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Found 292 with Last Name = 'breitfelder' and Initial = 's'
TargetMitogen-activated protein kinase 9(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50215054(1-(3-tert-butyl-1-p-tolyl-1H-pyrazol-5-yl)-3-(4-(6...)
Affinity DataIC50:  2nMAssay Description:Inhibition of Jnk2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 9(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50277623(CHEMBL451523 | N-(5-tert-butyl-2-methoxy-3-(3-(4-(...)
Affinity DataIC50:  3nMAssay Description:Inhibition of JNK2alpha2 (unknown origin) by by exchange curve binding kinetic analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50218689(CHEMBL245230 | N-(5-tert-butyl-2-methoxy-3-(3-naph...)
Affinity DataIC50:  79nMAssay Description:Binding affinity to p38alpha (unknown origin) assessed as inhibition of ATF2 phosphorylation preincubated for 4 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 9(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM13533(1-[2-(4-methylphenyl)-5-tert-butyl-pyrazol-3-yl]-3...)
Affinity DataIC50:  100nMAssay Description:Selectivity against c-Jun N-terminal kinase 2-alpha 2 protein kinaseMore data for this Ligand-Target Pair
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50215054(1-(3-tert-butyl-1-p-tolyl-1H-pyrazol-5-yl)-3-(4-(6...)
Affinity DataIC50:  400nMAssay Description:Inhibition of cRafMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50277623(CHEMBL451523 | N-(5-tert-butyl-2-methoxy-3-(3-(4-(...)
Affinity DataIC50:  480nMAssay Description:Inhibition of Abl (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50277623(CHEMBL451523 | N-(5-tert-butyl-2-methoxy-3-(3-(4-(...)
Affinity DataIC50:  880nMAssay Description:Inhibition of craf (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lyn(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50215054(1-(3-tert-butyl-1-p-tolyl-1H-pyrazol-5-yl)-3-(4-(6...)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of LynMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50215054(1-(3-tert-butyl-1-p-tolyl-1H-pyrazol-5-yl)-3-(4-(6...)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of AblMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50215054(1-(3-tert-butyl-1-p-tolyl-1H-pyrazol-5-yl)-3-(4-(6...)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of SrcMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM13533(1-[2-(4-methylphenyl)-5-tert-butyl-pyrazol-3-yl]-3...)
Affinity DataIC50:  1.40E+3nMAssay Description:Selectivity against RAF proto-oncogene serine/threonine-protein kinase (c-Raf-1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lyn(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50277623(CHEMBL451523 | N-(5-tert-butyl-2-methoxy-3-(3-(4-(...)
Affinity DataIC50:  2.40E+3nMAssay Description:Inhibition of Lyn (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50218677(CHEMBL242005 | N-(5-tert-butyl-2-methoxy-3-(methyl...)
Affinity DataIC50:  2.70E+3nMAssay Description:Binding affinity to p38alpha (unknown origin) assessed as inhibition of ATF2 phosphorylation preincubated for 4 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEphrin type-A receptor 3(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50277623(CHEMBL451523 | N-(5-tert-butyl-2-methoxy-3-(3-(4-(...)
Affinity DataIC50:  3.20E+3nMAssay Description:Inhibition of HEK (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50277627(1-(5-tert-butyl-2-methoxyphenyl)-3-(naphthalen-1-y...)
Affinity DataIC50:  3.90E+3nMAssay Description:Binding affinity to p38alpha (unknown origin) assessed as inhibition of ATF2 phosphorylation preincubated for 4 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50218695(CHEMBL390254 | N-(5-tert-butyl-2-methoxy-3-(methyl...)
Affinity DataIC50:  4.10E+3nMAssay Description:Binding affinity to p38alpha (unknown origin) assessed as inhibition of ATF2 phosphorylation preincubated for 4 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEphrin type-A receptor 2(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50277623(CHEMBL451523 | N-(5-tert-butyl-2-methoxy-3-(3-(4-(...)
Affinity DataIC50:  5.20E+3nMAssay Description:Inhibition of ECK (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50277623(CHEMBL451523 | N-(5-tert-butyl-2-methoxy-3-(3-(4-(...)
Affinity DataIC50:  5.40E+3nMAssay Description:Inhibition of EGFR (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50277623(CHEMBL451523 | N-(5-tert-butyl-2-methoxy-3-(3-(4-(...)
Affinity DataIC50:  6.40E+3nMAssay Description:Inhibition of PKBalpha/Akt1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50277623(CHEMBL451523 | N-(5-tert-butyl-2-methoxy-3-(3-(4-(...)
Affinity DataIC50:  7.20E+3nMAssay Description:Inhibition of bRaf (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50277662(CHEMBL484405 | N-(5-tert-butyl-2-methoxyphenyl)ben...)
Affinity DataIC50: >1.00E+4nMAssay Description:Binding affinity to p38alpha (unknown origin) assessed as inhibition of ATF2 phosphorylation preincubated for 4 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50277663(CHEMBL519511 | N-(5-tert-butyl-2-methoxyphenyl)ben...)
Affinity DataIC50: >1.00E+4nMAssay Description:Binding affinity to p38alpha (unknown origin) assessed as inhibition of ATF2 phosphorylation preincubated for 4 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM13533(1-[2-(4-methylphenyl)-5-tert-butyl-pyrazol-3-yl]-3...)
Affinity DataIC50: >2.00E+4nMAssay Description:Selectivity against p56 Lck tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM13533(1-[2-(4-methylphenyl)-5-tert-butyl-pyrazol-3-yl]-3...)
Affinity DataIC50: >2.00E+4nMAssay Description:Selectivity against Syk protein tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM13533(1-[2-(4-methylphenyl)-5-tert-butyl-pyrazol-3-yl]-3...)
Affinity DataIC50: >2.00E+4nMAssay Description:Selectivity against I-kappa-B-kinase betaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ZAP-70(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM13533(1-[2-(4-methylphenyl)-5-tert-butyl-pyrazol-3-yl]-3...)
Affinity DataIC50: >2.00E+4nMAssay Description:Selectivity against Zeta-chain (TCR) associated protein kinase 70 kDa (ZAP70)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Fyn(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM13533(1-[2-(4-methylphenyl)-5-tert-butyl-pyrazol-3-yl]-3...)
Affinity DataIC50: >2.00E+4nMAssay Description:Selectivity against p59 Fyn tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 3(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM13533(1-[2-(4-methylphenyl)-5-tert-butyl-pyrazol-3-yl]-3...)
Affinity DataIC50: >2.00E+4nMAssay Description:Selectivity against Extracellular signal-regulated kinase 1 (Erk-1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM13533(1-[2-(4-methylphenyl)-5-tert-butyl-pyrazol-3-yl]-3...)
Affinity DataIC50: >2.00E+4nMAssay Description:Selectivity against HER2 kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM13533(1-[2-(4-methylphenyl)-5-tert-butyl-pyrazol-3-yl]-3...)
Affinity DataIC50: >2.00E+4nMAssay Description:Selectivity against Epidermal growth factor receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucose-dependent insulinotropic receptor(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM180490(US8772323, 52)
Affinity DataEC50:  189nMpH: 7.4 T: 2°CAssay Description:MIN6 cells [Miyazaki J et al. Endocrinology. 1990 July; 127(1):126-32] were stably transfected with an expression vector for human GPR119 cDNA (Acc. ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGlucose-dependent insulinotropic receptor(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM180491(US8772323, 53)
Affinity DataEC50:  205nMpH: 7.4 T: 2°CAssay Description:MIN6 cells [Miyazaki J et al. Endocrinology. 1990 July; 127(1):126-32] were stably transfected with an expression vector for human GPR119 cDNA (Acc. ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGlucose-dependent insulinotropic receptor(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM180492(US8772323, 54)
Affinity DataEC50:  145nMpH: 7.4 T: 2°CAssay Description:MIN6 cells [Miyazaki J et al. Endocrinology. 1990 July; 127(1):126-32] were stably transfected with an expression vector for human GPR119 cDNA (Acc. ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGlucose-dependent insulinotropic receptor(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM180493(US8772323, 55)
Affinity DataEC50:  486nMpH: 7.4 T: 2°CAssay Description:MIN6 cells [Miyazaki J et al. Endocrinology. 1990 July; 127(1):126-32] were stably transfected with an expression vector for human GPR119 cDNA (Acc. ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGlucose-dependent insulinotropic receptor(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM180494(US8772323, 56)
Affinity DataEC50:  170nMpH: 7.4 T: 2°CAssay Description:MIN6 cells [Miyazaki J et al. Endocrinology. 1990 July; 127(1):126-32] were stably transfected with an expression vector for human GPR119 cDNA (Acc. ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGlucose-dependent insulinotropic receptor(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM180495(US8772323, 57)
Affinity DataEC50:  37nMpH: 7.4 T: 2°CAssay Description:MIN6 cells [Miyazaki J et al. Endocrinology. 1990 July; 127(1):126-32] were stably transfected with an expression vector for human GPR119 cDNA (Acc. ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGlucose-dependent insulinotropic receptor(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM180496(US8772323, 58)
Affinity DataEC50:  76nMpH: 7.4 T: 2°CAssay Description:MIN6 cells [Miyazaki J et al. Endocrinology. 1990 July; 127(1):126-32] were stably transfected with an expression vector for human GPR119 cDNA (Acc. ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGlucose-dependent insulinotropic receptor(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM180497(US8772323, 59)
Affinity DataEC50:  1.59E+3nMpH: 7.4 T: 2°CAssay Description:MIN6 cells [Miyazaki J et al. Endocrinology. 1990 July; 127(1):126-32] were stably transfected with an expression vector for human GPR119 cDNA (Acc. ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGlucose-dependent insulinotropic receptor(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM180498(US8772323, 60)
Affinity DataEC50:  639nMpH: 7.4 T: 2°CAssay Description:MIN6 cells [Miyazaki J et al. Endocrinology. 1990 July; 127(1):126-32] were stably transfected with an expression vector for human GPR119 cDNA (Acc. ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGlucose-dependent insulinotropic receptor(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM180499(US8772323, 61)
Affinity DataEC50:  342nMpH: 7.4 T: 2°CAssay Description:MIN6 cells [Miyazaki J et al. Endocrinology. 1990 July; 127(1):126-32] were stably transfected with an expression vector for human GPR119 cDNA (Acc. ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGlucose-dependent insulinotropic receptor(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM180500(US8772323, 62)
Affinity DataEC50:  552nMpH: 7.4 T: 2°CAssay Description:MIN6 cells [Miyazaki J et al. Endocrinology. 1990 July; 127(1):126-32] were stably transfected with an expression vector for human GPR119 cDNA (Acc. ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGlucose-dependent insulinotropic receptor(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM180501(US8772323, 63)
Affinity DataEC50:  324nMpH: 7.4 T: 2°CAssay Description:MIN6 cells [Miyazaki J et al. Endocrinology. 1990 July; 127(1):126-32] were stably transfected with an expression vector for human GPR119 cDNA (Acc. ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGlucose-dependent insulinotropic receptor(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM180502(US8772323, 64)
Affinity DataEC50:  237nMpH: 7.4 T: 2°CAssay Description:MIN6 cells [Miyazaki J et al. Endocrinology. 1990 July; 127(1):126-32] were stably transfected with an expression vector for human GPR119 cDNA (Acc. ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGlucose-dependent insulinotropic receptor(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM180503(US8772323, 65)
Affinity DataEC50:  426nMpH: 7.4 T: 2°CAssay Description:MIN6 cells [Miyazaki J et al. Endocrinology. 1990 July; 127(1):126-32] were stably transfected with an expression vector for human GPR119 cDNA (Acc. ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGlucose-dependent insulinotropic receptor(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM180504(US8772323, 66)
Affinity DataEC50:  112nMpH: 7.4 T: 2°CAssay Description:MIN6 cells [Miyazaki J et al. Endocrinology. 1990 July; 127(1):126-32] were stably transfected with an expression vector for human GPR119 cDNA (Acc. ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGlucose-dependent insulinotropic receptor(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM180505(US8772323, 67)
Affinity DataEC50:  51nMpH: 7.4 T: 2°CAssay Description:MIN6 cells [Miyazaki J et al. Endocrinology. 1990 July; 127(1):126-32] were stably transfected with an expression vector for human GPR119 cDNA (Acc. ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGlucose-dependent insulinotropic receptor(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM180506(US8772323, 68)
Affinity DataEC50:  60nMpH: 7.4 T: 2°CAssay Description:MIN6 cells [Miyazaki J et al. Endocrinology. 1990 July; 127(1):126-32] were stably transfected with an expression vector for human GPR119 cDNA (Acc. ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGlucose-dependent insulinotropic receptor(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM180507(US8772323, 69)
Affinity DataEC50:  143nMpH: 7.4 T: 2°CAssay Description:MIN6 cells [Miyazaki J et al. Endocrinology. 1990 July; 127(1):126-32] were stably transfected with an expression vector for human GPR119 cDNA (Acc. ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGlucose-dependent insulinotropic receptor(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM180543(US8772323, 70)
Affinity DataEC50:  3.91E+3nMpH: 7.4 T: 2°CAssay Description:MIN6 cells [Miyazaki J et al. Endocrinology. 1990 July; 127(1):126-32] were stably transfected with an expression vector for human GPR119 cDNA (Acc. ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGlucose-dependent insulinotropic receptor(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM180544(US8772323, 71)
Affinity DataEC50: >1.00E+4nMpH: 7.4 T: 2°CAssay Description:MIN6 cells [Miyazaki J et al. Endocrinology. 1990 July; 127(1):126-32] were stably transfected with an expression vector for human GPR119 cDNA (Acc. ...More data for this Ligand-Target Pair
In DepthDetails US Patent
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