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Found 115 with Last Name = 'bui' and Initial = 'c'
LigandPNGBDBM50445231(CHEMBL3102950)
Affinity DataKi:  2.30nMAssay Description:Competitive inhibition of rat recombinant 6xHis-tagged DYRK1A catalytic domain (1 to 502) expressed in Escherichia coli BL21 (DE3) using ATP as subst...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50445230(CHEMBL3102951)
Affinity DataKi:  5.5nMAssay Description:Competitive inhibition of rat recombinant 6xHis-tagged DYRK1A catalytic domain (1 to 502) expressed in Escherichia coli BL21 (DE3) using ATP as subst...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50445229(CHEMBL3102953)
Affinity DataKi:  7.60nMAssay Description:Competitive inhibition of rat recombinant 6xHis-tagged DYRK1A catalytic domain (1 to 502) expressed in Escherichia coli BL21 (DE3) using ATP as subst...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50445227(CHEMBL3102955)
Affinity DataKi:  10nMAssay Description:Competitive inhibition of rat recombinant 6xHis-tagged DYRK1A catalytic domain (1 to 502) expressed in Escherichia coli BL21 (DE3) using ATP as subst...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50445228(CHEMBL3102954)
Affinity DataKi:  12nMAssay Description:Competitive inhibition of rat recombinant 6xHis-tagged DYRK1A catalytic domain (1 to 502) expressed in Escherichia coli BL21 (DE3) using ATP as subst...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity protein kinase TTK(Homo sapiens (Human))
Netherlands Translational Research Center

US Patent
LigandPNGBDBM532308(JDM666A | N-(2,6-dimethylphenyl-2-[4-[4-[2-ethylam...)
Affinity DataIC50:  0.410nMAssay Description:The inhibitory activity of compounds on biochemically purified full-length TTK (Life Technologies, Madison, Wis., U.S.A.) was determined in the IMAP®...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDual specificity protein kinase TTK(Homo sapiens (Human))
Netherlands Translational Research Center

US Patent
LigandPNGBDBM532304(JDM697A | N-[1-[2-(2-ethoxyethoxy)ethyl]-3,5-dieth...)
Affinity DataIC50:  0.410nMAssay Description:The inhibitory activity of compounds on biochemically purified full-length TTK (Life Technologies, Madison, Wis., U.S.A.) was determined in the IMAP®...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDual specificity protein kinase TTK(Homo sapiens (Human))
Netherlands Translational Research Center

US Patent
LigandPNGBDBM532294(JDM0684A | N-[3,5-diethyl-1-[2-[2-(2-methoxyethoxy...)
Affinity DataIC50:  0.430nMAssay Description:The inhibitory activity of compounds on biochemically purified full-length TTK (Life Technologies, Madison, Wis., U.S.A.) was determined in the IMAP®...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetDual specificity protein kinase TTK(Homo sapiens (Human))
Netherlands Translational Research Center

US Patent
LigandPNGBDBM532306(JDM703A | N-[3,5-diethyl-1-[2-[2-(2-methoxyethoxy)...)
Affinity DataIC50:  0.430nMAssay Description:The inhibitory activity of compounds on biochemically purified full-length TTK (Life Technologies, Madison, Wis., U.S.A.) was determined in the IMAP®...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDual specificity protein kinase TTK(Homo sapiens (Human))
Netherlands Translational Research Center

US Patent
LigandPNGBDBM532285(N-(2,6-diethylphenyl)-8-(2-methoxy-4-piperazin-1-y...)
Affinity DataIC50:  0.490nMAssay Description:The inhibitory activity of compounds on biochemically purified full-length TTK (Life Technologies, Madison, Wis., U.S.A.) was determined in the IMAP®...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDual specificity protein kinase TTK(Homo sapiens (Human))
Netherlands Translational Research Center

US Patent
LigandPNGBDBM258443(US11208696, Example 6 | US9512130, 1)
Affinity DataIC50:  0.600nMAssay Description:The inhibitory activity of compounds on biochemically purified full-length TTK (Life Technologies, Madison, Wis., U.S.A.) was determined in the IMAP®...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDual specificity protein kinase TTK(Homo sapiens (Human))
Netherlands Translational Research Center

US Patent
LigandPNGBDBM532292(JGS79C | N-(2,6-diethylphenyl)-2-[2-methoxy-4-(4-m...)
Affinity DataIC50:  0.600nMAssay Description:The inhibitory activity of compounds on biochemically purified full-length TTK (Life Technologies, Madison, Wis., U.S.A.) was determined in the IMAP®...More data for this Ligand-Target Pair
TargetDual specificity protein kinase TTK(Homo sapiens (Human))
Netherlands Translational Research Center

US Patent
LigandPNGBDBM532289(JGS439C | N-(2,6-dimethylphenyl)-2-[2-methoxy-4-(t...)
Affinity DataIC50:  0.600nMAssay Description:The inhibitory activity of compounds on biochemically purified full-length TTK (Life Technologies, Madison, Wis., U.S.A.) was determined in the IMAP®...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDual specificity protein kinase TTK(Homo sapiens (Human))
Netherlands Translational Research Center

US Patent
LigandPNGBDBM532301(JDM677A | N-[1-[2-[2-(2-methoxyethoxy)ethoxyethyl]...)
Affinity DataIC50:  0.620nMAssay Description:The inhibitory activity of compounds on biochemically purified full-length TTK (Life Technologies, Madison, Wis., U.S.A.) was determined in the IMAP®...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDual specificity protein kinase TTK(Homo sapiens (Human))
Netherlands Translational Research Center

US Patent
LigandPNGBDBM50349102(CHEMBL1236095 | US11208696, Example 3)
Affinity DataIC50:  0.630nMAssay Description:The inhibitory activity of compounds on biochemically purified full-length TTK (Life Technologies, Madison, Wis., U.S.A.) was determined in the IMAP®...More data for this Ligand-Target Pair
TargetDual specificity protein kinase TTK(Homo sapiens (Human))
Netherlands Translational Research Center

US Patent
LigandPNGBDBM258445(US11208696, Example 5 | US9512130, 3)
Affinity DataIC50:  0.650nMAssay Description:The inhibitory activity of compounds on biochemically purified full-length TTK (Life Technologies, Madison, Wis., U.S.A.) was determined in the IMAP®...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDual specificity protein kinase TTK(Homo sapiens (Human))
Netherlands Translational Research Center

US Patent
LigandPNGBDBM532307(2-[4-[4-[(2R)-azetidine-2-carbonyl]piperazin-1-yl]...)
Affinity DataIC50:  0.660nMAssay Description:The inhibitory activity of compounds on biochemically purified full-length TTK (Life Technologies, Madison, Wis., U.S.A.) was determined in the IMAP®...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDual specificity protein kinase TTK(Homo sapiens (Human))
Netherlands Translational Research Center

US Patent
LigandPNGBDBM532288(N-(2,6-dimethylphenyl)-2-(2-methyl-4-piperazin-1-y...)
Affinity DataIC50:  0.700nMAssay Description:The inhibitory activity of compounds on biochemically purified full-length TTK (Life Technologies, Madison, Wis., U.S.A.) was determined in the IMAP®...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDual specificity protein kinase TTK(Homo sapiens (Human))
Netherlands Translational Research Center

US Patent
LigandPNGBDBM532303(JDM713A | N-[3,5-diethyl-1-[2-(2-methoxyethoxy)eth...)
Affinity DataIC50:  0.710nMAssay Description:The inhibitory activity of compounds on biochemically purified full-length TTK (Life Technologies, Madison, Wis., U.S.A.) was determined in the IMAP®...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDual specificity protein kinase TTK(Homo sapiens (Human))
Netherlands Translational Research Center

US Patent
LigandPNGBDBM532290(JDM0641A | N-[1-[2-[2-(2-methoxyethoxyethoxy]ethyl...)
Affinity DataIC50:  0.730nMAssay Description:The inhibitory activity of compounds on biochemically purified full-length TTK (Life Technologies, Madison, Wis., U.S.A.) was determined in the IMAP®...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDual specificity protein kinase TTK(Homo sapiens (Human))
Netherlands Translational Research Center

US Patent
LigandPNGBDBM532309(JGS0715B | N-cyclopropyl-4-[6-(2,3-difluoro-4-meth...)
Affinity DataIC50:  0.790nMAssay Description:The inhibitory activity of compounds on biochemically purified full-length TTK (Life Technologies, Madison, Wis., U.S.A.) was determined in the IMAP®...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDual specificity protein kinase TTK(Homo sapiens (Human))
Netherlands Translational Research Center

US Patent
LigandPNGBDBM532305(JDM636A | N-[3,5-diethyl-1-[2-[2-(2-methoxyethoxy)...)
Affinity DataIC50:  0.910nMAssay Description:The inhibitory activity of compounds on biochemically purified full-length TTK (Life Technologies, Madison, Wis., U.S.A.) was determined in the IMAP®...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDual specificity protein kinase TTK(Homo sapiens (Human))
Netherlands Translational Research Center

US Patent
LigandPNGBDBM532291(JDM0443A | N-[1-[2-[2-(2-methoxyethoxy)ethoxy]ethy...)
Affinity DataIC50:  0.930nMAssay Description:The inhibitory activity of compounds on biochemically purified full-length TTK (Life Technologies, Madison, Wis., U.S.A.) was determined in the IMAP®...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDual specificity protein kinase TTK(Homo sapiens (Human))
Netherlands Translational Research Center

US Patent
LigandPNGBDBM532302(JDM711A | N-[3,5-diethyl-1-[2-(2-methoxyethoxy eth...)
Affinity DataIC50:  0.960nMAssay Description:The inhibitory activity of compounds on biochemically purified full-length TTK (Life Technologies, Madison, Wis., U.S.A.) was determined in the IMAP®...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDual specificity protein kinase TTK(Homo sapiens (Human))
Netherlands Translational Research Center

US Patent
LigandPNGBDBM532293(N-(3,5-diethyl-1H-pyrazol-4-yl)-2-[2-(difluorometh...)
Affinity DataIC50:  0.970nMAssay Description:The inhibitory activity of compounds on biochemically purified full-length TTK (Life Technologies, Madison, Wis., U.S.A.) was determined in the IMAP®...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDual specificity protein kinase TTK(Homo sapiens (Human))
Netherlands Translational Research Center

US Patent
LigandPNGBDBM532295(JDM0466A | N-[3,5-diethyl-1-[2-(2-methoxy)ethyl]py...)
Affinity DataIC50:  0.980nMAssay Description:The inhibitory activity of compounds on biochemically purified full-length TTK (Life Technologies, Madison, Wis., U.S.A.) was determined in the IMAP®...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDual specificity protein kinase TTK(Homo sapiens (Human))
Netherlands Translational Research Center

US Patent
LigandPNGBDBM532297(JDM323A | N-(3,5-dimethyl-1H-pyrazol-4-≡(1-2...)
Affinity DataIC50:  1nMAssay Description:The inhibitory activity of compounds on biochemically purified full-length TTK (Life Technologies, Madison, Wis., U.S.A.) was determined in the IMAP®...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDual specificity protein kinase TTK(Homo sapiens (Human))
Netherlands Translational Research Center

US Patent
LigandPNGBDBM532298(N-(2,6-dimethylphenyl)-2-[2-methoxy-4-[4-(2-methox...)
Affinity DataIC50:  1nMAssay Description:The inhibitory activity of compounds on biochemically purified full-length TTK (Life Technologies, Madison, Wis., U.S.A.) was determined in the IMAP®...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBcl-2-like protein 1(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50020938(CHEMBL3287301)
Affinity DataIC50:  1nMAssay Description:Displacement of 26-mer BIMBH3 peptide from GST-tagged Bcl-Xl (unknown origin) by AlphaScreen assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity protein kinase TTK(Homo sapiens (Human))
Netherlands Translational Research Center

US Patent
LigandPNGBDBM532296(N-[1-(2-m ethoxy yl-3,5-dimethyl-pyrazol-4-yl]-2-(...)
Affinity DataIC50:  1.10nMAssay Description:The inhibitory activity of compounds on biochemically purified full-length TTK (Life Technologies, Madison, Wis., U.S.A.) was determined in the IMAP®...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDual specificity protein kinase TTK(Homo sapiens (Human))
Netherlands Translational Research Center

US Patent
LigandPNGBDBM532300(JDM640A | N-[1-[2-(2-ethoxyethoxy)ethyl]-3,5-dimet...)
Affinity DataIC50:  1.14nMAssay Description:The inhibitory activity of compounds on biochemically purified full-length TTK (Life Technologies, Madison, Wis., U.S.A.) was determined in the IMAP®...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDual specificity protein kinase TTK(Homo sapiens (Human))
Netherlands Translational Research Center

US Patent
LigandPNGBDBM532299(N-(2,6-dimethylphenyl)-2-[2-methoxy-4-[(1-methyl-4...)
Affinity DataIC50:  1.40nMAssay Description:The inhibitory activity of compounds on biochemically purified full-length TTK (Life Technologies, Madison, Wis., U.S.A.) was determined in the IMAP®...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDual specificity protein kinase TTK(Homo sapiens (Human))
Netherlands Translational Research Center

US Patent
LigandPNGBDBM329334((2R)-2-(4-fluorophenyl)-N-[4-(2-{[2-methoxy-4-(met...)
Affinity DataIC50:  2.55nMAssay Description:The inhibitory activity of compounds on biochemically purified full-length TTK (Life Technologies, Madison, Wis., U.S.A.) was determined in the IMAP®...More data for this Ligand-Target Pair
TargetDual specificity protein kinase TTK(Homo sapiens (Human))
Netherlands Translational Research Center

US Patent
LigandPNGBDBM532282(N6-cyclohexyl-N2-(2-methyl-4-morpholino-phenyl)-9H...)
Affinity DataIC50:  2.60nMAssay Description:The inhibitory activity of compounds on biochemically purified full-length TTK (Life Technologies, Madison, Wis., U.S.A.) was determined in the IMAP®...More data for this Ligand-Target Pair
In DepthDetails US Patent
LigandPNGBDBM50445232(CHEMBL3102952)
Affinity DataIC50:  3nMAssay Description:Inhibition of rat recombinant 6xHis-tagged DYRK1A catalytic domain (1 to 502) expressed in Escherichia coli BL21 (DE3) using N-terminal fluorescein c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBcl-2-like protein 1(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50020936(CHEMBL3287299)
Affinity DataIC50:  4nMAssay Description:Displacement of 26-mer BIMBH3 peptide from GST-tagged Bcl-Xl (unknown origin) by AlphaScreen assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity protein kinase TTK(Homo sapiens (Human))
Netherlands Translational Research Center

US Patent
LigandPNGBDBM50072833(CHEMBL3410060 | US11208696, Example 2)
Affinity DataIC50:  4.10nMAssay Description:The inhibitory activity of compounds on biochemically purified full-length TTK (Life Technologies, Madison, Wis., U.S.A.) was determined in the IMAP®...More data for this Ligand-Target Pair
LigandPNGBDBM50445232(CHEMBL3102952)
Affinity DataIC50:  5.5nMAssay Description:Inhibition of rat recombinant 6xHis-tagged DYRK1A catalytic domain (1 to 502) expressed in Escherichia coli BL21 (DE3) using N-terminal fluorescein c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBcl-2-like protein 1(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50020939(CHEMBL3287302)
Affinity DataIC50:  7nMAssay Description:Displacement of 26-mer BIMBH3 peptide from GST-tagged Bcl-Xl (unknown origin) by AlphaScreen assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity protein kinase TTK(Homo sapiens (Human))
Netherlands Translational Research Center

US Patent
LigandPNGBDBM50420401(CHEMBL2089255 | US11208696, Example 31)
Affinity DataIC50:  7nMAssay Description:The inhibitory activity of compounds on biochemically purified full-length TTK (Life Technologies, Madison, Wis., U.S.A.) was determined in the IMAP®...More data for this Ligand-Target Pair
LigandPNGBDBM50445227(CHEMBL3102955)
Affinity DataIC50:  12nMAssay Description:Inhibition of rat recombinant 6xHis-tagged DYRK1A catalytic domain (1 to 502) expressed in Escherichia coli BL21 (DE3) using N-terminal fluorescein c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50445230(CHEMBL3102951)
Affinity DataIC50:  12nMAssay Description:Inhibition of rat recombinant 6xHis-tagged DYRK1A catalytic domain (1 to 502) expressed in Escherichia coli BL21 (DE3) using N-terminal fluorescein c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBcl-2-like protein 1(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50020920(CHEMBL3287283)
Affinity DataIC50:  13nMAssay Description:Displacement of 26-mer BIMBH3 peptide from GST-tagged Bcl-Xl (unknown origin) by AlphaScreen assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50445229(CHEMBL3102953)
Affinity DataIC50:  14nMAssay Description:Inhibition of rat recombinant 6xHis-tagged DYRK1A catalytic domain (1 to 502) expressed in Escherichia coli BL21 (DE3) using N-terminal fluorescein c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBcl-2-like protein 1(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50020933(CHEMBL3287296)
Affinity DataIC50:  16nMAssay Description:Displacement of 26-mer BIMBH3 peptide from GST-tagged Bcl-Xl (unknown origin) by AlphaScreen assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBcl-2-like protein 1(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50020919(CHEMBL3287282)
Affinity DataIC50:  20nMAssay Description:Displacement of 26-mer BIMBH3 peptide from GST-tagged Bcl-Xl (unknown origin) by AlphaScreen assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50445231(CHEMBL3102950)
Affinity DataIC50:  23nMAssay Description:Inhibition of rat recombinant 6xHis-tagged DYRK1A catalytic domain (1 to 502) expressed in Escherichia coli BL21 (DE3) using N-terminal fluorescein c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBcl-2-like protein 1(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50020932(CHEMBL3287295)
Affinity DataIC50:  32nMAssay Description:Displacement of 26-mer BIMBH3 peptide from GST-tagged Bcl-Xl (unknown origin) by AlphaScreen assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50445227(CHEMBL3102955)
Affinity DataIC50:  32nMAssay Description:Inhibition of rat recombinant 6xHis-tagged DYRK1A catalytic domain (1 to 502) expressed in Escherichia coli BL21 (DE3) using N-terminal fluorescein c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
Upr 2301, Cnrs

Curated by ChEMBL
LigandPNGBDBM100152(7-methoxy-1-methyl-9H-beta-carboline;hydrochloride...)
Affinity DataIC50:  33nMAssay Description:Competitive inhibition of DYRK1A (unknown origin) using ATPMore data for this Ligand-Target Pair
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