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Found 393 with Last Name = 'brissette' and Initial = 'wh'
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50193995(3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyr...)
Affinity DataIC50:  1nMAssay Description:Inhibition of GST-tagged human JAK3 catalytic domain expressed in Sf9 cells by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50193995(3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyr...)
Affinity DataIC50:  1nMAssay Description:Inhibition of GST-tagged human JAK3 catalytic domain expressed in Sf9 cells by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50144428(CHEMBL66159 | Quinoxaline-2-carboxylic acid ((1S,2...)
Affinity DataIC50:  1nMAssay Description:Inhibition of CCL3 induced chemotaxis in human T lymphocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50193995(3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyr...)
Affinity DataIC50:  1.60nMAssay Description:Inhibition of JAK2 by solution phase kinase assayMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50332622(CHEMBL1630782 | N-Methyl-N-((1S,2R,5S)-2-methyl-5-...)
Affinity DataIC50:  2nMAssay Description:Inhibition of GST-tagged human JAK3 catalytic domain expressed in Sf9 cells by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50144400(CHEMBL304358 | Quinoxaline-2-carboxylic acid ((1S,...)
Affinity DataIC50:  2nMAssay Description:Inhibition of CCL3 induced chemotaxis in human T lymphocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50193995(3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyr...)
Affinity DataIC50:  3.20nMAssay Description:Inhibition of JAK3 by solution phase kinase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50332622(CHEMBL1630782 | N-Methyl-N-((1S,2R,5S)-2-methyl-5-...)
Affinity DataIC50:  4nMAssay Description:Inhibition of GST-tagged human JAK3 catalytic domain expressed in Sf9 cells by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50193995(3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyr...)
Affinity DataIC50:  4.10nMAssay Description:Inhibition of JAK1 by solution phase kinase assayMore data for this Ligand-Target Pair
TargetC-C chemokine receptor type 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50144420(CHEMBL68145 | Quinoxaline-2-carboxylic acid ((1S,2...)
Affinity DataIC50:  5nMAssay Description:Inhibition of CCL3 induced chemotaxis in human T lymphocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50144431(CHEMBL303673 | Quinoxaline-2-carboxylic acid [(1S,...)
Affinity DataIC50:  7nMAssay Description:Inhibition of CCL3 binding to C-C chemokine receptor type 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50144428(CHEMBL66159 | Quinoxaline-2-carboxylic acid ((1S,2...)
Affinity DataIC50:  7nMAssay Description:Inhibition of CCL3 induced chemotaxis in human T lymphocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50144396(CHEMBL69375 | Quinoxaline-2-carboxylic acid ((1S,2...)
Affinity DataIC50:  8nMAssay Description:Inhibition of CCL3 binding to C-C chemokine receptor type 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50144431(CHEMBL303673 | Quinoxaline-2-carboxylic acid [(1S,...)
Affinity DataIC50:  8nMAssay Description:Inhibition of CCL3 induced chemotaxis in human T lymphocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50209006(1-(2-(2-((2R,5S)-4-(4-fluorobenzyl)-2,5-dimethylpi...)
Affinity DataIC50:  8nMAssay Description:Binding Affinity at CCL3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50144420(CHEMBL68145 | Quinoxaline-2-carboxylic acid ((1S,2...)
Affinity DataIC50:  8nMAssay Description:Inhibition of CCL3 binding to C-C chemokine receptor type 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50144417(CHEMBL68366 | Quinoxaline-2-carboxylic acid ((1S,2...)
Affinity DataIC50:  9nMAssay Description:Inhibition of CCL3 binding to C-C chemokine receptor type 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50209001(4-(2-(2-((2R,5S)-4-(4-fluorobenzyl)-2,5-dimethylpi...)
Affinity DataIC50:  13nMAssay Description:Binding Affinity at CCL3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50144417(CHEMBL68366 | Quinoxaline-2-carboxylic acid ((1S,2...)
Affinity DataIC50:  13nMAssay Description:Inhibition of CCL3 induced chemotaxis in human T lymphocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50332620(2-Methyl-3-(4-methyl-3-(methyl(7H-pyrrolo[2,3-d]py...)
Affinity DataIC50:  13nMAssay Description:Inhibition of GST-tagged human JAK3 catalytic domain expressed in Sf9 cells by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50332623(CHEMBL1630786 | N-Benzyl-2-((R)-2-((1S,3S,4R)-4-me...)
Affinity DataIC50:  13nMAssay Description:Inhibition of GST-tagged human JAK3 catalytic domain expressed in Sf9 cells by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50332604(CHEMBL1630788 | cis-N-Methyl-N-(4-methyl-1-(2,2,2-...)
Affinity DataIC50:  14nMAssay Description:Inhibition of GST-tagged human JAK3 catalytic domain expressed in Sf9 cells by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50144412(CHEMBL69659 | Quinoxaline-2-carboxylic acid [(1S,2...)
Affinity DataIC50:  15nMAssay Description:Inhibition of CCL3 binding to C-C chemokine receptor type 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50332597(CHEMBL1630801 | cis-3,3,3-Trifluoro-1-(4-methyl-3-...)
Affinity DataIC50:  19nMAssay Description:Inhibition of GST-tagged human JAK3 catalytic domain expressed in Sf9 cells by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50332601(CHEMBL1630800 | cis-2-Cyclopropyl-1-(4-methyl-3-(m...)
Affinity DataIC50:  20nMAssay Description:Inhibition of GST-tagged human JAK3 catalytic domain expressed in Sf9 cells by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50332625((R)-2-((1S,3S,4R)-4-Methyl-3-(methyl(7H-pyrrolo[2,...)
Affinity DataIC50:  20nMAssay Description:Inhibition of GST-tagged human JAK3 catalytic domain expressed in Sf9 cells by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50332624(CHEMBL1630774 | N-(2,5-Dimethylcyclohexyl)-N-methy...)
Affinity DataIC50:  20nMAssay Description:Inhibition of GST-tagged human JAK3 catalytic domain expressed in Sf9 cells by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50193995(3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyr...)
Affinity DataIC50:  20nMAssay Description:Inhibition of JAK2More data for this Ligand-Target Pair
TargetC-C chemokine receptor type 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50144421(CHEMBL302533 | Quinoxaline-2-carboxylic acid [(1S,...)
Affinity DataIC50:  20nMAssay Description:Inhibition of CCL3 binding to C-C chemokine receptor type 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50144415(CHEMBL304845 | Quinoxaline-2-carboxylic acid ((1S,...)
Affinity DataIC50:  22nMAssay Description:Inhibition of CCL3 binding to C-C chemokine receptor type 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50209003((2-(2-((2R,5S)-4-(4-fluorobenzyl)-2,5-dimethylpipe...)
Affinity DataIC50:  23nMAssay Description:Binding Affinity at CCL3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50144393(CHEMBL69274 | Quinoxaline-2-carboxylic acid ((1S,2...)
Affinity DataIC50:  26nMAssay Description:Inhibition of CCL3 binding to C-C chemokine receptor type 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50332593(CHEMBL1630789 | cis-4-Methyl-3-(methyl(7H-pyrrolo[...)
Affinity DataIC50:  26nMAssay Description:Inhibition of GST-tagged human JAK3 catalytic domain expressed in Sf9 cells by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50144419(CHEMBL305423 | Quinoxaline-2-carboxylic acid ((1S,...)
Affinity DataIC50:  27nMAssay Description:Inhibition of CCL3 binding to C-C chemokine receptor type 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50144400(CHEMBL304358 | Quinoxaline-2-carboxylic acid ((1S,...)
Affinity DataIC50:  28nMAssay Description:Inhibition of CCL3 binding to C-C chemokine receptor type 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50144400(CHEMBL304358 | Quinoxaline-2-carboxylic acid ((1S,...)
Affinity DataIC50:  28nMAssay Description:Inhibition of CCL3 binding to C-C chemokine receptor type 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50332598(3-(4-Methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4...)
Affinity DataIC50:  29nMAssay Description:Inhibition of GST-tagged human JAK3 catalytic domain expressed in Sf9 cells by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50209000(2-(2-((2R,5S)-4-(4-fluorobenzyl)-2,5-dimethylpiper...)
Affinity DataIC50:  30nMAssay Description:Binding Affinity at CCL3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50208999((R)-1-(2-(2-(4-(4-fluorobenzyl)-2-methylpiperazin-...)
Affinity DataIC50:  31nMAssay Description:Binding Affinity at CCL3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50144419(CHEMBL305423 | Quinoxaline-2-carboxylic acid ((1S,...)
Affinity DataIC50:  31nMAssay Description:Inhibition of CCL3 induced chemotaxis in human T lymphocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50332592(CHEMBL1630791 | D3RKN_90 | cis-2-Hydroxy-1-(4-meth...)
Affinity DataIC50:  32nMAssay Description:Inhibition of GST-tagged human JAK3 catalytic domain expressed in Sf9 cells by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50332626(CHEMBL1630784 | N,N-Diethyl-2-((R)-2-((1S,3S,4R)-4...)
Affinity DataIC50:  32nMAssay Description:Inhibition of GST-tagged human JAK3 catalytic domain expressed in Sf9 cells by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50193995(3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyr...)
Affinity DataIC50:  34nMAssay Description:Inhibition of Tyk2 by solution phase kinase assayMore data for this Ligand-Target Pair
TargetC-C chemokine receptor type 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50209004(2-(2-(2-((2R,5S)-4-(4-fluorobenzyl)-2,5-dimethylpi...)
Affinity DataIC50:  38nMAssay Description:Binding Affinity at CCL3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50332627(CHEMBL1630785 | N-Methyl-2-((R)-2-((1S,3S,4R)-4-me...)
Affinity DataIC50:  38nMAssay Description:Inhibition of GST-tagged human JAK3 catalytic domain expressed in Sf9 cells by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50332628(CHEMBL1630798 | cis-Cyclopentyl(4-methyl-3-(methyl...)
Affinity DataIC50:  39nMAssay Description:Inhibition of GST-tagged human JAK3 catalytic domain expressed in Sf9 cells by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50332611((4-Methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-y...)
Affinity DataIC50:  40nMAssay Description:Inhibition of GST-tagged human JAK3 catalytic domain expressed in Sf9 cells by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50332596(CHEMBL1630790 | cis-N-(1-(2,3-Difluorobenzyl)-4-me...)
Affinity DataIC50:  42nMAssay Description:Inhibition of GST-tagged human JAK3 catalytic domain expressed in Sf9 cells by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50273930(3-((3S,4S)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyr...)
Affinity DataIC50:  43nMAssay Description:Inhibition of GST-tagged human JAK3 catalytic domain expressed in Sf9 cells by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50209002(CHEMBL391239 | methyl 2-(2-(2-((2R,5S)-4-(4-fluoro...)
Affinity DataIC50:  44nMAssay Description:Binding Affinity at CCL3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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