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Found 1083 with Last Name = 'das' and Initial = 'd'
TargetProtease(Human immunodeficiency virus 1 (HIV-1))
Kumamoto University Graduate School Of Medical And Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM13925((3aS,5R,6aR)-hexahydro-2H-cyclopenta[b]furan-5-yl ...)
Affinity DataKi:  0.00350nMAssay Description:Inhibition of HIV1 protease dimerization in MT2 cellsMore data for this Ligand-Target Pair
TargetDimer of Gag-Pol polyprotein [501-599,Q508K,L534I,L564I,C568A,C596A](Human immunodeficiency virus type 1)
Purdue University

LigandPNGBDBM13925((3aS,5R,6aR)-hexahydro-2H-cyclopenta[b]furan-5-yl ...)
Affinity DataKi:  0.00450nM ΔG°:  -64.8kJ/molepH: 6.4 T: 2°CAssay Description:The Ki values were determined by substrate cleavage assay using fluorogenic substrate, 2-(aminobenzoyl)-Thr-Ile-Nle-Phe(p-NO2)-Gln-Arg-NH2. A standar...More data for this Ligand-Target Pair
TargetProtease(Human immunodeficiency virus 1 (HIV-1))
Kumamoto University Graduate School Of Medical And Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM4685((3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl N-[(2S...)
Affinity DataKi:  0.00680nMAssay Description:Inhibition of HIV1 protease dimerization in MT2 cellsMore data for this Ligand-Target Pair
TargetProtease(Human immunodeficiency virus 1 (HIV-1))
Kumamoto University Graduate School Of Medical And Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM9236((3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl N-[(2S...)
Affinity DataKi:  0.0100nMAssay Description:Inhibition of HIV1 protease dimerization in MT2 cellsMore data for this Ligand-Target Pair
TargetBeta-2 adrenergic receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50379086(CHEMBL2012521 | CHEMBL2012522 | LY-377604)
Affinity DataKi:  0.0120nMAssay Description:Displacement of [125I]Iodocyanopindolol from human adrenergic beta2 receptor expressed in insect sf9 cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Gag-Pol polyprotein [501-599,Q508K,L534I,L564I,C568A,C596A](Human immunodeficiency virus type 1)
Purdue University

LigandPNGBDBM8125((3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl N-[(2S...)
Affinity DataKi:  0.0140nM ΔG°:  -62.0kJ/molepH: 6.4 T: 2°CAssay Description:The Ki values were determined by substrate cleavage assay using fluorogenic substrate, 2-(aminobenzoyl)-Thr-Ile-Nle-Phe(p-NO2)-Gln-Arg-NH2. A standar...More data for this Ligand-Target Pair
TargetProtease(Human immunodeficiency virus 1 (HIV-1))
Kumamoto University Graduate School Of Medical And Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50476647(CHEMBL178593 | GRL-98065)
Affinity DataKi:  0.0140nMAssay Description:Inhibition of HIV1 protease dimerization in MT2 cellsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetProtease(Human immunodeficiency virus 1 (HIV-1))
Kumamoto University Graduate School Of Medical And Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM8125((3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl N-[(2S...)
Affinity DataKi:  0.0160nMAssay Description:Inhibition of HIV1 protease dimerization in MT2 cellsMore data for this Ligand-Target Pair
TargetBeta-1 adrenergic receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50379086(CHEMBL2012521 | CHEMBL2012522 | LY-377604)
Affinity DataKi:  0.0230nMAssay Description:Displacement of [125I]Iodocyanopindolol from human adrenergic beta1 receptor expressed in insect sf9 cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtease(Human immunodeficiency virus 1 (HIV-1))
Kumamoto University Graduate School Of Medical And Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50478337(CHEMBL403306 | GRL-0036A)
Affinity DataKi:  0.0290nMAssay Description:Inhibition of HIV1 protease dimerization in MT2 cellsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDimer of Gag-Pol polyprotein [501-599,Q508K,L534I,L564I,C568A,C596A](Human immunodeficiency virus type 1)
Purdue University

LigandPNGBDBM13924((3aS,5R,6aR)-hexahydro-2H-cyclopenta[b]furan-5-yl ...)
Affinity DataKi:  0.140nM ΔG°:  -56.2kJ/molepH: 6.4 T: 2°CAssay Description:The Ki values were determined by substrate cleavage assay using fluorogenic substrate, 2-(aminobenzoyl)-Thr-Ile-Nle-Phe(p-NO2)-Gln-Arg-NH2. A standar...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50186291(2-isopropyl-7-(3-(piperidin-1-yl)propoxy)-1,2,3,4-...)
Affinity DataKi:  0.170nMAssay Description:Displacement of [3H]N-alpha-methylhistamine from human cloned H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50186270(2-benzyl-7-(3-(piperidin-1-yl)propoxy)-2,3,4,5-tet...)
Affinity DataKi:  0.200nMAssay Description:Displacement of [3H]N-alpha-methylhistamine from human cloned H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50186278(2-isopropyl-7-(3-(piperidin-1-yl)propoxy)-2,3,4,5-...)
Affinity DataKi:  0.200nMAssay Description:Displacement of [3H]N-alpha-methylhistamine from human cloned H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50186290(3-ethyl-7-(3-(piperidin-1-yl)propoxy)-2,3,4,5-tetr...)
Affinity DataKi:  0.260nMAssay Description:Displacement of [3H]N-alpha-methylhistamine from human cloned H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50186309(2-ethyl-7-(3-(piperidin-1-yl)propoxy)-2,3,4,5-tetr...)
Affinity DataKi:  0.340nMAssay Description:Displacement of [3H]N-alpha-methylhistamine from human cloned H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50186269(2-ethyl-7-(3-(piperidin-1-yl)propoxy)-1,2,3,4-tetr...)
Affinity DataKi:  0.340nMAssay Description:Displacement of [3H]N-alpha-methylhistamine from human cloned H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50186292(2-(cyclohexylmethyl)-7-(3-(piperidin-1-yl)propoxy)...)
Affinity DataKi:  0.350nMAssay Description:Displacement of [3H]N-alpha-methylhistamine from human cloned H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Rattus norvegicus (rat))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50186292(2-(cyclohexylmethyl)-7-(3-(piperidin-1-yl)propoxy)...)
Affinity DataKi:  0.460nMAssay Description:Displacement of [3H]N-alpha-methylhistamine from rat cloned H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50186306(3-(cyclohexylmethyl)-7-(3-(piperidin-1-yl)propoxy)...)
Affinity DataKi:  0.530nMAssay Description:Displacement of [3H]N-alpha-methylhistamine from human cloned H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50186316(2-(phenylsulfonyl)-7-(3-(piperidin-1-yl)propoxy)-1...)
Affinity DataKi:  0.530nMAssay Description:Displacement of [3H]N-alpha-methylhistamine from human cloned H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50186283(2-ethyl-6-(3-(piperidin-1-yl)propoxy)-1,2,3,4-tetr...)
Affinity DataKi:  0.540nMAssay Description:Displacement of [3H]N-alpha-methylhistamine from human cloned H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Rattus norvegicus (rat))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50186309(2-ethyl-7-(3-(piperidin-1-yl)propoxy)-2,3,4,5-tetr...)
Affinity DataKi:  0.560nMAssay Description:Displacement of [3H]N-alpha-methylhistamine from rat cloned H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50186293(7-(3-(piperidin-1-yl)propoxy)-1,2,3,4-tetrahydrois...)
Affinity DataKi:  0.600nMAssay Description:Displacement of [3H]N-alpha-methylhistamine from human cloned H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Rattus norvegicus (rat))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50186269(2-ethyl-7-(3-(piperidin-1-yl)propoxy)-1,2,3,4-tetr...)
Affinity DataKi:  0.640nMAssay Description:Displacement of [3H]N-alpha-methylhistamine from rat cloned H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50186311(3-isopropyl-7-(3-(piperidin-1-yl)propoxy)-2,3,4,5-...)
Affinity DataKi:  0.720nMAssay Description:Displacement of [3H]N-alpha-methylhistamine from human cloned H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Rattus norvegicus (rat))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50186270(2-benzyl-7-(3-(piperidin-1-yl)propoxy)-2,3,4,5-tet...)
Affinity DataKi:  0.800nMAssay Description:Displacement of [3H]N-alpha-methylhistamine from rat cloned H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Rattus norvegicus (rat))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50186291(2-isopropyl-7-(3-(piperidin-1-yl)propoxy)-1,2,3,4-...)
Affinity DataKi:  0.890nMAssay Description:Displacement of [3H]N-alpha-methylhistamine from rat cloned H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Rattus norvegicus (rat))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50186306(3-(cyclohexylmethyl)-7-(3-(piperidin-1-yl)propoxy)...)
Affinity DataKi:  0.970nMAssay Description:Displacement of [3H]N-alpha-methylhistamine from rat cloned H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50396808(CHEMBL2170081 | US8772480, 148)
Affinity DataKi:  1nMAssay Description:Inhibition of human N-terminal polyHis-tagged PI3K p110gamma expressed in baculovirus infected Hi5 cells using ATP as substrate after 20 mins by spec...More data for this Ligand-Target Pair
LigandPNGBDBM50396820(CHEMBL2170088 | US8772480, 272)
Affinity DataKi:  1nMAssay Description:Inhibition of human N-terminal polyHis-tagged PI3K p110alpha/p85alpha expressed in baculovirus infected Sf9 cells using phosphatidylinositol-4,5-bisp...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50396806(CHEMBL2170083 | US8772480, 270)
Affinity DataKi:  1nMAssay Description:Inhibition of human N-terminal polyHis-tagged PI3K p110delta/p85alpha expressed in baculovirus infected Sf9 cells using phosphatidylinositol-4,5-bisp...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50396807(CHEMBL2170082 | US8772480, 316)
Affinity DataKi:  1nMAssay Description:Inhibition of human N-terminal polyHis-tagged PI3K p110delta/p85alpha expressed in baculovirus infected Sf9 cells using phosphatidylinositol-4,5-bisp...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50396809(CHEMBL2170099 | US8772480, 147)
Affinity DataKi:  1nMAssay Description:Inhibition of human N-terminal polyHis-tagged PI3K p110delta/p85alpha expressed in baculovirus infected Sf9 cells using phosphatidylinositol-4,5-bisp...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50186296(2-(cyclohexylmethyl)-6-(3-(piperidin-1-yl)propoxy)...)
Affinity DataKi:  1.01nMAssay Description:Displacement of [3H]N-alpha-methylhistamine from human cloned H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Rattus norvegicus (rat))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50186290(3-ethyl-7-(3-(piperidin-1-yl)propoxy)-2,3,4,5-tetr...)
Affinity DataKi:  1.10nMAssay Description:Displacement of [3H]N-alpha-methylhistamine from rat cloned H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Rattus norvegicus (rat))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50186278(2-isopropyl-7-(3-(piperidin-1-yl)propoxy)-2,3,4,5-...)
Affinity DataKi:  1.29nMAssay Description:Displacement of [3H]N-alpha-methylhistamine from rat cloned H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Rattus norvegicus (rat))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50186311(3-isopropyl-7-(3-(piperidin-1-yl)propoxy)-2,3,4,5-...)
Affinity DataKi:  1.60nMAssay Description:Displacement of [3H]N-alpha-methylhistamine from rat cloned H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen phosphorylase, muscle form(Homo sapiens (Human))
University Of Thessaly

Curated by ChEMBL
LigandPNGBDBM50056221(CHEMBL3322297)
Affinity DataKi:  1.60nMAssay Description:Inhibition of glycogen phosphorylase b (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50396822(CHEMBL2170086 | US8772480, 360)
Affinity DataKi:  2nMAssay Description:Inhibition of human N-terminal polyHis-tagged PI3K p110delta/p85alpha expressed in baculovirus infected Sf9 cells using phosphatidylinositol-4,5-bisp...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50396821(CHEMBL2170087 | US8772480, 361)
Affinity DataKi:  2nMAssay Description:Inhibition of human N-terminal polyHis-tagged PI3K p110alpha/p85alpha expressed in baculovirus infected Sf9 cells using phosphatidylinositol-4,5-bisp...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50396821(CHEMBL2170087 | US8772480, 361)
Affinity DataKi:  2nMAssay Description:Inhibition of human N-terminal polyHis-tagged PI3K p110delta/p85alpha expressed in baculovirus infected Sf9 cells using phosphatidylinositol-4,5-bisp...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50396806(CHEMBL2170083 | US8772480, 270)
Affinity DataKi:  2nMAssay Description:Inhibition of human N-terminal polyHis-tagged PI3K p110alpha/p85alpha expressed in baculovirus infected Sf9 cells using phosphatidylinositol-4,5-bisp...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50396808(CHEMBL2170081 | US8772480, 148)
Affinity DataKi:  2nMAssay Description:Inhibition of human N-terminal polyHis-tagged PI3K p110delta/p85alpha expressed in baculovirus infected Sf9 cells using phosphatidylinositol-4,5-bisp...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50186281((6-(3-(piperidin-1-yl)propoxy)-3,4-dihydroisoquino...)
Affinity DataKi:  2.10nMAssay Description:Displacement of [3H]N-alpha-methylhistamine from human cloned H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50186295(2-(methylsulfonyl)-7-(3-(piperidin-1-yl)propoxy)-2...)
Affinity DataKi:  2.90nMAssay Description:Displacement of [3H]N-alpha-methylhistamine from human cloned H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50396807(CHEMBL2170082 | US8772480, 316)
Affinity DataKi:  3nMAssay Description:Inhibition of human N-terminal polyHis-tagged PI3K p110alpha/p85alpha expressed in baculovirus infected Sf9 cells using phosphatidylinositol-4,5-bisp...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50396805(CHEMBL2170084)
Affinity DataKi:  3nMAssay Description:Inhibition of human N-terminal polyHis-tagged PI3K p110delta/p85alpha expressed in baculovirus infected Sf9 cells using phosphatidylinositol-4,5-bisp...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50394846(CHEMBL2165017 | US8772480, 35)
Affinity DataKi:  4nMAssay Description:Inhibition of human N-terminal polyHis-tagged PI3K p110delta/p85alpha expressed in baculovirus infected Sf9 cells using phosphatidylinositol-4,5-bisp...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50396818(CHEMBL2170090 | US8772480, 280)
Affinity DataKi:  4nMAssay Description:Inhibition of human N-terminal polyHis-tagged PI3K p110alpha/p85alpha expressed in baculovirus infected Sf9 cells using phosphatidylinositol-4,5-bisp...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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