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Found 451 with Last Name = 'chen' and Initial = 'sh'
TargetCathepsin B(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50137733((1S,5S,6R)-2-((S)-3,3-Dimethyl-2-{(S)-3-methyl-2-[...)
Affinity DataKi:  1.60nMAssay Description:Inhibitory activity of the compound against cathepsin BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM16250(CHEMBL290001 | N-(tert-butoxycarbonyl)-L-valyl-N-[...)
Affinity DataKi:  2.5nMAssay Description:In vitro inhibition of Beta-secretase-1 in HEK293 (Human Embryonic Kidney) cell line.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin B(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50137736((1S,5S,6R)-2-((S)-3,3-Dimethyl-2-{(S)-3-methyl-2-[...)
Affinity DataKi:  3.70nMAssay Description:Inhibitory activity of the compound against cathepsin BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin B(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50137720((1S,3aR,6aS)-2-((S)-3-Methyl-2-{(S)-3-methyl-2-[(p...)
Affinity DataKi:  4nMAssay Description:Inhibitory activity of the compound against cathepsin BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin B(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50137730((1S,5S,6R)-2-((S)-3,3-Dimethyl-2-{(S)-3-methyl-2-[...)
Affinity DataKi:  5nMAssay Description:Inhibitory activity of the compound against cathepsin BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50150593(3,4-Dihydro-1H-isoquinoline-2-carboxylic acid (S)-...)
Affinity DataKi:  6.10nMAssay Description:Inhibitory potency against HCV NS3 proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProcathepsin L(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50137720((1S,3aR,6aS)-2-((S)-3-Methyl-2-{(S)-3-methyl-2-[(p...)
Affinity DataKi:  12nMAssay Description:Inhibitory activity of the compound against cathepsin LMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Human rhinovirus B)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50137724((3aR,5S)-2-((S)-3-Methyl-2-{(S)-3-methyl-2-[(pyraz...)
Affinity DataKi:  17nMAssay Description:Binding affinity towards Protease using PNA assay in ratsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50152750(2-((S)-2-{(S)-2-Cyclohexyl-2-[(pyrazine-2-carbonyl...)
Affinity DataKi:  20nMAssay Description:Inhibition of HCV NS3 protease in the pNA based inhibition assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50150591((S)-2-{(S)-3-Methyl-2-[(S)-3-methyl-2-(5-1H-tetraz...)
Affinity DataKi:  22nMAssay Description:Inhibitory potency against HCV NS3 proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Human rhinovirus B)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50137747((1S,3aR,6aS)-2-((S)-3,3-Dimethyl-2-{(S)-3-methyl-2...)
Affinity DataKi:  23nMAssay Description:Binding affinity towards Protease using PNA assay in ratsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProcathepsin L(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50137732((1S,5S,6R)-2-((S)-3,3-Dimethyl-2-{(S)-3-methyl-2-[...)
Affinity DataKi:  29nMAssay Description:Inhibitory activity of the compound against cathepsin LMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProcathepsin L(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50137730((1S,5S,6R)-2-((S)-3,3-Dimethyl-2-{(S)-3-methyl-2-[...)
Affinity DataKi:  30nMAssay Description:Inhibitory activity of the compound against cathepsin LMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50150599(2-{(S)-2-[(S)-2-Cyclohexyl-2-(2-2H-tetrazol-5-yl-a...)
Affinity DataKi:  30nMAssay Description:Inhibitory potency against HCV NS3 proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50150595((S)-2-{(S)-3-Methyl-2-[(S)-3-methyl-2-(5-1H-tetraz...)
Affinity DataKi:  31nMAssay Description:Inhibitory potency against HCV NS3 proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin B(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50137732((1S,5S,6R)-2-((S)-3,3-Dimethyl-2-{(S)-3-methyl-2-[...)
Affinity DataKi:  52nMAssay Description:Inhibitory activity of the compound against cathepsin BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProcathepsin L(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50137736((1S,5S,6R)-2-((S)-3,3-Dimethyl-2-{(S)-3-methyl-2-[...)
Affinity DataKi:  52nMAssay Description:Inhibitory activity of the compound against cathepsin LMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymotrypsinogen A(Bos taurus (bovine))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50137732((1S,5S,6R)-2-((S)-3,3-Dimethyl-2-{(S)-3-methyl-2-[...)
Affinity DataKi:  62nMAssay Description:Inhibitory activity of the compound against ChymotrypsinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50150606(3,4-Dihydro-1H-isoquinoline-2-carboxylic acid (S)-...)
Affinity DataKi:  65nMAssay Description:Inhibitory potency against HCV NS3 proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Human rhinovirus B)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50137721(2-(3-{[(1S,5S,6R)-2-((S)-3-Methyl-2-{(S)-3-methyl-...)
Affinity DataKi:  68nMAssay Description:Binding affinity towards Protease using PNA assay in ratsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50152754(2-((S)-2-{(S)-2-Cyclohexyl-2-[(pyrazine-2-carbonyl...)
Affinity DataKi:  70nMAssay Description:Inhibition of HCV NS3 protease in the pNA based inhibition assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50150602(3,4-Dihydro-1H-isoquinoline-2-carboxylic acid (S)-...)
Affinity DataKi:  74nMAssay Description:Inhibitory potency against HCV NS3 proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50152753((S)-2-((S)-3,3-Dimethyl-2-{(S)-3-methyl-2-[(pyrazi...)
Affinity DataKi:  80nMAssay Description:Inhibition of HCV NS3 protease in the pNA based inhibition assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50152748((S)-2-((S)-2-{(S)-2-Cyclohexyl-2-[(pyrazine-2-carb...)
Affinity DataKi:  80nMAssay Description:Inhibition of HCV NS3 protease in the pNA based inhibition assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50137733((1S,5S,6R)-2-((S)-3,3-Dimethyl-2-{(S)-3-methyl-2-[...)
Affinity DataKi:  80nMAssay Description:Inhibition of HCV NS3 protease in the pNA based inhibition assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50150604(2-{(S)-3-Methyl-2-[(S)-3-methyl-2-(5-1H-tetrazol-5...)
Affinity DataKi:  82nMAssay Description:Inhibitory potency against HCV NS3 proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Human rhinovirus B)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50137713((S)-2-((S)-3-{[(1S,5S,6R)-4-Fluoro-2-((S)-3-methyl...)
Affinity DataKi:  82nMAssay Description:Binding affinity towards Protease using PNA assay in ratsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Human rhinovirus B)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50137733((1S,5S,6R)-2-((S)-3,3-Dimethyl-2-{(S)-3-methyl-2-[...)
Affinity DataKi:  84nMAssay Description:Binding affinity of the compound towards Protease using PNA assay in ratsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Human rhinovirus B)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50137739((1S,3aR,6aS)-2-((S)-3,3-Dimethyl-2-{(S)-3-methyl-2...)
Affinity DataKi:  84nMAssay Description:Binding affinity towards Protease using PNA assay in ratsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Human rhinovirus B)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50137718((1S,5S,6R)-2-((S)-3-Methyl-2-{(S)-3-methyl-2-[(pyr...)
Affinity DataKi:  90nMAssay Description:Binding affinity towards Protease using PNA assay in ratsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50152751(2-((S)-2-{(S)-2-Cyclohexyl-2-[((R)-pyrazine-2-carb...)
Affinity DataKi:  90nMAssay Description:Inhibition of HCV NS3 protease in the pNA based inhibition assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Wuxi Pharmatech

Curated by ChEMBL
LigandPNGBDBM50302101(3-(2-(2-ethyl-2-phenylhydrazinyl)-3,4-dioxocyclobu...)
Affinity DataKi:  110nMAssay Description:Displacement of [125I]IL-8 from human CXCR2 expressed in mouse BaF3 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50150605(CHEMBL360805 | Naphthalene-2-carboxylic acid (S)-1...)
Affinity DataKi:  110nMAssay Description:Inhibitory potency against HCV NS3 proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50150598((S)-2-{(S)-3-Methyl-2-[(S)-3-methyl-2-(5-1H-tetraz...)
Affinity DataKi:  112nMAssay Description:Inhibitory potency against HCV NS3 proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Human rhinovirus B)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50137738((1S,5S,6R)-2-((S)-3,3-Dimethyl-2-{(S)-3-methyl-2-[...)
Affinity DataKi:  120nMAssay Description:Binding affinity of the compound towards Protease using PNA assay in ratsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Human rhinovirus B)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50137720((1S,3aR,6aS)-2-((S)-3-Methyl-2-{(S)-3-methyl-2-[(p...)
Affinity DataKi:  120nMAssay Description:Binding affinity of the compound towards Protease using PNA assay in ratsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Wuxi Pharmatech

Curated by ChEMBL
LigandPNGBDBM50302098(3-(2-(2,2-diethylhydrazinyl)-3,4-dioxocyclobut-1-e...)
Affinity DataKi:  120nMAssay Description:Displacement of [125I]IL-8 from human CXCR2 expressed in mouse BaF3 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50150601(2-((S)-3-Methyl-2-{(S)-3-methyl-2-[(pyrazine-2-car...)
Affinity DataKi:  123nMAssay Description:Inhibitory potency against HCV NS3 proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Human rhinovirus B)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50137720((1S,3aR,6aS)-2-((S)-3-Methyl-2-{(S)-3-methyl-2-[(p...)
Affinity DataKi:  123nMAssay Description:Binding affinity towards Protease using PNA assay in ratsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Human rhinovirus B)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50137720((1S,3aR,6aS)-2-((S)-3-Methyl-2-{(S)-3-methyl-2-[(p...)
Affinity DataKi:  123nMAssay Description:Cytotoxic activity in rat liver Huh-7 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Wuxi Pharmatech

Curated by ChEMBL
LigandPNGBDBM50302104(3-(2-(2-ethyl-2-(pyridin-2-yl)hydrazinyl)-3,4-diox...)
Affinity DataKi:  130nMAssay Description:Displacement of [125I]IL-8 from human CXCR2 expressed in mouse BaF3 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50152755(2-((S)-2-{(S)-3-Methoxy-2-[(pyrazine-2-carbonyl)-a...)
Affinity DataKi:  150nMAssay Description:Inhibition of HCV NS3 protease in the pNA based inhibition assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProcathepsin L(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50137733((1S,5S,6R)-2-((S)-3,3-Dimethyl-2-{(S)-3-methyl-2-[...)
Affinity DataKi:  154nMAssay Description:Inhibitory activity of the compound against cathepsin LMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50152752((S)-2-((S)-2-{(S)-3,3-Dimethyl-2-[(pyrazine-2-carb...)
Affinity DataKi:  160nMAssay Description:Inhibition of HCV NS3 protease in the pNA based inhibition assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50150594((S)-2-{(S)-3-Methyl-2-[(S)-3-methyl-2-(5-1H-tetraz...)
Affinity DataKi:  170nMAssay Description:Inhibitory potency against HCV NS3 proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Human rhinovirus B)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50404057(CHEMBL118534)
Affinity DataKi:  170nMAssay Description:Antiviral activity against human rhinovirus-14 (HRV-14) 3C protease using enzyme assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Human rhinovirus B)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50137722((S)-2-(3-{[(1S,5S,6R)-4,4-Difluoro-2-((S)-3-methyl...)
Affinity DataKi:  176nMAssay Description:Binding affinity towards Protease using PNA assay in ratsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Wuxi Pharmatech

Curated by ChEMBL
LigandPNGBDBM50302103(3-(2-(2-ethyl-2-(4-methoxyphenyl)hydrazinyl)-3,4-d...)
Affinity DataKi:  180nMAssay Description:Displacement of [125I]IL-8 from human CXCR2 expressed in mouse BaF3 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Human rhinovirus B)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50137732((1S,5S,6R)-2-((S)-3,3-Dimethyl-2-{(S)-3-methyl-2-[...)
Affinity DataKi:  190nMAssay Description:Binding affinity of the compound towards Protease using PNA assay in ratsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Human rhinovirus B)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50137748((1S,3aR,6aS)-2-((S)-3,3-Dimethyl-2-{(3S,4S)-3-meth...)
Affinity DataKi:  190nMAssay Description:Binding affinity towards Protease using PNA assay in ratsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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