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Found 604 with Last Name = 'currie' and Initial = 'mg'
TargetNitric oxide synthase, inducible(Mus musculus (mouse))
Washington University

Curated by ChEMBL
LigandPNGBDBM50055281(2-Ethyl-isothiourea | CHEMBL321691 | ETHYLISOTHIOU...)
Affinity DataKi:  5.20nMAssay Description:Binding affinity against mouse Inducible nitric oxide synthase (iNOS)More data for this Ligand-Target Pair
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50064015(7-Propyl-azepan-(2Z)-ylideneamine; hydrochloride |...)
Affinity DataKi:  90nMAssay Description:Inhibitory activity against L-arginine binding to Inducible nitric oxide synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Homo sapiens (Human))
G. D. Searle Research And Development

Curated by ChEMBL
LigandPNGBDBM50062142(4,6-Dimethyl-piperidin-(2Z)-ylideneamine | CHEMBL2...)
Affinity DataIC50:  60nMAssay Description:Inhibition of human Neuronal nitric oxide synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50062142(4,6-Dimethyl-piperidin-(2Z)-ylideneamine | CHEMBL2...)
Affinity DataIC50:  80nMAssay Description:Inhibition of human Inducible nitric oxide synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50062133(4-Methyl-piperidin-(2E)-ylideneamine | 4-Methyl-pi...)
Affinity DataIC50:  100nMAssay Description:Inhibition of human Inducible nitric oxide synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50055280(2-(2-Fluoro-ethyl)-isothiourea | CHEMBL148951)
Affinity DataIC50:  140nMAssay Description:The compound was evaluated for the inhibitory potencies using human Inducible nitric oxide synthase (hiNOS)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50055281(2-Ethyl-isothiourea | CHEMBL321691 | ETHYLISOTHIOU...)
Affinity DataIC50:  160nMAssay Description:The compound was evaluated for the inhibitory potencies using human Inducible nitric oxide synthase (hiNOS)More data for this Ligand-Target Pair
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50064015(7-Propyl-azepan-(2Z)-ylideneamine; hydrochloride |...)
Affinity DataIC50:  160nMAssay Description:Inhibitory activity evaluated for soluble cell extract of human Inducible nitric oxide synthase and partially purified by DEAE-sepharose chromatograp...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Homo sapiens (Human))
G. D. Searle Research And Development

Curated by ChEMBL
LigandPNGBDBM50066778(5-Ethyl-4-methyl-pyrrolidin-(2E)-ylideneamine; hyd...)
Affinity DataIC50:  170nMAssay Description:Inhibition of cloned (from RNA) human Neuronal nitric oxide synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50066778(5-Ethyl-4-methyl-pyrrolidin-(2E)-ylideneamine; hyd...)
Affinity DataIC50:  170nMAssay Description:Inhibition of cloned (from RNA) human inducible nitric oxide synthase (hiNOS)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50064018(7-Allyl-azepan-(2Z)-ylideneamine; hydrochloride | ...)
Affinity DataIC50:  190nMAssay Description:Inhibitory activity evaluated for soluble cell extract of human Inducible nitric oxide synthase and partially purified by DEAE-sepharose chromatograp...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Homo sapiens (Human))
G. D. Searle Research And Development

Curated by ChEMBL
LigandPNGBDBM50062133(4-Methyl-piperidin-(2E)-ylideneamine | 4-Methyl-pi...)
Affinity DataIC50:  200nMAssay Description:Inhibition of human Neuronal nitric oxide synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50062132(6-Propyl-piperidin-(2Z)-ylideneamine | CHEMBL6760)
Affinity DataIC50:  200nMAssay Description:Inhibition of human Inducible nitric oxide synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50066775(5-Pentyl-4-trifluoromethyl-pyrrolidin-(2E)-ylidene...)
Affinity DataIC50:  230nMAssay Description:Inhibition of cloned (from RNA) human inducible nitric oxide synthase (hiNOS)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50066785(4-Methyl-5-propyl-pyrrolidin-(2E)-ylideneamine; hy...)
Affinity DataIC50:  300nMAssay Description:Inhibition of cloned (from RNA) human inducible nitric oxide synthase (hiNOS)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, endothelial(Homo sapiens (Human))
G. D. Searle Research And Development

Curated by ChEMBL
LigandPNGBDBM50062142(4,6-Dimethyl-piperidin-(2Z)-ylideneamine | CHEMBL2...)
Affinity DataIC50:  300nMAssay Description:inhibition of human endothelial constitutive Endothelial nitric oxide synthase (heNOS)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50066774(4-Methyl-5-pentyl-pyrrolidin-(2E)-ylideneamine; hy...)
Affinity DataIC50:  360nMAssay Description:Inhibition of cloned (from RNA) human inducible nitric oxide synthase (hiNOS)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50066774(4-Methyl-5-pentyl-pyrrolidin-(2E)-ylideneamine; hy...)
Affinity DataIC50:  360nMAssay Description:Inhibition of cloned (from RNA) human inducible nitric oxide synthase (hiNOS)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Homo sapiens (Human))
G. D. Searle Research And Development

Curated by ChEMBL
LigandPNGBDBM50066785(4-Methyl-5-propyl-pyrrolidin-(2E)-ylideneamine; hy...)
Affinity DataIC50:  390nMAssay Description:Inhibition of cloned (from RNA) human Neuronal nitric oxide synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Homo sapiens (Human))
G. D. Searle Research And Development

Curated by ChEMBL
LigandPNGBDBM50062137(6-Methyl-piperidin-(2Z)-ylideneamine | CHEMBL26567...)
Affinity DataIC50:  400nMAssay Description:Inhibition of human Neuronal nitric oxide synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Homo sapiens (Human))
G. D. Searle Research And Development

Curated by ChEMBL
LigandPNGBDBM50064015(7-Propyl-azepan-(2Z)-ylideneamine; hydrochloride |...)
Affinity DataIC50:  460nMAssay Description:Inhibitory activity evaluated from soluble cell extract of human Neuronal nitric oxide synthase and partially purified by DEAE-sepharose chromatograp...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, endothelial(Homo sapiens (Human))
G. D. Searle Research And Development

Curated by ChEMBL
LigandPNGBDBM50049252(2-Amino-5-(N-nitro-guanidino)-pentanoic acid | CHE...)
Affinity DataIC50:  500nMAssay Description:Inhibitory activity against human Endothelial nitric oxide synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Homo sapiens (Human))
G. D. Searle Research And Development

Curated by ChEMBL
LigandPNGBDBM50049252(2-Amino-5-(N-nitro-guanidino)-pentanoic acid | CHE...)
Affinity DataIC50:  500nMAssay Description:Inhibitory activity against human Neuronal nitric oxide synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Homo sapiens (Human))
G. D. Searle Research And Development

Curated by ChEMBL
LigandPNGBDBM50062132(6-Propyl-piperidin-(2Z)-ylideneamine | CHEMBL6760)
Affinity DataIC50:  500nMAssay Description:Inhibition of human Neuronal nitric oxide synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50064011(7-Butyl-azepan-(2Z)-ylideneamine; hydrochloride | ...)
Affinity DataIC50:  500nMAssay Description:Inhibitory activity evaluated for soluble cell extract of human Inducible nitric oxide synthase and partially purified by DEAE-sepharose chromatograp...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Homo sapiens (Human))
G. D. Searle Research And Development

Curated by ChEMBL
LigandPNGBDBM50225106((2S)-2-amino-5-{[(E)-amino(nitroimino)methyl]amino...)
Affinity DataIC50:  500nMAssay Description:Inhibition of cloned (from RNA) human Neuronal nitric oxide synthaseMore data for this Ligand-Target Pair
TargetNitric oxide synthase, inducible(Mus musculus (mouse))
Washington University

Curated by ChEMBL
LigandPNGBDBM50225106((2S)-2-amino-5-{[(E)-amino(nitroimino)methyl]amino...)
Affinity DataIC50:  500nMAssay Description:Tested for inhibition of mouse inducible nitric oxide synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, endothelial(Homo sapiens (Human))
G. D. Searle Research And Development

Curated by ChEMBL
LigandPNGBDBM50225106((2S)-2-amino-5-{[(E)-amino(nitroimino)methyl]amino...)
Affinity DataIC50:  500nMAssay Description:Inhibition of cloned (from RNA) human endothelial constitutive Endothelial nitric oxide synthase (heNOS)More data for this Ligand-Target Pair
TargetNitric oxide synthase, brain(Homo sapiens (Human))
G. D. Searle Research And Development

Curated by ChEMBL
LigandPNGBDBM50062131(6-Trifluoromethyl-piperidin-(2Z)-ylideneamine | CH...)
Affinity DataIC50:  500nMAssay Description:Inhibition of human Neuronal nitric oxide synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50062131(6-Trifluoromethyl-piperidin-(2Z)-ylideneamine | CH...)
Affinity DataIC50:  500nMAssay Description:Inhibition of human Inducible nitric oxide synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50062137(6-Methyl-piperidin-(2Z)-ylideneamine | CHEMBL26567...)
Affinity DataIC50:  500nMAssay Description:Inhibition of human Inducible nitric oxide synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, endothelial(Homo sapiens (Human))
G. D. Searle Research And Development

Curated by ChEMBL
LigandPNGBDBM50062137(6-Methyl-piperidin-(2Z)-ylideneamine | CHEMBL26567...)
Affinity DataIC50:  600nMAssay Description:inhibition of human endothelial constitutive Endothelial nitric oxide synthase (heNOS)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Mus musculus (mouse))
Washington University

Curated by ChEMBL
LigandPNGBDBM50064015(7-Propyl-azepan-(2Z)-ylideneamine; hydrochloride |...)
Affinity DataIC50:  600nMAssay Description:The ability of compound to inhibit mouse Inducible nitric oxide synthase in LPS stimulated mouse RAW cells was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Mus musculus (mouse))
Washington University

Curated by ChEMBL
LigandPNGBDBM50064018(7-Allyl-azepan-(2Z)-ylideneamine; hydrochloride | ...)
Affinity DataIC50:  600nMAssay Description:The ability of compound to inhibit mouse Inducible nitric oxide synthase in LPS stimulated mouse RAW cells was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50066779(5-Butyl-4-methyl-pyrrolidin-(2E)-ylideneamine; hyd...)
Affinity DataIC50:  660nMAssay Description:Inhibition of cloned (from RNA) human inducible nitric oxide synthase (hiNOS)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Homo sapiens (Human))
G. D. Searle Research And Development

Curated by ChEMBL
LigandPNGBDBM50062145(3-Methyl-piperidin-(2Z)-ylideneamine | CHEMBL26716...)
Affinity DataIC50:  700nMAssay Description:Inhibition of human Neuronal nitric oxide synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Homo sapiens (Human))
G. D. Searle Research And Development

Curated by ChEMBL
LigandPNGBDBM50064011(7-Butyl-azepan-(2Z)-ylideneamine; hydrochloride | ...)
Affinity DataIC50:  850nMAssay Description:Inhibitory activity evaluated from soluble cell extract of human nNeuronal nitric oxide synthase and partially purified by DEAE-sepharose chromatogra...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Homo sapiens (Human))
G. D. Searle Research And Development

Curated by ChEMBL
LigandPNGBDBM50066779(5-Butyl-4-methyl-pyrrolidin-(2E)-ylideneamine; hyd...)
Affinity DataIC50:  850nMAssay Description:Inhibition of cloned (from RNA) human Neuronal nitric oxide synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Homo sapiens (Human))
G. D. Searle Research And Development

Curated by ChEMBL
LigandPNGBDBM50064018(7-Allyl-azepan-(2Z)-ylideneamine; hydrochloride | ...)
Affinity DataIC50:  870nMAssay Description:Inhibitory activity evaluated from soluble cell extract of human Neuronal nitric oxide synthase and partially purified by DEAE-sepharose chromatograp...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Homo sapiens (Human))
G. D. Searle Research And Development

Curated by ChEMBL
LigandPNGBDBM50062136(6-Benzyl-piperidin-(2Z)-ylideneamine | CHEMBL6875)
Affinity DataIC50:  900nMAssay Description:Inhibition of human Neuronal nitric oxide synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50049255(CHEMBL269058 | PIPERIDIN-2-IMINE | Piperidin-(2E)-...)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibitory activity against human inducible nitric oxide synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Homo sapiens (Human))
G. D. Searle Research And Development

Curated by ChEMBL
LigandPNGBDBM50049255(CHEMBL269058 | PIPERIDIN-2-IMINE | Piperidin-(2E)-...)
Affinity DataIC50:  1.10E+3nMAssay Description:Inhibitory activity against human Neuronal nitric oxide synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, endothelial(Homo sapiens (Human))
G. D. Searle Research And Development

Curated by ChEMBL
LigandPNGBDBM50062133(4-Methyl-piperidin-(2E)-ylideneamine | 4-Methyl-pi...)
Affinity DataIC50:  1.10E+3nMAssay Description:inhibition of human endothelial constitutive Endothelial nitric oxide synthase (heNOS)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Homo sapiens (Human))
G. D. Searle Research And Development

Curated by ChEMBL
LigandPNGBDBM50049255(CHEMBL269058 | PIPERIDIN-2-IMINE | Piperidin-(2E)-...)
Affinity DataIC50:  1.10E+3nMAssay Description:Inhibition of human Neuronal nitric oxide synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50049255(CHEMBL269058 | PIPERIDIN-2-IMINE | Piperidin-(2E)-...)
Affinity DataIC50:  1.10E+3nMAssay Description:Inhibition of human Inducible nitric oxide synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Ironwood Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50175274(CHEMBL3809864 | US10189809, Compound I-97)
Affinity DataIC50:  1.20E+3nMAssay Description:Binding affinity to KOP receptor (unknown origin) at 10 uMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, endothelial(Homo sapiens (Human))
G. D. Searle Research And Development

Curated by ChEMBL
LigandPNGBDBM50055280(2-(2-Fluoro-ethyl)-isothiourea | CHEMBL148951)
Affinity DataIC50:  1.26E+3nMAssay Description:The compound was evaluated for the inhibitory potencies using human Endothelial nitric oxide synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, endothelial(Homo sapiens (Human))
G. D. Searle Research And Development

Curated by ChEMBL
LigandPNGBDBM50055281(2-Ethyl-isothiourea | CHEMBL321691 | ETHYLISOTHIOU...)
Affinity DataIC50:  1.30E+3nMAssay Description:The compound was evaluated for the inhibitory potencies using human Endothelial nitric oxide synthaseMore data for this Ligand-Target Pair
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50066780(4-Methyl-pyrrolidin-(2E)-ylideneamine; hydrochlori...)
Affinity DataIC50:  1.40E+3nMAssay Description:Inhibition of cloned (from RNA) human inducible nitric oxide synthase (hiNOS)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50064010(3-Ethyl-azepan-(2Z)-ylideneamine; hydrochloride | ...)
Affinity DataIC50:  1.60E+3nMAssay Description:Inhibitory activity evaluated for soluble cell extract of human Inducible nitric oxide synthase and partially purified by DEAE-sepharose chromatograp...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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