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Found 321 with Last Name = 'bebbington' and Initial = 'd'
TargetAurora kinase A(Homo sapiens (Human))
Vertex Pharmaceuticals

LigandPNGBDBM13534(CHEMBL572878 | N-[4-({4-[(3-methyl-1H-pyrazol-5-yl...)
Affinity DataKi:  0.600nM ΔG°:  -52.1kJ/molepH: 7.5 T: 2°CAssay Description:The kinase activity was determined by incubation of enzyme and its substrate, and test compound, in the presence ATP/[gamma-32P] ATP. After incubatio...More data for this Ligand-Target Pair
TargetAurora kinase A(Homo sapiens (Human))
Vertex Pharmaceuticals

LigandPNGBDBM13534(CHEMBL572878 | N-[4-({4-[(3-methyl-1H-pyrazol-5-yl...)
Affinity DataKi:  0.600nMAssay Description:Inhibition of Aurora-A by coupled assayMore data for this Ligand-Target Pair
TargetAurora kinase B(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50277679(CHEMBL484006 | N-(4-(4-(4-tert-butylpiperazin-1-yl...)
Affinity DataKi:  0.800nMAssay Description:Inhibition of Aurora-B by time dependent kinetic studyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Vertex Pharmaceuticals

LigandPNGBDBM50277640(CHEMBL485351 | N-(4-(4-(4-ethylpiperazin-1-yl)-6-(...)
Affinity DataKi: <1nMAssay Description:Inhibition of Aurora-A by coupled assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Vertex Pharmaceuticals

LigandPNGBDBM50293690(CHEMBL564941 | N-(4-(4-(5-methyl-1H-pyrazol-3-ylam...)
Affinity DataKi:  1nMAssay Description:Inhibition of Aurora-A by coupled assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Vertex Pharmaceuticals

LigandPNGBDBM50293686(CHEMBL559900 | N-(5-methyl-1H-pyrazol-3-yl)-2-(nap...)
Affinity DataKi:  1nMAssay Description:Inhibition of Aurora-A by coupled assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Vertex Pharmaceuticals

LigandPNGBDBM50293671(CHEMBL561421 | N-(4-(4-(5-cyclopropyl-1H-pyrazol-3...)
Affinity DataKi: <1nMAssay Description:Inhibition of Aurora-A by coupled assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Vertex Pharmaceuticals

LigandPNGBDBM50293699(CHEMBL554941 | N-(4-(4-(5-methyl-1H-pyrazol-3-ylam...)
Affinity DataKi: <1nMAssay Description:Inhibition of Aurora-A by coupled assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Vertex Pharmaceuticals

LigandPNGBDBM50293669(CHEMBL564449 | N-(4-(4-(5-methyl-1H-pyrazol-3-ylam...)
Affinity DataKi: <1nMAssay Description:Inhibition of Aurora-A by coupled assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Vertex Pharmaceuticals

LigandPNGBDBM50293689(CHEMBL549668 | N-methyl-N-(4-(4-(5-methyl-1H-pyraz...)
Affinity DataKi: <1nMAssay Description:Inhibition of Aurora-A by coupled assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Vertex Pharmaceuticals

LigandPNGBDBM50277678(CHEMBL485186 | N-(4-(4-(4-cyclopropylpiperazin-1-y...)
Affinity DataKi: <1nMAssay Description:Inhibition of Aurora-A by coupled assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Vertex Pharmaceuticals

LigandPNGBDBM50277679(CHEMBL484006 | N-(4-(4-(4-tert-butylpiperazin-1-yl...)
Affinity DataKi:  1.30nMAssay Description:Inhibition of Aurora-A by coupled assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Vertex Pharmaceuticals

LigandPNGBDBM50277586(CHEMBL484951 | N-(4-(4-(5-methyl-1H-pyrazol-3-ylam...)
Affinity DataKi:  1.60nMAssay Description:Inhibition of Aurora-A by coupled assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Vertex Pharmaceuticals

LigandPNGBDBM50277639(CHEMBL484609 | N-(4-(4-(5-methyl-1H-pyrazol-3-ylam...)
Affinity DataKi:  1.60nMAssay Description:Inhibition of Aurora-A by coupled assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Vertex Pharmaceuticals

LigandPNGBDBM50277637(CHEMBL482778 | N-(4-(4-(5-methyl-1H-pyrazol-3-ylam...)
Affinity DataKi:  1.70nMAssay Description:Inhibition of Aurora-A by coupled assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM13534(CHEMBL572878 | N-[4-({4-[(3-methyl-1H-pyrazol-5-yl...)
Affinity DataKi:  1.80nMAssay Description:Inhibition of Aurora-B by time dependent kinetic studyMore data for this Ligand-Target Pair
TargetAurora kinase A(Homo sapiens (Human))
Vertex Pharmaceuticals

LigandPNGBDBM50293682(2-(3,4-dichlorophenylthio)-N-(5-methyl-1H-pyrazol-...)
Affinity DataKi:  2nMAssay Description:Inhibition of Aurora-A by coupled assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Vertex Pharmaceuticals

LigandPNGBDBM50293687(CHEMBL552033 | N-(4-(4-(5-methyl-1H-pyrazol-3-ylam...)
Affinity DataKi:  2nMAssay Description:Inhibition of Aurora-A by coupled assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Vertex Pharmaceuticals

LigandPNGBDBM50293680(2-(2,4-dichlorophenylthio)-N-(5-methyl-1H-pyrazol-...)
Affinity DataKi:  2nMAssay Description:Inhibition of Aurora-A by coupled assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Vernalis Research

Curated by ChEMBL
LigandPNGBDBM50144841((S)-1-(6-chloro-5-fluoro-1H-indol-1-yl)propan-2-am...)
Affinity DataKi:  2.30nMAssay Description:Affinity for human 5-hydroxytryptamine 2C receptor expressed in mammalian cell lineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Vertex Pharmaceuticals

LigandPNGBDBM50293698(CHEMBL563682 | N-(4-(4-(azetidin-1-yl)-6-(5-methyl...)
Affinity DataKi:  2.40nMAssay Description:Inhibition of Aurora-A by coupled assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Vertex Pharmaceuticals

LigandPNGBDBM50293693(CHEMBL557279 | N-(4-(4-(5-methyl-1H-pyrazol-3-ylam...)
Affinity DataKi:  2.40nMAssay Description:Inhibition of Aurora-A by coupled assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Vertex Pharmaceuticals

LigandPNGBDBM50293679(2-(2,3-dichlorophenylthio)-N-(5-methyl-1H-pyrazol-...)
Affinity DataKi:  3nMAssay Description:Inhibition of Aurora-A by coupled assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Vertex Pharmaceuticals

LigandPNGBDBM50293700(CHEMBL560630 | N-(4-(4-(5-methyl-1H-pyrazol-3-ylam...)
Affinity DataKi: <3nMAssay Description:Inhibition of Aurora-A by coupled assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Vernalis Research

Curated by ChEMBL
LigandPNGBDBM50144846((S)-2-(5-Fluoro-6-methylsulfanyl-2,3-dihydro-indol...)
Affinity DataKi:  3.20nMAssay Description:Affinity for human 5-hydroxytryptamine 2C receptor expressed in mammalian cell lineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Vertex Pharmaceuticals

LigandPNGBDBM50277638(CHEMBL482779 | N-(4-(4-(5-methyl-1H-pyrazol-3-ylam...)
Affinity DataKi:  3.70nMAssay Description:Inhibition of Aurora-A by coupled assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Vertex Pharmaceuticals

LigandPNGBDBM50293695(CHEMBL561617 | N-(4-(4-cyclopropyl-6-(5-methyl-1H-...)
Affinity DataKi:  3.90nMAssay Description:Inhibition of Aurora-A by coupled assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Vertex Pharmaceuticals

LigandPNGBDBM50293697(CHEMBL557682 | N-(4-(4-(5-methyl-1H-pyrazol-3-ylam...)
Affinity DataKi:  3.90nMAssay Description:Inhibition of Aurora-A by coupled assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Vertex Pharmaceuticals

LigandPNGBDBM50277585(CHEMBL484950 | N-(4-(4-(3-methyl-1H-pyrazol-5-ylam...)
Affinity DataKi:  4nMAssay Description:Inhibition of Aurora-A by coupled assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Vertex Pharmaceuticals

LigandPNGBDBM50293677(2-(3-chlorophenylthio)-N-(5-methyl-1H-pyrazol-3-yl...)
Affinity DataKi:  4nMAssay Description:Inhibition of Aurora-A by coupled assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Vernalis (R&D)

Curated by ChEMBL
LigandPNGBDBM50377448(CHEMBL405234)
Affinity DataKi:  4.30nMAssay Description:Binding affinity to human adenosine A2A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase C(Homo sapiens (Human))
Vertex Pharmaceuticals

LigandPNGBDBM13534(CHEMBL572878 | N-[4-({4-[(3-methyl-1H-pyrazol-5-yl...)
Affinity DataKi:  4.60nM ΔG°:  -47.1kJ/molepH: 7.5 T: 2°CAssay Description:The kinase activity was determined by incubation of enzyme and its substrate, and test compound, in the presence ATP/[gamma-32P] ATP. After incubatio...More data for this Ligand-Target Pair
TargetAurora kinase A(Homo sapiens (Human))
Vertex Pharmaceuticals

LigandPNGBDBM50293676(2-(2-chlorophenylthio)-N-(5-methyl-1H-pyrazol-3-yl...)
Affinity DataKi:  5nMAssay Description:Inhibition of Aurora-A by coupled assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Vertex Pharmaceuticals

LigandPNGBDBM50293681(2-(2,6-dichlorophenylthio)-N-(5-methyl-1H-pyrazol-...)
Affinity DataKi:  5nMAssay Description:Inhibition of Aurora-A by coupled assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Vertex Pharmaceuticals

LigandPNGBDBM50293694(CHEMBL560556 | N-(4-(4-methyl-6-(5-methyl-1H-pyraz...)
Affinity DataKi:  5.10nMAssay Description:Inhibition of Aurora-A by coupled assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2B(Homo sapiens (Human))
Vernalis Research

Curated by ChEMBL
LigandPNGBDBM50144841((S)-1-(6-chloro-5-fluoro-1H-indol-1-yl)propan-2-am...)
Affinity DataKi:  5.10nMAssay Description:Affinity for human 5-hydroxytryptamine 2B receptor expressed in mammalian cell lineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Vernalis Research

Curated by ChEMBL
LigandPNGBDBM50144835((S)-1-Methyl-2-(6-methylsulfanyl-2,3-dihydro-indol...)
Affinity DataKi:  5.70nMAssay Description:Affinity for human 5-hydroxytryptamine 2C receptor expressed in mammalian cell lineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Vertex Pharmaceuticals

LigandPNGBDBM50293678(2-(4-chlorophenylthio)-N-(5-methyl-1H-pyrazol-3-yl...)
Affinity DataKi:  6nMAssay Description:Inhibition of Aurora-A by coupled assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Vernalis Research

Curated by ChEMBL
LigandPNGBDBM50144839((S)-2-(6-Ethylsulfanyl-5-fluoro-2,3-dihydro-indol-...)
Affinity DataKi:  6.40nMAssay Description:Affinity for human 5-hydroxytryptamine 2B receptor expressed in mammalian cell lineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Vernalis Research

Curated by ChEMBL
LigandPNGBDBM10755(14C-5-hydroxy tryptamine creatinine disulfate | 2-...)
Affinity DataKi:  6.90nMAssay Description:Affinity for human 5-hydroxytryptamine 2B receptor expressed in mammalian cell lineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50293680(2-(2,4-dichlorophenylthio)-N-(5-methyl-1H-pyrazol-...)
Affinity DataKi:  8nMAssay Description:Inhibition of GSK3-betaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50277586(CHEMBL484951 | N-(4-(4-(5-methyl-1H-pyrazol-3-ylam...)
Affinity DataKi:  8nMAssay Description:Inhibition of Aurora-BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Vernalis (R&D)

Curated by ChEMBL
LigandPNGBDBM50377447(CHEMBL405235)
Affinity DataKi:  8.10nMAssay Description:Binding affinity to human adenosine A2A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Vernalis Research

Curated by ChEMBL
LigandPNGBDBM50144842((S)-1-Methyl-2-(2,3,7,8-tetrahydro-furo[2,3-g]indo...)
Affinity DataKi:  8.70nMAssay Description:Affinity for human 5-hydroxytryptamine 2C receptor expressed in mammalian cell lineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Vernalis Research

Curated by ChEMBL
LigandPNGBDBM50001915(1-(3-chlorophenyl)piperazine | CHEMBL478 | m-Chlor...)
Affinity DataKi:  9nMAssay Description:Affinity for human 5-hydroxytryptamine 2A receptor expressed in mammalian cell lineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Vertex Pharmaceuticals

LigandPNGBDBM50293688(CHEMBL556460 | tert-butyl 4-(4-(5-methyl-1H-pyrazo...)
Affinity DataKi:  9nMAssay Description:Inhibition of Aurora-A by coupled assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Vertex Pharmaceuticals

LigandPNGBDBM50293684(2-(4-methoxyphenylthio)-N-(5-methyl-1H-pyrazol-3-y...)
Affinity DataKi:  9nMAssay Description:Inhibition of Aurora-A by coupled assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50277678(CHEMBL485186 | N-(4-(4-(4-cyclopropylpiperazin-1-y...)
Affinity DataKi:  9.5nMAssay Description:Inhibition of Aurora-BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Vertex Pharmaceuticals

LigandPNGBDBM50293696(CHEMBL565183 | N-(4-(4-tert-butyl-6-(5-methyl-1H-p...)
Affinity DataKi:  10nMAssay Description:Inhibition of Aurora-A by coupled assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase C(Homo sapiens (Human))
Vertex Pharmaceuticals

LigandPNGBDBM50277585(CHEMBL484950 | N-(4-(4-(3-methyl-1H-pyrazol-5-ylam...)
Affinity DataKi:  11nMAssay Description:Inhibition of Aurora-CMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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