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Found 2422 with Last Name = 'deschamps' and Initial = 'jr'
TargetMu-type opioid receptor(Rattus norvegicus (rat))
National Institute On Drug Abuse And The National Institute On Alcohol Abuse

Curated by ChEMBL
LigandPNGBDBM50256671(CHEMBL4085431)
Affinity DataKi:  0.0730nMAssay Description:Non-competitive inhibition of recombinant human MAO-B expressed in baculovirus infected BTI insect cells using varying levels of tyramine as substrat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Rattus norvegicus (rat))
National Institute Of Environmental Health Sciences

Curated by ChEMBL
LigandPNGBDBM50121640(2-[2-Dimethylamino-3-(4-hydroxy-2,6-dimethyl-pheny...)
Affinity DataKi:  0.120nMAssay Description:Binding affinity of compound towards the Opioid receptor delta 1 in rat synaptosomal membrane was determined using [3H]-DPDPE as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Rattus norvegicus (rat))
National Institute Of Environmental Health Sciences

Curated by ChEMBL
LigandPNGBDBM50121639(1-[3-(Adamantan-1-ylamino)-3,4-dihydro-1H-isoquino...)
Affinity DataKi:  0.160nMAssay Description:Binding affinity of compound towards the Opioid receptor delta 1 in rat synaptosomal membrane was determined using [3H]-DPDPE as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
University Of Michigan Comprehensive Cancer Center And Departments Of Internal Medicine

Curated by ChEMBL
LigandPNGBDBM50041086(CHEMBL3355430)
Affinity DataKi:  0.160nMAssay Description:Binding affinity to human His-tagged MDM2 (1 to 118 residues) using FAM tagged p53-based peptide by fluorescence prolarization based protein binding ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Homo sapiens (Human))
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50266969(CHEMBL4093656)
Affinity DataKi:  0.172nMAssay Description:Displacement of [3H]-N-methylspiperone from human dopamine D3 receptor expressed in HEK293 cells after 1 hr by MicroBeta microplate counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
National Institute On Drug Abuse

Curated by ChEMBL
LigandPNGBDBM50217952((1R,5R,9S)-(-)-9-hydroxy-5-(3-hydroxyphenyl-2-phen...)
Affinity DataKi:  0.190nMAssay Description:Displacement of [125I]IOXY from human mu opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Homo sapiens (Human))
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50119386(Benzo[b]thiophene-2-carboxylic acid {4-[4-(2-metho...)
Affinity DataKi:  0.190nMAssay Description:Displacement of [125]IABN from human D3 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
National Institute On Drug Abuse

Curated by ChEMBL
LigandPNGBDBM50217956((1R,5S)-(+)-5-(3-hydroxyphenyl)-9-methylene-2-phen...)
Affinity DataKi:  0.190nMAssay Description:Displacement of [125I]IOXY from human mu opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Mus musculus (Mouse))
Northeastern University

Curated by ChEMBL
LigandPNGBDBM50172545((2-Iodo-phenyl)-[1-((S)-1-methyl-piperidin-2-ylmet...)
Affinity DataKi:  0.200nMAssay Description:Binding affinity towards mouse hippocampal membranes cannabinoid receptor 1 using [131I]-(R)-8More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Homo sapiens (Human))
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50097834(CHEMBL3589652)
Affinity DataKi:  0.233nMAssay Description:Displacement of [3H]-N-methylspiperone from human dopamine D3 receptor expressed in HEK293 cell membranes after 1 hr by liquid scintillation counting...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Rattus norvegicus (rat))
National Institute Of Environmental Health Sciences

Curated by ChEMBL
LigandPNGBDBM50121638(1-[3-(Adamantan-1-ylamino)-3,4-dihydro-1H-isoquino...)
Affinity DataKi:  0.260nMAssay Description:Binding affinity of compound towards the Opioid receptor delta 1 in rat synaptosomal membrane was determined using [3H]-DPDPE as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Homo sapiens (Human))
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50378001(CHEMBL1627321 | US8748608, 36)
Affinity DataKi:  0.260nMAssay Description:Displacement of [125]IABN from human D3 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
National Institute On Drug Abuse And The National Institute On Alcohol Abuse

Curated by ChEMBL
LigandPNGBDBM50217952((1R,5R,9S)-(-)-9-hydroxy-5-(3-hydroxyphenyl-2-phen...)
Affinity DataKi:  0.265nMAssay Description:Displacement of [3H]DAMGO from mu opioid receptor in rat brain after 60 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Homo sapiens (Human))
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50131922(1H-Indole-2-carboxylic acid {4-[4-(2-methoxy-pheny...)
Affinity DataKi:  0.320nMAssay Description:Displacement of [125]IABN from human D3 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Homo sapiens (Human))
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50253620(CHEMBL523328 | endo-8-(Benzofur-3-ylmethyl)-3-(3,4...)
Affinity DataKi:  0.340nMAssay Description:Displacement of [125I]IABN from human dopamine D3 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Rattus norvegicus (Rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50400513(CHEMBL2203404)
Affinity DataKi:  0.350nMAssay Description:Displacement of [3H]R(+)-7-OH-DPAT from Sprague-Dawley rat dopamine D3 receptor after 90 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Homo sapiens (Human))
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50253638(CHEMBL518816 | endo-8-(5-Fluorobenzofur-3-ylmethyl...)
Affinity DataKi:  0.370nMAssay Description:Displacement of [125I]IABN from human dopamine D3 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Rattus norvegicus (Rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50400512(CHEMBL2203405)
Affinity DataKi:  0.400nMAssay Description:Displacement of [3H]R(+)-7-OH-DPAT from Sprague-Dawley rat dopamine D3 receptor after 90 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Rattus norvegicus (Rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50400514(CHEMBL2203403)
Affinity DataKi:  0.410nMAssay Description:Displacement of [3H]R(+)-7-OH-DPAT from Sprague-Dawley rat dopamine D3 receptor after 90 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Homo sapiens (Human))
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50378019(CHEMBL1627323)
Affinity DataKi:  0.440nMAssay Description:Displacement of [125]IABN from human D3 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Rattus norvegicus (Rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50116766((-)-Pramipexole | (6S)-N(6)-propyl-4,5,6,7-tetrahy...)
Affinity DataKi:  0.450nMAssay Description:Displacement of [3H]R(+)-7-OH-DPAT from Sprague-Dawley rat dopamine D3 receptor after 90 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGABA-A receptor; alpha-5/beta-3/gamma-2(Homo sapiens (Human))
University Of Wisconsin-Milwaukee

Curated by ChEMBL
LigandPNGBDBM25877(CHEMBL286594 | RY-80, 1 | ethyl 12-ethynyl-8-methy...)
Affinity DataKi:  0.490nMAssay Description:In vitro inhibition of [3H]-Ro- 15-1788 binding to human GABA-A receptor alpha3-beta3-gamma2 subunits expressed in L(tk-)cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit alpha-5 [32-462]/beta-3 [26-473]/gamma-2 [40-467](Homo sapiens (Human))
University Of Wisconsin-Milwaukee

LigandPNGBDBM25877(CHEMBL286594 | RY-80, 1 | ethyl 12-ethynyl-8-methy...)
Affinity DataKi:  0.490nMAssay Description:The affinity of compounds for human recombinant GABA (A) receptors was measured by competition binding using [3H]flunitrazepam. Assays were carried o...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Rattus norvegicus (Rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50400511(CHEMBL2203406)
Affinity DataKi:  0.5nMAssay Description:Displacement of [3H]R(+)-7-OH-DPAT from Sprague-Dawley rat dopamine D3 receptor after 90 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Homo sapiens (Human))
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50378018(CHEMBL1627322 | US8748608, 37)
Affinity DataKi:  0.510nMAssay Description:Displacement of [125]IABN from human D3 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Homo sapiens (Human))
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50129425(5-Fluoro-1H-indole-2-carboxylic acid {4-[4-(2,3-di...)
Affinity DataKi:  0.520nMAssay Description:Displacement of [125]IABN from human D3 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Homo sapiens (Human))
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50342720((R)-N-(4-(4-(2,3-dichlorophenyl)piperazin-1-yl)-3-...)
Affinity DataKi:  0.530nMAssay Description:Displacement of [3H]N-methylspiperone from human dopamine D3 receptor expressed in human HEK293 cell membrane for 1 hr by liquid scintillation counti...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Homo sapiens (Human))
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50253664(CHEMBL518037 | endo-8-(5-Fluorobenzofur-3-ylmethyl...)
Affinity DataKi:  0.530nMAssay Description:Displacement of [125I]IABN from human dopamine D3 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
National Institute On Drug Abuse

Curated by ChEMBL
LigandPNGBDBM50217950((1R,5S,9R)-(+)-5-(3-hydroxyphenyl)-9-methyl-2-phen...)
Affinity DataKi:  0.600nMAssay Description:Displacement of [125I]IOXY from human mu opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
National Institute On Drug Abuse

Curated by ChEMBL
LigandPNGBDBM50217956((1R,5S)-(+)-5-(3-hydroxyphenyl)-9-methylene-2-phen...)
Affinity DataKi:  0.650nMAssay Description:Displacement of [125I]IOXY from human kappa opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
National Institute On Drug Abuse

Curated by ChEMBL
LigandPNGBDBM50017231((4aS,9aR)-4a-Ethyl-2-phenethyl-1,2,3,4,4a,9a-hexah...)
Affinity DataKi:  0.700nMAssay Description:Displacement of [3H]DAMGO from human recombinant mu opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
National Institute On Drug Abuse

Curated by ChEMBL
LigandPNGBDBM50017231((4aS,9aR)-4a-Ethyl-2-phenethyl-1,2,3,4,4a,9a-hexah...)
Affinity DataKi:  0.700nMAssay Description:Displacement of [3H]DAMGO from mu opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Homo sapiens (Human))
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50253619(CHEMBL493278 | endo-8-(Benzofur-3-ylmethyl)-3-(4-c...)
Affinity DataKi:  0.710nMAssay Description:Displacement of [125I]IABN from human dopamine D3 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Homo sapiens (Human))
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50149708(5-Iodo-benzofuran-2-carboxylic acid {4-[4-(2-metho...)
Affinity DataKi:  0.720nMAssay Description:Displacement of [125]IABN from human D3 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
National Institute On Drug Abuse And The National Institute On Alcohol Abuse

Curated by ChEMBL
LigandPNGBDBM50256672(CHEMBL4078283)
Affinity DataKi:  0.741nMAssay Description:Displacement of [3H]DAMGO from mu opioid receptor in rat brain after 60 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Rattus norvegicus (rat))
Northeastern University

Curated by ChEMBL
LigandPNGBDBM50172553(CHEMBL68641 | [1-(1-Methyl-piperidin-2-ylmethyl)-1...)
Affinity DataKi:  0.75nMAssay Description:Binding affinity towards rat forebrain cannabinoid receptor 1 using [3H]CP-55940More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
National Institute On Drug Abuse And The National Institute On Alcohol Abuse

Curated by ChEMBL
LigandPNGBDBM50121638(1-[3-(Adamantan-1-ylamino)-3,4-dihydro-1H-isoquino...)
Affinity DataKi:  0.760nMAssay Description:Binding affinity of compound towards the Opioid receptor mu 1 in rat synaptosomal membrane was determined using [3H]-DAGO as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Rattus norvegicus (Rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50253393(CHEMBL495327 | Naphthalene-2-carboxylic acid (4-{2...)
Affinity DataKi:  0.800nMAssay Description:Displacement of [3H]R(+)-7-OH-DPAT from Sprague-Dawley rat dopamine D3 receptor after 90 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Homo sapiens (Human))
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50119390(Benzo[b]thiophene-2-carboxylic acid {4-[4-(2,3-dic...)
Affinity DataKi:  0.810nMAssay Description:Displacement of [125]IABN from human D3 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Homo sapiens (Human))
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50119384(Benzofuran-2-carboxylic acid {4-[4-(2,3-dichloro-p...)
Affinity DataKi:  0.810nMAssay Description:Displacement of [125]IABN from human D3 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50515232(CHEMBL4471817)
Affinity DataKi:  0.844nMAssay Description:Displacement of [3H]-(R)-(+)-7-OH-DPAT from recombinant human D2L receptor expressed in HEK293 cell membranes measured after 90 mins by microbeta sci...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
National Institute On Drug Abuse

Curated by ChEMBL
LigandPNGBDBM50308923(2-phenethyl-1,2,3,4,4a,9a-hexahydrobenzofuro[2,3-c...)
Affinity DataKi:  0.900nMAssay Description:Displacement of [3H]DAMGO from mu opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50258612(3-Fluoro-5-cyano-1-(2-methylthiazol-4-ylethynyl)be...)
Affinity DataKi:  0.900nMAssay Description:Displacement of [3H]MPEP from cloned mGluR5 (unknown origin) expressed in HEK293T cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
National Institute On Drug Abuse

Curated by ChEMBL
LigandPNGBDBM50493039(CHEMBL2418733)
Affinity DataKi:  0.900nMAssay Description:Displacement of [3H]DAMGO from human mu opioid receptor expressed in CHO cells after 2 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Homo sapiens (Human))
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50119377(Benzofuran-2-carboxylic acid {4-[4-(2-methoxy-phen...)
Affinity DataKi:  0.920nMAssay Description:Displacement of [125]IABN from human D3 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Homo sapiens (Human))
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50253636(CHEMBL461835 | endo-8-(Benzofur-3-ylmethyl)-3-(4-b...)
Affinity DataKi:  0.920nMAssay Description:Displacement of [125I]IABN from human dopamine D3 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Rattus norvegicus (Rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50400515(CHEMBL2203402)
Affinity DataKi:  0.930nMAssay Description:Displacement of [3H]R(+)-7-OH-DPAT from Sprague-Dawley rat dopamine D3 receptor after 90 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Massachusetts College Of Pharmacy And Health Sciences

Curated by ChEMBL
LigandPNGBDBM50202396((RR/SS)-2-[1-(3,4-dichlorophenyl)butyl]piperidine ...)
Affinity DataKi:  0.970nMAssay Description:Displacement of [125I]RTI-55 from human DAT expressing HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Massachusetts College Of Pharmacy And Health Sciences

Curated by ChEMBL
LigandPNGBDBM50202396((RR/SS)-2-[1-(3,4-dichlorophenyl)butyl]piperidine ...)
Affinity DataKi:  0.970nMAssay Description:Displacement of [125I]RTI-55 from human DAT expressing HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Homo sapiens (Human))
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50097841(CHEMBL3588919)
Affinity DataKi:  1nMAssay Description:Displacement of [3H]-N-methylspiperone from human dopamine D3 receptor expressed in HEK293 cell membranes after 1 hr by liquid scintillation counting...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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