Affinity DataKi: 3.09E+4nMAssay Description:Non-competitive inhibition of recombinant human MIF assessed as inhibition constant using varying levels of p-hydroxyphenylpyruvate as substrate by L...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 9(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals
Curated by ChEMBL
Boehringer Ingelheim Pharmaceuticals
Curated by ChEMBL
TargetMitogen-activated protein kinase 9(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals
Curated by ChEMBL
Boehringer Ingelheim Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 3nMAssay Description:Inhibition of JNK2alpha2 (unknown origin) by by exchange curve binding kinetic analysisMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals
Curated by ChEMBL
Boehringer Ingelheim Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 79nMAssay Description:Binding affinity to p38alpha (unknown origin) assessed as inhibition of ATF2 phosphorylation preincubated for 4 hrsMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 9(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals
Curated by ChEMBL
Boehringer Ingelheim Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 100nMAssay Description:Selectivity against c-Jun N-terminal kinase 2-alpha 2 protein kinaseMore data for this Ligand-Target Pair
Affinity DataIC50: 370nMAssay Description:Inhibition of recombinant biotinylated human MIF tautomerase activity expressed in Escherichia coli BL21 DE3 assessed as reduction in tautomerization...More data for this Ligand-Target Pair
Affinity DataIC50: 400nMAssay Description:Inhibition of recombinant human MIF expressed in Escherichia coli BL21 DE3 binding to recombinant soluble human CD74 receptor ectodomain (73 to 232 r...More data for this Ligand-Target Pair
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals
Curated by ChEMBL
Boehringer Ingelheim Pharmaceuticals
Curated by ChEMBL
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals
Curated by ChEMBL
Boehringer Ingelheim Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 480nMAssay Description:Inhibition of Abl (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 810nMAssay Description:Inhibition of recombinant biotinylated human MIF expressed in Escherichia coli BL21 DE3 binding to immobilized soluble human CD74 receptor ectodomain...More data for this Ligand-Target Pair
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals
Curated by ChEMBL
Boehringer Ingelheim Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 880nMAssay Description:Inhibition of craf (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 930nMAssay Description:Inhibition of recombinant human MIF expressed in Escherichia coli BL21 DE3 binding to recombinant soluble human CD74 receptor ectodomain (73 to 232 r...More data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals
Curated by ChEMBL
Boehringer Ingelheim Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of SrcMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals
Curated by ChEMBL
Boehringer Ingelheim Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of AblMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase Lyn(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals
Curated by ChEMBL
Boehringer Ingelheim Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of LynMore data for this Ligand-Target Pair
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals
Curated by ChEMBL
Boehringer Ingelheim Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 1.40E+3nMAssay Description:Selectivity against RAF proto-oncogene serine/threonine-protein kinase (c-Raf-1)More data for this Ligand-Target Pair
TargetTyrosine-protein kinase Lyn(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals
Curated by ChEMBL
Boehringer Ingelheim Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 2.40E+3nMAssay Description:Inhibition of Lyn (unknown origin)More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals
Curated by ChEMBL
Boehringer Ingelheim Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 2.70E+3nMAssay Description:Binding affinity to p38alpha (unknown origin) assessed as inhibition of ATF2 phosphorylation preincubated for 4 hrsMore data for this Ligand-Target Pair
TargetEphrin type-A receptor 3(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals
Curated by ChEMBL
Boehringer Ingelheim Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 3.20E+3nMAssay Description:Inhibition of HEK (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 3.90E+3nMAssay Description:Inhibition of MIF-induced IL-8 secretion in human foreskin fibroblasts incubated for 30 mins by ELISAMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals
Curated by ChEMBL
Boehringer Ingelheim Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 3.90E+3nMAssay Description:Binding affinity to p38alpha (unknown origin) assessed as inhibition of ATF2 phosphorylation preincubated for 4 hrsMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals
Curated by ChEMBL
Boehringer Ingelheim Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 4.10E+3nMAssay Description:Binding affinity to p38alpha (unknown origin) assessed as inhibition of ATF2 phosphorylation preincubated for 4 hrsMore data for this Ligand-Target Pair
Affinity DataIC50: 4.42E+3nMAssay Description:Inhibition of MIF-induced IL-8 secretion in human foreskin fibroblasts incubated for 30 mins by ELISAMore data for this Ligand-Target Pair
TargetEphrin type-A receptor 2(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals
Curated by ChEMBL
Boehringer Ingelheim Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 5.20E+3nMAssay Description:Inhibition of ECK (unknown origin)More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals
Curated by ChEMBL
Boehringer Ingelheim Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 5.40E+3nMAssay Description:Inhibition of EGFR (unknown origin)More data for this Ligand-Target Pair
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals
Curated by ChEMBL
Boehringer Ingelheim Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 6.40E+3nMAssay Description:Inhibition of PKBalpha/Akt1 (unknown origin)More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals
Curated by ChEMBL
Boehringer Ingelheim Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 7.20E+3nMAssay Description:Inhibition of bRaf (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 7.59E+3nMAssay Description:Inhibition of recombinant biotinylated human MIF tautomerase activity expressed in Escherichia coli BL21 DE3 assessed as reduction in tautomerization...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals
Curated by ChEMBL
Boehringer Ingelheim Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Binding affinity to p38alpha (unknown origin) assessed as inhibition of ATF2 phosphorylation preincubated for 4 hrsMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals
Curated by ChEMBL
Boehringer Ingelheim Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Binding affinity to p38alpha (unknown origin) assessed as inhibition of ATF2 phosphorylation preincubated for 4 hrsMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase ZAP-70(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals
Curated by ChEMBL
Boehringer Ingelheim Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: >2.00E+4nMAssay Description:Selectivity against Zeta-chain (TCR) associated protein kinase 70 kDa (ZAP70)More data for this Ligand-Target Pair
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals
Curated by ChEMBL
Boehringer Ingelheim Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: >2.00E+4nMAssay Description:Selectivity against HER2 kinaseMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals
Curated by ChEMBL
Boehringer Ingelheim Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: >2.00E+4nMAssay Description:Selectivity against Syk protein tyrosine kinaseMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals
Curated by ChEMBL
Boehringer Ingelheim Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: >2.00E+4nMAssay Description:Selectivity against Epidermal growth factor receptorMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 3(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals
Curated by ChEMBL
Boehringer Ingelheim Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: >2.00E+4nMAssay Description:Selectivity against Extracellular signal-regulated kinase 1 (Erk-1)More data for this Ligand-Target Pair
TargetTyrosine-protein kinase Fyn(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals
Curated by ChEMBL
Boehringer Ingelheim Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: >2.00E+4nMAssay Description:Selectivity against p59 Fyn tyrosine kinaseMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals
Curated by ChEMBL
Boehringer Ingelheim Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: >2.00E+4nMAssay Description:Selectivity against p56 Lck tyrosine kinaseMore data for this Ligand-Target Pair
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals
Curated by ChEMBL
Boehringer Ingelheim Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: >2.00E+4nMAssay Description:Selectivity against I-kappa-B-kinase betaMore data for this Ligand-Target Pair
TargetCytochrome P450 2C19(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals Inc
Curated by ChEMBL
Boehringer Ingelheim Pharmaceuticals Inc
Curated by ChEMBL
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of human CYP2C19More data for this Ligand-Target Pair
TargetCytochrome P450 3A4(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals Inc
Curated by ChEMBL
Boehringer Ingelheim Pharmaceuticals Inc
Curated by ChEMBL
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of CYP3A4 using flourescent probe 7-benzyloxyquinoline and 7-benzyloxy-4-(trifluoromethyl)-coumarin)More data for this Ligand-Target Pair
TargetCytochrome P450 2C9(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals Inc
Curated by ChEMBL
Boehringer Ingelheim Pharmaceuticals Inc
Curated by ChEMBL
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of CYP2C9 using flourescent probe 7-methoxy-4-trifluoromethylcoumarinMore data for this Ligand-Target Pair
TargetCytochrome P450 2D6(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals Inc
Curated by ChEMBL
Boehringer Ingelheim Pharmaceuticals Inc
Curated by ChEMBL
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of CYP2D6 flourescent probe 3-[2-(N,N-diethyl-N-methylamino)ethyl]-7-methoxy-4-methylcoumarinMore data for this Ligand-Target Pair
TargetCytochrome P450 3A4(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals Inc
Curated by ChEMBL
Boehringer Ingelheim Pharmaceuticals Inc
Curated by ChEMBL
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of CYP3A4 using flourescent probe 7-benzyloxyquinoline and 7-benzyloxy-4-(trifluoromethyl)-coumarin)More data for this Ligand-Target Pair
TargetCytochrome P450 2C9(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals Inc
Curated by ChEMBL
Boehringer Ingelheim Pharmaceuticals Inc
Curated by ChEMBL
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of CYP2C9 using flourescent probe 7-methoxy-4-trifluoromethylcoumarinMore data for this Ligand-Target Pair
TargetCytochrome P450 2D6(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals Inc
Curated by ChEMBL
Boehringer Ingelheim Pharmaceuticals Inc
Curated by ChEMBL
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of CYP2D6 flourescent probe 3-[2-(N,N-diethyl-N-methylamino)ethyl]-7-methoxy-4-methylcoumarinMore data for this Ligand-Target Pair
TargetCytochrome P450 3A4(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals Inc
Curated by ChEMBL
Boehringer Ingelheim Pharmaceuticals Inc
Curated by ChEMBL
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of CYP3A4 using flourescent probe 7-benzyloxyquinoline and 7-benzyloxy-4-(trifluoromethyl)-coumarin)More data for this Ligand-Target Pair
TargetCytochrome P450 2D6(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals Inc
Curated by ChEMBL
Boehringer Ingelheim Pharmaceuticals Inc
Curated by ChEMBL
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of CYP2D6 flourescent probe 3-[2-(N,N-diethyl-N-methylamino)ethyl]-7-methoxy-4-methylcoumarinMore data for this Ligand-Target Pair
TargetCytochrome P450 2C9(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals Inc
Curated by ChEMBL
Boehringer Ingelheim Pharmaceuticals Inc
Curated by ChEMBL
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of CYP2C9 using flourescent probe 7-methoxy-4-trifluoromethylcoumarinMore data for this Ligand-Target Pair
TargetCytochrome P450 2D6(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals Inc
Curated by ChEMBL
Boehringer Ingelheim Pharmaceuticals Inc
Curated by ChEMBL
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of human CYP2D6More data for this Ligand-Target Pair
TargetCytochrome P450 3A4(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals Inc
Curated by ChEMBL
Boehringer Ingelheim Pharmaceuticals Inc
Curated by ChEMBL
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of human CYP3A4More data for this Ligand-Target Pair