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Found 1865 with Last Name = 'davies' and Initial = 'p'
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50193774((+)1-(3-((2S,4R)-4-(4-fluorobenzyl)piperidin-2-yl)...)
Affinity DataKi:  3.5nMAssay Description:Inhibition of 5HTTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-activating factor receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50002823(2-{3-Methoxy-2-propoxy-5-[(2S,5S)-5-(3,4,5-trimeth...)
Affinity DataKi:  6.10nMAssay Description:Compound was tested for it''s ability to inhibit [3H]C18-PAF binding to PMN membrane receptorsMore data for this Ligand-Target Pair
In DepthDetails Article
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50193770(1-(3-((2S,4R)-4-(4-fluorobenzyl)-1-(2-oxopropyl)pi...)
Affinity DataKi:  11nMAssay Description:Inhibition of 5HTTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50193763((+)1-(3-((2S,4R)-4-(4-fluorobenzyl)piperidin-2-yl)...)
Affinity DataKi:  18nMAssay Description:Inhibition of 5HTTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50193764((2S,4R)-2-{3-[3-(3,5-diacetyl-phenyl)-ureido]-prop...)
Affinity DataKi:  19nMAssay Description:Inhibition of 5HTTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50193764((2S,4R)-2-{3-[3-(3,5-diacetyl-phenyl)-ureido]-prop...)
Affinity DataKi:  31nMAssay Description:Inhibition of DATMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50193768((+/-)1-(3-acetylphenyl)-3-(3-((2S,4R)-4-benzylpipe...)
Affinity DataKi:  32nMAssay Description:Inhibition of DATMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50193762((+)1-(3-((2S,4R)-4-benzylpiperidin-2-yl)propyl)-3-...)
Affinity DataKi:  34nMAssay Description:Inhibition of DATMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50193762((+)1-(3-((2S,4R)-4-benzylpiperidin-2-yl)propyl)-3-...)
Affinity DataKi:  34nMAssay Description:Inhibition of DATMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50193762((+)1-(3-((2S,4R)-4-benzylpiperidin-2-yl)propyl)-3-...)
Affinity DataKi:  35nMAssay Description:Inhibition of 5HTTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50193762((+)1-(3-((2S,4R)-4-benzylpiperidin-2-yl)propyl)-3-...)
Affinity DataKi:  35nMAssay Description:Inhibition of 5HTTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50193762((+)1-(3-((2S,4R)-4-benzylpiperidin-2-yl)propyl)-3-...)
Affinity DataKi:  37nMAssay Description:Inhibition of NETMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50193762((+)1-(3-((2S,4R)-4-benzylpiperidin-2-yl)propyl)-3-...)
Affinity DataKi:  37nMAssay Description:Inhibition of NETMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50193768((+/-)1-(3-acetylphenyl)-3-(3-((2S,4R)-4-benzylpipe...)
Affinity DataKi:  39nMAssay Description:Inhibition of NETMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50193760(1-(3-((2S,4R)-4-(4-fluorobenzyl)-1-(2-hydroxyethyl...)
Affinity DataKi:  40nMAssay Description:Inhibition of 5HTTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50193768((+/-)1-(3-acetylphenyl)-3-(3-((2S,4R)-4-benzylpipe...)
Affinity DataKi:  42nMAssay Description:Inhibition of 5HTTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50193769(1-(3-((2S,4R)-4-(4-fluorobenzyl)-1-(2-fluoroethyl)...)
Affinity DataKi:  49nMAssay Description:Inhibition of 5HTTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50193781(1-(3-((2S,4R)-4-(4-fluorobenzyl)-1-(2-hydroxyethyl...)
Affinity DataKi:  50nMAssay Description:Inhibition of 5HTTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-activating factor receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50002823(2-{3-Methoxy-2-propoxy-5-[(2S,5S)-5-(3,4,5-trimeth...)
Affinity DataKi:  59nMAssay Description:Compound was tested for it''s ability to inhibit [3H]C18-PAF binding to human plateletMore data for this Ligand-Target Pair
In DepthDetails Article
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50193759(1-(3-((2S,4R)-4-(4-fluorobenzyl)-1-allylpiperidin-...)
Affinity DataKi:  69nMAssay Description:Inhibition of 5HTTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50193774((+)1-(3-((2S,4R)-4-(4-fluorobenzyl)piperidin-2-yl)...)
Affinity DataKi:  95nMAssay Description:Inhibition of NETMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50193779(1-(3-((2S,4R)-4-(4-fluorobenzyl)-1-methylpiperidin...)
Affinity DataKi:  96nMAssay Description:Inhibition of DATMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-activating factor receptor(Cavia porcellus)
TBA

Curated by ChEMBL
LigandPNGBDBM50366241(CHEMBL297624 | L-652731)
Affinity DataKi:  103nMAssay Description:Inhibitory concentration required to inhibit PAF binding to rabbit platelet membraneMore data for this Ligand-Target Pair
In DepthDetails Article
TargetPlatelet-activating factor receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50002823(2-{3-Methoxy-2-propoxy-5-[(2S,5S)-5-(3,4,5-trimeth...)
Affinity DataKi:  116nMAssay Description:Compound was tested for it''s ability to inhibit [3H]C18-PAF binding to human plateletMore data for this Ligand-Target Pair
In DepthDetails Article
TargetPlatelet-activating factor receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50002823(2-{3-Methoxy-2-propoxy-5-[(2S,5S)-5-(3,4,5-trimeth...)
Affinity DataKi:  116nMAssay Description:Compound was tested for it''s ability to inhibit [3H]C18-PAF binding to human plateletMore data for this Ligand-Target Pair
In DepthDetails Article
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50193777(1-(3-((2S,4R)-4-(4-fluorobenzyl)-1-(cyclopropylmet...)
Affinity DataKi:  117nMAssay Description:Inhibition of 5HTTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50193774((+)1-(3-((2S,4R)-4-(4-fluorobenzyl)piperidin-2-yl)...)
Affinity DataKi:  119nMAssay Description:Inhibition of DATMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50193765(1-(3-((2S,4R)-4-(4-fluorobenzyl)-1-propylpiperidin...)
Affinity DataKi:  157nMAssay Description:Inhibition of DATMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50193765(1-(3-((2S,4R)-4-(4-fluorobenzyl)-1-propylpiperidin...)
Affinity DataKi:  166nMAssay Description:Inhibition of 5HTTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50115021(1-(3-Cyano-phenyl)-3-{3-[4-(4-fluoro-benzyl)-piper...)
Affinity DataKi:  167nMAssay Description:Inhibition of [125I]-eotaxin binding to serotonin 5-hydroxytryptamine 2A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50142464(1-(3-Cyano-phenyl)-3-{3-[3-(4-fluoro-benzyl)-pyrro...)
Affinity DataKi:  178nMAssay Description:Inhibition of [125I]-eotaxin binding to serotonin 5-hydroxytryptamine 2A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50115023(1-(3-Acetyl-phenyl)-3-{3-[4-(4-fluoro-benzyl)-pipe...)
Affinity DataKi:  193nMAssay Description:Inhibition of [125I]-eotaxin binding to serotonin 5-hydroxytryptamine 2A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50193775(1-(3-((2S,4R)-4-(4-fluorobenzyl)-1-(3-hydroxypropy...)
Affinity DataKi:  212nMAssay Description:Inhibition of 5HTTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50193771(1-(3-((2S,4R)-4-(4-fluorobenzyl)-1-allylpiperidin-...)
Affinity DataKi:  217nMAssay Description:Inhibition of 5HTTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50193763((+)1-(3-((2S,4R)-4-(4-fluorobenzyl)piperidin-2-yl)...)
Affinity DataKi:  219nMAssay Description:Inhibition of DATMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50193776(1-(3-((2S,4R)-4-(4-fluorobenzyl)-1-propionylpiperi...)
Affinity DataKi:  224nMAssay Description:Inhibition of 5HTTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50115071(1-{3-[4-(4-Fluoro-benzyl)-piperidin-1-yl]-propyl}-...)
Affinity DataKi:  224nMAssay Description:Inhibition of [125I]-eotaxin binding to serotonin 5-hydroxytryptamine 2A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50193763((+)1-(3-((2S,4R)-4-(4-fluorobenzyl)piperidin-2-yl)...)
Affinity DataKi:  233nMAssay Description:Inhibition of NETMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50003164(1-[3-(6-Hydroxy-2-methyl-5-oxo-2,5-dihydro-[1,2,4]...)
Affinity DataKi:  250nMAssay Description:In vitro inhibitory activity against human leukocyte elastaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50193777(1-(3-((2S,4R)-4-(4-fluorobenzyl)-1-(cyclopropylmet...)
Affinity DataKi:  251nMAssay Description:Inhibition of DATMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50193779(1-(3-((2S,4R)-4-(4-fluorobenzyl)-1-methylpiperidin...)
Affinity DataKi:  257nMAssay Description:Inhibition of NETMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50193767(1-(3-((2S,4R)-4-(4-fluorobenzyl)-1-propylpiperidin...)
Affinity DataKi:  296nMAssay Description:Inhibition of 5HTTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50193759(1-(3-((2S,4R)-4-(4-fluorobenzyl)-1-allylpiperidin-...)
Affinity DataKi:  297nMAssay Description:Inhibition of DATMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50193758(1-(3-((2S,4R)-4-(4-fluorobenzyl)-1-(prop-2-ynyl)pi...)
Affinity DataKi:  305nMAssay Description:Inhibition of 5HTTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50193769(1-(3-((2S,4R)-4-(4-fluorobenzyl)-1-(2-fluoroethyl)...)
Affinity DataKi:  317nMAssay Description:Inhibition of NETMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50193773(1-(3-((2S,4R)-4-(4-fluorobenzyl)-1-(2,2-difluoroet...)
Affinity DataKi:  328nMAssay Description:Inhibition of 5HTTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50193770(1-(3-((2S,4R)-4-(4-fluorobenzyl)-1-(2-oxopropyl)pi...)
Affinity DataKi:  381nMAssay Description:Inhibition of NETMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50193764((2S,4R)-2-{3-[3-(3,5-diacetyl-phenyl)-ureido]-prop...)
Affinity DataKi:  388nMAssay Description:Inhibition of NETMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50193760(1-(3-((2S,4R)-4-(4-fluorobenzyl)-1-(2-hydroxyethyl...)
Affinity DataKi:  451nMAssay Description:Inhibition of DATMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50209971(1-((1R,2S)-2-(((S)-3-(4-fluorobenzyl)piperidin-1-y...)
Affinity DataKi:  490nMAssay Description:Binding affinity to dopamine transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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