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Found 257 with Last Name = 'dennis' and Initial = 'm'
TargetEstrogen receptor(Mus musculus)
University Of New Mexico Health Sciences Center

Curated by ChEMBL
LigandPNGBDBM50303803(1-((3aS,4R,9bR)-4-(6-bromobenzo[d][1,3]dioxol-5-yl...)
Affinity DataKi:  0.300nMAssay Description:Binding affinity to ERalpha receptor in mouse COS7 cells by competitive binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor beta(Mus musculus)
University Of New Mexico Health Sciences Center

Curated by ChEMBL
LigandPNGBDBM50303804((3aS,4R,9bR)-4-(6-bromobenzo[d][1,3]dioxol-5-yl)-3...)
Affinity DataKi:  0.300nMAssay Description:Binding affinity to ERbeta receptor in mouse COS7 cells by competitive binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50263148(CHEMBL476578 | N-((R)-1-(4-(5-fluoro-4-(1-isopropy...)
Affinity DataIC50: >0.300nMAssay Description:Inhibition of CDK2/Cyclin E (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50263147(CHEMBL476577 | N-(1-(4-(5-fluoro-4-(1-isopropyl-2-...)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of CDK2/Cyclin E (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50422267(CHEMBL263079)
Affinity DataIC50:  2.5nMAssay Description:Inhibition of specific binding of [125-I]ET-1 to human endothelin A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50263068(CHEMBL477785 | N-(4-(4-(2-(dimethylamino)ethylsulf...)
Affinity DataIC50:  3nMAssay Description:Inhibition of CDK2/Cyclin E (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50263026(CHEMBL478407 | N-(4-fluorophenyl)-4-(1-isopropyl-2...)
Affinity DataIC50:  3nMAssay Description:Inhibition of CDK2/Cyclin E (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-1 angiotensin II receptor(Cavia porcellus)
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50047133(CHEMBL434768 | {6-Ethyl-2-methyl-4-[2'-(1H-tetrazo...)
Affinity DataIC50:  4nMAssay Description:Inhibition of [125I]-Angiotensin binding to a guinea pig adrenal membrane preparation which corresponds to Angiotensin II receptor, type 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-1 angiotensin II receptor(Cavia porcellus)
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50047111(6-Ethyl-2-methyl-4-[2'-(1H-tetrazol-5-yl)-biphenyl...)
Affinity DataIC50:  5nMAssay Description:Inhibition of [125I]-Angiotensin binding to a guinea pig adrenal membrane preparation which corresponds to Angiotensin II receptor, type 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-1 angiotensin II receptor(Cavia porcellus)
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50047117(2,6-Diethyl-4-[2'-(1H-tetrazol-5-yl)-biphenyl-4-yl...)
Affinity DataIC50:  5nMAssay Description:Inhibition of [125I]-Angiotensin binding to a guinea pig adrenal membrane preparation which corresponds to Angiotensin II receptor, type 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50263112(1-(4-(4-(5-fluoro-4-(1-isopropyl-2-methyl-1H-imida...)
Affinity DataIC50:  6nMAssay Description:Inhibition of CDK2/Cyclin E (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-1 angiotensin II receptor(Cavia porcellus)
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50047113(2,6-Dimethyl-3-phenyl-4-[2'-(1H-tetrazol-5-yl)-bip...)
Affinity DataIC50:  6nMAssay Description:Inhibition of [125I]-Angiotensin binding to a guinea pig adrenal membrane preparation which corresponds to Angiotensin II receptor, type 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-1 angiotensin II receptor(Cavia porcellus)
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50047130(CHEMBL280189 | {2,6-Dimethyl-4-[2'-(1H-tetrazol-5-...)
Affinity DataIC50:  6nMAssay Description:Inhibition of [125I]-Angiotensin binding to a guinea pig adrenal membrane preparation which corresponds to Angiotensin II receptor, type 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50422250(CHEMBL268174)
Affinity DataIC50:  7.90nMAssay Description:Inhibition of specific binding of [125-I]ET-1 to human endothelin A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50263146(5-fluoro-4-(1-isopropyl-2-methyl-1H-imidazol-5-yl)...)
Affinity DataIC50:  8nMAssay Description:Inhibition of CDK2/Cyclin E (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50262981(4-(1-isopropyl-2-methyl-1H-imidazol-5-yl)-N-(4-met...)
Affinity DataIC50:  8nMAssay Description:Inhibition of CDK2/Cyclin E (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-1 angiotensin II receptor(Cavia porcellus)
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50047129(2-Ethyl-4-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmeth...)
Affinity DataIC50:  8nMAssay Description:Inhibition of [125I]-Angiotensin binding to a guinea pig adrenal membrane preparation which corresponds to Angiotensin II receptor, type 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-1 angiotensin II receptor(Cavia porcellus)
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50047122(1-{6-Ethyl-2-methyl-4-[2'-(1H-tetrazol-5-yl)-biphe...)
Affinity DataIC50:  8nMAssay Description:Inhibition of [125I]-Angiotensin binding to a guinea pig adrenal membrane preparation which corresponds to Angiotensin II receptor, type 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50263113(4-(1-isopropyl-2-methyl-1H-imidazol-5-yl)-N-(4-mor...)
Affinity DataIC50:  9nMAssay Description:Inhibition of CDK2/Cyclin E (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-1 angiotensin II receptor(Cavia porcellus)
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50047112(2-Methyl-6-propyl-4-[2'-(1H-tetrazol-5-yl)-bipheny...)
Affinity DataIC50:  9nMAssay Description:Inhibition of [125I]-Angiotensin binding to a guinea pig adrenal membrane preparation which corresponds to Angiotensin II receptor, type 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50422234(CHEMBL6412)
Affinity DataIC50:  10nMAssay Description:Inhibition of specific binding of [125-I]ET-1 to human endothelin A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetG-protein coupled estrogen receptor 1(Homo sapiens (Human))
New Mexico State University

Curated by ChEMBL
LigandPNGBDBM50303803(1-((3aS,4R,9bR)-4-(6-bromobenzo[d][1,3]dioxol-5-yl...)
Affinity DataIC50:  11nMAssay Description:Binding affinity to GPR30More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50422254(CHEMBL6785)
Affinity DataIC50:  13nMAssay Description:Inhibition of specific binding of [125-I] ET-1 to human Endothelin A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-1 angiotensin II receptor(Cavia porcellus)
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50003386(2-Ethyl-5-methyl-4-[2'-(1H-tetrazol-5-yl)-biphenyl...)
Affinity DataIC50:  13nMAssay Description:In vitro inhibition of the specific binding of [125I]-angiotensin II to a guinea pig adrenal membrane preparationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-1 angiotensin II receptor(Cavia porcellus)
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50047119(3-Benzyl-2,6-dimethyl-4-[2'-(1H-tetrazol-5-yl)-bip...)
Affinity DataIC50:  14nMAssay Description:Inhibition of [125I]-Angiotensin binding to a guinea pig adrenal membrane preparation which corresponds to Angiotensin II receptor, type 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-1 angiotensin II receptor(Cavia porcellus)
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50047132(2,6-Diethyl-3-iodo-4-[2'-(2H-tetrazol-5-yl)-biphen...)
Affinity DataIC50:  14nMAssay Description:Inhibition of [125I]-Angiotensin binding to a guinea pig adrenal membrane preparation which corresponds to Angiotensin II receptor, type 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50422257(CHEMBL6555)
Affinity DataIC50:  16nMAssay Description:Inhibition of specific binding of [125-I]ET-1 to human endothelin A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-1 angiotensin II receptor(Cavia porcellus)
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50003392(2-Methyl-4-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmet...)
Affinity DataIC50:  16nMAssay Description:Inhibition of [125I]-Angiotensin binding to a guinea pig adrenal membrane preparation which corresponds to Angiotensin II receptor, type 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-1 angiotensin II receptor(Cavia porcellus)
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50003392(2-Methyl-4-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmet...)
Affinity DataIC50:  16nMAssay Description:In vitro inhibition of the specific binding of [125I]-angiotensin II to a guinea pig adrenal membrane preparationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50263110(2-(dimethylamino)-1-(4-(4-(4-(1-isopropyl-2-methyl...)
Affinity DataIC50:  16nMAssay Description:Inhibition of CDK2/Cyclin E (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50263070(2-hydroxy-1-(4-(4-(4-(1-isopropyl-2-methyl-1H-imid...)
Affinity DataIC50:  17nMAssay Description:Inhibition of CDK2/Cyclin E (unknown origin)More data for this Ligand-Target Pair
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50263071((2S)-2-hydroxy-1-(4-(4-(4-(1-isopropyl-2-methyl-1H...)
Affinity DataIC50:  17nMAssay Description:Inhibition of CDK2/Cyclin E (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-1 angiotensin II receptor(Cavia porcellus)
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50009714(CHEMBL191 | {2-Butyl-5-chloro-3-[2'-(2H-tetrazol-5...)
Affinity DataIC50:  18nMAssay Description:Inhibition of [125I]-Angiotensin binding to a guinea pig adrenal membrane preparation which corresponds to Angiotensin II receptor, type 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-1 angiotensin II receptor(Cavia porcellus)
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50406795(Cozaar | LOSARTAN POTASSIUM)
Affinity DataIC50:  18nMAssay Description:In vitro inhibition of the specific binding of [125I]-angiotensin II to a guinea pig adrenal membrane preparationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetG-protein coupled estrogen receptor 1(Homo sapiens (Human))
New Mexico State University

Curated by ChEMBL
LigandPNGBDBM50303804((3aS,4R,9bR)-4-(6-bromobenzo[d][1,3]dioxol-5-yl)-3...)
Affinity DataIC50:  20nMAssay Description:Binding affinity to GPR30More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-1 angiotensin II receptor(Cavia porcellus)
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50003400(2-Ethyl-6-methoxy-4-[2'-(1H-tetrazol-5-yl)-bipheny...)
Affinity DataIC50:  22nMAssay Description:In vitro inhibition of the specific binding of [125I]-angiotensin II to a guinea pig adrenal membrane preparationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-1 angiotensin II receptor(Cavia porcellus)
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50047125(2-Ethyl-6-methyl-4-[2'-(1H-tetrazol-5-yl)-biphenyl...)
Affinity DataIC50:  23nMAssay Description:Inhibition of [125I]-Angiotensin binding to a guinea pig adrenal membrane preparation which corresponds to Angiotensin II receptor, type 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50262980(CHEMBL476518 | N1-(4-(1-isopropyl-2-methyl-1H-imid...)
Affinity DataIC50:  24nMAssay Description:Inhibition of CDK2/Cyclin E (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-1 angiotensin II receptor(Cavia porcellus)
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50047115(2,6-Dimethyl-4-[2'-(1H-tetrazol-5-yl)-biphenyl-4-y...)
Affinity DataIC50:  25nMAssay Description:Inhibition of [125I]-Angiotensin binding to a guinea pig adrenal membrane preparation which corresponds to Angiotensin II receptor, type 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-1 angiotensin II receptor(Cavia porcellus)
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50047127(2-Ethyl-4-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmeth...)
Affinity DataIC50:  25nMAssay Description:Inhibition of [125I]-Angiotensin binding to a guinea pig adrenal membrane preparation which corresponds to Angiotensin II receptor, type 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-1 angiotensin II receptor(Cavia porcellus)
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50003403(2-Ethyl-6-isopropoxy-4-[2'-(1H-tetrazol-5-yl)-biph...)
Affinity DataIC50:  26nMAssay Description:In vitro inhibition of the specific binding of [125I]-angiotensin II to a guinea pig adrenal membrane preparationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-1 angiotensin II receptor(Cavia porcellus)
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50003377(2-Ethyl-4-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmeth...)
Affinity DataIC50:  26nMAssay Description:In vitro inhibition of the specific binding of [125I]-angiotensin II to a guinea pig adrenal membrane preparationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-1 angiotensin II receptor(Cavia porcellus)
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50047131(1-{2,6-Dimethyl-4-[2'-(1H-tetrazol-5-yl)-biphenyl-...)
Affinity DataIC50:  30nMAssay Description:Inhibition of [125I]-Angiotensin binding to a guinea pig adrenal membrane preparation which corresponds to Angiotensin II receptor, type 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-1 angiotensin II receptor(Cavia porcellus)
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50003387(2-Ethyl-4-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmeth...)
Affinity DataIC50:  31nMAssay Description:In vitro inhibition of the specific binding of [125I]-angiotensin II to a guinea pig adrenal membrane preparationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-1 angiotensin II receptor(Cavia porcellus)
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50003387(2-Ethyl-4-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmeth...)
Affinity DataIC50:  31nMAssay Description:Inhibition of [125I]-Angiotensin binding to a guinea pig adrenal membrane preparation which corresponds to Angiotensin II receptor, type 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-1 angiotensin II receptor(Cavia porcellus)
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50047118(3-Iodo-2,6-dimethyl-4-[2'-(1H-tetrazol-5-yl)-biphe...)
Affinity DataIC50:  34nMAssay Description:Inhibition of [125I]-Angiotensin binding to a guinea pig adrenal membrane preparation which corresponds to Angiotensin II receptor, type 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-1 angiotensin II receptor(Cavia porcellus)
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50003394(2-Methyl-4-{1-[2'-(1H-tetrazol-5-yl)-biphenyl-4-yl...)
Affinity DataIC50:  40nMAssay Description:In vitro inhibition of the specific binding of [125I]-angiotensin II to a guinea pig adrenal membrane preparationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50263149((2S)-1-(4-(5-fluoro-4-(1-isopropyl-2-methyl-1H-imi...)
Affinity DataIC50:  46nMAssay Description:Inhibition of CDK2/Cyclin E (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-1 angiotensin II receptor(Cavia porcellus)
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50047126(2-Ethyl-4-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmeth...)
Affinity DataIC50:  50nMAssay Description:Inhibition of [125I]-Angiotensin binding to a guinea pig adrenal membrane preparation which corresponds to Angiotensin II receptor, type 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-1 angiotensin II receptor(Cavia porcellus)
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50047124(2,6-Dimethyl-4-[2'-(1H-tetrazol-5-yl)-biphenyl-4-y...)
Affinity DataIC50:  50nMAssay Description:Inhibition of [125I]-Angiotensin binding to a guinea pig adrenal membrane preparation which corresponds to Angiotensin II receptor, type 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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