Compile Data Set for Download or QSAR
maximum 50k data
Found 816 with Last Name = 'cooper' and Initial = 'm'
TargetMonocarboxylate transporter 1(Homo sapiens (Human))
Astrazeneca

LigandPNGBDBM21995(5-{[(4S)-4-hydroxy-1,2-oxazolidin-2-yl]carbonyl}-3...)
Affinity DataKi:  0.0900nM ΔG°:  -56.8kJ/molepH: 7.8 T: 2°CAssay Description:Jurkat cell membranes were incubated with [3H]-labeled ligand in the absence or presence of increasing concentrations of test compound. The reagents ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMonocarboxylate transporter 1(Homo sapiens (Human))
Astrazeneca

LigandPNGBDBM22000(7-[(3-hydroxypropyl)sulfanyl]-2-methyl-4-(2-methyl...)
Affinity DataKi:  0.100nM ΔG°:  -56.5kJ/molepH: 7.8 T: 2°CAssay Description:Jurkat cell membranes were incubated with [3H]-labeled ligand in the absence or presence of increasing concentrations of test compound. The reagents ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
Cyclacel

LigandPNGBDBM81438(CDK Inhibitor, 11)
Affinity DataKi:  0.110nMAssay Description:Kinase assay using cyclin-dependant kinases (CDK).More data for this Ligand-Target Pair
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50070824(CHEMBL47920 | N-(6-Amino-2-methyl-pyridin-3-ylmeth...)
Affinity DataKi:  0.120nMAssay Description:Compound was evaluated to inhibit the thrombin enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Vrije Universiteit Brussel

Curated by ChEMBL
LigandPNGBDBM85731([Dmt1]DALDA)
Affinity DataKi:  0.143nMAssay Description:Binding affinity to mu opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
Vrije Universiteit Brussel

Curated by ChEMBL
LigandPNGBDBM85731([Dmt1]DALDA)
Affinity DataKi:  0.143nMAssay Description:Displacement of [3H]DAMGO from mu opioid receptor in rat brain membranes after 2 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
Vrije Universiteit Brussel

Curated by ChEMBL
LigandPNGBDBM50346330((R)-N-((S)-2-(2-amino-2-oxoethyl)-3-oxo-2,3,4,5-te...)
Affinity DataKi:  0.150nMAssay Description:Displacement of [3H]DAMGO from mu opioid receptor in rat brain membranes after 2 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
Vrije Universiteit Brussel

Curated by ChEMBL
LigandPNGBDBM50399643(CHEMBL2181201)
Affinity DataKi:  0.230nMAssay Description:Displacement of [3H]DAMGO from mu opioid receptor in rat brain membranes after 2 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
Vrije Universiteit Brussel

Curated by ChEMBL
LigandPNGBDBM50399639(CHEMBL2181197)
Affinity DataKi:  0.260nMAssay Description:Displacement of [3H]DAMGO from mu opioid receptor in rat brain membranes after 2 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
Vrije Universiteit Brussel

Curated by ChEMBL
LigandPNGBDBM50399640(CHEMBL2181198)
Affinity DataKi:  0.260nMAssay Description:Displacement of [3H]DAMGO from mu opioid receptor in rat brain membranes after 2 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50060708((S)-1-(3-Benzo[1,3]dioxol-5-yl-3-pyridin-3-yl-prop...)
Affinity DataKi:  0.280nM Koff:  2.51E+3s-1Assay Description:Inhibition of ThrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMonocarboxylate transporter 1(Homo sapiens (Human))
Astrazeneca

LigandPNGBDBM22001(5-[(3-hydroxypropyl)sulfanyl]-3-methyl-1-(2-methyl...)
Affinity DataKi:  0.280nM ΔG°:  -54.0kJ/molepH: 7.8 T: 2°CAssay Description:Jurkat cell membranes were incubated with [3H]-labeled ligand in the absence or presence of increasing concentrations of test compound. The reagents ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMonocarboxylate transporter 1(Homo sapiens (Human))
Astrazeneca

LigandPNGBDBM22009(5-{[(1R,3R)-3-hydroxycyclopentyl]sulfanyl}-3-methy...)
Affinity DataKi:  0.290nM ΔG°:  -53.9kJ/molepH: 7.8 T: 2°CAssay Description:Jurkat cell membranes were incubated with [3H]-labeled ligand in the absence or presence of increasing concentrations of test compound. The reagents ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 9(Homo sapiens (Human))
Cyclacel

LigandPNGBDBM81433(CDK Inhibitor, 6)
Affinity DataKi:  0.290nMAssay Description:Kinase assay using cyclin-dependant kinases (CDK).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50066331((S)-1-[(R)-2-Cyclohexyl-2-(diethylcarbamoylmethyl-...)
Affinity DataKi:  0.310nMAssay Description:Binding affinity of the compound was evaluated on serine protease thrombin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMonocarboxylate transporter 1(Homo sapiens (Human))
Astrazeneca

LigandPNGBDBM21992(5-{[(3R)-3-hydroxypyrrolidin-1-yl]carbonyl}-3-meth...)
Affinity DataKi:  0.310nM ΔG°:  -53.7kJ/molepH: 7.8 T: 2°CAssay Description:Jurkat cell membranes were incubated with [3H]-labeled ligand in the absence or presence of increasing concentrations of test compound. The reagents ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMonocarboxylate transporter 1(Homo sapiens (Human))
Astrazeneca

LigandPNGBDBM21986(5-[(3-hydroxypropyl)sulfanyl]-3-methyl-1-(2-methyl...)
Affinity DataKi:  0.330nM ΔG°:  -53.6kJ/molepH: 7.8 T: 2°CAssay Description:Jurkat cell membranes were incubated with [3H]-labeled ligand in the absence or presence of increasing concentrations of test compound. The reagents ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMonocarboxylate transporter 1(Homo sapiens (Human))
Astrazeneca

LigandPNGBDBM22002(5-[(3-hydroxypropyl)sulfanyl]-3-methyl-1-(2-methyl...)
Affinity DataKi:  0.350nM ΔG°:  -53.4kJ/molepH: 7.8 T: 2°CAssay Description:Jurkat cell membranes were incubated with [3H]-labeled ligand in the absence or presence of increasing concentrations of test compound. The reagents ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50067795(CHEMBL138855 | N-(6-Amino-2,4-dimethyl-pyridin-3-y...)
Affinity DataKi:  0.350nMAssay Description:Inhibitory activity of the compound against thrombin (IIa) was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 9(Homo sapiens (Human))
Cyclacel

LigandPNGBDBM81441(CDK Inhibitor, 14)
Affinity DataKi:  0.380nMAssay Description:Kinase assay using cyclin-dependant kinases (CDK).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMonocarboxylate transporter 1(Homo sapiens (Human))
Astrazeneca

LigandPNGBDBM22010(5-{[(1R,3S)-3-hydroxycyclopentyl]sulfanyl}-3-methy...)
Affinity DataKi:  0.420nM ΔG°:  -53.0kJ/molepH: 7.8 T: 2°CAssay Description:Jurkat cell membranes were incubated with [3H]-labeled ligand in the absence or presence of increasing concentrations of test compound. The reagents ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
Vrije Universiteit Brussel

Curated by ChEMBL
LigandPNGBDBM50399636(CHEMBL2181193)
Affinity DataKi:  0.430nMAssay Description:Displacement of [3H]DAMGO from mu opioid receptor in rat brain membranes after 2 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMonocarboxylate transporter 1(Homo sapiens (Human))
Astrazeneca

LigandPNGBDBM21996(5-{[(4S)-4-hydroxy-1,2-oxazolidin-2-yl]carbonyl}-3...)
Affinity DataKi:  0.430nM ΔG°:  -52.9kJ/molepH: 7.8 T: 2°CAssay Description:Jurkat cell membranes were incubated with [3H]-labeled ligand in the absence or presence of increasing concentrations of test compound. The reagents ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50066338(CHEMBL327115 | [2-({[(S)-1-((R)-2-Amino-2-cyclohex...)
Affinity DataKi:  0.450nMAssay Description:Binding affinity of the compound was evaluated on serine protease thrombin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50067796(CHEMBL11157 | L-374087 | N-((6-amino-2-methylpyrid...)
Affinity DataKi:  0.5nMAssay Description:Compound was evaluated to inhibit the thrombin enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50066332((S)-1-((R)-2-Amino-2-cyclohexyl-acetyl)-pyrrolidin...)
Affinity DataKi:  0.5nMAssay Description:Binding affinity of the compound was evaluated on serine protease thrombin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50067796(CHEMBL11157 | L-374087 | N-((6-amino-2-methylpyrid...)
Affinity DataKi:  0.5nMAssay Description:Inhibitory activity of the compound against thrombin (IIa) was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
Cyclacel

LigandPNGBDBM81439(CDK Inhibitor, 12)
Affinity DataKi:  0.520nMAssay Description:Kinase assay using cyclin-dependant kinases (CDK).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50067798(CHEMBL336438 | N-(6-Amino-2-methyl-pyridin-3-ylmet...)
Affinity DataKi:  0.520nMAssay Description:Inhibitory activity of the compound against thrombin (IIa) was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMonocarboxylate transporter 1(Homo sapiens (Human))
Astrazeneca

LigandPNGBDBM21994(5-{[(4S)-4-hydroxy-1,2-oxazolidin-2-yl]carbonyl}-3...)
Affinity DataKi:  0.520nM ΔG°:  -52.5kJ/molepH: 7.8 T: 2°CAssay Description:Jurkat cell membranes were incubated with [3H]-labeled ligand in the absence or presence of increasing concentrations of test compound. The reagents ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 7(Homo sapiens (Human))
Cyclacel

LigandPNGBDBM81440(CDK Inhibitor, 13)
Affinity DataKi:  0.560nMAssay Description:Kinase assay using cyclin-dependant kinases (CDK).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
Vrije Universiteit Brussel

Curated by ChEMBL
LigandPNGBDBM50399642(CHEMBL2181200)
Affinity DataKi:  0.570nMAssay Description:Displacement of [3H]DAMGO from mu opioid receptor in rat brain membranes after 2 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Rattus norvegicus (rat))
Vrije Universiteit Brussel

Curated by ChEMBL
LigandPNGBDBM50346330((R)-N-((S)-2-(2-amino-2-oxoethyl)-3-oxo-2,3,4,5-te...)
Affinity DataKi:  0.600nMAssay Description:Displacement of [3H]DSLET from delta opioid receptor in rat brain membranes after 2 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
Vrije Universiteit Brussel

Curated by ChEMBL
LigandPNGBDBM50399644(CHEMBL2181194)
Affinity DataKi:  0.610nMAssay Description:Displacement of [3H]DAMGO from mu opioid receptor in rat brain membranes after 2 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50066333((S)-1-((R)-2-Amino-2-cyclohexyl-acetyl)-pyrrolidin...)
Affinity DataKi:  0.610nMAssay Description:Binding affinity of the compound was evaluated on serine protease thrombin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMonocarboxylate transporter 1(Homo sapiens (Human))
Astrazeneca

LigandPNGBDBM22011(5-{[(1S,3R,4S)-3,4-dihydroxycyclopentyl]sulfanyl}-...)
Affinity DataKi:  0.680nM ΔG°:  -51.8kJ/molepH: 7.8 T: 2°CAssay Description:Jurkat cell membranes were incubated with [3H]-labeled ligand in the absence or presence of increasing concentrations of test compound. The reagents ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50066334((S)-1-((R)-2-Amino-2-cyclohexyl-acetyl)-pyrrolidin...)
Affinity DataKi:  0.740nMAssay Description:Binding affinity of the compound was evaluated on serine protease thrombin.More data for this Ligand-Target Pair
TargetMonocarboxylate transporter 1(Homo sapiens (Human))
Astrazeneca

LigandPNGBDBM22025(5-{[(3R)-3-hydroxypyrrolidin-1-yl]carbonyl}-6-(1H-...)
Affinity DataKi:  0.790nM ΔG°:  -51.4kJ/molepH: 7.4 T: 2°CAssay Description:A radioligand-binding assay was developed using scintillation proximity assay (SPA) technology. The wheat germ agglutinin SPA beads (Amersham) (0.2 m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
Vrije Universiteit Brussel

Curated by ChEMBL
LigandPNGBDBM50399641(CHEMBL2181199)
Affinity DataKi:  0.790nMAssay Description:Displacement of [3H]DAMGO from mu opioid receptor in rat brain membranes after 2 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50067797(CHEMBL19080 | L-37378 | N-(6-Amino-2-methyl-pyridi...)
Affinity DataKi:  0.800nMAssay Description:Inhibitory activity of the compound against thrombin (IIa) was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 9(Homo sapiens (Human))
Cyclacel

LigandPNGBDBM81430(CDK Inhibitor, 3)
Affinity DataKi:  0.800nMAssay Description:Kinase assay using cyclin-dependant kinases (CDK).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMonocarboxylate transporter 1(Homo sapiens (Human))
Astrazeneca

LigandPNGBDBM21987(6-[(6-fluoroquinolin-4-yl)methyl]-5-{[(3R)-3-hydro...)
Affinity DataKi:  0.810nM ΔG°:  -51.4kJ/molepH: 7.8 T: 2°CAssay Description:Jurkat cell membranes were incubated with [3H]-labeled ligand in the absence or presence of increasing concentrations of test compound. The reagents ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50070823(CHEMBL45480 | N-(6-Amino-2-methyl-pyridin-3-ylmeth...)
Affinity DataKi:  0.850nMAssay Description:Compound was evaluated to inhibit the thrombin enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
Vrije Universiteit Brussel

Curated by ChEMBL
LigandPNGBDBM50399634(CHEMBL2181191)
Affinity DataKi:  0.930nMAssay Description:Displacement of [3H]DAMGO from mu opioid receptor in rat brain membranes after 2 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
Vrije Universiteit Brussel

Curated by ChEMBL
LigandPNGBDBM50399638(CHEMBL2181196)
Affinity DataKi:  0.940nMAssay Description:Displacement of [3H]DAMGO from mu opioid receptor in rat brain membranes after 2 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 9(Homo sapiens (Human))
Cyclacel

LigandPNGBDBM81434(CDK Inhibitor, 7)
Affinity DataKi:  0.960nMAssay Description:Kinase assay using cyclin-dependant kinases (CDK).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
Cyclacel

LigandPNGBDBM8061(2-Anilino-4-(thiazol-5-yl)pyrimidine deriv. 32 | 4...)
Affinity DataKi: <1nMAssay Description:Kinase assay using cyclin-dependant kinases (CDK).More data for this Ligand-Target Pair
TargetMonocarboxylate transporter 1(Homo sapiens (Human))
Astrazeneca

LigandPNGBDBM22014(5-{[(3R)-3-hydroxypyrrolidine-1-]sulfonyl}-3-methy...)
Affinity DataKi:  1.10nM ΔG°:  -50.6kJ/molepH: 7.8 T: 2°CAssay Description:Jurkat cell membranes were incubated with [3H]-labeled ligand in the absence or presence of increasing concentrations of test compound. The reagents ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
Vrije Universiteit Brussel

Curated by ChEMBL
LigandPNGBDBM50399636(CHEMBL2181193)
Affinity DataKi:  1.12nMAssay Description:Displacement of [3H]U69,593 from kappa opioid receptor in guinea pig ileum membranes after 2 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMonocarboxylate transporter 1(Homo sapiens (Human))
Astrazeneca

LigandPNGBDBM21998(6-[(3,5-dimethyl-1H-pyrazol-4-yl)methyl]-5-{[(4S)-...)
Affinity DataKi:  1.20nM ΔG°:  -50.4kJ/molepH: 7.8 T: 2°CAssay Description:Jurkat cell membranes were incubated with [3H]-labeled ligand in the absence or presence of increasing concentrations of test compound. The reagents ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Displayed 1 to 50 (of 816 total ) | Next | Last >>
Jump to: