Ligand-Target Pair
TargetTransthyretin(Homo sapiens (Human))
Universidade De Coimbra

Curated by ChEMBL
LigandPNGBDBM50301375(3,3',5,5'-tetraiodo-L-thyronine | 3,5,3',5'-tetrai...)
Affinity DataIC50:  2.20E+3nMAssay Description:Stabilization of recombinant human wild type TTR expressed in Escherichia coli BL21 (DE3) assessed as inhibition of amyloid beta formation by measuri...More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Ovis aries (Sheep))
Tohoku Medical And Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50128688(CHEMBL3628727)
Affinity DataIC50:  2.31E+3nMAssay Description:Inhibition of ovine COX-2 using arachidonic acid after 5 mins by colorimetric methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransthyretin(Homo sapiens (Human))
Universidade De Coimbra

Curated by ChEMBL
LigandPNGBDBM50197881(CHEMBL3890392)
Affinity DataIC50:  2.49E+3nMAssay Description:Stabilization of recombinant human wild type TTR expressed in Escherichia coli BL21 (DE3) assessed as inhibition of amyloid beta formation by measuri...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransthyretin(Homo sapiens (Human))
Universidade De Coimbra

Curated by ChEMBL
LigandPNGBDBM50197881(CHEMBL3890392)
Affinity DataIC50:  2.51E+3nMAssay Description:Stabilization of recombinant human wild type TTR expressed in Escherichia coli BL21 (DE3) assessed as inhibition of amyloid beta formation by measuri...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransthyretin(Homo sapiens (Human))
Universidade De Coimbra

Curated by ChEMBL
LigandPNGBDBM50301372((E/Z)-3-(4-nitrophenylimino)indolin-2-one | CHEMBL...)
Affinity DataIC50:  2.80E+3nMAssay Description:Inhibition of TTR mediated fibrillogenesis assessed as acid-induced protein aggregation turbidity after 1.5 hrs by turbidimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransthyretin(Homo sapiens (Human))
Universidade De Coimbra

Curated by ChEMBL
LigandPNGBDBM50197883(CHEBI:78538 | FX-1006 | Tafamidis | US10377729, Co...)
Affinity DataIC50:  3.09E+3nMAssay Description:Stabilization of recombinant human wild type TTR expressed in Escherichia coli BL21 (DE3) assessed as inhibition of amyloid beta formation by measuri...More data for this Ligand-Target Pair
TargetTransthyretin(Homo sapiens (Human))
Universidade De Coimbra

Curated by ChEMBL
LigandPNGBDBM50197883(CHEBI:78538 | FX-1006 | Tafamidis | US10377729, Co...)
Affinity DataIC50:  3.10E+3nMAssay Description:Stabilization of recombinant human wild type TTR expressed in Escherichia coli BL21 (DE3) assessed as inhibition of amyloid beta formation by measuri...More data for this Ligand-Target Pair
TargetTransthyretin(Homo sapiens (Human))
Universidade De Coimbra

Curated by ChEMBL
LigandPNGBDBM50301374(2,4,6-Triiodo-phenol | 2,4,6-Triiodo-phenol(TIP) |...)
Affinity DataIC50:  3.20E+3nMAssay Description:Inhibition of TTR mediated fibrillogenesis assessed as acid-induced protein aggregation turbidity after 1.5 hrs by turbidimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransthyretin(Homo sapiens (Human))
Universidade De Coimbra

Curated by ChEMBL
LigandPNGBDBM50301380((E/Z)-1-methyl-3-(p-tolylimino)indolin-2-one | CHE...)
Affinity DataIC50:  6.30E+3nMAssay Description:Inhibition of TTR mediated fibrillogenesis assessed as acid-induced protein aggregation turbidity after 1.5 hrs by turbidimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransthyretin(Homo sapiens (Human))
Universidade De Coimbra

Curated by ChEMBL
LigandPNGBDBM10304(1-methyl-2,3-dihydro-1H-indole-2,3-dione | CHEMBL6...)
Affinity DataIC50:  6.30E+3nMAssay Description:Inhibition of TTR mediated fibrillogenesis assessed as acid-induced protein aggregation turbidity after 1.5 hrs by turbidimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransthyretin(Homo sapiens (Human))
Universidade De Coimbra

Curated by ChEMBL
LigandPNGBDBM50301373((E/Z)-1-methyl-3-(4-nitrophenylimino)indolin-2-one...)
Affinity DataIC50:  6.30E+3nMAssay Description:Inhibition of TTR mediated fibrillogenesis assessed as acid-induced protein aggregation turbidity after 1.5 hrs by turbidimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransthyretin(Homo sapiens (Human))
Universidade De Coimbra

Curated by ChEMBL
LigandPNGBDBM50197884(CHEMBL3969733)
Affinity DataIC50:  7.10E+3nMAssay Description:Stabilization of recombinant human wild type TTR expressed in Escherichia coli BL21 (DE3) assessed as inhibition of amyloid beta formation by measuri...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransthyretin(Homo sapiens (Human))
Universidade De Coimbra

Curated by ChEMBL
LigandPNGBDBM50301381((E/Z)-3-(4-methoxyphenylimino)-1-methylindolin-2-o...)
Affinity DataIC50:  7.70E+3nMAssay Description:Inhibition of TTR mediated fibrillogenesis assessed as acid-induced protein aggregation turbidity after 1.5 hrs by turbidimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransthyretin(Homo sapiens (Human))
Universidade De Coimbra

Curated by ChEMBL
LigandPNGBDBM50189601((E)-3-(4-methoxyphenylimino)indolin-2-one | (E/Z)-...)
Affinity DataIC50:  8.10E+3nMAssay Description:Inhibition of TTR mediated fibrillogenesis assessed as acid-induced protein aggregation turbidity after 1.5 hrs by turbidimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransthyretin(Homo sapiens (Human))
Universidade De Coimbra

Curated by ChEMBL
LigandPNGBDBM50301375(3,3',5,5'-tetraiodo-L-thyronine | 3,5,3',5'-tetrai...)
Affinity DataIC50:  1.05E+4nMAssay Description:Inhibition of TTR mediated fibrillogenesis assessed as acid-induced protein aggregation turbidity after 1.5 hrs by turbidimetric assayMore data for this Ligand-Target Pair
TargetTransthyretin(Homo sapiens (Human))
Universidade De Coimbra

Curated by ChEMBL
LigandPNGBDBM50301377((E/Z)-1-methyl-3-(phenylimino)indolin-2-one | CHEM...)
Affinity DataIC50:  1.10E+4nMAssay Description:Inhibition of TTR mediated fibrillogenesis assessed as acid-induced protein aggregation turbidity after 1.5 hrs by turbidimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Ovis aries (Sheep))
Tohoku Medical And Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM17638(2-{1-[(4-chlorophenyl)carbonyl]-5-methoxy-2-methyl...)
Affinity DataIC50:  1.18E+4nMAssay Description:Inhibition of ovine COX-2 using arachidonic acid after 5 mins by colorimetric methodMore data for this Ligand-Target Pair
TargetTransthyretin(Homo sapiens (Human))
Universidade De Coimbra

Curated by ChEMBL
LigandPNGBDBM50301379((E/Z)-3-(p-tolylimino)indolin-2-one | CHEMBL571380)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of TTR mediated fibrillogenesis assessed as acid-induced protein aggregation turbidity after 1.5 hrs by turbidimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransthyretin(Homo sapiens (Human))
Universidade De Coimbra

Curated by ChEMBL
LigandPNGBDBM50301378((E/Z)-5-iodo-3-(phenylimino)indolin-2-one | CHEMBL...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of TTR mediated fibrillogenesis assessed as acid-induced protein aggregation turbidity after 1.5 hrs by turbidimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransthyretin(Homo sapiens (Human))
Universidade De Coimbra

Curated by ChEMBL
LigandPNGBDBM50198047((E/Z)-3-(phenylimino)indolin-2-one | 3-(phenylimin...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of TTR mediated fibrillogenesis assessed as acid-induced protein aggregation turbidity after 1.5 hrs by turbidimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransthyretin(Homo sapiens (Human))
Universidade De Coimbra

Curated by ChEMBL
LigandPNGBDBM11022(2,3-dihydro-1H-indole-2,3-dione | CHEMBL326294 | I...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of TTR mediated fibrillogenesis assessed as acid-induced protein aggregation turbidity after 1.5 hrs by turbidimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransthyretin(Homo sapiens (Human))
Universidade De Coimbra

Curated by ChEMBL
LigandPNGBDBM50301376((E/Z)-3-(4-iodophenylimino)-5-nitroindolin-2-one |...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of TTR mediated fibrillogenesis assessed as acid-induced protein aggregation turbidity after 1.5 hrs by turbidimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransthyretin(Homo sapiens (Human))
Universidade De Coimbra

Curated by ChEMBL
LigandPNGBDBM50301389((E/Z)-5-bromo-3-(4-iodophenylimino)indolin-2-one |...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of TTR mediated fibrillogenesis assessed as acid-induced protein aggregation turbidity after 1.5 hrs by turbidimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransthyretin(Homo sapiens (Human))
Universidade De Coimbra

Curated by ChEMBL
LigandPNGBDBM50301390((E/Z)-5-iodo-3-(4-iodophenylimino)indolin-2-one | ...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of TTR mediated fibrillogenesis assessed as acid-induced protein aggregation turbidity after 1.5 hrs by turbidimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransthyretin(Homo sapiens (Human))
Universidade De Coimbra

Curated by ChEMBL
LigandPNGBDBM50301388((E/Z)-3-(4-iodophenylimino)-5-methylindolin-2-one ...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of TTR mediated fibrillogenesis assessed as acid-induced protein aggregation turbidity after 1.5 hrs by turbidimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransthyretin(Homo sapiens (Human))
Universidade De Coimbra

Curated by ChEMBL
LigandPNGBDBM50301387((E/Z)-3-(4-iodophenylimino)-1-methylindolin-2-one ...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of TTR mediated fibrillogenesis assessed as acid-induced protein aggregation turbidity after 1.5 hrs by turbidimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransthyretin(Homo sapiens (Human))
Universidade De Coimbra

Curated by ChEMBL
LigandPNGBDBM50301386((E/Z)-3-(4-iodophenylimino)indolin-2-one | CHEMBL5...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of TTR mediated fibrillogenesis assessed as acid-induced protein aggregation turbidity after 1.5 hrs by turbidimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransthyretin(Homo sapiens (Human))
Universidade De Coimbra

Curated by ChEMBL
LigandPNGBDBM50301385((E/Z)-3-(4-methoxyphenylimino)-5-nitroindolin-2-on...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of TTR mediated fibrillogenesis assessed as acid-induced protein aggregation turbidity after 1.5 hrs by turbidimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransthyretin(Homo sapiens (Human))
Universidade De Coimbra

Curated by ChEMBL
LigandPNGBDBM50301384((E/Z)-5-iodo-3-(4-methoxyphenylimino)indolin-2-one...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of TTR mediated fibrillogenesis assessed as acid-induced protein aggregation turbidity after 1.5 hrs by turbidimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransthyretin(Homo sapiens (Human))
Universidade De Coimbra

Curated by ChEMBL
LigandPNGBDBM50301383((E/Z)-5-bromo-3-(4-methoxyphenylimino)indolin-2-on...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of TTR mediated fibrillogenesis assessed as acid-induced protein aggregation turbidity after 1.5 hrs by turbidimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransthyretin(Homo sapiens (Human))
Universidade De Coimbra

Curated by ChEMBL
LigandPNGBDBM50301382((E/Z)-3-(4-methoxyphenylimino)-5-methylindolin-2-o...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of TTR mediated fibrillogenesis assessed as acid-induced protein aggregation turbidity after 1.5 hrs by turbidimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
Tohoku Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50182989(CHEMBL3819010)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of heme catalyzed hydroperoxidase activity of ovine COX-1 using arachidonic acid as substrate preincubated for 5 mins followed by substrat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Ovis aries (Sheep))
Tohoku Medical And Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50182990(CHEMBL3818762)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of heme catalyzed hydroperoxidase activity of ovine COX-2 using arachidonic acid as substrate preincubated for 5 mins followed by substrat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Ovis aries (Sheep))
Tohoku Medical And Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50182989(CHEMBL3819010)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of heme catalyzed hydroperoxidase activity of ovine COX-2 using arachidonic acid as substrate preincubated for 5 mins followed by substrat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
Tohoku Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50128691(CHEMBL3628630)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of ovine COX-1 using arachidonic acid after 5 mins by colorimetric methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
Tohoku Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50128688(CHEMBL3628727)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of ovine COX-1 using arachidonic acid after 5 mins by colorimetric methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
Tohoku Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM11639(4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyraz...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of ovine COX-1 using arachidonic acid after 5 mins by colorimetric methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Ovis aries (Sheep))
Tohoku Medical And Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50128748(CHEMBL3628629)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of ovine COX-2 using arachidonic acid after 5 mins by colorimetric methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Ovis aries (Sheep))
Tohoku Medical And Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50128691(CHEMBL3628630)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of ovine COX-2 using arachidonic acid after 5 mins by colorimetric methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
Tohoku Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50182990(CHEMBL3818762)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of heme catalyzed hydroperoxidase activity of ovine COX-1 using arachidonic acid as substrate preincubated for 5 mins followed by substrat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
Tohoku Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50182889(CHEMBL3818849)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of heme catalyzed hydroperoxidase activity of ovine COX-1 using arachidonic acid as substrate preincubated for 5 mins followed by substrat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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