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Found 397 with Last Name = 'ceci' and Initial = 'a'
TargetHistone deacetylase 1(Homo sapiens (Human))
University Of Southampton

LigandPNGBDBM19153((1S,7R,10S,16E,21R)-7,21-bis(propan-2-yl)-2-oxa-12...)
Affinity DataIC50:  1.60nMpH: 8.0 T: 2°CAssay Description:For the enzyme assay, the enzyme fraction was added to fluorescent substrate in the presence of test compounds, and the mixture was incubated for add...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
University Of Southampton

LigandPNGBDBM19152((1S,7R,10S,16E,21R)-21-methyl-7-(propan-2-yl)-2-ox...)
Affinity DataIC50:  1.60nMpH: 8.0 T: 2°CAssay Description:For the enzyme assay, the enzyme fraction was added to fluorescent substrate in the presence of test compounds, and the mixture was incubated for add...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
Karus Therapeutics

US Patent
LigandPNGBDBM310701(US10150763, Example A)
Affinity DataIC50:  1.76nMAssay Description:The assay is described in WO2008/062201.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone deacetylase 1(Homo sapiens (Human))
University Of Southampton

LigandPNGBDBM19151((1S,4S,7Z,10S,16E,21R)-7-ethylidene-4,21-bis(propa...)
Affinity DataIC50:  3.97nMpH: 8.0 T: 2°CAssay Description:For the enzyme assay, the enzyme fraction was added to fluorescent substrate in the presence of test compounds, and the mixture was incubated for add...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
University Of Southampton

LigandPNGBDBM136702(US8865655, 10)
Affinity DataIC50:  4.40nMT: 2°CAssay Description:In vitro HDAC assays were performed using a HDAC fluorescent activity assay kit (Biomol, UK) according to the manufacturer's instructions. Compounds ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Karus Therapeutics

US Patent
LigandPNGBDBM291359((E)-3-[2-(1H-Indol-4-yl)-4-morpholin-4-yl-pyrido[3...)
Affinity DataIC50:  5nMAssay Description:PI3K Isoform using biochemical assay.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Karus Therapeutics

US Patent
LigandPNGBDBM291359((E)-3-[2-(1H-Indol-4-yl)-4-morpholin-4-yl-pyrido[3...)
Affinity DataIC50:  5nMAssay Description:Please see articleMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Karus Therapeutics

US Patent
LigandPNGBDBM387173(US9938290, F)
Affinity DataIC50:  6nMAssay Description:Please see articleMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Karus Therapeutics

US Patent
LigandPNGBDBM291363(2-(1H-Indol-4-yl)-4-morpholin-4-yl-8-morpholin-4-y...)
Affinity DataIC50:  6nMAssay Description:PI3K Isoform using biochemical assay.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Karus Therapeutics

US Patent
LigandPNGBDBM291360(US9580442, Example H | US9938290, H | [2-(1H-Indol...)
Affinity DataIC50:  6nMAssay Description:Please see articleMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Karus Therapeutics

US Patent
LigandPNGBDBM291355(2-(1H-Indol-4-yl)-4-morpholin-4-yl-pyrido[3′...)
Affinity DataIC50:  6nMAssay Description:PI3K Isoform using biochemical assay.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Karus Therapeutics

US Patent
LigandPNGBDBM291358((E)-1-(4-Methyl-piperazin-1-yl)-3-[4-morpholin-4-y...)
Affinity DataIC50:  6nMAssay Description:PI3K Isoform using biochemical assay.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Karus Therapeutics

US Patent
LigandPNGBDBM291363(2-(1H-Indol-4-yl)-4-morpholin-4-yl-8-morpholin-4-y...)
Affinity DataIC50:  6nMAssay Description:Please see articleMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Karus Therapeutics

US Patent
LigandPNGBDBM291360(US9580442, Example H | US9938290, H | [2-(1H-Indol...)
Affinity DataIC50:  6nMAssay Description:PI3K Isoform using biochemical assay.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Karus Therapeutics

US Patent
LigandPNGBDBM291355(2-(1H-Indol-4-yl)-4-morpholin-4-yl-pyrido[3′...)
Affinity DataIC50:  6nMAssay Description:Please see articleMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Karus Therapeutics

US Patent
LigandPNGBDBM291357(2,8-Bis-(1H-indol-4-yl)-4-morpholin-4-yl-pyrido[3&...)
Affinity DataIC50:  7nMAssay Description:PI3K Isoform using biochemical assay.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Karus Therapeutics

US Patent
LigandPNGBDBM291357(2,8-Bis-(1H-indol-4-yl)-4-morpholin-4-yl-pyrido[3&...)
Affinity DataIC50:  7nMAssay Description:Please see articleMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Karus Therapeutics

US Patent
LigandPNGBDBM291365(2-(1H-Indol-4-yl)-4,8-di-morpholin-4-yl-pyrido[3&#...)
Affinity DataIC50:  10nMAssay Description:PI3K Isoform using biochemical assay.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Karus Therapeutics

US Patent
LigandPNGBDBM291361(2-(1H-Indol-4-yl)-4-morpholin-4-yl-8-piperidin-1-y...)
Affinity DataIC50:  10nMAssay Description:Please see articleMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Karus Therapeutics

US Patent
LigandPNGBDBM291361(2-(1H-Indol-4-yl)-4-morpholin-4-yl-8-piperidin-1-y...)
Affinity DataIC50:  10nMAssay Description:PI3K Isoform using biochemical assay.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Karus Therapeutics

US Patent
LigandPNGBDBM291365(2-(1H-Indol-4-yl)-4,8-di-morpholin-4-yl-pyrido[3&#...)
Affinity DataIC50:  10nMAssay Description:Please see articleMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Karus Therapeutics

US Patent
LigandPNGBDBM291354(2-(1H-Indol-4-yl)-4-morpholin-4-yl-pyrido[3′...)
Affinity DataIC50:  15nMAssay Description:Please see articleMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Karus Therapeutics

US Patent
LigandPNGBDBM291354(2-(1H-Indol-4-yl)-4-morpholin-4-yl-pyrido[3′...)
Affinity DataIC50:  15nMAssay Description:PI3K Isoform using biochemical assay.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone deacetylase 1(Homo sapiens (Human))
University Of Southampton

LigandPNGBDBM19154((6R,9R,12R,16R)-9,12-dimethyl-6-(propan-2-yl)-16-[...)
Affinity DataIC50:  17.5nMpH: 8.0 T: 2°CAssay Description:For the enzyme assay, the enzyme fraction was added to fluorescent substrate in the presence of test compounds, and the mixture was incubated for add...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Homo sapiens (Human))
Karus Therapeutics

US Patent
LigandPNGBDBM291355(2-(1H-Indol-4-yl)-4-morpholin-4-yl-pyrido[3′...)
Affinity DataIC50:  19nMAssay Description:Please see articleMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Homo sapiens (Human))
Karus Therapeutics

US Patent
LigandPNGBDBM291355(2-(1H-Indol-4-yl)-4-morpholin-4-yl-pyrido[3′...)
Affinity DataIC50:  19nMAssay Description:PI3K Isoform using biochemical assay.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Karus Therapeutics

US Patent
LigandPNGBDBM291364(US9580442, Example L | US9938290, L | [2-(1H-Indol...)
Affinity DataIC50:  21nMAssay Description:PI3K Isoform using biochemical assay.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Karus Therapeutics

US Patent
LigandPNGBDBM291364(US9580442, Example L | US9938290, L | [2-(1H-Indol...)
Affinity DataIC50:  21nMAssay Description:Please see articleMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone deacetylase 1(Homo sapiens (Human))
University Of Southampton

LigandPNGBDBM136703(US8865655, 11)
Affinity DataIC50:  21.6nMT: 2°CAssay Description:In vitro HDAC assays were performed using a HDAC fluorescent activity assay kit (Biomol, UK) according to the manufacturer's instructions. Compounds ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Karus Therapeutics

US Patent
LigandPNGBDBM291366(3-{4-[2-(1H-Indol-4-yl)-4-morpholin-4-yl-pyrido[3&...)
Affinity DataIC50:  22nMAssay Description:Please see articleMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Karus Therapeutics

US Patent
LigandPNGBDBM291366(3-{4-[2-(1H-Indol-4-yl)-4-morpholin-4-yl-pyrido[3&...)
Affinity DataIC50:  22nMAssay Description:PI3K Isoform using biochemical assay.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Homo sapiens (Human))
Karus Therapeutics

US Patent
LigandPNGBDBM291365(2-(1H-Indol-4-yl)-4,8-di-morpholin-4-yl-pyrido[3&#...)
Affinity DataIC50:  25nMAssay Description:PI3K Isoform using biochemical assay.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Homo sapiens (Human))
Karus Therapeutics

US Patent
LigandPNGBDBM291365(2-(1H-Indol-4-yl)-4,8-di-morpholin-4-yl-pyrido[3&#...)
Affinity DataIC50:  25nMAssay Description:Please see articleMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Karus Therapeutics

US Patent
LigandPNGBDBM291362(2-(1H-Indol-4-yl)-8-(4-methyl-piperazin-1-ylmethyl...)
Affinity DataIC50:  26nMAssay Description:Please see articleMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Karus Therapeutics

US Patent
LigandPNGBDBM291362(2-(1H-Indol-4-yl)-8-(4-methyl-piperazin-1-ylmethyl...)
Affinity DataIC50:  26nMAssay Description:PI3K Isoform using biochemical assay.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Karus Therapeutics

US Patent
LigandPNGBDBM291356(4-Morpholin-4-yl-2-(1H-pyrrolo[2,3-b]pyridin-4-yl)...)
Affinity DataIC50:  33nMAssay Description:Please see articleMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Karus Therapeutics

US Patent
LigandPNGBDBM291356(4-Morpholin-4-yl-2-(1H-pyrrolo[2,3-b]pyridin-4-yl)...)
Affinity DataIC50:  33nMAssay Description:PI3K Isoform using biochemical assay.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone deacetylase 1(Homo sapiens (Human))
University Of Southampton

LigandPNGBDBM136704(US8865655, 16)
Affinity DataIC50:  47nMT: 2°CAssay Description:In vitro HDAC assays were performed using a HDAC fluorescent activity assay kit (Biomol, UK) according to the manufacturer's instructions. Compounds ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
Karus Therapeutics

US Patent
LigandPNGBDBM291354(2-(1H-Indol-4-yl)-4-morpholin-4-yl-pyrido[3′...)
Affinity DataIC50:  54nMAssay Description:PI3K Isoform using biochemical assay.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
Karus Therapeutics

US Patent
LigandPNGBDBM291354(2-(1H-Indol-4-yl)-4-morpholin-4-yl-pyrido[3′...)
Affinity DataIC50:  54nMAssay Description:Please see articleMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Homo sapiens (Human))
Karus Therapeutics

US Patent
LigandPNGBDBM291356(4-Morpholin-4-yl-2-(1H-pyrrolo[2,3-b]pyridin-4-yl)...)
Affinity DataIC50:  57nMAssay Description:Please see articleMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Homo sapiens (Human))
Karus Therapeutics

US Patent
LigandPNGBDBM291356(4-Morpholin-4-yl-2-(1H-pyrrolo[2,3-b]pyridin-4-yl)...)
Affinity DataIC50:  57nMAssay Description:PI3K Isoform using biochemical assay.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Homo sapiens (Human))
Karus Therapeutics

US Patent
LigandPNGBDBM291360(US9580442, Example H | US9938290, H | [2-(1H-Indol...)
Affinity DataIC50:  63nMAssay Description:PI3K Isoform using biochemical assay.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Homo sapiens (Human))
Karus Therapeutics

US Patent
LigandPNGBDBM291360(US9580442, Example H | US9938290, H | [2-(1H-Indol...)
Affinity DataIC50:  63nMAssay Description:Please see articleMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Homo sapiens (Human))
Karus Therapeutics

US Patent
LigandPNGBDBM291363(2-(1H-Indol-4-yl)-4-morpholin-4-yl-8-morpholin-4-y...)
Affinity DataIC50:  64nMAssay Description:Please see articleMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Homo sapiens (Human))
Karus Therapeutics

US Patent
LigandPNGBDBM291363(2-(1H-Indol-4-yl)-4-morpholin-4-yl-8-morpholin-4-y...)
Affinity DataIC50:  64nMAssay Description:PI3K Isoform using biochemical assay.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Homo sapiens (Human))
Karus Therapeutics

US Patent
LigandPNGBDBM291357(2,8-Bis-(1H-indol-4-yl)-4-morpholin-4-yl-pyrido[3&...)
Affinity DataIC50:  69nMAssay Description:Please see articleMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Homo sapiens (Human))
Karus Therapeutics

US Patent
LigandPNGBDBM291357(2,8-Bis-(1H-indol-4-yl)-4-morpholin-4-yl-pyrido[3&...)
Affinity DataIC50:  69nMAssay Description:PI3K Isoform using biochemical assay.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Homo sapiens (Human))
Karus Therapeutics

US Patent
LigandPNGBDBM291359((E)-3-[2-(1H-Indol-4-yl)-4-morpholin-4-yl-pyrido[3...)
Affinity DataIC50:  83nMAssay Description:PI3K Isoform using biochemical assay.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Homo sapiens (Human))
Karus Therapeutics

US Patent
LigandPNGBDBM291359((E)-3-[2-(1H-Indol-4-yl)-4-morpholin-4-yl-pyrido[3...)
Affinity DataIC50:  83nMAssay Description:Please see articleMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
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