Compile Data Set for Download or QSAR
maximum 50k data
Found 99 with Last Name = 'brady' and Initial = 'sf'
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50454822(CHEMBL2062141 | L-370518)
Affinity DataKi:  0.0900nMAssay Description:Binding affinity towards thrombin was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50057828((S)-1-((R)-2-Amino-3,3-diphenyl-propionyl)-pyrroli...)
Affinity DataKi:  0.100nMAssay Description:Binding affinity towards thrombin was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50063555(1-(2-Amino-3,3-diphenyl-propionyl)-pyrrolidine-2-c...)
Affinity DataKi:  0.100nMAssay Description:Binding affinity towards thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50066331((S)-1-[(R)-2-Cyclohexyl-2-(diethylcarbamoylmethyl-...)
Affinity DataKi:  0.310nMAssay Description:Binding affinity of the compound was evaluated on serine protease thrombin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50066338(CHEMBL327115 | [2-({[(S)-1-((R)-2-Amino-2-cyclohex...)
Affinity DataKi:  0.450nMAssay Description:Binding affinity of the compound was evaluated on serine protease thrombin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50066332((S)-1-((R)-2-Amino-2-cyclohexyl-acetyl)-pyrrolidin...)
Affinity DataKi:  0.5nMAssay Description:Binding affinity of the compound was evaluated on serine protease thrombin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50066333((S)-1-((R)-2-Amino-2-cyclohexyl-acetyl)-pyrrolidin...)
Affinity DataKi:  0.610nMAssay Description:Binding affinity of the compound was evaluated on serine protease thrombin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50066334((S)-1-((R)-2-Amino-2-cyclohexyl-acetyl)-pyrrolidin...)
Affinity DataKi:  0.740nMAssay Description:Binding affinity of the compound was evaluated on serine protease thrombin.More data for this Ligand-Target Pair
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50164268((S)-1-(9-Hydroxy-9H-fluorene-9-carbonyl)-pyrrolidi...)
Affinity DataKi:  1.5nMAssay Description:Binding affinity towards thrombin was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50062623((S)-1-[2-Hydroxy-2-(4-hydroxy-3-methoxy-phenyl)-ac...)
Affinity DataKi:  2.5nMAssay Description:Binding affinity towards thrombin was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50062634((S)-1-[3-(4-Hydroxy-phenyl)-2-phenyl-propionyl]-py...)
Affinity DataKi:  2.5nMAssay Description:Binding affinity towards thrombin was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50066340((S)-1-((R)-2-Amino-2-cyclohexyl-acetyl)-pyrrolidin...)
Affinity DataKi:  2.5nMAssay Description:Binding affinity of the compound was evaluated on serine protease thrombin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50066337((S)-1-(2-Amino-3,3-diphenyl-propionyl)-pyrrolidine...)
Affinity DataKi:  3nMAssay Description:Binding affinity of the compound was evaluated on serine protease thrombin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50063562(1-(2-Amino-3,3-diphenyl-propionyl)-pyrrolidine-2-c...)
Affinity DataKi:  3nMAssay Description:Binding affinity towards thrombinMore data for this Ligand-Target Pair
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50062628((S)-1-((S)-2-Amino-2-cyclohexyl-acetyl)-pyrrolidin...)
Affinity DataKi:  3nMAssay Description:Binding affinity towards thrombin was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50366827(CHEMBL125181 | L-371912)
Affinity DataKi:  4.90nMAssay Description:Binding affinity towards thrombin was determinedMore data for this Ligand-Target Pair
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50066336((S)-1-((R)-2-Amino-2-cyclohexyl-acetyl)-pyrrolidin...)
Affinity DataKi:  5nMAssay Description:Binding affinity of the compound was evaluated on serine protease thrombin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50066339((S)-1-[(R)-2-Cyclohexyl-2-(diethylcarbamoylmethyl-...)
Affinity DataKi:  18nMAssay Description:Binding affinity of the compound was evaluated on serine protease thrombin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50066341((S)-1-[(R)-2-Cyclohexyl-2-(diethylcarbamoylmethyl-...)
Affinity DataKi:  20nMAssay Description:Binding affinity of the compound was evaluated on serine protease thrombin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50063549(1-(2-Amino-3,3-diphenyl-propionyl)-pyrrolidine-2-c...)
Affinity DataKi:  40nMAssay Description:Binding affinity towards thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50066335(CHEMBL111051 | [2-({[(S)-1-((R)-2-Amino-2-cyclohex...)
Affinity DataKi:  60nMAssay Description:Binding affinity of the compound was evaluated on serine protease thrombin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50063558(1-(2-Amino-3,3-diphenyl-propionyl)-pyrrolidine-2-c...)
Affinity DataKi:  70nMAssay Description:Binding affinity towards thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50062624((S)-1-(2,3-Dihydro-benzo[1,4]dioxine-2-carbonyl)-p...)
Affinity DataKi:  75nMAssay Description:Binding affinity towards thrombin was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50063559(1-(2-Amino-3,3-diphenyl-propionyl)-pyrrolidine-2-c...)
Affinity DataKi:  110nMAssay Description:Binding affinity towards thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50164268((S)-1-(9-Hydroxy-9H-fluorene-9-carbonyl)-pyrrolidi...)
Affinity DataKi:  860nMAssay Description:Binding affinity towards trypsin was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50139111((4R,6S,7S)-7-[(S)-3-Carboxy-3-(3-methyl-butyrylami...)
Affinity DataKi:  1.70E+3nMAssay Description:Tested for inhibition of Beta-secretase 1 (BACE 1) expressed in insect cell using baculovirusMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50139112((S)-N-((1S,2S,4R)-1-Benzyl-2,6-dihydroxy-4-isobuty...)
Affinity DataKi:  1.90E+3nMAssay Description:Tested for inhibition of Beta-secretase 1 (BACE 1) expressed in insect cell using baculovirusMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50139109((S)-N-((1S,2S,4R)-6-Acetoxy-1-benzyl-2-hydroxy-4-i...)
Affinity DataKi:  1.90E+3nMAssay Description:Compound was tested for inhibition of human reninMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50139109((S)-N-((1S,2S,4R)-6-Acetoxy-1-benzyl-2-hydroxy-4-i...)
Affinity DataKi:  2.20E+3nMAssay Description:Compound was tested for inhibition of cathepsin DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50139109((S)-N-((1S,2S,4R)-6-Acetoxy-1-benzyl-2-hydroxy-4-i...)
Affinity DataKi:  2.70E+3nMAssay Description:Tested for inhibition of Beta-secretase 1 (BACE 1) expressed in insect cell using baculovirusMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50066337((S)-1-(2-Amino-3,3-diphenyl-propionyl)-pyrrolidine...)
Affinity DataKi:  7.00E+3nMAssay Description:Selectivity of the compound was evaluated as the binding affinity between thrombin versus trypsin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50066332((S)-1-((R)-2-Amino-2-cyclohexyl-acetyl)-pyrrolidin...)
Affinity DataKi:  9.00E+3nMAssay Description:Binding affinity of the compound was evaluated on serine protease trypsin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50139112((S)-N-((1S,2S,4R)-1-Benzyl-2,6-dihydroxy-4-isobuty...)
Affinity DataKi:  1.09E+4nMAssay Description:Compound was tested for inhibition of human reninMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTissue-type plasminogen activator(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50066332((S)-1-((R)-2-Amino-2-cyclohexyl-acetyl)-pyrrolidin...)
Affinity DataKi:  1.10E+4nMAssay Description:Binding affinity of the compound was evaluated on serine protease TPA.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50139112((S)-N-((1S,2S,4R)-1-Benzyl-2,6-dihydroxy-4-isobuty...)
Affinity DataKi:  1.25E+4nMAssay Description:Compound was tested for inhibition of cathepsin DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50066333((S)-1-((R)-2-Amino-2-cyclohexyl-acetyl)-pyrrolidin...)
Affinity DataKi:  1.80E+4nMAssay Description:Binding affinity of the compound was evaluated on serine protease trypsin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTissue-type plasminogen activator(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50066336((S)-1-((R)-2-Amino-2-cyclohexyl-acetyl)-pyrrolidin...)
Affinity DataKi:  1.90E+4nMAssay Description:Binding affinity of the compound was evaluated on serine protease TPA.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50066334((S)-1-((R)-2-Amino-2-cyclohexyl-acetyl)-pyrrolidin...)
Affinity DataKi:  2.30E+4nMAssay Description:Binding affinity of the compound was evaluated on serine protease trypsin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50139110((S)-N-((1S,2S,4R)-1-Benzyl-2-hydroxy-4-isobutylcar...)
Affinity DataKi:  2.44E+4nMAssay Description:Compound was tested for inhibition of human reninMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50066331((S)-1-[(R)-2-Cyclohexyl-2-(diethylcarbamoylmethyl-...)
Affinity DataKi:  2.70E+4nMAssay Description:Binding affinity of the compound was evaluated on serine protease trypsin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50139110((S)-N-((1S,2S,4R)-1-Benzyl-2-hydroxy-4-isobutylcar...)
Affinity DataKi:  2.80E+4nMAssay Description:Compound was tested for inhibition of cathepsin DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50066336((S)-1-((R)-2-Amino-2-cyclohexyl-acetyl)-pyrrolidin...)
Affinity DataKi:  2.90E+4nMAssay Description:Binding affinity of the compound was evaluated on serine protease trypsin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTissue-type plasminogen activator(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50066331((S)-1-[(R)-2-Cyclohexyl-2-(diethylcarbamoylmethyl-...)
Affinity DataKi:  2.90E+4nMAssay Description:Binding affinity of the compound was evaluated on serine protease TPA.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTissue-type plasminogen activator(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50066333((S)-1-((R)-2-Amino-2-cyclohexyl-acetyl)-pyrrolidin...)
Affinity DataKi:  3.60E+4nMAssay Description:Binding affinity of the compound was evaluated on serine protease TPA.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymotrypsinogen A(Bos taurus (bovine))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50066336((S)-1-((R)-2-Amino-2-cyclohexyl-acetyl)-pyrrolidin...)
Affinity DataKi:  4.90E+4nMAssay Description:Binding affinity of the compound was evaluated on serine protease ChymotrypsinogenMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymotrypsinogen A(Bos taurus (bovine))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50066337((S)-1-(2-Amino-3,3-diphenyl-propionyl)-pyrrolidine...)
Affinity DataKi: >5.00E+4nMAssay Description:Selectivity of the compound was evaluated as the binding affinity between thrombin versus ChymotrypsinogenMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymotrypsinogen A(Bos taurus (bovine))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50066333((S)-1-((R)-2-Amino-2-cyclohexyl-acetyl)-pyrrolidin...)
Affinity DataKi:  6.70E+4nMAssay Description:Binding affinity of the compound was evaluated on serine protease ChymotrypsinogenMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50139110((S)-N-((1S,2S,4R)-1-Benzyl-2-hydroxy-4-isobutylcar...)
Affinity DataKi:  6.95E+4nMAssay Description:Tested for inhibition of Beta-secretase 1 (BACE 1) expressed in insect cell using baculovirusMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymotrypsinogen A(Bos taurus (bovine))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50066334((S)-1-((R)-2-Amino-2-cyclohexyl-acetyl)-pyrrolidin...)
Affinity DataKi:  7.10E+4nMAssay Description:Binding affinity of the compound was evaluated on serine protease ChymotrypsinogenMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50139111((4R,6S,7S)-7-[(S)-3-Carboxy-3-(3-methyl-butyrylami...)
Affinity DataKi:  7.36E+4nMAssay Description:Compound was tested for inhibition of human reninMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Displayed 1 to 50 (of 99 total ) | Next | Last >>
Jump to: