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Found 74 with Last Name = 'costi' and Initial = 'pm'
TargetDihydrofolate reductase(Homo sapiens (Human))
Universita` Degli Studi Di Sassari

Curated by ChEMBL
LigandPNGBDBM18050(2-[(4-{[(2,4-diaminopteridin-6-yl)methyl](methyl)a...)
Affinity DataKi:  0.000340nMAssay Description:Inhibition of human DHFR by spectrophotometric analysisMore data for this Ligand-Target Pair
TargetThymidylate synthase(Homo sapiens (Human))
UniversitÀ

LigandPNGBDBM18771((2S)-2-[(4-{[(2-amino-4-oxo-1,4-dihydroquinazolin-...)
Affinity DataKi:  30nM ΔG°:  -42.2kJ/molepH: 7.0 T: 2°CAssay Description:The inhibition assay pattern for all of the compounds was determined by steady-state kinetic analysis of the dependence of the TS enzyme activity on ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPteridine reductase 1(Leishmania major)
Universita` Degli Studi Di Sassari

Curated by ChEMBL
LigandPNGBDBM50398391(CHEMBL2178602)
Affinity DataKi:  30nMAssay Description:Inhibition of Leishmania major PTR1 by spectrophotometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPteridine reductase 1(Leishmania major)
Universita` Degli Studi Di Sassari

Curated by ChEMBL
LigandPNGBDBM50398394(CHEMBL1232702)
Affinity DataKi:  37nMAssay Description:Inhibition of Leishmania major PTR1 by spectrophotometric assayMore data for this Ligand-Target Pair
TargetThymidylate synthase(Lactobacillus casei)
UniversitÀ

LigandPNGBDBM18771((2S)-2-[(4-{[(2-amino-4-oxo-1,4-dihydroquinazolin-...)
Affinity DataKi:  60nM ΔG°:  -40.5kJ/molepH: 7.0 T: 2°CAssay Description:The inhibition assay pattern for all of the compounds was determined by steady-state kinetic analysis of the dependence of the TS enzyme activity on ...More data for this Ligand-Target Pair
TargetThymidylate synthase(Escherichia coli)
UniversitÀ

LigandPNGBDBM18771((2S)-2-[(4-{[(2-amino-4-oxo-1,4-dihydroquinazolin-...)
Affinity DataKi:  60nM ΔG°:  -40.5kJ/molepH: 7.0 T: 2°CAssay Description:The inhibition assay pattern for all of the compounds was determined by steady-state kinetic analysis of the dependence of the TS enzyme activity on ...More data for this Ligand-Target Pair
TargetPteridine reductase 1(Leishmania major)
Universita` Degli Studi Di Sassari

Curated by ChEMBL
LigandPNGBDBM50398392(CHEMBL2178603)
Affinity DataKi:  60nMAssay Description:Inhibition of Leishmania major PTR1 by spectrophotometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPteridine reductase 1(Leishmania major)
Universita` Degli Studi Di Sassari

Curated by ChEMBL
LigandPNGBDBM50398390(CHEMBL2177120)
Affinity DataKi:  78nMAssay Description:Inhibition of Leishmania major PTR1 by spectrophotometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM18771((2S)-2-[(4-{[(2-amino-4-oxo-1,4-dihydroquinazolin-...)
Affinity DataKi:  80nM ΔG°:  -39.8kJ/molepH: 7.0 T: 2°CAssay Description:The inhibition assay pattern for all of the compounds was determined by steady-state kinetic analysis of the dependence of the TS enzyme activity on ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Escherichia coli)
UniversitÀ

LigandPNGBDBM50008294(2-(4-(((2-amino-4-oxo-1,4-dihydroquinazolin-6-yl)m...)
Affinity DataKi:  95nMAssay Description:In vitro inhibition of Lactobacillus casei Thymidylate synthase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPteridine reductase 1(Leishmania major)
Universita` Degli Studi Di Sassari

Curated by ChEMBL
LigandPNGBDBM50398389(CHEMBL2178601)
Affinity DataKi:  100nMAssay Description:Inhibition of Leishmania major PTR1 by spectrophotometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPteridine reductase 1(Leishmania major)
Universita` Degli Studi Di Sassari

Curated by ChEMBL
LigandPNGBDBM50398395(CHEMBL1232399)
Affinity DataKi:  100nMAssay Description:Inhibition of Leishmania major PTR1 by spectrophotometric assayMore data for this Ligand-Target Pair
TargetPteridine reductase 1(Leishmania major)
Universita` Degli Studi Di Sassari

Curated by ChEMBL
LigandPNGBDBM18050(2-[(4-{[(2,4-diaminopteridin-6-yl)methyl](methyl)a...)
Affinity DataKi:  180nMAssay Description:Inhibition of Leishmania major PTR1 by spectrophotometric assayMore data for this Ligand-Target Pair
TargetPteridine reductase 1(Leishmania major)
Universita` Degli Studi Di Sassari

Curated by ChEMBL
LigandPNGBDBM50398396(CHEMBL2178600)
Affinity DataKi:  210nMAssay Description:Inhibition of Leishmania major PTR1 by spectrophotometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Pneumocystis carinii)
UniversitÀ

LigandPNGBDBM18771((2S)-2-[(4-{[(2-amino-4-oxo-1,4-dihydroquinazolin-...)
Affinity DataKi:  240nM ΔG°:  -37.2kJ/molepH: 7.0 T: 2°CAssay Description:The inhibition assay pattern for all of the compounds was determined by steady-state kinetic analysis of the dependence of the TS enzyme activity on ...More data for this Ligand-Target Pair
TargetThymidylate synthase(Escherichia coli)
UniversitÀ

LigandPNGBDBM50077837(3-(3-Chloro-4-hydroxy-phenyl)-3-hydroxy-6-nitro-3H...)
Affinity DataKi:  250nMAssay Description:In vitro inhibition of Lactobacillus casei Thymidylate synthase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPteridine reductase 1(Leishmania major)
Universita` Degli Studi Di Sassari

Curated by ChEMBL
LigandPNGBDBM50398393(CHEMBL2178599)
Affinity DataKi:  390nMAssay Description:Inhibition of Leishmania major PTR1 by spectrophotometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
Universita` Degli Studi Di Sassari

Curated by ChEMBL
LigandPNGBDBM50398388(CHEMBL2178604)
Affinity DataKi:  590nMAssay Description:Inhibition of human DHFR by spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Escherichia coli)
UniversitÀ

LigandPNGBDBM18763(1,8-naphthalein derivative, 10 | 4,4-bis(3-chloro-...)
Affinity DataKi:  600nM ΔG°:  -34.9kJ/molepH: 7.0 T: 2°CAssay Description:The inhibition assay pattern for all of the compounds was determined by steady-state kinetic analysis of the dependence of the TS enzyme activity on ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Homo sapiens (Human))
UniversitÀ

LigandPNGBDBM18050(2-[(4-{[(2,4-diaminopteridin-6-yl)methyl](methyl)a...)
Affinity DataKi:  600nMAssay Description:Inhibition of human TS by spectrophotometric analysisMore data for this Ligand-Target Pair
TargetThymidylate synthase(Escherichia coli)
UniversitÀ

LigandPNGBDBM18763(1,8-naphthalein derivative, 10 | 4,4-bis(3-chloro-...)
Affinity DataKi:  700nMAssay Description:In vitro inhibition of Lactobacillus casei Thymidylate synthase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Escherichia coli)
UniversitÀ

LigandPNGBDBM18763(1,8-naphthalein derivative, 10 | 4,4-bis(3-chloro-...)
Affinity DataKi:  700nM ΔG°:  -34.5kJ/molepH: 7.0 T: 2°CAssay Description:The inhibition assay pattern for all of the compounds was determined by steady-state kinetic analysis of the dependence of the TS enzyme activity on ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Escherichia coli)
UniversitÀ

LigandPNGBDBM50077852(6-Chloro-3,3-bis-(4-hydroxy-phenyl)-3H-benzo[de]is...)
Affinity DataKi:  700nMAssay Description:In vitro inhibition of Lactobacillus casei Thymidylate synthase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Escherichia coli)
UniversitÀ

LigandPNGBDBM18764(1,8-naphthalein derivative, 11 | 8-chloro-4,4-bis(...)
Affinity DataKi:  730nMAssay Description:In vitro inhibition of Lactobacillus casei Thymidylate synthase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
Universita` Degli Studi Di Sassari

Curated by ChEMBL
LigandPNGBDBM50398394(CHEMBL1232702)
Affinity DataKi:  800nMAssay Description:Inhibition of human DHFR by spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Lactobacillus casei)
UniversitÀ

LigandPNGBDBM18772(1,8-naphthalein derivative, 16 | 4,4-bis(3-bromo-4...)
Affinity DataKi:  800nM ΔG°:  -34.2kJ/molepH: 7.0 T: 2°CAssay Description:The inhibition assay pattern for all of the compounds was determined by steady-state kinetic analysis of the dependence of the TS enzyme activity on ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Escherichia coli)
UniversitÀ

LigandPNGBDBM18758(1,2-naphthalein derivative, 4 | 3,3-bis(3-bromo-4-...)
Affinity DataKi:  900nM ΔG°:  -33.9kJ/molepH: 7.0 T: 2°CAssay Description:The inhibition assay pattern for all of the compounds was determined by steady-state kinetic analysis of the dependence of the TS enzyme activity on ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Escherichia coli)
UniversitÀ

LigandPNGBDBM50077849(3,3-Bis-(4-hydroxy-phenyl)-6-nitro-3H-benzo[de]iso...)
Affinity DataKi:  1.00E+3nMAssay Description:In vitro inhibition of Lactobacillus casei Thymidylate synthase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Escherichia coli)
UniversitÀ

LigandPNGBDBM18769(1,8-naphthalein derivative, 17 | 4,4-bis(3-fluoro-...)
Affinity DataKi:  1.10E+3nM ΔG°:  -33.4kJ/molepH: 7.0 T: 2°CAssay Description:The inhibition assay pattern for all of the compounds was determined by steady-state kinetic analysis of the dependence of the TS enzyme activity on ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Escherichia coli)
UniversitÀ

LigandPNGBDBM18770(1,8-naphthalein derivative, 18 | 8-chloro-4,4-bis(...)
Affinity DataKi:  1.10E+3nM ΔG°:  -33.4kJ/molepH: 7.0 T: 2°CAssay Description:The inhibition assay pattern for all of the compounds was determined by steady-state kinetic analysis of the dependence of the TS enzyme activity on ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Escherichia coli)
UniversitÀ

LigandPNGBDBM50077838(3,3-Bis-(3-fluoro-4-hydroxy-phenyl)-3H-naphtho[2,3...)
Affinity DataKi:  1.50E+3nMAssay Description:In vitro inhibition of Lactobacillus casei Thymidylate synthase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Escherichia coli)
UniversitÀ

LigandPNGBDBM50077836(7,7-Bis-(4-hydroxy-phenyl)-2,7-dihydro-1H-6-oxa-cy...)
Affinity DataKi:  1.50E+3nMAssay Description:In vitro inhibition of Lactobacillus casei Thymidylate synthase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Escherichia coli)
UniversitÀ

LigandPNGBDBM50077847(3-(4-Hydroxy-naphthalen-1-yl)-3-(4-hydroxy-phenyl)...)
Affinity DataKi:  1.50E+3nMAssay Description:In vitro inhibition of Lactobacillus casei Thymidylate synthase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Escherichia coli)
UniversitÀ

LigandPNGBDBM50077850(3,3-Bis-(3-chloro-4-hydroxy-phenyl)-3H-naphtho[2,3...)
Affinity DataKi:  1.50E+3nMAssay Description:In vitro inhibition of Lactobacillus casei Thymidylate synthase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Escherichia coli)
UniversitÀ

LigandPNGBDBM18769(1,8-naphthalein derivative, 17 | 4,4-bis(3-fluoro-...)
Affinity DataKi:  1.60E+3nMAssay Description:In vitro inhibition of Lactobacillus casei Thymidylate synthase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Lactobacillus casei)
UniversitÀ

LigandPNGBDBM18769(1,8-naphthalein derivative, 17 | 4,4-bis(3-fluoro-...)
Affinity DataKi:  1.60E+3nM ΔG°:  -32.5kJ/molepH: 7.0 T: 2°CAssay Description:The inhibition assay pattern for all of the compounds was determined by steady-state kinetic analysis of the dependence of the TS enzyme activity on ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Escherichia coli)
UniversitÀ

LigandPNGBDBM50077841(6-Bromo-3,3-bis-(4-hydroxy-phenyl)-3H-benzo[de]iso...)
Affinity DataKi:  1.70E+3nMAssay Description:In vitro inhibition of Lactobacillus casei Thymidylate synthase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Lactobacillus casei)
UniversitÀ

LigandPNGBDBM18759(1,2-naphthalein derivative, 5 | 3,3-bis(3,5-dibrom...)
Affinity DataKi:  1.70E+3nM ΔG°:  -32.4kJ/molepH: 7.0 T: 2°CAssay Description:The inhibition assay pattern for all of the compounds was determined by steady-state kinetic analysis of the dependence of the TS enzyme activity on ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Lactobacillus casei)
UniversitÀ

LigandPNGBDBM18770(1,8-naphthalein derivative, 18 | 8-chloro-4,4-bis(...)
Affinity DataKi:  1.80E+3nM ΔG°:  -32.2kJ/molepH: 7.0 T: 2°CAssay Description:The inhibition assay pattern for all of the compounds was determined by steady-state kinetic analysis of the dependence of the TS enzyme activity on ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Escherichia coli)
UniversitÀ

LigandPNGBDBM50077845(3,3-Bis-(3-chloro-4-hydroxy-phenyl)-3H-isobenzofur...)
Affinity DataKi:  1.90E+3nMAssay Description:In vitro inhibition of Lactobacillus casei Thymidylate synthase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Escherichia coli)
UniversitÀ

LigandPNGBDBM50077848(3,3-Bis-(4-hydroxy-phenyl)-3H-benzo[de]isochromen-...)
Affinity DataKi:  2.80E+3nMAssay Description:In vitro inhibition of Lactobacillus casei Thymidylate synthase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Escherichia coli)
UniversitÀ

LigandPNGBDBM18772(1,8-naphthalein derivative, 16 | 4,4-bis(3-bromo-4...)
Affinity DataKi:  4.10E+3nM ΔG°:  -30.2kJ/molepH: 7.0 T: 2°CAssay Description:The inhibition assay pattern for all of the compounds was determined by steady-state kinetic analysis of the dependence of the TS enzyme activity on ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPteridine reductase 1(Leishmania major)
Universita` Degli Studi Di Sassari

Curated by ChEMBL
LigandPNGBDBM50398388(CHEMBL2178604)
Affinity DataKi:  4.17E+3nMAssay Description:Inhibition of Leishmania major PTR1 by spectrophotometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
Universita` Degli Studi Di Sassari

Curated by ChEMBL
LigandPNGBDBM50398391(CHEMBL2178602)
Affinity DataKi:  4.33E+3nMAssay Description:Inhibition of human DHFR by spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
Universita` Degli Studi Di Sassari

Curated by ChEMBL
LigandPNGBDBM50398392(CHEMBL2178603)
Affinity DataKi:  4.68E+3nMAssay Description:Inhibition of human DHFR by spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Escherichia coli)
UniversitÀ

LigandPNGBDBM50077844(3,3-Bis-(4-hydroxy-phenyl)-3H-isobenzofuran-1-one ...)
Affinity DataKi:  4.70E+3nMAssay Description:In vitro inhibition of Lactobacillus casei Thymidylate synthase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Escherichia coli)
UniversitÀ

LigandPNGBDBM50077846(6-Bromo-3,3-bis-(3-chloro-4-hydroxy-phenyl)-3H-ben...)
Affinity DataKi:  6.30E+3nMAssay Description:In vitro inhibition of Lactobacillus casei Thymidylate synthase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Lactobacillus casei)
UniversitÀ

LigandPNGBDBM18758(1,2-naphthalein derivative, 4 | 3,3-bis(3-bromo-4-...)
Affinity DataKi:  6.60E+3nM ΔG°:  -29.1kJ/molepH: 7.0 T: 2°CAssay Description:The inhibition assay pattern for all of the compounds was determined by steady-state kinetic analysis of the dependence of the TS enzyme activity on ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Escherichia coli)
UniversitÀ

LigandPNGBDBM50077851(3,3-Bis-(4-hydroxy-phenyl)-3H-naphtho[2,3-c]furan-...)
Affinity DataKi:  7.00E+3nMAssay Description:In vitro inhibition of Lactobacillus casei Thymidylate synthase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Escherichia coli)
UniversitÀ

LigandPNGBDBM18759(1,2-naphthalein derivative, 5 | 3,3-bis(3,5-dibrom...)
Affinity DataKi:  8.50E+3nM ΔG°:  -28.5kJ/molepH: 7.0 T: 2°CAssay Description:The inhibition assay pattern for all of the compounds was determined by steady-state kinetic analysis of the dependence of the TS enzyme activity on ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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