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Found 505 with Last Name = 'chan' and Initial = 'mf'
TargetEndothelin-1 receptor(Homo sapiens (Human))
Immunopharmaceutics

Curated by ChEMBL
LigandPNGBDBM50058126(2-[2-(6-Methyl-benzo[1,3]dioxol-5-yl)-acetyl]-thio...)
Affinity DataKi:  0.430nMAssay Description:Binding affinity against human Endothelin A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReplicase polyprotein 1a(Human SARS coronavirus (SARS-CoV))
National Taiwan University

LigandPNGBDBM31712(HEXACHLOROPHENE | Hexach-lorophene | MLS000028433 ...)
Affinity DataKi:  4.00E+3nMAssay Description:Kinetic parameters were obtained using various concentrations of FRET peptide in the fluorescent assay. The maximal velocity (Vmax) and Michaelis–Men...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Immunopharmaceutics

Curated by ChEMBL
LigandPNGBDBM50098772(3-(4-Chloro-3-methyl-isoxazol-5-ylsulfamoyl)-thiop...)
Affinity DataIC50:  0.630nMAssay Description:Inhibition of I-ET-1 binding to human Endothelin A receptorMore data for this Ligand-Target Pair
In DepthDetails Article
TargetEndothelin-1 receptor(Homo sapiens (Human))
Immunopharmaceutics

Curated by ChEMBL
LigandPNGBDBM50058138(2-[2-(6-Methyl-benzo[1,3]dioxol-5-yl)-acetyl]-thio...)
Affinity DataIC50:  0.630nMAssay Description:In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Immunopharmaceutics

Curated by ChEMBL
LigandPNGBDBM50058143(2-[2-(2,4-Dimethyl-phenyl)-acetyl]-thiophene-3-sul...)
Affinity DataIC50:  0.760nMAssay Description:In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Immunopharmaceutics

Curated by ChEMBL
LigandPNGBDBM50058144(2-[2-(2,4-Dimethyl-phenyl)-acetyl]-thiophene-3-sul...)
Affinity DataIC50:  0.970nMAssay Description:In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Immunopharmaceutics

Curated by ChEMBL
LigandPNGBDBM50288051(5-Dimethylamino-naphthalene-1-sulfonic acid (4-bro...)
Affinity DataIC50:  1.10nMAssay Description:Binding affinity against human ETA receptor in TE 671(ATCC# HTB 139) cell membrane preparationMore data for this Ligand-Target Pair
In DepthDetails Article
TargetEndothelin-1 receptor(Homo sapiens (Human))
Immunopharmaceutics

Curated by ChEMBL
LigandPNGBDBM50058133(2-[2-(6-Cyano-benzo[1,3]dioxol-5-yl)-acetyl]-thiop...)
Affinity DataIC50:  1.30nMAssay Description:In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Immunopharmaceutics

Curated by ChEMBL
LigandPNGBDBM50288038(Biphenyl-2-sulfonic acid (4-bromo-3-methyl-isoxazo...)
Affinity DataIC50:  1.40nMAssay Description:Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationMore data for this Ligand-Target Pair
In DepthDetails Article
TargetEndothelin-1 receptor(Homo sapiens (Human))
Immunopharmaceutics

Curated by ChEMBL
LigandPNGBDBM50058126(2-[2-(6-Methyl-benzo[1,3]dioxol-5-yl)-acetyl]-thio...)
Affinity DataIC50:  1.40nMAssay Description:In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Immunopharmaceutics

Curated by ChEMBL
LigandPNGBDBM50058111(3-(4-Chloro-3-methyl-isoxazol-5-ylsulfamoyl)-thiop...)
Affinity DataIC50:  2.60nMAssay Description:In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Immunopharmaceutics

Curated by ChEMBL
LigandPNGBDBM50058111(3-(4-Chloro-3-methyl-isoxazol-5-ylsulfamoyl)-thiop...)
Affinity DataIC50:  2.60nMAssay Description:In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Immunopharmaceutics

Curated by ChEMBL
LigandPNGBDBM50058141(2-[2-(2,4-Dimethyl-phenyl)-acetyl]-thiophene-3-sul...)
Affinity DataIC50:  2.70nMAssay Description:In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Immunopharmaceutics

Curated by ChEMBL
LigandPNGBDBM50288013(5-Bromo-N-(4-bromo-3-methyl-isoxazol-5-yl)-2-ethyl...)
Affinity DataIC50:  2.80nMAssay Description:Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationMore data for this Ligand-Target Pair
In DepthDetails Article
TargetEndothelin-1 receptor(Homo sapiens (Human))
Immunopharmaceutics

Curated by ChEMBL
LigandPNGBDBM50058080(3-(4-Chloro-3-methyl-isoxazol-5-ylsulfamoyl)-thiop...)
Affinity DataIC50:  3nMAssay Description:In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Immunopharmaceutics

Curated by ChEMBL
LigandPNGBDBM50058134(3-(4-Chloro-3-methyl-isoxazol-5-ylsulfamoyl)-thiop...)
Affinity DataIC50:  3nMAssay Description:In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Immunopharmaceutics

Curated by ChEMBL
LigandPNGBDBM50058132(2-[2-(6-Methyl-benzo[1,3]dioxol-5-yl)-acetyl]-thio...)
Affinity DataIC50:  3.30nMAssay Description:In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Immunopharmaceutics

Curated by ChEMBL
LigandPNGBDBM50058106(3-(4-Chloro-3-methyl-isoxazol-5-ylsulfamoyl)-thiop...)
Affinity DataIC50:  3.40nMAssay Description:In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Immunopharmaceutics

Curated by ChEMBL
LigandPNGBDBM50058146(3-(4-Chloro-3-methyl-isoxazol-5-ylsulfamoyl)-thiop...)
Affinity DataIC50:  3.40nMAssay Description:In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Immunopharmaceutics

Curated by ChEMBL
LigandPNGBDBM50288040(Biphenyl-2-sulfonic acid (4-chloro-3-methyl-isoxaz...)
Affinity DataIC50:  3.80nMAssay Description:Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationMore data for this Ligand-Target Pair
In DepthDetails Article
TargetEndothelin-1 receptor(Homo sapiens (Human))
Immunopharmaceutics

Curated by ChEMBL
LigandPNGBDBM50058114(3-(4-Chloro-3-methyl-isoxazol-5-ylsulfamoyl)-thiop...)
Affinity DataIC50:  3.80nMAssay Description:In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Immunopharmaceutics

Curated by ChEMBL
LigandPNGBDBM50058120(3-(4-Chloro-3-methyl-isoxazol-5-ylsulfamoyl)-thiop...)
Affinity DataIC50:  3.90nMAssay Description:In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Immunopharmaceutics

Curated by ChEMBL
LigandPNGBDBM50058105(3-(4-Chloro-3-methyl-isoxazol-5-ylsulfamoyl)-thiop...)
Affinity DataIC50:  3.90nMAssay Description:In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Immunopharmaceutics

Curated by ChEMBL
LigandPNGBDBM50058099(Acetic acid 2-(6-{[3-(4-chloro-3-methyl-isoxazol-5...)
Affinity DataIC50:  4.5nMAssay Description:In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Immunopharmaceutics

Curated by ChEMBL
LigandPNGBDBM50058117(3-(4-Chloro-3-methyl-isoxazol-5-ylsulfamoyl)-thiop...)
Affinity DataIC50:  5.10nMAssay Description:In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Immunopharmaceutics

Curated by ChEMBL
LigandPNGBDBM50058097(3-(4-Chloro-3-methyl-isoxazol-5-ylsulfamoyl)-thiop...)
Affinity DataIC50:  5.60nMAssay Description:In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Immunopharmaceutics

Curated by ChEMBL
LigandPNGBDBM50034435(5-Dimethylamino-naphthalene-1-sulfonic acid (3,4-d...)
Affinity DataIC50:  5.80nMAssay Description:Binding affinity against human ETA receptor in TE 671(ATCC# HTB 139) cell membrane preparationMore data for this Ligand-Target Pair
In DepthDetails Article
TargetEndothelin-1 receptor(Homo sapiens (Human))
Immunopharmaceutics

Curated by ChEMBL
LigandPNGBDBM50058103(3-(4-Chloro-3-methyl-isoxazol-5-ylsulfamoyl)-thiop...)
Affinity DataIC50:  6nMAssay Description:In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Immunopharmaceutics

Curated by ChEMBL
LigandPNGBDBM50058075(Acetic acid 2-(6-{[3-(4-chloro-3-methyl-isoxazol-5...)
Affinity DataIC50:  6.10nMAssay Description:In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Immunopharmaceutics

Curated by ChEMBL
LigandPNGBDBM50288007(CHEMBL311138 | N-(4-Bromo-3-methyl-isoxazol-5-yl)-...)
Affinity DataIC50:  6.20nMAssay Description:Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationMore data for this Ligand-Target Pair
In DepthDetails Article
TargetEndothelin-1 receptor(Homo sapiens (Human))
Immunopharmaceutics

Curated by ChEMBL
LigandPNGBDBM50058084(3-(4-Chloro-3-methyl-isoxazol-5-ylsulfamoyl)-thiop...)
Affinity DataIC50:  6.60nMAssay Description:In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Immunopharmaceutics

Curated by ChEMBL
LigandPNGBDBM50058092(3-(4-Chloro-3-methyl-isoxazol-5-ylsulfamoyl)-thiop...)
Affinity DataIC50:  6.80nMAssay Description:In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Immunopharmaceutics

Curated by ChEMBL
LigandPNGBDBM50058124(2-[2-(2,5-Dimethyl-phenyl)-acetyl]-thiophene-3-sul...)
Affinity DataIC50:  7.20nMAssay Description:In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Immunopharmaceutics

Curated by ChEMBL
LigandPNGBDBM50288045(CHEMBL78563 | N-(4-Bromo-3-methyl-isoxazol-5-yl)-5...)
Affinity DataIC50:  8.10nMAssay Description:Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationMore data for this Ligand-Target Pair
In DepthDetails Article
TargetEndothelin-1 receptor(Homo sapiens (Human))
Immunopharmaceutics

Curated by ChEMBL
LigandPNGBDBM50289940(3-(4-Chloro-3-methyl-isoxazol-5-ylsulfamoyl)-thiop...)
Affinity DataIC50:  8.30nMAssay Description:In vitro binding affinity in a radioligand binding experiment by competition with [125I]-labeled endothelin-1 for ETA receptorMore data for this Ligand-Target Pair
In DepthDetails Article
TargetEndothelin-1 receptor(Homo sapiens (Human))
Immunopharmaceutics

Curated by ChEMBL
LigandPNGBDBM50068700(Biphenyl-2-sulfonic acid (3,4-dimethyl-isoxazol-5-...)
Affinity DataIC50:  8.30nMAssay Description:Binding affinity against human ETA receptor in TE 671(ATCC# HTB 139) cell membrane preparationMore data for this Ligand-Target Pair
In DepthDetails Article
TargetEndothelin-1 receptor(Homo sapiens (Human))
Immunopharmaceutics

Curated by ChEMBL
LigandPNGBDBM50289945(3-(4-Bromo-3-methyl-isoxazol-5-ylsulfamoyl)-thioph...)
Affinity DataIC50:  8.90nMAssay Description:Inhibition of I-ET-1 binding to human Endothelin A receptorMore data for this Ligand-Target Pair
In DepthDetails Article
TargetEndothelin-1 receptor(Homo sapiens (Human))
Immunopharmaceutics

Curated by ChEMBL
LigandPNGBDBM50289945(3-(4-Bromo-3-methyl-isoxazol-5-ylsulfamoyl)-thioph...)
Affinity DataIC50:  8.90nMAssay Description:In vitro binding affinity in a radioligand binding experiment by competition with [125I]-labeled endothelin-1 for ETA receptorMore data for this Ligand-Target Pair
In DepthDetails Article
TargetBromodomain-containing protein 4(Homo sapiens (Human))
Southern Research

Curated by ChEMBL
LigandPNGBDBM50365262((+)-JQ1 | (S)-JQ1 (1) | CHEMBL1957266 | JQ1 | US10...)
Affinity DataIC50:  9nMAssay Description:Displacement of biotinylated acetylated histone H4 peptide from human recombinant N-terminal GST-tagged BRD4 BD1 (49 to 170 residues) expressed in Es...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Immunopharmaceutics

Curated by ChEMBL
LigandPNGBDBM50058077(3-(4-Chloro-3-methyl-isoxazol-5-ylsulfamoyl)-thiop...)
Affinity DataIC50:  9.30nMAssay Description:In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Immunopharmaceutics

Curated by ChEMBL
LigandPNGBDBM50289943(3-(4-Bromo-3-methyl-isoxazol-5-ylsulfamoyl)-thioph...)
Affinity DataIC50:  9.30nMAssay Description:In vitro binding affinity in a radioligand binding experiment by competition with [125I]-labeled endothelin-1 for ETA receptorMore data for this Ligand-Target Pair
In DepthDetails Article
TargetEndothelin-1 receptor(Homo sapiens (Human))
Immunopharmaceutics

Curated by ChEMBL
LigandPNGBDBM50058115(3-(4-Chloro-3-methyl-isoxazol-5-ylsulfamoyl)-thiop...)
Affinity DataIC50:  10nMAssay Description:In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Immunopharmaceutics

Curated by ChEMBL
LigandPNGBDBM50058148(3-(4-Chloro-3-methyl-isoxazol-5-ylsulfamoyl)-thiop...)
Affinity DataIC50:  10nMAssay Description:In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Immunopharmaceutics

Curated by ChEMBL
LigandPNGBDBM50058116(3-(4-Chloro-3-methyl-isoxazol-5-ylsulfamoyl)-thiop...)
Affinity DataIC50:  10.8nMAssay Description:In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Immunopharmaceutics

Curated by ChEMBL
LigandPNGBDBM50058093(3-(4-Bromo-3-methyl-isoxazol-5-ylsulfamoyl)-thioph...)
Affinity DataIC50:  12nMAssay Description:In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Immunopharmaceutics

Curated by ChEMBL
LigandPNGBDBM50058100(3-(4-Chloro-3-methyl-isoxazol-5-ylsulfamoyl)-thiop...)
Affinity DataIC50:  13nMAssay Description:In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Immunopharmaceutics

Curated by ChEMBL
LigandPNGBDBM50058121(2-(2-Benzo[1,3]dioxol-5-yl-acetyl)-thiophene-3-sul...)
Affinity DataIC50:  14nMAssay Description:In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Immunopharmaceutics

Curated by ChEMBL
LigandPNGBDBM50058095(3-(4-Chloro-3-methyl-isoxazol-5-ylsulfamoyl)-thiop...)
Affinity DataIC50:  15nMAssay Description:In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Immunopharmaceutics

Curated by ChEMBL
LigandPNGBDBM50058095(3-(4-Chloro-3-methyl-isoxazol-5-ylsulfamoyl)-thiop...)
Affinity DataIC50:  15nMAssay Description:In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Immunopharmaceutics

Curated by ChEMBL
LigandPNGBDBM50058108(3-(4-Chloro-3-methyl-isoxazol-5-ylsulfamoyl)-thiop...)
Affinity DataIC50:  15nMAssay Description:In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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