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Found 290 with Last Name = 'bretz' and Initial = 'a'
TargetCyclin-dependent kinase 4(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50267899((4Z)-6-(3-Furyl)-4-{[(3-hydroxy-4-methoxybenzyl)am...)
Affinity DataIC50:  2nMAssay Description:Inhibition of CDK4/Cyclin D1 (unknown origin) assessed as inhibition of retinoblastoma susceptibility gene product phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50267898((4Z)-4-{[(3-Hydroxy-4-methoxybenzyl)amino]methylen...)
Affinity DataIC50:  2nMAssay Description:Inhibition of CDK4/Cyclin D1 (unknown origin) assessed as inhibition of retinoblastoma susceptibility gene product phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50267867((4Z)-4-{[(3-hydroxy-4-methoxybenzyl)amino]methylen...)
Affinity DataIC50:  4nMAssay Description:Inhibition of CDK4/Cyclin D1 (unknown origin) assessed as inhibition of retinoblastoma susceptibility gene product phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50267482(6-Cyclopentyl-4-{[(4-hydroxy-5-propoxy-pyridin-2-y...)
Affinity DataIC50: <5nMAssay Description:Inhibition of CDK4/Cyclin D1 (unknown origin) assessed as inhibition of retinoblastoma susceptibility gene product phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50267540(6-Cyclopentyl-4-{[(5-furan-3-yl-4-hydroxy-pyridin-...)
Affinity DataIC50: <5nMAssay Description:Inhibition of CDK4/Cyclin D1 (unknown origin) assessed as inhibition of retinoblastoma susceptibility gene product phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50003643(CHEMBL484477)
Affinity DataIC50: <7nMAssay Description:Inhibition of CDK4/Cyclin D1 (unknown origin) assessed as inhibition of retinoblastoma susceptibility gene product phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50267399(4-[(3-Hydroxy-4-pyridin-4-yl-benzylamino)-methylen...)
Affinity DataIC50:  8nMAssay Description:Inhibition of CDK4/Cyclin D1 (unknown origin) assessed as inhibition of retinoblastoma susceptibility gene product phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50267900(4-[(3-Hydroxy-4-methoxy-benzylamino)-methylene]-6-...)
Affinity DataIC50:  10nMAssay Description:Inhibition of CDK4/Cyclin D1 (unknown origin) assessed as inhibition of retinoblastoma susceptibility gene product phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50267398(4-[(3-Hydroxy-4-pyridin-3-yl-benzylamino)-methylen...)
Affinity DataIC50:  10nMAssay Description:Inhibition of CDK4/Cyclin D1 (unknown origin) assessed as inhibition of retinoblastoma susceptibility gene product phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50267479(6-Iodo-4-{[(4-hydroxy-5-methoxy-pyridin-2-ylmethyl...)
Affinity DataIC50:  10nMAssay Description:Inhibition of CDK4/Cyclin D1 (unknown origin) assessed as inhibition of retinoblastoma susceptibility gene product phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50267865((4Z)-6-Iodo-4-{[(3-hydroxy-4-methoxybenzyl)amino]m...)
Affinity DataIC50:  10nMAssay Description:Inhibition of CDK4/Cyclin D1 (unknown origin) assessed as inhibition of retinoblastoma susceptibility gene product phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50267402(4-{[(6-Hydroxy-5-propoxy-pyridin-2-ylmethyl)-amino...)
Affinity DataIC50:  20nMAssay Description:Inhibition of CDK4/Cyclin D1 (unknown origin) assessed as inhibition of retinoblastoma susceptibility gene product phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50267400((4Z)-4-{[(3-Hydroxy-4-propoxybenzyl)amino]methylen...)
Affinity DataIC50:  20nMAssay Description:Inhibition of CDK4/Cyclin D1 (unknown origin) assessed as inhibition of retinoblastoma susceptibility gene product phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50267481(6-tert-Butyl-4-{[(4-hydroxy-5-propoxy-pyridin-2-yl...)
Affinity DataIC50:  20nMAssay Description:Inhibition of CDK4/Cyclin D1 (unknown origin) assessed as inhibition of retinoblastoma susceptibility gene product phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50267539(6-tert-Butyl-4-{[(5-furan-3-yl-4-hydroxy-pyridin-2...)
Affinity DataIC50:  20nMAssay Description:Inhibition of CDK4/Cyclin D1 (unknown origin) assessed as inhibition of retinoblastoma susceptibility gene product phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50267538((4Z)-{[(5-Furan-3-yl-4-hydroxy-pyridin-2-ylmethyl)...)
Affinity DataIC50:  30nMAssay Description:Inhibition of CDK4/Cyclin D1 (unknown origin) assessed as inhibition of retinoblastoma susceptibility gene product phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50267252((4Z)-4-{[(4-Methyl-3-hydroxybenzyl)amino]methylene...)
Affinity DataIC50:  30nMAssay Description:Inhibition of CDK4/Cyclin D1 (unknown origin) assessed as inhibition of retinoblastoma susceptibility gene product phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50267483(6-tert-Butyl-4-{[(4-hydroxy-5-phenyl-pyridin-2-ylm...)
Affinity DataIC50:  30nMAssay Description:Inhibition of CDK4/Cyclin D1 (unknown origin) assessed as inhibition of retinoblastoma susceptibility gene product phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50267937((4Z)-6-bromo-4-{[(4-ethoxy-3-hydroxybenzyl)amino]m...)
Affinity DataIC50:  30nMAssay Description:Inhibition of CDK4/Cyclin D1 (unknown origin) assessed as inhibition of retinoblastoma susceptibility gene product phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50267480(4-{[(4-Hydroxy-5-propoxy-pyridin-2-ylmethyl)-amino...)
Affinity DataIC50:  30nMAssay Description:Inhibition of CDK4/Cyclin D1 (unknown origin) assessed as inhibition of retinoblastoma susceptibility gene product phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50267864((4Z)-6-Bromo-4-{[(3-hydroxy-4-methoxybenzyl)amino]...)
Affinity DataIC50:  30nMAssay Description:Inhibition of CDK4/Cyclin D1 (unknown origin) assessed as inhibition of retinoblastoma susceptibility gene product phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50267866(4-[(3-Hydroxy-4-methoxy-benzylamino)-methylene]-6-...)
Affinity DataIC50:  31nMAssay Description:Inhibition of CDK4/Cyclin D1 (unknown origin) assessed as inhibition of retinoblastoma susceptibility gene product phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50003645(CHEMBL520020)
Affinity DataIC50: <40nMAssay Description:Inhibition of CDK4/Cyclin D1 (unknown origin) assessed as inhibition of retinoblastoma susceptibility gene product phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50003644(CHEMBL485503)
Affinity DataIC50: <40nMAssay Description:Inhibition of CDK4/Cyclin D1 (unknown origin) assessed as inhibition of retinoblastoma susceptibility gene product phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50267255(4-[(4-Furan-3-yl-3-hydroxy-benzylamino)-methylene]...)
Affinity DataIC50:  60nMAssay Description:Inhibition of CDK4/Cyclin D1 (unknown origin) assessed as inhibition of retinoblastoma susceptibility gene product phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50267581((4Z)-4-[({[1-(3-Furyl)-2-oxo-1,2-dihydropyridin-4-...)
Affinity DataIC50:  60nMAssay Description:Inhibition of CDK4/Cyclin D1 (unknown origin) assessed as inhibition of retinoblastoma susceptibility gene product phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50267251((4Z)-4-{[(4-Amino-3-hydroxybenzyl)amino]methylene}...)
Affinity DataIC50:  80nMAssay Description:Inhibition of CDK4/Cyclin D1 (unknown origin) assessed as inhibition of retinoblastoma susceptibility gene product phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetG-protein coupled bile acid receptor 1(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50003407(CHEMBL3234568)
Affinity DataIC50:  90nMAssay Description:Agonist activity at TGR5 in human PBMC assessed as inhibition of LPS-induced TNFalpha production preincubated for 30 mins followed by LPS stimulation...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50003477(CHEMBL3234569)
Affinity DataIC50: <100nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50267254(4-[(4-Furan-2-yl-3-hydroxy-benzylamino)-methylene]...)
Affinity DataIC50:  100nMAssay Description:Inhibition of CDK4/Cyclin D1 (unknown origin) assessed as inhibition of retinoblastoma susceptibility gene product phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50267253(4-{[(2-Hydroxy-biphenyl-4-ylmethyl)-amino]-methyle...)
Affinity DataIC50:  130nMAssay Description:Inhibition of CDK4/Cyclin D1 (unknown origin) assessed as inhibition of retinoblastoma susceptibility gene product phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50267817((4Z)-6-Fluoro-4-{[(3-hydroxy-4-methoxybenzyl)amino...)
Affinity DataIC50:  170nMAssay Description:Inhibition of CDK4/Cyclin D1 (unknown origin) assessed as inhibition of retinoblastoma susceptibility gene product phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50267815((4Z)-4-{[(3-Hydroxy-4-methoxybenzyl)amino]methylen...)
Affinity DataIC50:  190nMAssay Description:Inhibition of CDK4/Cyclin D1 (unknown origin) assessed as inhibition of retinoblastoma susceptibility gene product phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRetinoblastoma-associated protein(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50267481(6-tert-Butyl-4-{[(4-hydroxy-5-propoxy-pyridin-2-yl...)
Affinity DataIC50:  200nMAssay Description:Inhibition of retinoblastoma susceptibility gene product phosphorylation in human MCF7 cells after 24 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetG-protein coupled bile acid receptor 1(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50003573(CHEMBL3234871)
Affinity DataIC50:  215nMAssay Description:Agonist activity at TGR5 in human PBMC assessed as inhibition of LPS-induced TNFalpha production preincubated for 30 mins followed by LPS stimulation...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50267818((4Z)-6-Chloro-4-{[(3-hydroxy-4-methoxybenzyl)amino...)
Affinity DataIC50:  230nMAssay Description:Inhibition of CDK4/Cyclin D1 (unknown origin) assessed as inhibition of retinoblastoma susceptibility gene product phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50267580((4Z)-6-Iodo-4-({[(2-oxo-1-phenyl-1,2dihydropyridin...)
Affinity DataIC50:  270nMAssay Description:Inhibition of CDK4/Cyclin D1 (unknown origin) assessed as inhibition of retinoblastoma susceptibility gene product phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50003562(CHEMBL3234572)
Affinity DataIC50: <300nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50267935((4Z)-6-Bromo-4-{[(3-hydroxy-4propoxybenzyl)amino]m...)
Affinity DataIC50:  350nMAssay Description:Inhibition of CDK4/Cyclin D1 (unknown origin) assessed as inhibition of retinoblastoma susceptibility gene product phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRetinoblastoma-associated protein(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50267581((4Z)-4-[({[1-(3-Furyl)-2-oxo-1,2-dihydropyridin-4-...)
Affinity DataIC50:  370nMAssay Description:Inhibition of retinoblastoma susceptibility gene product phosphorylation in human MCF7 cells after 24 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50003642(CHEMBL489854)
Affinity DataIC50: <370nMAssay Description:Inhibition of CDK4/Cyclin D1 (unknown origin) assessed as inhibition of retinoblastoma susceptibility gene product phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50003076(CHEMBL3234574)
Affinity DataIC50:  400nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50267401(4-{[(4-Hydroxy-5-methoxy-pyrimidin-2-ylmethyl)-ami...)
Affinity DataIC50:  440nMAssay Description:Inhibition of CDK4/Cyclin D1 (unknown origin) assessed as inhibition of retinoblastoma susceptibility gene product phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50267479(6-Iodo-4-{[(4-hydroxy-5-methoxy-pyridin-2-ylmethyl...)
Affinity DataIC50:  500nMAssay Description:Inhibition of CDK2/Cyclin E (unknown origin) assessed as inhibition of retinoblastoma susceptibility gene product phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50267579((4Z)-6-Bromo-4-({[(2-oxo-1,2-dihydropyridin-4-yl)m...)
Affinity DataIC50:  560nMAssay Description:Inhibition of CDK4/Cyclin D1 (unknown origin) assessed as inhibition of retinoblastoma susceptibility gene product phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRetinoblastoma-associated protein(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50267255(4-[(4-Furan-3-yl-3-hydroxy-benzylamino)-methylene]...)
Affinity DataIC50:  610nMAssay Description:Inhibition of retinoblastoma susceptibility gene product phosphorylation in human MCF7 cells after 24 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50267402(4-{[(6-Hydroxy-5-propoxy-pyridin-2-ylmethyl)-amino...)
Affinity DataIC50:  700nMAssay Description:Inhibition of CDK2/Cyclin E (unknown origin) assessed as inhibition of retinoblastoma susceptibility gene product phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50003286(CHEMBL3234576)
Affinity DataIC50:  700nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50267814((4Z)-4-{[(3-Hydroxybenzyl)amino]methylene}isoquino...)
Affinity DataIC50:  780nMAssay Description:Inhibition of CDK4/Cyclin D1 (unknown origin) assessed as inhibition of retinoblastoma susceptibility gene product phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50003289(CHEMBL3234578)
Affinity DataIC50:  800nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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