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Found 772 with Last Name = 'eltze' and Initial = 't'
TargetD(2) dopamine receptor(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50048302(4-[(R)-5-(4-Phenyl-3,6-dihydro-2H-pyridin-1-ylmeth...)
Affinity DataKi:  0.200nMAssay Description:Binding affinity of the compound towards human Dopamine receptor D2L evaluated using [3H]-N-0437More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Homo sapiens (Human))
University Centre For Pharmacy

Curated by ChEMBL
LigandPNGBDBM50020217((4aR,10bR)-4-propyl-3,4,4a,5,6,10b-hexahydro-2H-na...)
Affinity DataKi:  0.210nMAssay Description:Tested for antagonist binding affinity by measuring displacement of [3H]spiperone from Human Dopamine receptor D3 expressed in CHO K-1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Homo sapiens (Human))
University Centre For Pharmacy

Curated by ChEMBL
LigandPNGBDBM50052535(3-[4-(4-Phenyl-3,6-dihydro-2H-pyridin-1-yl)-but-1-...)
Affinity DataKi:  0.360nMAssay Description:Binding affinity of the compound to rat Dopamine receptor D3 expressed in CHO cells was determined using [125 I] iodosulpride as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Homo sapiens (Human))
University Centre For Pharmacy

Curated by ChEMBL
LigandPNGBDBM50002173(3-(4-(3,6-dihydro-4-phenyl-1(2H)-pyridinyl)butyl)-...)
Affinity DataKi:  0.400nMAssay Description:Binding affinity against human Dopamine receptor D3 in CHO-K1 cells using [3H]-Spiperone as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50281503(4-{4-[4-(4-Methoxy-phenyl)-3,6-dihydro-2H-pyridin-...)
Affinity DataKi:  0.450nMAssay Description:Binding affinity against sigma receptor in guinea pig brain preparation was estimated using [3H]-3-PPP as radioligandMore data for this Ligand-Target Pair
In DepthDetails Article
TargetD(2) dopamine receptor(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM21398(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Affinity DataKi:  0.5nMAssay Description:Tested for binding affinity towards human D2L receptor using [3H]-spiperone as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetD(3) dopamine receptor(Homo sapiens (Human))
University Centre For Pharmacy

Curated by ChEMBL
LigandPNGBDBM50048302(4-[(R)-5-(4-Phenyl-3,6-dihydro-2H-pyridin-1-ylmeth...)
Affinity DataKi:  0.520nMAssay Description:Binding affinity of the compound towards human Dopamine receptor D3 evaluated using [3H]-spiperoneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Pfizer

LigandPNGBDBM28586(1-{3-[(3-chlorophenyl)methoxy]-2-methylphenyl}pipe...)
Affinity DataKi:  0.600nM ΔG°:  -52.1kJ/molepH: 7.5 T: 2°CAssay Description:Competition experiments were performed in the presence radioligand with membrane protein (obtained from cells expressing the receptor) and test compo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Pfizer

LigandPNGBDBM28583(5-chloro-N-[4-methoxy-3-(piperazin-1-yl)phenyl]-3-...)
Affinity DataKi:  0.660nM ΔG°:  -51.9kJ/molepH: 7.5 T: 2°CAssay Description:Competition experiments were performed in the presence radioligand with membrane protein (obtained from cells expressing the receptor) and test compo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50052531(4-[4-(4-Phenyl-3,6-dihydro-2H-pyridin-1-yl)-but-1-...)
Affinity DataKi:  0.670nMAssay Description:Binding affinityagainst Dopamine receptor D2 in CHO-K1 cells using radioligand [3H]-NPA binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Homo sapiens (Human))
University Centre For Pharmacy

Curated by ChEMBL
LigandPNGBDBM21398(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Affinity DataKi:  0.690nMAssay Description:Tested for binding affinity towards human D3 receptor using [3H]-spiperone as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50281500(4-{4-[4-(4-Chloro-phenyl)-3,6-dihydro-2H-pyridin-1...)
Affinity DataKi:  1.04nMAssay Description:Binding affinity against sigma receptor in guinea pig brain preparation was estimated using [3H]-3-PPP as radioligandMore data for this Ligand-Target Pair
In DepthDetails Article
TargetD(2) dopamine receptor(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50090828((-)-1-Propyl-2,3,10,10a-tetrahydro-1H,4aH-4-oxa-9-...)
Affinity DataKi:  1.10nMAssay Description:Tested for agonist binding affinity by measuring displacement of [3H]NPA from Human Dopamine receptor D2L expressed in CHO K-1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Pfizer

LigandPNGBDBM28584(1-[3-(benzyloxy)-2-methylphenyl]piperazine | tolyl...)
Affinity DataKi:  1.30nM ΔG°:  -50.2kJ/molepH: 7.5 T: 2°CAssay Description:Competition experiments were performed in the presence radioligand with membrane protein (obtained from cells expressing the receptor) and test compo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Homo sapiens (Human))
University Centre For Pharmacy

Curated by ChEMBL
LigandPNGBDBM50092173(CHEMBL325710 | N*6*,N*6*-Dipropyl-6,7-dihydro-5H-1...)
Affinity DataKi:  1.40nMAssay Description:in vitro binding affinity was determined on human Dopamine receptor D3 expressed in chinese hamster ovary(CHO) K-1 cells using [3H]spiperone as radio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Homo sapiens (Human))
University Centre For Pharmacy

Curated by ChEMBL
LigandPNGBDBM50010586((+)-1-Propyl-2,3,10,10a-tetrahydro-1H,4aH-4,9-diox...)
Affinity DataKi:  1.40nMAssay Description:Tested for antagonist binding affinity by measuring displacement of [3H]spiperone from Human Dopamine receptor D3 expressed in CHO K-1 cellsMore data for this Ligand-Target Pair
TargetD(3) dopamine receptor(Homo sapiens (Human))
University Centre For Pharmacy

Curated by ChEMBL
LigandPNGBDBM50010586((+)-1-Propyl-2,3,10,10a-tetrahydro-1H,4aH-4,9-diox...)
Affinity DataKi:  1.40nMAssay Description:Tested for antagonist binding affinity by measuring displacement of [3H]spiperone from Human Dopamine receptor D3 expressed in CHO K-1 cellsMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Pfizer

LigandPNGBDBM28635(2-methyl-3-(piperidin-4-yl)phenyl naphthalene-1-su...)
Affinity DataKi:  1.5nM ΔG°:  -50.4kJ/moleT: 2°CAssay Description:Competition experiments were performed in the presence radioligand with membrane protein (obtained from cells expressing the receptor) and test compo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Homo sapiens (Human))
University Centre For Pharmacy

Curated by ChEMBL
LigandPNGBDBM50090829((trans)1-Propyl-2,3,10,10a-tetrahydro-1H,4aH-4-oxa...)
Affinity DataKi:  1.60nMAssay Description:Tested for antagonist binding affinity by measuring displacement of [3H]spiperone from Human Dopamine receptor D3 expressed in CHO K-1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50281497(4-{4-[4-(4-Fluoro-phenyl)-3,6-dihydro-2H-pyridin-1...)
Affinity DataKi:  1.75nMAssay Description:Binding affinity against sigma receptor in guinea pig brain preparation was estimated using [3H]-3-PPP as radioligandMore data for this Ligand-Target Pair
In DepthDetails Article
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM21398(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Affinity DataKi:  1.86nMAssay Description:Tested for binding affinity towards rat striatal D2 receptor using [3H]-spiperone as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50052532(6-[4-(4-Phenyl-3,6-dihydro-2H-pyridin-1-yl)-but-1-...)
Affinity DataKi:  1.90nMAssay Description:Binding affinityagainst Dopamine receptor D2 in CHO-K1 cells using radioligand [3H]-NPA binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(BOVINE)
University Centre For Pharmacy

Curated by ChEMBL
LigandPNGBDBM50123627((S)-6-Dipropylamino-5,6,7,8-tetrahydro-naphthalene...)
Affinity DataKi:  2nMAssay Description:Binding affinity of compound for Dopamine receptor D2 using [3H]-N-0437More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50281504(4-[4-(4-Thiophen-2-yl-3,6-dihydro-2H-pyridin-1-yl)...)
Affinity DataKi:  2.13nMAssay Description:Binding affinity against sigma receptor in guinea pig brain preparation was estimated using [3H]-3-PPP as radioligandMore data for this Ligand-Target Pair
In DepthDetails Article
TargetD(2) dopamine receptor(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50048300(4-(1-[methyl cyclohex-3-en-3-yl phenol]-1,2,3,6-te...)
Affinity DataKi:  2.20nMAssay Description:Binding affinity of the compound towards human Dopamine receptor D2L evaluated using [3H]-N-0437More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50001955((-)6-Methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]qu...)
Affinity DataKi:  2.20nMAssay Description:Tested for binding affinity towards rat striatal D2 receptor using [3H]-NPA as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Pfizer

LigandPNGBDBM28620(2-[1-(3-chlorophenyl)-2,2,2-trifluoroethoxy]-3-met...)
Affinity DataKi:  2.40nM ΔG°:  -49.2kJ/moleT: 2°CAssay Description:Competition experiments were performed in the presence radioligand with membrane protein (obtained from cells expressing the receptor) and test compo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Pfizer

LigandPNGBDBM28594(4-{3-[(3-fluorophenyl)methoxy]-2-methylphenyl}pipe...)
Affinity DataKi:  2.5nM ΔG°:  -48.6kJ/molepH: 7.5 T: 2°CAssay Description:Competition experiments were performed in the presence radioligand with membrane protein (obtained from cells expressing the receptor) and test compo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Homo sapiens (Human))
University Centre For Pharmacy

Curated by ChEMBL
LigandPNGBDBM50052532(6-[4-(4-Phenyl-3,6-dihydro-2H-pyridin-1-yl)-but-1-...)
Affinity DataKi:  2.60nMAssay Description:Binding affinity against human Dopamine receptor D3 in CHO-K1 cells using [3H]-Spiperone as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Pfizer

LigandPNGBDBM28636(2-methyl-3-(piperidin-4-yl)phenyl naphthalene-2-su...)
Affinity DataKi:  2.70nM ΔG°:  -48.9kJ/moleT: 2°CAssay Description:Competition experiments were performed in the presence radioligand with membrane protein (obtained from cells expressing the receptor) and test compo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50281498(4-[4-(4-Phenyl-3,6-dihydro-2H-pyridin-1-yl)-butyl]...)
Affinity DataKi:  2.72nMAssay Description:Binding affinity against sigma receptor in guinea pig brain preparation was estimated using [3H]-3-PPP as radioligandMore data for this Ligand-Target Pair
In DepthDetails Article
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Pfizer

LigandPNGBDBM28603(4-{3-[(1S)-1-(3-chlorophenyl)ethoxy]-2-methylpheny...)
Affinity DataKi:  2.80nM ΔG°:  -48.3kJ/molepH: 7.5 T: 2°CAssay Description:Competition experiments were performed in the presence radioligand with membrane protein (obtained from cells expressing the receptor) and test compo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Homo sapiens (Human))
University Centre For Pharmacy

Curated by ChEMBL
LigandPNGBDBM50090828((-)-1-Propyl-2,3,10,10a-tetrahydro-1H,4aH-4-oxa-9-...)
Affinity DataKi:  2.90nMAssay Description:Tested for antagonist binding affinity by measuring displacement of [3H]spiperone from Human Dopamine receptor D3 expressed in CHO K-1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50026553((+)-6-Dipropylamino-5,6,7,8-tetrahydro-naphthalene...)
Affinity DataKi:  3nMAssay Description:In vitro binding affinity of the compound towards Dopamine receptor D2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(1A) dopamine receptor(BOVINE)
University Centre For Pharmacy

Curated by ChEMBL
LigandPNGBDBM50123627((S)-6-Dipropylamino-5,6,7,8-tetrahydro-naphthalene...)
Affinity DataKi:  3nMAssay Description:Binding affinity of compound for Dopamine receptor D1 using [3H]-SCH- 23390More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50281499(4-[4-(4-Naphthalen-2-yl-3,6-dihydro-2H-pyridin-1-y...)
Affinity DataKi:  3.07nMAssay Description:Binding affinity against sigma receptor in guinea pig brain preparation was estimated using [3H]-3-PPP as radioligandMore data for this Ligand-Target Pair
In DepthDetails Article
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50052528(3-[4-(4-Phenyl-3,6-dihydro-2H-pyridin-1-yl)-but-1-...)
Affinity DataKi:  3.30nMAssay Description:Binding affinity against Dopamine receptor D2 in CHO-K1 cells using radioligand [3H]-NPA binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Pfizer

LigandPNGBDBM28595(4-{3-[(3-chlorophenyl)methoxy]-2-methylphenyl}pipe...)
Affinity DataKi:  3.30nM ΔG°:  -47.9kJ/molepH: 7.5 T: 2°CAssay Description:Competition experiments were performed in the presence radioligand with membrane protein (obtained from cells expressing the receptor) and test compo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50048299(4-Phenyl-1-((R)-3-phenyl-cyclohex-3-enylmethyl)-1,...)
Affinity DataKi:  3.30nMAssay Description:Tested for binding affinity towards rat striatal D2 receptor using [3H]-NPA as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Homo sapiens (Human))
University Centre For Pharmacy

Curated by ChEMBL
LigandPNGBDBM50048300(4-(1-[methyl cyclohex-3-en-3-yl phenol]-1,2,3,6-te...)
Affinity DataKi:  3.40nMAssay Description:Binding affinity of the compound towards human Dopamine receptor D3 evaluated using [3H]-spiperoneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Pfizer

LigandPNGBDBM28623(4-[3-(3-chlorophenoxymethyl)-2-methylphenyl]piperi...)
Affinity DataKi:  3.5nM ΔG°:  -48.3kJ/moleT: 2°CAssay Description:Competition experiments were performed in the presence radioligand with membrane protein (obtained from cells expressing the receptor) and test compo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50048302(4-[(R)-5-(4-Phenyl-3,6-dihydro-2H-pyridin-1-ylmeth...)
Affinity DataKi:  3.5nMAssay Description:Binding affinity of the compound towards human Dopamine receptor D2L evaluated using [3H]-spiperoneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Homo sapiens (Human))
University Centre For Pharmacy

Curated by ChEMBL
LigandPNGBDBM50090832((cis)1-Propyl-2,3,10,10a-tetrahydro-1H,4aH-4-oxa-9...)
Affinity DataKi:  3.60nMAssay Description:Tested for antagonist binding affinity by measuring displacement of [3H]spiperone from Human Dopamine receptor D3 expressed in CHO K-1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50052533(4-[4-(4-Phenyl-3,6-dihydro-2H-pyridin-1-yl)-but-1-...)
Affinity DataKi:  4.10nMAssay Description:Binding affinityagainst Dopamine receptor D2 in CHO-K1 cells using radioligand [3H]-NPA binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Pfizer

LigandPNGBDBM28621(3-methyl-4-(piperidin-4-yl)-2-[2,2,2-trifluoro-1-(...)
Affinity DataKi:  4.30nM ΔG°:  -47.8kJ/moleT: 2°CAssay Description:Competition experiments were performed in the presence radioligand with membrane protein (obtained from cells expressing the receptor) and test compo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50048301(4-[1-((R)-3-Phenyl-cyclohex-3-enylmethyl)-1,2,3,6-...)
Affinity DataKi:  5.70nMAssay Description:Binding affinity of the compound towards human Dopamine receptor D2L evaluated using [3H]-N-0437More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Pfizer

LigandPNGBDBM28628(2-methyl-3-(piperidin-4-yl)phenyl 2-chlorobenzene-...)
Affinity DataKi:  5.80nM ΔG°:  -47.0kJ/moleT: 2°CAssay Description:Competition experiments were performed in the presence radioligand with membrane protein (obtained from cells expressing the receptor) and test compo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50281502(4-[4-(4-p-Tolyl-3,6-dihydro-2H-pyridin-1-yl)-butyl...)
Affinity DataKi:  5.86nMAssay Description:Binding affinity against sigma receptor in guinea pig brain preparation was estimated using [3H]-3-PPP as radioligandMore data for this Ligand-Target Pair
In DepthDetails Article
TargetD(2) dopamine receptor(BOVINE)
University Centre For Pharmacy

Curated by ChEMBL
LigandPNGBDBM50123625((S)-6-[Propyl-(2-thiophen-2-yl-ethyl)-amino]-5,6,7...)
Affinity DataKi:  6nMAssay Description:Binding affinity of compound for Dopamine receptor D2 using [3H]-N-0437More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50020217((4aR,10bR)-4-propyl-3,4,4a,5,6,10b-hexahydro-2H-na...)
Affinity DataKi:  6.20nMAssay Description:Human Dopamine receptor D2L affinities to determine agonist activity, using [3H]spip as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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