Affinity DataKi: 0.170nMAssay Description:Evaluated for the binding affinity towards NK1 receptor in the striatal membranes of guinea pigMore data for this Ligand-Target Pair
Affinity DataKi: 0.170nMAssay Description:Evaluated for the binding affinity towards NK1 receptor in the striatal membranes of guinea pigMore data for this Ligand-Target Pair
Affinity DataKi: 0.170nMAssay Description:In vitro binding affinity against substance P (NK-1) receptor in human IM-9 cell using [125I]-BH-SPMore data for this Ligand-Target Pair
Affinity DataKi: 0.480nMAssay Description:In vitro binding affinity for the Tachykinin receptor 1 in human IM-9 cell using [125I]-BH-SP of the compound.More data for this Ligand-Target Pair
Affinity DataKi: 0.480nMAssay Description:In vitro binding affinity for the Tachykinin receptor 1 in human IM-9 cell using [125I]-BH-SP of the compound.More data for this Ligand-Target Pair
Affinity DataKi: 0.600nMAssay Description:Displacement of [125I]PYY from human NPY5 receptor expressed in thymidine kinase deficient mouse LM cells after 120 mins by scintillation countingMore data for this Ligand-Target Pair
Affinity DataKi: 0.660nMAssay Description:In vitro binding affinity for the Tachykinin receptor 1 in human IM-9 cell using [125I]-BH-SP of the compound.More data for this Ligand-Target Pair
Affinity DataKi: 0.660nMAssay Description:In vitro binding affinity for the Tachykinin receptor 1 in human IM-9 cell using [125I]-BH-SP of the compound.More data for this Ligand-Target Pair
Affinity DataKi: 0.800nMAssay Description:Displacement of [125I]PYY from human NPY5 receptor expressed in thymidine kinase deficient mouse LM cells after 120 mins by scintillation countingMore data for this Ligand-Target Pair
Affinity DataKi: 0.800nMAssay Description:Antagonist activity at human NPY5 receptor assessed as calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
Affinity DataKi: 0.900nMAssay Description:Displacement of [125I]PYY from human NPY5 receptor expressed in thymidine kinase deficient mouse LM cells after 120 mins by scintillation countingMore data for this Ligand-Target Pair
Affinity DataKi: 0.900nMAssay Description:Antagonist activity at human NPY5 receptor assessed as calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
Affinity DataKi: 1nMAssay Description:Displacement of [125I]PYY from human NPY5 receptor expressed in thymidine kinase deficient mouse LM cells after 120 mins by scintillation countingMore data for this Ligand-Target Pair
Affinity DataKi: 1.10nMAssay Description:Antagonist activity at human NPY5 receptor assessed as calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
Affinity DataKi: 1.10nMAssay Description:Antagonist activity at human NPY5 receptor assessed as calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
Affinity DataKi: 1.40nMAssay Description:Antagonist activity at human NPY5 receptor assessed as calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
Affinity DataKi: 1.40nMAssay Description:Antagonist activity at rat NPY5 receptorMore data for this Ligand-Target Pair
Affinity DataKi: 1.40nMAssay Description:Binding affinity to NPY5 receptorMore data for this Ligand-Target Pair
Affinity DataKi: 1.5nMAssay Description:Antagonist activity at human NPY5 receptor assessed as calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
Affinity DataKi: 1.5nMAssay Description:In vitro binding affinity of the compound towards human NK-1 receptor in IM-9 cells using [3H]-SP of substance P antagonistMore data for this Ligand-Target Pair
Affinity DataKi: 1.70nMAssay Description:Antagonist activity at human NPY5 receptor assessed as calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
Affinity DataKi: 1.80nMAssay Description:Binding affinity to human cloned NPY Y5 receptor expressed in african green monkey COS7 cells by radioligand binding assayMore data for this Ligand-Target Pair
Affinity DataKi: 1.80nMAssay Description:Displacement of [125I]PYY from human NPY5 receptor expressed in thymidine kinase deficient mouse LM cells after 120 mins by scintillation countingMore data for this Ligand-Target Pair
Affinity DataKi: 1.90nMAssay Description:Binding affinity to human cloned NPY Y5 receptor expressed in african green monkey COS7 cells by radioligand binding assayMore data for this Ligand-Target Pair
Affinity DataKi: 1.90nMAssay Description:Antagonist activity at human NPY5 receptor assessed as calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
Affinity DataKi: 2nMAssay Description:Binding affinity to human cloned NPY Y5 receptor expressed in african green monkey COS7 cells by radioligand binding assayMore data for this Ligand-Target Pair
Affinity DataKi: 2nMAssay Description:In vitro binding affinity against substance P (NK-1) receptor in human IM-9 cell using [125I]-BH-SPMore data for this Ligand-Target Pair
Affinity DataKi: 2.40nMAssay Description:Antagonist activity at human NPY5 receptor assessed as calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
Affinity DataKi: 2.40nMAssay Description:In vitro binding affinity of the compound towards human NK-1 receptor in IM-9 cells using [3H]-SP of substance P antagonistMore data for this Ligand-Target Pair
Affinity DataKi: 2.80nMAssay Description:Antagonist activity at human NPY5 receptor assessed as calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
Affinity DataKi: 3.40nMAssay Description:Antagonist activity at human NPY5 receptor assessed as calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
Affinity DataKi: 3.40nMAssay Description:Binding affinity to human cloned NPY Y5 receptor expressed in african green monkey COS7 cells by radioligand binding assayMore data for this Ligand-Target Pair
Affinity DataKi: 3.40nMAssay Description:Displacement of [125I]PYY from human NPY5 receptor expressed in thymidine kinase deficient mouse LM cells after 120 mins by scintillation countingMore data for this Ligand-Target Pair
Affinity DataKi: 3.5nMAssay Description:Displacement of [125I]PYY from human NPY5 receptor expressed in thymidine kinase deficient mouse LM cells after 120 mins by scintillation countingMore data for this Ligand-Target Pair
Affinity DataKi: 3.70nMAssay Description:Binding affinity to human cloned NPY Y5 receptor expressed in african green monkey COS7 cells by radioligand binding assayMore data for this Ligand-Target Pair
Affinity DataKi: 4.40nMAssay Description:Displacement of [125I]PYY from human NPY5 receptor expressed in thymidine kinase deficient mouse LM cells after 120 mins by scintillation countingMore data for this Ligand-Target Pair
Affinity DataKi: 4.90nMAssay Description:Antagonist activity at human NPY5 receptor assessed as calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
Affinity DataKi: 5.40nMAssay Description:Antagonist activity at rat NPY Y5 receptorMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Lundbeck Research Usa
Curated by ChEMBL
Lundbeck Research Usa
Curated by ChEMBL
Affinity DataKi: 6.20nMAssay Description:Inhibition of serotonin transporterMore data for this Ligand-Target Pair
Affinity DataKi: 6.70nMAssay Description:Antagonist activity at human NPY5 receptor assessed as calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
Affinity DataKi: 6.90nMAssay Description:Displacement of [125I]PYY from human NPY5 receptor expressed in thymidine kinase deficient mouse LM cells after 120 mins by scintillation countingMore data for this Ligand-Target Pair
Affinity DataKi: 7.5nMAssay Description:Antagonist activity at human NPY5 receptor assessed as calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
Affinity DataKi: 7.60nMAssay Description:Binding affinity to human cloned NPY Y5 receptor expressed in african green monkey COS7 cells by radioligand binding assayMore data for this Ligand-Target Pair
Affinity DataKi: 8nMAssay Description:Binding affinity to human cloned NPY Y5 receptor expressed in african green monkey COS7 cells by radioligand binding assayMore data for this Ligand-Target Pair
Affinity DataKi: 8.40nMAssay Description:Displacement of [125I]PYY from human NPY5 receptor expressed in thymidine kinase deficient mouse LM cells after 120 mins by scintillation countingMore data for this Ligand-Target Pair
Affinity DataKi: 8.80nMAssay Description:Antagonist activity at human NPY5 receptor assessed as calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
Affinity DataKi: 9.20nMAssay Description:Displacement of [125I]PYY from human NPY5 receptor expressed in thymidine kinase deficient mouse LM cells after 120 mins by scintillation countingMore data for this Ligand-Target Pair
Affinity DataKi: 12nMAssay Description:Binding affinity to human cloned NPY Y5 receptor expressed in african green monkey COS7 cells by radioligand binding assayMore data for this Ligand-Target Pair
Affinity DataKi: 13.9nMAssay Description:Antagonist activity at human NPY5 receptor assessed as calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
Affinity DataKi: 14nMAssay Description:Displacement of [125I]PYY from human NPY5 receptor expressed in thymidine kinase deficient mouse LM cells after 120 mins by scintillation countingMore data for this Ligand-Target Pair