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Found 100 with Last Name = 'brink' and Initial = 'm'
TargetCytochrome P450 3A4(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50361983(CHEMBL1939697)
Affinity DataKi:  730nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate assessed as unbound inhibitor concentration required for half maximal enz...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50361983(CHEMBL1939697)
Affinity DataKi:  740nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using testosterone as substrate assessed as unbound inhibitor concentration required for half maximal ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50361983(CHEMBL1939697)
Affinity DataKi:  1.90E+3nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using testosterone as substrate assessed as residual enzyme activity after 2 to 10 mins by LC-MS/MS an...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50361983(CHEMBL1939697)
Affinity DataKi:  1.90E+3nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate assessed as residual enzyme activity after 2 to 10 mins by LC-MS/MS analy...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50371232(CARNOSIC ACID)
Affinity DataKi:  4.30E+3nMAssay Description:Inhibition of CYP3A4 activity in human hepatocytes after 30 mins by liquid chromatography/tandem mass spectroscopyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50371232(CARNOSIC ACID)
Affinity DataKi:  9.20E+3nMAssay Description:Inhibition of CYP2C9 activity in human hepatocytes after 30 mins by liquid chromatography/tandem mass spectroscopyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxypeptidase B2(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50008271(CHEMBL3235132)
Affinity DataIC50:  8nMAssay Description:Inhibition of human TAF1a using hippuryl-L-arginine/hippuryl-L-lysine as substrate by liquid chromatographic analysisMore data for this Ligand-Target Pair
TargetCytochrome P450 3A4(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50361983(CHEMBL1939697)
Affinity DataIC50:  27nMAssay Description:Time dependent inhibition of CYP3A4 in human liver microsomes using midazolam as substrate preincubated for 30 mins followed by 10-fold dilution and ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxypeptidase B2(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50008279(CHEMBL3235140)
Affinity DataIC50: <41nMAssay Description:Inhibition of human TAF1aMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxypeptidase B2(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50008272(CHEMBL3235133)
Affinity DataIC50: <41nMAssay Description:Inhibition of human TAF1aMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxypeptidase B2(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50008278(CHEMBL3235139)
Affinity DataIC50:  66nMAssay Description:Inhibition of human TAF1aMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50361983(CHEMBL1939697)
Affinity DataIC50:  68nMAssay Description:Time dependent inhibition of CYP3A4 in human liver microsomes using testosterone as substrate preincubated for 30 mins followed by 10-fold dilution a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxypeptidase B2(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50008271(CHEMBL3235132)
Affinity DataIC50:  76nMAssay Description:Inhibition of human TAF1aMore data for this Ligand-Target Pair
TargetCarboxypeptidase B2(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50008273(CHEMBL3235134)
Affinity DataIC50:  80nMAssay Description:Inhibition of TAF1a in human plasma assessed as clot lysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxypeptidase B2(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50008269(CHEMBL3235130)
Affinity DataIC50:  87nMAssay Description:Inhibition of human TAF1a using hippuryl-L-arginine/hippuryl-L-lysine as substrate by liquid chromatographic analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50004704((+)-cis-Diltiazem | (2S,3S)-5-(2-(dimethylamino)et...)
Affinity DataIC50:  100nMAssay Description:Time dependent inhibition of CYP3A4 in human liver microsomes using midazolam as substrate preincubated for 90 mins followed by 10-fold dilution and ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetCytochrome P450 3A4(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50004704((+)-cis-Diltiazem | (2S,3S)-5-(2-(dimethylamino)et...)
Affinity DataIC50:  100nMAssay Description:Time dependent inhibition of CYP3A4 in human liver microsomes using testosterone as substrate preincubated for 90 mins followed by 10-fold dilution a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetCarboxypeptidase B2(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50008272(CHEMBL3235133)
Affinity DataIC50:  100nMAssay Description:Inhibition of TAF1a in human plasma assessed as clot lysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxypeptidase B2(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50008274(CHEMBL3235135)
Affinity DataIC50:  106nMAssay Description:Inhibition of human TAF1aMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxypeptidase B2(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50008273(CHEMBL3235134)
Affinity DataIC50:  117nMAssay Description:Inhibition of human TAF1aMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxypeptidase B2(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50008275(CHEMBL3235136)
Affinity DataIC50:  124nMAssay Description:Inhibition of human TAF1aMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxypeptidase B2(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50008269(CHEMBL3235130)
Affinity DataIC50:  400nMAssay Description:Inhibition of TAF1a in human plasma assessed as clot lysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxypeptidase B2(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50226610((2S)-5-AMINO-2-[(1-PROPYL-1H-IMIDAZOL-4-YL)METHYL]...)
Affinity DataIC50:  450nMAssay Description:Inhibition of human TAF1a using hippuryl-L-arginine/hippuryl-L-lysine as substrate by liquid chromatographic analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxypeptidase B2(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50008276(CHEMBL3235137)
Affinity DataIC50:  585nMAssay Description:Inhibition of human TAF1aMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxypeptidase B2(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50008270(CHEMBL3235131)
Affinity DataIC50:  620nMAssay Description:Inhibition of human TAF1a using hippuryl-L-arginine/hippuryl-L-lysine as substrate by liquid chromatographic analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50361983(CHEMBL1939697)
Affinity DataIC50:  650nMAssay Description:Time dependent inhibition of CYP3A4 in human liver microsomes using midazolam as substrate preincubated for 30 mins followed by 10-fold dilution and ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxypeptidase B2(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50008271(CHEMBL3235132)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of TAF1a in human plasma assessed as clot lysisMore data for this Ligand-Target Pair
TargetCarboxypeptidase B2(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50008278(CHEMBL3235139)
Affinity DataIC50:  1.30E+3nMAssay Description:Inhibition of TAF1a in human plasma assessed as clot lysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxypeptidase B2(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50135933(3-(6-Amino-pyridin-3-yl)-2-(1H-imidazol-4-yl)-prop...)
Affinity DataIC50:  1.50E+3nMAssay Description:Inhibition of human TAF1a using hippuryl-L-arginine/hippuryl-L-lysine as substrate by liquid chromatographic analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50361983(CHEMBL1939697)
Affinity DataIC50:  2.10E+3nMAssay Description:Time dependent inhibition of CYP3A4 in human liver microsomes using testosterone as substrate preincubated for 30 mins followed by 10-fold dilution a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxypeptidase B2(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50008277(CHEMBL3235138)
Affinity DataIC50:  2.27E+3nMAssay Description:Inhibition of human TAF1aMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxypeptidase B2(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50008274(CHEMBL3235135)
Affinity DataIC50:  2.50E+3nMAssay Description:Inhibition of TAF1a in human plasma assessed as clot lysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50211114((-)-(R)-N-(1-(3-(4-ethoxyphenyl)-4-oxo-3,4-dihydro...)
Affinity DataIC50:  2.70E+3nMAssay Description:Time dependent inhibition of CYP3A4 in human liver microsomes using midazolam as substrate preincubated for 90 mins followed by 10-fold dilution and ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50211114((-)-(R)-N-(1-(3-(4-ethoxyphenyl)-4-oxo-3,4-dihydro...)
Affinity DataIC50:  2.90E+3nMAssay Description:Time dependent inhibition of CYP3A4 in human liver microsomes using midazolam as substrate preincubated for 90 mins followed by substrate addition by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxypeptidase B2(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50008279(CHEMBL3235140)
Affinity DataIC50:  3.20E+3nMAssay Description:Inhibition of TAF1a in human plasma assessed as clot lysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxypeptidase B2(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50226610((2S)-5-AMINO-2-[(1-PROPYL-1H-IMIDAZOL-4-YL)METHYL]...)
Affinity DataIC50:  5.00E+3nMAssay Description:Inhibition of TAF1a in human plasma assessed as clot lysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50211114((-)-(R)-N-(1-(3-(4-ethoxyphenyl)-4-oxo-3,4-dihydro...)
Affinity DataIC50:  5.20E+3nMAssay Description:Time dependent inhibition of CYP3A4 in human liver microsomes using midazolam as substrate preincubated for 30 mins followed by 10-fold dilution and ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50211114((-)-(R)-N-(1-(3-(4-ethoxyphenyl)-4-oxo-3,4-dihydro...)
Affinity DataIC50:  5.70E+3nMAssay Description:Time dependent inhibition of CYP3A4 in human liver microsomes using midazolam as substrate preincubated for 30 mins followed by substrate addition by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50211114((-)-(R)-N-(1-(3-(4-ethoxyphenyl)-4-oxo-3,4-dihydro...)
Affinity DataIC50:  7.00E+3nMAssay Description:Time dependent inhibition of CYP3A4 in human liver microsomes using midazolam as substrate preincubated for 30 mins followed by 10-fold dilution and ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxypeptidase B2(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50008276(CHEMBL3235137)
Affinity DataIC50:  7.10E+3nMAssay Description:Inhibition of TAF1a in human plasma assessed as clot lysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50211114((-)-(R)-N-(1-(3-(4-ethoxyphenyl)-4-oxo-3,4-dihydro...)
Affinity DataIC50:  8.00E+3nMAssay Description:Time dependent inhibition of CYP3A4 in human liver microsomes using midazolam as substrate preincubated for 90 mins followed by 10-fold dilution and ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxypeptidase B2(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50008270(CHEMBL3235131)
Affinity DataIC50:  8.00E+3nMAssay Description:Inhibition of TAF1a in human plasma assessed as clot lysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50004704((+)-cis-Diltiazem | (2S,3S)-5-(2-(dimethylamino)et...)
Affinity DataIC50:  8.10E+3nMAssay Description:Time dependent inhibition of CYP3A4 in human liver microsomes using testosterone as substrate preincubated for 30 mins followed by 10-fold dilution a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetCytochrome P450 3A4(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50211114((-)-(R)-N-(1-(3-(4-ethoxyphenyl)-4-oxo-3,4-dihydro...)
Affinity DataIC50:  8.30E+3nMAssay Description:Time dependent inhibition of CYP3A4 in human liver microsomes using midazolam as substrate preincubated for 30 mins followed by substrate addition by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50211114((-)-(R)-N-(1-(3-(4-ethoxyphenyl)-4-oxo-3,4-dihydro...)
Affinity DataIC50:  9.20E+3nMAssay Description:Time dependent inhibition of CYP3A4 in human liver microsomes using midazolam as substrate preincubated for 90 mins followed by substrate addition by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50004704((+)-cis-Diltiazem | (2S,3S)-5-(2-(dimethylamino)et...)
Affinity DataIC50:  9.60E+3nMAssay Description:Time dependent inhibition of CYP3A4 in human liver microsomes using testosterone as substrate preincubated for 90 mins followed by substrate addition...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetCytochrome P450 3A4(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50004704((+)-cis-Diltiazem | (2S,3S)-5-(2-(dimethylamino)et...)
Affinity DataIC50:  1.20E+4nMAssay Description:Time dependent inhibition of CYP3A4 in human liver microsomes using midazolam as substrate preincubated for 30 mins followed by 10-fold dilution and ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetCarboxypeptidase B2(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50008275(CHEMBL3235136)
Affinity DataIC50:  1.60E+4nMAssay Description:Inhibition of TAF1a in human plasma assessed as clot lysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50004704((+)-cis-Diltiazem | (2S,3S)-5-(2-(dimethylamino)et...)
Affinity DataIC50:  1.90E+4nMAssay Description:Time dependent inhibition of CYP3A4 in human liver microsomes using midazolam as substrate preincubated for 90 mins followed by substrate addition by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetCytochrome P450 3A4(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50211114((-)-(R)-N-(1-(3-(4-ethoxyphenyl)-4-oxo-3,4-dihydro...)
Affinity DataIC50:  2.00E+4nMAssay Description:Time dependent inhibition of CYP3A4 in human liver microsomes using testosterone as substrate preincubated for 30 mins followed by substrate addition...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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