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Found 1840 with Last Name = 'culshaw' and Initial = 'aj'
TargetB1 bradykinin receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50151885(1-[4-(2,2-Diphenyl-ethylamino)-3-(morpholine-4-car...)
Affinity DataKi:  1nMAssay Description:Binding affinity for Bradykinin receptor B1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetB1 bradykinin receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50151884(CHEMBL185551 | N,N-Bis-(3-dimethylamino-propyl)-3-...)
Affinity DataKi:  10nMAssay Description:Binding affinity for Bradykinin receptor B1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetB1 bradykinin receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50151886(CHEMBL181695 | {2-(2,2-Diphenyl-ethylamino)-5-[4-(...)
Affinity DataKi:  10nMAssay Description:Binding affinity for Bradykinin receptor B1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetB1 bradykinin receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50151894(1-[4-(2,2-Diphenyl-ethylamino)-3-nitro-benzenesulf...)
Affinity DataKi:  10nMAssay Description:Binding affinity for Bradykinin receptor B1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetB1 bradykinin receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50151891(CHEMBL273869 | {2-(2,2-Diphenyl-ethylamino)-5-[4-(...)
Affinity DataKi:  10nMAssay Description:Binding affinity for Bradykinin receptor B1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetB1 bradykinin receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50151888(3-[3-Acetyl-4-(2,2-diphenyl-ethylamino)-benzenesul...)
Affinity DataKi:  130nMAssay Description:Binding affinity for Bradykinin receptor B1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetB1 bradykinin receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50151889(CHEMBL180143 | N,N-Bis-(3-dimethylamino-propyl)-3-...)
Affinity DataKi:  140nMAssay Description:Binding affinity for Bradykinin receptor B1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetB1 bradykinin receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50151890(CHEMBL181098 | N,N-Bis-(3-dimethylamino-propyl)-4-...)
Affinity DataKi:  230nMAssay Description:Binding affinity for Bradykinin receptor B1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetB1 bradykinin receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50151893(4-(1-Benzyl-2-phenyl-ethylamino)-N,N-bis-(3-dimeth...)
Affinity DataKi:  250nMAssay Description:Binding affinity for Bradykinin receptor B1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetB1 bradykinin receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50151892(3-[3-Chloro-4-(2,2-diphenyl-ethylamino)-benzenesul...)
Affinity DataKi: >1.00E+3nMAssay Description:Binding affinity for Bradykinin receptor B1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetB2 bradykinin receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50151887(4-(Benzhydryl-amino)-N,N-bis-(3-dimethylamino-prop...)
Affinity DataKi:  1.40E+3nMAssay Description:Binding affinity for Bradykinin receptor B2 expressed in COS7 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetB1 bradykinin receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50151887(4-(Benzhydryl-amino)-N,N-bis-(3-dimethylamino-prop...)
Affinity DataKi:  3.00E+3nMAssay Description:Binding affinity for Bradykinin receptor B1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50072775(2-((1R,2R,5R)-5-hydroxy-2-(3-hydroxypropyl)cyclohe...)
Affinity DataIC50:  0.770nMAssay Description:Displacement of [3H]CP-55940 from human CB1 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
TargetCannabinoid receptor 2(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50072775(2-((1R,2R,5R)-5-hydroxy-2-(3-hydroxypropyl)cyclohe...)
Affinity DataIC50:  1.30nMAssay Description:Displacement of [3H]CP-55940 human CB2 receptor expressed in CHOK1 cellsMore data for this Ligand-Target Pair
TargetCathepsin S(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50263555(2-cyano-N-methyl-4-((1-methylpiperidin-4-yl)methox...)
Affinity DataIC50:  3nMAssay Description:Inhibition of human recombinant cathepsin S by fluorometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin S(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50263557(2-cyano-4-((1-isopropylpiperidin-4-yl)methoxy)-N-m...)
Affinity DataIC50:  3nMAssay Description:Inhibition of human recombinant cathepsin S by fluorometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM295115(5-(5-((3-Methoxy-3-methylazetidin-1-yl)sulfonyl)-2...)
Affinity DataIC50: <3nMpH: 7.5Assay Description:The TR-FRET Adapta Universal Kinase Assay Kit was purchased from Invitrogen Corporation (Carlsbad, Calif., USA) (Cat. No. PV5099). The kit contains t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM295065(US10112926, Example 19 | trans 3-[6-Amino-5-(3-met...)
Affinity DataIC50: <3nMpH: 7.5Assay Description:The TR-FRET Adapta Universal Kinase Assay Kit was purchased from Invitrogen Corporation (Carlsbad, Calif., USA) (Cat. No. PV5099). The kit contains t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM295114(3-(6-Amino-5-(3-methylisoxazol-5-yl)pyridin-3-yl)-...)
Affinity DataIC50: <3nMpH: 7.5Assay Description:The TR-FRET Adapta Universal Kinase Assay Kit was purchased from Invitrogen Corporation (Carlsbad, Calif., USA) (Cat. No. PV5099). The kit contains t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCathepsin S(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50263609(2-cyano-4-((1-(2-hydroxyethyl)piperidin-4-yl)metho...)
Affinity DataIC50:  3nMAssay Description:Inhibition of human recombinant cathepsin S by fluorometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin S(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50263554(2-cyano-N-methyl-4-(2-(1-methylpiperidin-4-yl)etho...)
Affinity DataIC50:  4nMAssay Description:Inhibition of human recombinant cathepsin S by fluorometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM295116(3-(6-Amino-5-(3-methylisoxazol-5-yl)pyridin-3-yl)-...)
Affinity DataIC50:  4nMpH: 7.5Assay Description:The TR-FRET Adapta Universal Kinase Assay Kit was purchased from Invitrogen Corporation (Carlsbad, Calif., USA) (Cat. No. PV5099). The kit contains t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM295052(3-[6-Amino-5-(3-methyl-[1,2,4]oxadiazol-5-yl)-pyri...)
Affinity DataIC50:  4nMpH: 7.5Assay Description:The TR-FRET Adapta Universal Kinase Assay Kit was purchased from Invitrogen Corporation (Carlsbad, Calif., USA) (Cat. No. PV5099). The kit contains t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCathepsin S(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM25138(2-cyano-pyrropyrimidine, 7d | 7-(2-cyclopentylethy...)
Affinity DataIC50:  5nMpH: 7.0 T: 2°CAssay Description:The substrate hydrolysis with or without inhibitor was monitored at an excitation wavelength of 360nm and an emission wavelength of 460 nm on a fluor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin S(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50263610(2-cyano-N-methyl-4-(piperidin-4-ylmethoxy)-6-(spir...)
Affinity DataIC50:  5nMAssay Description:Inhibition of human recombinant cathepsin S by fluorometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM295089(US10112926, Example 21b)
Affinity DataIC50:  5nMpH: 7.5Assay Description:The TR-FRET Adapta Universal Kinase Assay Kit was purchased from Invitrogen Corporation (Carlsbad, Calif., USA) (Cat. No. PV5099). The kit contains t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM295053(US10112926, Example 8.1 | US10112926, Example 8.2)
Affinity DataIC50:  5nMpH: 7.5Assay Description:The TR-FRET Adapta Universal Kinase Assay Kit was purchased from Invitrogen Corporation (Carlsbad, Calif., USA) (Cat. No. PV5099). The kit contains t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCathepsin S(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50263611(2-cyano-N-methyl-4-(spiro[3.5]nonan-7-ylmethylamin...)
Affinity DataIC50:  5nMAssay Description:Inhibition of human recombinant cathepsin S by fluorometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM364540(Trans N-(4-Hydroxy-cyclohexyl)-4-methyl-3-[6-(5-mo...)
Affinity DataIC50:  6nMAssay Description:PI 3-Kinase Gamma (E), PI 3-Kinase Delta (F):The TR-FRET Adapta™ Universal Kinase Assay Kit was purchased from Invitrogen Corporation (Carlsbad/CA, U...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCathepsin S(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50263667(2-cyano-4-(2-hydroxyethoxy)-N-methyl-6-(spiro[3.5]...)
Affinity DataIC50:  6nMAssay Description:Inhibition of human recombinant cathepsin S by fluorometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM295044(US10112926, Example 5.2 | trans 3-(6-Amino-5- (5-m...)
Affinity DataIC50:  7nMpH: 7.5Assay Description:The TR-FRET Adapta Universal Kinase Assay Kit was purchased from Invitrogen Corporation (Carlsbad, Calif., USA) (Cat. No. PV5099). The kit contains t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM295239(3-(6-amino-5-(2- methyloxazol-5- yl)pyridin-3-yl)-...)
Affinity DataIC50:  7nMpH: 7.5Assay Description:The TR-FRET Adapta Universal Kinase Assay Kit was purchased from Invitrogen Corporation (Carlsbad, Calif., USA) (Cat. No. PV5099). The kit contains t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM295029(3-{6-Amino-5-[1-(2,2,2-trifluoro-ethyl)-1H-pyrazol...)
Affinity DataIC50:  7nMpH: 7.5Assay Description:The TR-FRET Adapta Universal Kinase Assay Kit was purchased from Invitrogen Corporation (Carlsbad, Calif., USA) (Cat. No. PV5099). The kit contains t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM295058(US10112926, Example 12 | trans 3-[6-Amino-5-(3-met...)
Affinity DataIC50:  8nMpH: 7.5Assay Description:The TR-FRET Adapta Universal Kinase Assay Kit was purchased from Invitrogen Corporation (Carlsbad, Calif., USA) (Cat. No. PV5099). The kit contains t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM295034(US10112926, Example 4.2 | trans 3-(6-Amino-5-(1- (...)
Affinity DataIC50:  8nMpH: 7.5Assay Description:The TR-FRET Adapta Universal Kinase Assay Kit was purchased from Invitrogen Corporation (Carlsbad, Calif., USA) (Cat. No. PV5099). The kit contains t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM295205(US10112926, Example 84 | cis-3-(6-Amino-5-(3-methy...)
Affinity DataIC50:  8nMpH: 7.5Assay Description:The TR-FRET Adapta Universal Kinase Assay Kit was purchased from Invitrogen Corporation (Carlsbad, Calif., USA) (Cat. No. PV5099). The kit contains t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM295170(US10112926, Example 55 | trans-3-(6-Amino-5-(3-met...)
Affinity DataIC50:  8nMpH: 7.5Assay Description:The TR-FRET Adapta Universal Kinase Assay Kit was purchased from Invitrogen Corporation (Carlsbad, Calif., USA) (Cat. No. PV5099). The kit contains t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM295105(3-(6-Amino-5-(3-propyl isoxazol-5-yl)pyridin-3-yl)...)
Affinity DataIC50:  8nMpH: 7.5Assay Description:The TR-FRET Adapta Universal Kinase Assay Kit was purchased from Invitrogen Corporation (Carlsbad, Calif., USA) (Cat. No. PV5099). The kit contains t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCannabinoid receptor 2(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM21281((11R)-2-methyl-11-(morpholin-4-ylmethyl)-3-(naphth...)
Affinity DataIC50:  8.90nMAssay Description:Displacement of [3H]CP-55940 human CB2 receptor expressed in CHOK1 cellsMore data for this Ligand-Target Pair
TargetCathepsin S(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM25134(2-cyano-pyrropyrimidine, 2 | 7-(2-cyclohexylethyl)...)
Affinity DataIC50:  9nMpH: 7.0 T: 2°CAssay Description:The substrate hydrolysis with or without inhibitor was monitored at an excitation wavelength of 360nm and an emission wavelength of 460 nm on a fluor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin S(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM25136(2-cyano-pyrropyrimidine, 7b | 7-(2-cyclohexylethyl...)
Affinity DataIC50:  9nMpH: 7.0 T: 2°CAssay Description:The substrate hydrolysis with or without inhibitor was monitored at an excitation wavelength of 360nm and an emission wavelength of 460 nm on a fluor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM295182(3-(6-Amino-5-(2-methyloxazol-5-yl)pyridin-3-yl)-N-...)
Affinity DataIC50:  9nMpH: 7.5Assay Description:The TR-FRET Adapta Universal Kinase Assay Kit was purchased from Invitrogen Corporation (Carlsbad, Calif., USA) (Cat. No. PV5099). The kit contains t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM295218(US10112926, Example 96 | trans-3-(6-amino-5-(3-met...)
Affinity DataIC50:  9nMpH: 7.5Assay Description:The TR-FRET Adapta Universal Kinase Assay Kit was purchased from Invitrogen Corporation (Carlsbad, Calif., USA) (Cat. No. PV5099). The kit contains t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM295106(US10112926, Example 35.2 | trans-3-(6-Amino-5-(3-(...)
Affinity DataIC50:  9nMpH: 7.5Assay Description:The TR-FRET Adapta Universal Kinase Assay Kit was purchased from Invitrogen Corporation (Carlsbad, Calif., USA) (Cat. No. PV5099). The kit contains t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM295245(3-(6-amino-5-(5-methyl-1,3,4-thiadiazol-2-yl)pyrid...)
Affinity DataIC50:  9.40nMpH: 7.5Assay Description:The TR-FRET Adapta Universal Kinase Assay Kit was purchased from Invitrogen Corporation (Carlsbad, Calif., USA) (Cat. No. PV5099). The kit contains t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCathepsin S(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM25141(2-cyano-pyrropyrimidine, 7g | 7-[2-(4,4-difluorocy...)
Affinity DataIC50:  10nMpH: 7.0 T: 2°CAssay Description:The substrate hydrolysis with or without inhibitor was monitored at an excitation wavelength of 360nm and an emission wavelength of 460 nm on a fluor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin S(Mus musculus (Mouse))
Novartis

LigandPNGBDBM25134(2-cyano-pyrropyrimidine, 2 | 7-(2-cyclohexylethyl)...)
Affinity DataIC50:  10nMpH: 7.0 T: 2°CAssay Description:The substrate hydrolysis with or without inhibitor was monitored at an excitation wavelength of 360nm and an emission wavelength of 460 nm on a fluor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin S(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50263612(4-((1-acetylpiperidin-4-yl)methoxy)-2-cyano-N-meth...)
Affinity DataIC50:  10nMAssay Description:Inhibition of human recombinant cathepsin S by fluorometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM364540(Trans N-(4-Hydroxy-cyclohexyl)-4-methyl-3-[6-(5-mo...)
Affinity DataIC50:  10nMAssay Description:PI 3-Kinase Alpha (A), Pb 3-Kinase Beta (B), Vps34 (C), PI 4-Kinase Beta (D):The luminescence-based ATP detection reagent KinaseGlo was obtained from...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM295099(3-(6-Amino-5-(1-methyl-1H-pyrazol-4-yl)pyridin-3-y...)
Affinity DataIC50:  10nMpH: 7.5Assay Description:The TR-FRET Adapta Universal Kinase Assay Kit was purchased from Invitrogen Corporation (Carlsbad, Calif., USA) (Cat. No. PV5099). The kit contains t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
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