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Found 762 with Last Name = 'casara' and Initial = 'p'
TargetPeptidyl-glycine alpha-amidating monooxygenase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50288771(((E)-Styrylsulfanyl)-acetic acid | CHEMBL127222)
Affinity DataKi:  0.100nMAssay Description:Kinetic constant for inhibition of peptidylglycine alpha hydroxylating monooxygenase (PHM) was determinedMore data for this Ligand-Target Pair
In DepthDetails Article
TargetPeptidyl-glycine alpha-amidating monooxygenase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50288770(CHEMBL335660 | Phenylethynylsulfanyl-acetic acid)
Affinity DataKi:  0.190nMAssay Description:Kinetic constant for inhibition of peptidylglycine alpha hydroxylating monooxygenase (PHM) was determinedMore data for this Ligand-Target Pair
In DepthDetails Article
TargetPeroxisomal N(1)-acetyl-spermine/spermidine oxidase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50015358(CHEMBL417844 | N,N'-BIS(2,3-BUTADIENYL)-1,4-BUTANE...)
Affinity DataKi:  90nMAssay Description:Inhibitory activity measured as apparent dissociation constant against Polyamine oxidase (PAO) from pig liverMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisomal N(1)-acetyl-spermine/spermidine oxidase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50026232(CHEMBL293698 | N-Buta-2,3-dienyl-N'-methyl-butane-...)
Affinity DataKi:  300nMAssay Description:Inhibitory activity measured as apparent dissociation constant against Polyamine oxidase (PAO) from pig liverMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisomal N(1)-acetyl-spermine/spermidine oxidase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50026231(CHEMBL59622 | N*1*-Buta-2,3-dienyl-butane-1,4-diam...)
Affinity DataKi:  700nMAssay Description:Inhibitory activity measured as apparent dissociation constant against Polyamine oxidase (PAO) from pig liverMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Institut De Recherches Servier

Curated by ChEMBL
LigandPNGBDBM30344(Cipemastat | Trocade)
Affinity DataKi:  7.00E+3nMAssay Description:Inhibition of Matrix metalloprotease-1 (MMP1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisomal N(1)-acetyl-spermine/spermidine oxidase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50026230(CHEMBL59623 | N-Methyl-N'-prop-2-ynyl-butane-1,4-d...)
Affinity DataKi:  3.10E+5nMAssay Description:Inhibitory activity measured as apparent dissociation constant against Polyamine oxidase (PAO) from pig liverMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisomal N(1)-acetyl-spermine/spermidine oxidase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50026233(CHEMBL292770 | N*1*-Prop-2-ynyl-butane-1,4-diamine)
Affinity DataKi:  4.25E+5nMAssay Description:Inhibitory activity measured as apparent dissociation constant against Polyamine oxidase (PAO) from pig liverMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Institut De Recherches Servier

Curated by ChEMBL
LigandPNGBDBM50096646(2-(4'-Chloro-biphenyl-4-yloxymethyl)-N-hydroxy-4-(...)
Affinity DataIC50:  0.0160nMAssay Description:Inhibition of Matrix metalloproteinase-13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Institut De Recherches Servier

Curated by ChEMBL
LigandPNGBDBM50131941(2-(4'-Chloro-biphenyl-4-ylsulfanylmethyl)-N-hydrox...)
Affinity DataIC50:  0.0600nMAssay Description:Inhibitory activity against matrix metalloprotease-2 (MMP2)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-5(Homo sapiens (Human))
Institut De Recherches Servier

Curated by ChEMBL
LigandPNGBDBM50120519((7-{[4-(1,4,5,6-Tetrahydro-pyrimidin-2-ylamino)-bu...)
Affinity DataIC50:  0.100nMAssay Description:Displacement of vitronectin from Human integrin alphaV-beta3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Institut De Recherches Servier

Curated by ChEMBL
LigandPNGBDBM50096646(2-(4'-Chloro-biphenyl-4-yloxymethyl)-N-hydroxy-4-(...)
Affinity DataIC50:  0.100nMAssay Description:Inhibition of Matrix metalloproteinase-2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-5(Homo sapiens (Human))
Institut De Recherches Servier

Curated by ChEMBL
LigandPNGBDBM50120520((7-{[4-(4,5-Dihydro-1H-imidazol-2-ylamino)-butyryl...)
Affinity DataIC50:  0.200nMAssay Description:Displacement of fibrinogen from Human integrin alphaIIb-beta3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Institut De Recherches Servier

Curated by ChEMBL
LigandPNGBDBM50120519((7-{[4-(1,4,5,6-Tetrahydro-pyrimidin-2-ylamino)-bu...)
Affinity DataIC50:  0.200nMAssay Description:Displacement of vitronectin from Human integrin alphaV-beta3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Institut De Recherches Servier

Curated by ChEMBL
LigandPNGBDBM50082556((S)-2,2-Dimethyl-4-[4-(pyridin-4-yloxy)-benzenesul...)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of Matrix metalloproteinase-9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Institut De Recherches Servier

Curated by ChEMBL
LigandPNGBDBM50082556((S)-2,2-Dimethyl-4-[4-(pyridin-4-yloxy)-benzenesul...)
Affinity DataIC50:  0.200nMAssay Description:Inhibitory activity against matrix metalloprotease-9 (MMP9)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Institut De Recherches Servier

Curated by ChEMBL
LigandPNGBDBM50120520((7-{[4-(4,5-Dihydro-1H-imidazol-2-ylamino)-butyryl...)
Affinity DataIC50:  0.300nMAssay Description:Displacement of vitronectin from human integrin alphaV-beta5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Institut De Recherches Servier

Curated by ChEMBL
LigandPNGBDBM50120517(CHEMBL109703 | {7-[(4-5,6,7,8-Tetrahydro-[1,8]naph...)
Affinity DataIC50:  0.300nMAssay Description:Displacement of vitronectin from human integrin alphaV-beta5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-5(Homo sapiens (Human))
Institut De Recherches Servier

Curated by ChEMBL
LigandPNGBDBM50120517(CHEMBL109703 | {7-[(4-5,6,7,8-Tetrahydro-[1,8]naph...)
Affinity DataIC50:  0.300nMAssay Description:Displacement of fibrinogen from Human integrin alphaIIb-beta3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Institut De Recherches Servier

Curated by ChEMBL
LigandPNGBDBM50096651(2-(4'-Cyano-biphenyl-4-yloxymethyl)-N-hydroxy-4-(4...)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of Matrix metalloproteinase-2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Institut De Recherches Servier

Curated by ChEMBL
LigandPNGBDBM50131941(2-(4'-Chloro-biphenyl-4-ylsulfanylmethyl)-N-hydrox...)
Affinity DataIC50:  0.5nMAssay Description:Inhibitory activity against matrix metalloprotease-9 (MMP9)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Institut De Recherches Servier

Curated by ChEMBL
LigandPNGBDBM50082556((S)-2,2-Dimethyl-4-[4-(pyridin-4-yloxy)-benzenesul...)
Affinity DataIC50:  0.5nMAssay Description:Inhibitory activity against matrix metalloprotease-2 (MMP2)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-5(Homo sapiens (Human))
Institut De Recherches Servier

Curated by ChEMBL
LigandPNGBDBM50120523((7-{[4-(1H-Benzoimidazol-2-ylamino)-butyrylamino]-...)
Affinity DataIC50:  0.5nMAssay Description:Displacement of vitronectin from human integrin alphaV-beta5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Institut De Recherches Servier

Curated by ChEMBL
LigandPNGBDBM50082556((S)-2,2-Dimethyl-4-[4-(pyridin-4-yloxy)-benzenesul...)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of Matrix metalloproteinase-2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Institut De Recherches Servier

Curated by ChEMBL
LigandPNGBDBM50096649(2-(Biphenyl-4-yloxymethyl)-N-hydroxy-4-(4-oxo-4H-b...)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of Matrix metalloproteinase-2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Institut De Recherches Servier

Curated by ChEMBL
LigandPNGBDBM50096651(2-(4'-Cyano-biphenyl-4-yloxymethyl)-N-hydroxy-4-(4...)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of Matrix metalloproteinase-13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Institut De Recherches Servier

Curated by ChEMBL
LigandPNGBDBM50096646(2-(4'-Chloro-biphenyl-4-yloxymethyl)-N-hydroxy-4-(...)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of Matrix metalloproteinase-9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Institut De Recherches Servier

Curated by ChEMBL
LigandPNGBDBM50096651(2-(4'-Cyano-biphenyl-4-yloxymethyl)-N-hydroxy-4-(4...)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of Matrix metalloproteinase-9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Institut De Recherches Servier

Curated by ChEMBL
LigandPNGBDBM50120523((7-{[4-(1H-Benzoimidazol-2-ylamino)-butyrylamino]-...)
Affinity DataIC50:  0.600nMAssay Description:Displacement of vitronectin from human integrin alphaV-beta5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-5(Homo sapiens (Human))
Institut De Recherches Servier

Curated by ChEMBL
LigandPNGBDBM50120516((7-{[4-(Pyridin-2-ylamino)-butyrylamino]-methyl}-6...)
Affinity DataIC50:  0.800nMAssay Description:Displacement of fibrinogen from Human integrin alphaIIb-beta3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-5(Homo sapiens (Human))
Institut De Recherches Servier

Curated by ChEMBL
LigandPNGBDBM50120518((7-{[5-(Pyridin-2-ylamino)-pentanoylamino]-methyl}...)
Affinity DataIC50:  0.900nMAssay Description:Displacement of fibrinogen from Human integrin alphaIIb-beta3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Institut De Recherches Servier

Curated by ChEMBL
LigandPNGBDBM50096649(2-(Biphenyl-4-yloxymethyl)-N-hydroxy-4-(4-oxo-4H-b...)
Affinity DataIC50:  1nMAssay Description:Inhibition of Matrix metalloproteinase-9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Institut De Recherches Servier

Curated by ChEMBL
LigandPNGBDBM50452012(CHEMBL2110187)
Affinity DataIC50:  1nMAssay Description:Inhibition of farnesyltransferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
Institut De Recherches Servier

Curated by ChEMBL
LigandPNGBDBM50082556((S)-2,2-Dimethyl-4-[4-(pyridin-4-yloxy)-benzenesul...)
Affinity DataIC50:  1.10nMAssay Description:Inhibitory activity against matrix metalloprotease-3 (MMP3)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
Institut De Recherches Servier

Curated by ChEMBL
LigandPNGBDBM50096651(2-(4'-Cyano-biphenyl-4-yloxymethyl)-N-hydroxy-4-(4...)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of Matrix metalloproteinase-3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
Institut De Recherches Servier

Curated by ChEMBL
LigandPNGBDBM50082556((S)-2,2-Dimethyl-4-[4-(pyridin-4-yloxy)-benzenesul...)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of Matrix metalloproteinase-3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Institut De Recherches Servier

Curated by ChEMBL
LigandPNGBDBM50131941(2-(4'-Chloro-biphenyl-4-ylsulfanylmethyl)-N-hydrox...)
Affinity DataIC50:  1.20nMAssay Description:Inhibitory activity against matrix metalloprotease-13 (MMP13)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
Institut De Recherches Servier

Curated by ChEMBL
LigandPNGBDBM50131944(2-(4-Oxo-4H-benzo[d][1,2,3]triazin-3-ylmethyl)-5-(...)
Affinity DataIC50:  1.20nMAssay Description:Inhibitory activity against matrix metalloprotease-3 (MMP3)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Institut De Recherches Servier

Curated by ChEMBL
LigandPNGBDBM50092365((R)-1-((1H-imidazol-5-yl)methyl)-3-benzyl-4-(thiop...)
Affinity DataIC50:  1.30nMAssay Description:Inhibition of farnesyltransferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedMMDB

TargetCollagenase 3(Homo sapiens (Human))
Institut De Recherches Servier

Curated by ChEMBL
LigandPNGBDBM50082556((S)-2,2-Dimethyl-4-[4-(pyridin-4-yloxy)-benzenesul...)
Affinity DataIC50:  1.5nMAssay Description:Inhibitory activity against matrix metalloprotease-13 (MMP13)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Institut De Recherches Servier

Curated by ChEMBL
LigandPNGBDBM50063917((2S,3R)-N(4)-[(2S)-3,3-dimethyl-1-(methylamino)-1-...)
Affinity DataIC50:  1.5nMAssay Description:Inhibitory activity against matrix metalloprotease-1 (MMP1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetInterstitial collagenase(Homo sapiens (Human))
Institut De Recherches Servier

Curated by ChEMBL
LigandPNGBDBM50063917((2S,3R)-N(4)-[(2S)-3,3-dimethyl-1-(methylamino)-1-...)
Affinity DataIC50:  1.5nMAssay Description:Inhibition of Matrix metalloproteinase-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetCollagenase 3(Homo sapiens (Human))
Institut De Recherches Servier

Curated by ChEMBL
LigandPNGBDBM50082556((S)-2,2-Dimethyl-4-[4-(pyridin-4-yloxy)-benzenesul...)
Affinity DataIC50:  1.5nMAssay Description:Inhibition of Matrix metalloproteinase-13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Institut De Recherches Servier

Curated by ChEMBL
LigandPNGBDBM50063917((2S,3R)-N(4)-[(2S)-3,3-dimethyl-1-(methylamino)-1-...)
Affinity DataIC50:  1.60nMAssay Description:Inhibition of Matrix metalloproteinase-9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Institut De Recherches Servier

Curated by ChEMBL
LigandPNGBDBM50063917((2S,3R)-N(4)-[(2S)-3,3-dimethyl-1-(methylamino)-1-...)
Affinity DataIC50:  1.60nMAssay Description:Inhibitory activity against matrix metalloprotease-9 (MMP9)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

Target72 kDa type IV collagenase(Homo sapiens (Human))
Institut De Recherches Servier

Curated by ChEMBL
LigandPNGBDBM50131964(2-(4'-Chloro-biphenyl-4-ylsulfanyl)-5-(3-oxo-6,7,8...)
Affinity DataIC50:  1.70nMAssay Description:Inhibitory activity against matrix metalloprotease-2 (MMP2)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Institut De Recherches Servier

Curated by ChEMBL
LigandPNGBDBM50063917((2S,3R)-N(4)-[(2S)-3,3-dimethyl-1-(methylamino)-1-...)
Affinity DataIC50:  1.80nMAssay Description:Inhibitory activity against matrix metalloprotease-2 (MMP2)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetCollagenase 3(Homo sapiens (Human))
Institut De Recherches Servier

Curated by ChEMBL
LigandPNGBDBM50131962(2-(4'-Chloro-biphenyl-4-sulfonyl)-5-(4-oxo-4H-benz...)
Affinity DataIC50:  1.80nMAssay Description:Inhibitory activity against matrix metalloprotease-13 (MMP13)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Institut De Recherches Servier

Curated by ChEMBL
LigandPNGBDBM50063917((2S,3R)-N(4)-[(2S)-3,3-dimethyl-1-(methylamino)-1-...)
Affinity DataIC50:  1.80nMAssay Description:Inhibition of Matrix metalloproteinase-2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetCollagenase 3(Homo sapiens (Human))
Institut De Recherches Servier

Curated by ChEMBL
LigandPNGBDBM50131953(2-(4'-Chloro-biphenyl-4-ylsulfanyl)-5-(4-oxo-4H-be...)
Affinity DataIC50:  1.90nMAssay Description:Inhibitory activity against matrix metalloprotease-13 (MMP13)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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