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Found 894 with Last Name = 'flippen-anderson' and Initial = 'jl'
TargetDelta-type opioid receptor(Rattus norvegicus (rat))
National Institute Of Environmental Health Sciences

Curated by ChEMBL
LigandPNGBDBM50121640(2-[2-Dimethylamino-3-(4-hydroxy-2,6-dimethyl-pheny...)
Affinity DataKi:  0.120nMAssay Description:Binding affinity of compound towards the Opioid receptor delta 1 in rat synaptosomal membrane was determined using [3H]-DPDPE as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Rattus norvegicus (rat))
National Institute Of Environmental Health Sciences

Curated by ChEMBL
LigandPNGBDBM50121639(1-[3-(Adamantan-1-ylamino)-3,4-dihydro-1H-isoquino...)
Affinity DataKi:  0.160nMAssay Description:Binding affinity of compound towards the Opioid receptor delta 1 in rat synaptosomal membrane was determined using [3H]-DPDPE as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Mus musculus (Mouse))
Northeastern University

Curated by ChEMBL
LigandPNGBDBM50172545((2-Iodo-phenyl)-[1-((S)-1-methyl-piperidin-2-ylmet...)
Affinity DataKi:  0.200nMAssay Description:Binding affinity towards mouse hippocampal membranes cannabinoid receptor 1 using [131I]-(R)-8More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Rattus norvegicus (rat))
National Institute Of Environmental Health Sciences

Curated by ChEMBL
LigandPNGBDBM50121638(1-[3-(Adamantan-1-ylamino)-3,4-dihydro-1H-isoquino...)
Affinity DataKi:  0.260nMAssay Description:Binding affinity of compound towards the Opioid receptor delta 1 in rat synaptosomal membrane was determined using [3H]-DPDPE as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
National Institute Of Diabetes And Digestive And Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50021214(CHEMBL300019 | CHEMBL537996 | [3-(3,4-Dichloro-phe...)
Affinity DataKi:  0.300nMAssay Description:Displacement of [125I]RTI-55 from serotonin transporter of frozen rat caudate membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(GUINEA PIG)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50067447(3-((R)-9-Methyl-2-phenethyl-2-aza-bicyclo[3.3.1]no...)
Affinity DataKi:  0.340nMAssay Description:Inhibition of [35S]-GTP-gammaS, binding in guinea pig caudate stimulated by DAMGO (Opioid receptor mu 1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
National Institute Of Diabetes And Digestive And Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50021226(CHEMBL296602 | Indatraline | [3-(3,4-Dichloro-phen...)
Affinity DataKi:  0.400nMAssay Description:Displacement of [125I]RTI-55 from serotonin transporter of frozen rat caudate membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM60212((4R,4aS,7aR,12bS)-3-(cyclopropylmethyl)-4a,9-bis(o...)
Affinity DataKi:  0.560nMAssay Description:Binding affinity against Opioid receptor mu 1 using [3H]naloxone as radioligand.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetMu-type opioid receptor(GUINEA PIG)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM60212((4R,4aS,7aR,12bS)-3-(cyclopropylmethyl)-4a,9-bis(o...)
Affinity DataKi:  0.560nMAssay Description:Binding affinity was determined as ability to displace [3H]-U-69, radioligand from Opioid receptor kappa 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(RAT)
National Institute Of Diabetes And Digestive And Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50366775(BENZTROPINE | Benzatropine)
Affinity DataKi:  0.590nMAssay Description:Binding affinity against Muscarinic receptor from rat brain membranes using [3H]pirenzepineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
National Institute Of Diabetes And Digestive And Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50146043(CHEMBL543372 | [(1R,3S)-3-(3,4-Dichloro-phenyl)-6-...)
Affinity DataKi:  0.700nMAssay Description:Binding affinity for DA transporter using [125I]RTI-55 in frozen rat caudate membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
National Institute Of Diabetes And Digestive And Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50146042(1-(3,4-Dichloro-phenyl)-3-diethylamino-indan-5-ol ...)
Affinity DataKi:  0.700nMAssay Description:Displacement of [125I]RTI-55 from serotonin transporter of frozen rat caudate membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Rattus norvegicus (rat))
Northeastern University

Curated by ChEMBL
LigandPNGBDBM50172553(CHEMBL68641 | [1-(1-Methyl-piperidin-2-ylmethyl)-1...)
Affinity DataKi:  0.75nMAssay Description:Binding affinity towards rat forebrain cannabinoid receptor 1 using [3H]CP-55940More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
National Institute Of Environmental Health Sciences

Curated by ChEMBL
LigandPNGBDBM50121638(1-[3-(Adamantan-1-ylamino)-3,4-dihydro-1H-isoquino...)
Affinity DataKi:  0.760nMAssay Description:Binding affinity of compound towards the Opioid receptor mu 1 in rat synaptosomal membrane was determined using [3H]-DAGO as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Rattus norvegicus (rat))
National Institute Of Environmental Health Sciences

Curated by ChEMBL
LigandPNGBDBM50039026(4-((R)-((2S,5R)-4-allyl-2,5-dimethylpiperazin-1-yl...)
Affinity DataKi:  0.910nMAssay Description:Affinity of [H]DADLE to the delta opioid receptor from rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(GUINEA PIG)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM60212((4R,4aS,7aR,12bS)-3-(cyclopropylmethyl)-4a,9-bis(o...)
Affinity DataKi:  0.930nMAssay Description:Compound was tested for the inhibition of [35S]-GTP-gammaS, binding in Guinea pig Caudate stimulated by the opioid receptor agonist Mu-DAMGOMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(GUINEA PIG)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM60212((4R,4aS,7aR,12bS)-3-(cyclopropylmethyl)-4a,9-bis(o...)
Affinity DataKi:  0.930nMAssay Description:Inhibition of [35S]-GTP-gammaS, binding in guinea pig caudate stimulated by DAMGO (Opioid receptor mu 1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
National Institute Of Diabetes And Digestive And Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50094798(CHEMBL543688 | [3-(3,4-Dichloro-phenyl)-6-methoxy-...)
Affinity DataKi:  1.10nMAssay Description:Binding affinity for serotonin transporter labeled with [125 I]RTI-55More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
National Institute Of Diabetes And Digestive And Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50021214(CHEMBL300019 | CHEMBL537996 | [3-(3,4-Dichloro-phe...)
Affinity DataKi:  1.10nMAssay Description:Displacement of from norepinephrine transporter of frozen rat caudate membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
National Institute Of Environmental Health Sciences

Curated by ChEMBL
LigandPNGBDBM50121639(1-[3-(Adamantan-1-ylamino)-3,4-dihydro-1H-isoquino...)
Affinity DataKi:  1.12nMAssay Description:Binding affinity of compound towards the Opioid receptor mu 1 in rat synaptosomal membrane was determined using [3H]-DAGO as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
National Institute Of Diabetes And Digestive And Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50095137((3S,4R)-4-(4-Chloro-phenyl)-1-methyl-piperidine-3-...)
Affinity DataKi:  1.20nMAssay Description:Inhibition of high affinity serotonin uptake into rat synaptosomes using [3H]5-HTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50067447(3-((R)-9-Methyl-2-phenethyl-2-aza-bicyclo[3.3.1]no...)
Affinity DataKi:  1.30nMAssay Description:Inhibition of [35S]-GTP-gammaS, binding in guinea pig caudate stimulated by U69,593 in Opioid receptor kappa 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Mus musculus (Mouse))
Northeastern University

Curated by ChEMBL
LigandPNGBDBM50172545((2-Iodo-phenyl)-[1-((S)-1-methyl-piperidin-2-ylmet...)
Affinity DataKi:  1.30nMAssay Description:Binding affinity towards mouse hippocampal membranes cannabinoid receptor 1 using [3H]SR-141,716AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
National Institute Of Environmental Health Sciences

Curated by ChEMBL
LigandPNGBDBM60212((4R,4aS,7aR,12bS)-3-(cyclopropylmethyl)-4a,9-bis(o...)
Affinity DataKi:  1.40nMAssay Description:Binding affinity was determined as ability to displace [3H]-DAMGO radioligand from Mu opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
National Institute Of Environmental Health Sciences

Curated by ChEMBL
LigandPNGBDBM60212((4R,4aS,7aR,12bS)-3-(cyclopropylmethyl)-4a,9-bis(o...)
Affinity DataKi:  1.40nMAssay Description:Binding activity against Opioid receptor mu 1 using [3H]-DAMGO as radioligand in rat brain membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50045767((+)-N-phenethyl trans-3(R),4(R)-dimethyl-4-(3-hydr...)
Affinity DataKi:  1.5nMAssay Description:Binding affinity against Opioid receptor mu 1 using [3H]-Naloxone as radioligand.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(GUINEA PIG)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50045767((+)-N-phenethyl trans-3(R),4(R)-dimethyl-4-(3-hydr...)
Affinity DataKi:  1.5nMAssay Description:Binding affinity was determined against Mu opioid receptor using [3H]-Naltrexone as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Rattus norvegicus (rat))
National Institute Of Environmental Health Sciences

Curated by ChEMBL
LigandPNGBDBM50039029((+)-4-((alpha R)-((2S,5R)-4-allyl-2,5-dimethylpipe...)
Affinity DataKi:  1.57nMAssay Description:Affinity of [H]DADLE to the delta opioid receptor from rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Mus musculus (Mouse))
Northeastern University

Curated by ChEMBL
LigandPNGBDBM21281((11R)-2-methyl-11-(morpholin-4-ylmethyl)-3-(naphth...)
Affinity DataKi:  1.60nMAssay Description:Binding affinity towards mouse hippocampal membranes cannabinoid receptor 1 using [131I]-(R)-8More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
National Institute Of Diabetes And Digestive And Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50029792(5-(3-Hydroxy-phenyl)-8-[1-(3-iodo-phenyl)-meth-(E)...)
Affinity DataKi:  1.62nMAssay Description:Ability to inhibit [3H]-(+)-pentazocine binding to guinea pig brain Sigma receptor type 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
National Institute Of Diabetes And Digestive And Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50021226(CHEMBL296602 | Indatraline | [3-(3,4-Dichloro-phen...)
Affinity DataKi:  1.70nMAssay Description:Binding affinity for DA transporter using [125I]RTI-55 in frozen rat caudate membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
National Institute Of Diabetes And Digestive And Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50094791(CHEMBL542500 | [3-(3,4-Dichloro-phenyl)-4-methoxy-...)
Affinity DataKi:  1.70nMAssay Description:Binding affinity for dopamine transporter (DAT) labeled with [125 I]RTI-55More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
National Institute Of Diabetes And Digestive And Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50029787(5-(3-Hydroxy-phenyl)-8-[1-(4-iodo-phenyl)-meth-(E)...)
Affinity DataKi:  1.71nMAssay Description:Ability to inhibit [3H]-(+)-pentazocine binding to guinea pig brain Sigma receptor type 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Rattus norvegicus (rat))
National Institute Of Environmental Health Sciences

Curated by ChEMBL
LigandPNGBDBM50098462(4-[(1-Allyl-3-methyl-piperidin-4-yl)-(3-hydroxy-ph...)
Affinity DataKi:  1.85nMAssay Description:Affinity of [H]DADLE to the delta opioid receptor from rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
National Institute Of Diabetes And Digestive And Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50029786(5-(3-Hydroxy-phenyl)-8-[1-(4-methoxy-phenyl)-meth-...)
Affinity DataKi:  1.90nMAssay Description:Ability to inhibit [3H]-(+)-pentazocine binding to guinea pig brain Sigma receptor type 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(MOUSE)
Northeastern University

Curated by ChEMBL
LigandPNGBDBM50172553(CHEMBL68641 | [1-(1-Methyl-piperidin-2-ylmethyl)-1...)
Affinity DataKi:  1.91nMAssay Description:Binding affinity towards mouse spleen cannabinoid receptor 2 using [3H]CP-55940More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
National Institute Of Diabetes And Digestive And Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50021226(CHEMBL296602 | Indatraline | [3-(3,4-Dichloro-phen...)
Affinity DataKi:  2nMAssay Description:Reuptake inhibitory activity against dopamine DA transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
National Institute Of Diabetes And Digestive And Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50146040((1R,3S)-1-(3,4-Dichloro-phenyl)-3-methylamino-inda...)
Affinity DataKi:  2nMAssay Description:Reuptake inhibitory activity against Serotonin transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
National Institute Of Diabetes And Digestive And Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50146040((1R,3S)-1-(3,4-Dichloro-phenyl)-3-methylamino-inda...)
Affinity DataKi:  2nMAssay Description:Displacement of [125I]RTI-55 from serotonin transporter of frozen rat caudate membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
National Institute Of Diabetes And Digestive And Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50099300(3N-{8-[4-(4-chlorophenyl)-1-methyl-(3S,4R)-hexahyd...)
Affinity DataKi:  2.10nMAssay Description:Inhibition of high affinity serotonin uptake into rat synaptosomes using [3H]5-HTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM60212((4R,4aS,7aR,12bS)-3-(cyclopropylmethyl)-4a,9-bis(o...)
Affinity DataKi:  2.10nMAssay Description:Inhibition of [35S]-GTP-gammaS, binding in guinea pig caudate stimulated by U69,593 in Opioid receptor kappa 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM60212((4R,4aS,7aR,12bS)-3-(cyclopropylmethyl)-4a,9-bis(o...)
Affinity DataKi:  2.10nMAssay Description:Binding affinity was determined against Mu opioid receptor using [3H]naltrexone as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
National Institute Of Environmental Health Sciences

Curated by ChEMBL
LigandPNGBDBM50029789(5-(3-Hydroxy-phenyl)-2-methyl-8-[1-naphthalen-2-yl...)
Affinity DataKi:  2.20nMAssay Description:Ability to inhibit [3H]-DAMGO binding to rat brain Opioid receptor mu 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Rattus norvegicus (rat))
Northeastern University

Curated by ChEMBL
LigandPNGBDBM50172545((2-Iodo-phenyl)-[1-((S)-1-methyl-piperidin-2-ylmet...)
Affinity DataKi:  2.80nMAssay Description:Binding affinity towards rat forebrain cannabinoid receptor 1 using [3H]CP-55940More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(MOUSE)
Northeastern University

Curated by ChEMBL
LigandPNGBDBM50172545((2-Iodo-phenyl)-[1-((S)-1-methyl-piperidin-2-ylmet...)
Affinity DataKi:  2.90nMAssay Description:Binding affinity towards mouse spleen cannabinoid receptor 2 using [3H]CP-55940More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
National Institute Of Diabetes And Digestive And Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50146040((1R,3S)-1-(3,4-Dichloro-phenyl)-3-methylamino-inda...)
Affinity DataKi:  3nMAssay Description:Reuptake inhibitory activity against dopamine DA transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
National Institute Of Diabetes And Digestive And Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50021226(CHEMBL296602 | Indatraline | [3-(3,4-Dichloro-phen...)
Affinity DataKi:  3nMAssay Description:Reuptake inhibitory activity against Serotonin transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
National Institute Of Diabetes And Digestive And Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50021213(1-(3,4-Dichloro-phenyl)-3-methylamino-indan-5-ol |...)
Affinity DataKi:  3nMAssay Description:Displacement of [125I]RTI-55 from serotonin transporter of frozen rat caudate membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
National Institute Of Diabetes And Digestive And Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50029791(8-[1-(3-Chloro-phenyl)-meth-(E)-ylidene]-5-(3-hydr...)
Affinity DataKi:  3.10nMAssay Description:Ability to inhibit [3H]-(+)-pentazocine binding to guinea pig brain Sigma receptor type 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
National Institute Of Environmental Health Sciences

Curated by ChEMBL
LigandPNGBDBM50067447(3-((R)-9-Methyl-2-phenethyl-2-aza-bicyclo[3.3.1]no...)
Affinity DataKi:  3.10nMAssay Description:Binding activity against Opioid receptor mu 1 using [3H]-DAMGO as radioligand in rat brain membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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