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Found 689 with Last Name = 'bleakman' and Initial = 'd'
TargetGlutamate receptor ionotropic, kainate 5(Homo sapiens (Human))
University Of Bristol

Curated by ChEMBL
LigandPNGBDBM50060627((S)-2-Amino-3-(5-iodo-2,4-dioxo-3,4-dihydro-2H-pyr...)
Affinity DataKi:  0.240nMAssay Description:Displacement of [3H]kainate from human Ionotropic glutamate receptor ionotropic kainate 1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, kainate 2(Rattus norvegicus)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50053067((2S,3S,4S)-3-Carboxymethyl-4-(1-phenyl-vinyl)-pyrr...)
Affinity DataKi:  1.60nMAssay Description:Inhibition of [3H]-kainate binding at rat forebrain ionotropic glutamate receptor kainate 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, kainate 2(Rattus norvegicus)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50053071((2S,3S,4S)-3-Carboxymethyl-4-[1-(4-fluoro-3-methyl...)
Affinity DataKi:  1.90nMAssay Description:Inhibition of [3H]-kainate binding at rat forebrain ionotropic glutamate receptor kainate 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, kainate 2(Rattus norvegicus)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50053075((2S,3S,4S)-4-(1-Biphenyl-3-yl-vinyl)-3-carboxymeth...)
Affinity DataKi:  2.10nMAssay Description:Inhibition of [3H]-kainate binding at rat forebrain ionotropic glutamate receptor kainate 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, kainate 2(Rattus norvegicus)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50053083((2S,3S,4S)-3-Carboxymethyl-4-(1-m-tolyl-vinyl)-pyr...)
Affinity DataKi:  2.20nMAssay Description:Inhibition of [3H]-kainate binding at rat forebrain ionotropic glutamate receptor kainate 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, kainate 2(Rattus norvegicus)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50053080((2S,3S,4S)-3-Carboxymethyl-4-[1-(3,4-dimethyl-phen...)
Affinity DataKi:  2.30nMAssay Description:Inhibition of [3H]-kainate binding at rat forebrain ionotropic glutamate receptor kainate 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, kainate 2(Rattus norvegicus)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50053088((2S,3S,4S)-3-Carboxymethyl-4-(1-p-tolyl-vinyl)-pyr...)
Affinity DataKi:  2.60nMAssay Description:Inhibition of [3H]-kainate binding at rat forebrain ionotropic glutamate receptor kainate 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, kainate 2(Rattus norvegicus)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50053087((2S,3S,4S)-3-Carboxymethyl-4-[1-(4-fluoro-phenyl)-...)
Affinity DataKi:  2.70nMAssay Description:Inhibition of [3H]-kainate binding at rat forebrain ionotropic glutamate receptor kainate 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, kainate 2(Rattus norvegicus)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50053064((2S,3S,4S)-4-[1-(4-Butoxy-phenyl)-vinyl]-3-carboxy...)
Affinity DataKi:  2.80nMAssay Description:Inhibition of [3H]-kainate binding at rat forebrain ionotropic glutamate receptor kainate 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, kainate 5(Homo sapiens (Human))
University Of Bristol

Curated by ChEMBL
LigandPNGBDBM50060630((S)-2-Amino-3-(6-bromo-3,5-dioxo-4,5-dihydro-3H-[1...)
Affinity DataKi:  2.90nMAssay Description:Displacement of [3H]kainate from human Ionotropic glutamate receptor ionotropic kainate 1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor 2(Homo sapiens (Human))
Centro De Investigaci�N Lilly

Curated by ChEMBL
LigandPNGBDBM50494356(CHEMBL3088070)
Affinity DataKi:  3nMAssay Description:Displacement of [3H]AMPA from homomeric recombinant GluA2 receptor (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, kainate 1(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50031704((2S,4R)-2-Amino-4-methyl-pentanedioic acid | (2S,4...)
Affinity DataKi:  3nMAssay Description:Binding affinity against human ionotropic glutamate receptor kainate 1 in HK293 cells using [3H]-kainate as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, kainate 2(Rattus norvegicus)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50053063((2S,3S,4S)-3-Carboxymethyl-4-[1-(3-methoxy-phenyl)...)
Affinity DataKi:  3.5nMAssay Description:Inhibition of [3H]-kainate binding at rat forebrain ionotropic glutamate receptor kainate 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor 4(Homo sapiens (Human))
University Of Bristol

Curated by ChEMBL
LigandPNGBDBM50060628((S)-2-Amino-3-(6-chloro-3,5-dioxo-4,5-dihydro-3H-[...)
Affinity DataKi:  3.60nMAssay Description:Displacement of [3H]AMPA from human Ionotropic glutamate receptor AMPA 4 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, kainate 2(Rattus norvegicus)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50053068((2S,3S,4S)-3-Carboxymethyl-4-[1-(4-isopropenyl-phe...)
Affinity DataKi:  3.60nMAssay Description:Inhibition of [3H]-kainate binding at rat forebrain ionotropic glutamate receptor kainate 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, kainate 2(Rattus norvegicus)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50053059((2S,3S,4S)-3-Carboxymethyl-4-[1-(4-propyl-phenyl)-...)
Affinity DataKi:  3.60nMAssay Description:Inhibition of [3H]-kainate binding at rat forebrain ionotropic glutamate receptor kainate 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, kainate 2(Rattus norvegicus)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50002369((2S-(2alpha,3beta,4beta))-2-carboxy-4-(1-methyleth...)
Affinity DataKi:  3.70nMAssay Description:Inhibition of [3H]-kainate binding at rat forebrain ionotropic glutamate receptor kainate 2More data for this Ligand-Target Pair
TargetGlutamate receptor ionotropic, kainate 2(Rattus norvegicus)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50053073((2S,3S,4S)-3-Carboxymethyl-4-[1-(4-methoxy-phenyl)...)
Affinity DataKi:  3.90nMAssay Description:Inhibition of [3H]-kainate binding at rat forebrain ionotropic glutamate receptor kainate 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, kainate 2(Rattus norvegicus)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50053061((2S,3S,4S)-3-Carboxymethyl-4-[1-(4-chloro-phenyl)-...)
Affinity DataKi:  3.90nMAssay Description:Inhibition of [3H]-kainate binding at rat forebrain ionotropic glutamate receptor kainate 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, kainate 2(Rattus norvegicus)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50053082((2S,3S,4S)-4-[1-(4-Butyl-phenyl)-vinyl]-3-carboxym...)
Affinity DataKi:  4.80nMAssay Description:Inhibition of [3H]-kainate binding at rat forebrain ionotropic glutamate receptor kainate 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, kainate 2(Rattus norvegicus)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50053065((2S,3S,4S)-3-Carboxymethyl-4-[1-(4-phenethyloxy-ph...)
Affinity DataKi:  6.20nMAssay Description:Inhibition of [3H]-kainate binding at rat forebrain ionotropic glutamate receptor kainate 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, kainate 1(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50088223(CHEMBL61751 | E-2-Amino-4-(3-naphthalen-1-yl-allyl...)
Affinity DataKi:  7nMAssay Description:Binding affinity against human ionotropic glutamate receptor kainate 1 in HK293 cells using [3H]-kainate as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor 1(Homo sapiens (Human))
University Of Bristol

Curated by ChEMBL
LigandPNGBDBM50060628((S)-2-Amino-3-(6-chloro-3,5-dioxo-4,5-dihydro-3H-[...)
Affinity DataKi:  7.10nMAssay Description:Displacement of [3H]AMPA from human Ionotropic glutamate receptor AMPA 1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, kainate 2(Rattus norvegicus)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50053089((2S,3S,4S)-3-Carboxymethyl-4-[1-(4-ethyl-phenyl)-v...)
Affinity DataKi:  7.70nMAssay Description:Inhibition of [3H]-kainate binding at rat forebrain ionotropic glutamate receptor kainate 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor 4(Homo sapiens (Human))
University Of Bristol

Curated by ChEMBL
LigandPNGBDBM50060630((S)-2-Amino-3-(6-bromo-3,5-dioxo-4,5-dihydro-3H-[1...)
Affinity DataKi:  7.90nMAssay Description:Displacement of [3H]AMPA from human Ionotropic glutamate receptor AMPA 4 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, kainate 1(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50088197(CHEMBL58590 | E-2-Amino-4-[3-(4-chloro-phenyl)-all...)
Affinity DataKi:  8nMAssay Description:Compound was tested for binding affinity against Ionotropic glutamate receptor ionotropic kainate 1 in HK293 cells using [3H]-kainate as radioligand;...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, kainate 5(Homo sapiens (Human))
University Of Bristol

Curated by ChEMBL
LigandPNGBDBM50002369((2S-(2alpha,3beta,4beta))-2-carboxy-4-(1-methyleth...)
Affinity DataKi:  8nMAssay Description:Ability of the compound to bind to Ionotropic glutamate receptor kainate (kainate 2) was evaluated.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, kainate 1(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50088197(CHEMBL58590 | E-2-Amino-4-[3-(4-chloro-phenyl)-all...)
Affinity DataKi:  8nMAssay Description:Binding affinity against human ionotropic glutamate receptor kainate 1 in HK293 cells using [3H]-kainate as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, kainate 2(Rattus norvegicus)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50053070((2S,3S,4S)-3-Carboxymethyl-4-{1-[4-(1-methylene-pr...)
Affinity DataKi:  9nMAssay Description:Inhibition of [3H]-kainate binding at rat forebrain ionotropic glutamate receptor kainate 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, kainate 2(Rattus norvegicus)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50053076((2S,3S,4S)-4-(1-Biphenyl-4-yl-vinyl)-3-carboxymeth...)
Affinity DataKi:  9.10nMAssay Description:Inhibition of [3H]-kainate binding at rat forebrain ionotropic glutamate receptor kainate 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, kainate 5(Homo sapiens (Human))
University Of Bristol

Curated by ChEMBL
LigandPNGBDBM50060636((S)-2-Amino-3-(5-bromo-2,4-dioxo-3,4-dihydro-2H-py...)
Affinity DataKi:  9.10nMAssay Description:Displacement of [3H]kainate from human Ionotropic glutamate receptor ionotropic kainate 1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, kainate 2(Rattus norvegicus)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50053062((2S,3S,4S)-3-Carboxymethyl-4-[1-(3,5-dimethyl-phen...)
Affinity DataKi:  9.5nMAssay Description:Inhibition of [3H]-kainate binding at rat forebrain ionotropic glutamate receptor kainate 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, kainate 3(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50002369((2S-(2alpha,3beta,4beta))-2-carboxy-4-(1-methyleth...)
Affinity DataKi:  10nMAssay Description:Binding affinity of compound was determined against Ionotropic glutamate receptor ionotropic kainate 3 using cell membranes prepared from HEK293 cell...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, kainate 2(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50031704((2S,4R)-2-Amino-4-methyl-pentanedioic acid | (2S,4...)
Affinity DataKi:  10nMAssay Description:Binding affinity against human ionotropic glutamate receptor ionotropic kainate 2 in HEK293 cells using [3H]-kainate as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, kainate 3(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50002369((2S-(2alpha,3beta,4beta))-2-carboxy-4-(1-methyleth...)
Affinity DataKi:  10nMAssay Description:Ability of the compound to bind to Ionotropic glutamate receptor ionotropic kainate 3 was evaluatedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, kainate 1(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50088229(2-Amino-4-prop-2-ynyl-pentanedioic acid | CHEMBL59...)
Affinity DataKi:  11.6nMAssay Description:Binding affinity against human ionotropic glutamate receptor kainate 1 in HK293 cells using [3H]-kainate as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, kainate 2(Rattus norvegicus)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50053074((2S,3S,4S)-3-Carboxymethyl-4-[1-(4-phenoxy-phenyl)...)
Affinity DataKi:  11.9nMAssay Description:Inhibition of [3H]-kainate binding at rat forebrain ionotropic glutamate receptor kainate 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, kainate 1(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50088222((2S,4R)-2-Amino-4-((E)-3-naphthalen-2-yl-allyl)-pe...)
Affinity DataKi:  14nMAssay Description:Compound was tested for binding affinity against Ionotropic glutamate receptor ionotropic kainate 1 in HK293 cells using [3H]-kainate as radioligand;...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor 1(Homo sapiens (Human))
University Of Bristol

Curated by ChEMBL
LigandPNGBDBM50060635((S)-2-Amino-3-(5-fluoro-2,4-dioxo-3,4-dihydro-2H-p...)
Affinity DataKi:  15nMAssay Description:Displacement of [3H]AMPA from human Ionotropic glutamate receptor AMPA 1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
TargetGlutamate receptor ionotropic, kainate 1(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50088222((2S,4R)-2-Amino-4-((E)-3-naphthalen-2-yl-allyl)-pe...)
Affinity DataKi:  15nMAssay Description:Compound was tested for binding affinity against Ionotropic glutamate receptor ionotropic kainate 1 in HK293 cells using [3H]-kainate as radioligand;...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, kainate 1(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50088222((2S,4R)-2-Amino-4-((E)-3-naphthalen-2-yl-allyl)-pe...)
Affinity DataKi:  15nMAssay Description:Binding affinity of compound was determined against Ionotropic glutamate receptor ionotropic kainate 1 using cell membranes prepared from HEK293 cell...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, kainate 2(Rattus norvegicus)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50053077((2S,3S,4S)-3-Carboxymethyl-4-[1-(3-phenethyloxy-ph...)
Affinity DataKi:  16nMAssay Description:Inhibition of [3H]-kainate binding at rat forebrain ionotropic glutamate receptor kainate 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor 2(Homo sapiens (Human))
Centro De Investigaci�N Lilly

Curated by ChEMBL
LigandPNGBDBM50060628((S)-2-Amino-3-(6-chloro-3,5-dioxo-4,5-dihydro-3H-[...)
Affinity DataKi:  17nMAssay Description:Displacement of [3H]AMPA from human Ionotropic glutamate receptor AMPA 2 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, kainate 2(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50053058((4E,6E)-(R)-7-[4,5-Bis-(1-hydroxy-vinyl)-pyrrolidi...)
Affinity DataKi:  18.3nMAssay Description:Inhibition of [3H]-kainate binding at ionotropic glutamate receptor kainate 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, kainate 2(Rattus norvegicus)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50053060((2S,3S,4S)-4-[1-(4-tert-Butyl-phenyl)-vinyl]-3-car...)
Affinity DataKi:  18.5nMAssay Description:Inhibition of [3H]-kainate binding at rat forebrain ionotropic glutamate receptor kainate 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor 2(Homo sapiens (Human))
Centro De Investigaci�N Lilly

Curated by ChEMBL
LigandPNGBDBM50060630((S)-2-Amino-3-(6-bromo-3,5-dioxo-4,5-dihydro-3H-[1...)
Affinity DataKi:  19nMAssay Description:Displacement of [3H]AMPA from human Ionotropic glutamate receptor AMPA 2 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor 4(Homo sapiens (Human))
University Of Bristol

Curated by ChEMBL
LigandPNGBDBM50060629((S)-2-Amino-3-(6-iodo-3,5-dioxo-4,5-dihydro-3H-[1,...)
Affinity DataKi:  20nMAssay Description:Displacement of [3H]AMPA from human Ionotropic glutamate receptor AMPA 4 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, kainate 1(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50494356(CHEMBL3088070)
Affinity DataKi:  20nMAssay Description:Displacement of [3H]ATPA from human Gluk1 receptorMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, kainate 5(Homo sapiens (Human))
University Of Bristol

Curated by ChEMBL
LigandPNGBDBM50060629((S)-2-Amino-3-(6-iodo-3,5-dioxo-4,5-dihydro-3H-[1,...)
Affinity DataKi:  20nMAssay Description:Displacement of [3H]kainate from human Ionotropic glutamate receptor ionotropic kainate 1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, kainate 1(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50088212(2-Amino-4-but-2-enyl-pentanedioic acid(LY339180) |...)
Affinity DataKi:  21nMAssay Description:Binding affinity against human ionotropic glutamate receptor kainate 1 in HK293 cells using [3H]-kainate as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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