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Found 468 with Last Name = 'frearson' and Initial = 'j'
TargetPteridine reductase(Trypanosoma brucei brucei)
University Of Dundee

LigandPNGBDBM31801(2-aminobenzimidazole deriv., 12)
Affinity DataKi:  7nM ΔG°:  -46.2kJ/molepH: 6.0 T: 2°CAssay Description:TbPTR1 activity was measured in 96-well microtiter plates via reduction of cytochrome c (cytc) as a result of the enzymatic production of tetrahydrob...More data for this Ligand-Target Pair
TargetPteridine reductase(Trypanosoma brucei brucei)
University Of Dundee

LigandPNGBDBM31800(2-aminobenzimidazole deriv., 11)
Affinity DataKi:  47nM ΔG°:  -41.5kJ/molepH: 6.0 T: 2°CAssay Description:TbPTR1 activity was measured in 96-well microtiter plates via reduction of cytochrome c (cytc) as a result of the enzymatic production of tetrahydrob...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTrypanothione reductase(Trypanosoma brucei brucei)
University Of Dundee

Curated by ChEMBL
LigandPNGBDBM50354279(CHEMBL1836603)
Affinity DataKi:  190nMAssay Description:Competitive inhibition of recombinant trypanothione reductase from Trypanosoma brucei brucei S427 by Lineweaver burk methodMore data for this Ligand-Target Pair
TargetTrypanothione reductase(Trypanosoma brucei brucei)
University Of Dundee

Curated by ChEMBL
LigandPNGBDBM50354268(CHEMBL1836570)
Affinity DataKi:  270nMAssay Description:Competitive inhibition of recombinant trypanothione reductase from Trypanosoma brucei brucei S427 by Lineweaver burk methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrypanothione reductase(Trypanosoma brucei brucei)
University Of Dundee

Curated by ChEMBL
LigandPNGBDBM50354299(CHEMBL1836378)
Affinity DataKi:  320nMAssay Description:Competitive inhibition of recombinant trypanothione reductase from Trypanosoma brucei brucei S427 by Lineweaver burk methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPteridine reductase(Trypanosoma brucei brucei)
University Of Dundee

LigandPNGBDBM31798(2-aminobenzimidazole deriv., 9)
Affinity DataKi:  400nM ΔG°:  -36.3kJ/molepH: 6.0 T: 2°CAssay Description:TbPTR1 activity was measured in 96-well microtiter plates via reduction of cytochrome c (cytc) as a result of the enzymatic production of tetrahydrob...More data for this Ligand-Target Pair
TargetTrypanothione reductase(Trypanosoma brucei brucei)
University Of Dundee

Curated by ChEMBL
LigandPNGBDBM50354257(CHEMBL1836559)
Affinity DataKi:  440nMAssay Description:Competitive inhibition of recombinant trypanothione reductase from Trypanosoma brucei brucei S427 by Lineweaver burk methodMore data for this Ligand-Target Pair
TargetPteridine reductase(Trypanosoma brucei brucei)
University Of Dundee

LigandPNGBDBM31799(2-aminobenzimidazole deriv., 10)
Affinity DataKi:  510nM ΔG°:  -35.7kJ/molepH: 6.0 T: 2°CAssay Description:TbPTR1 activity was measured in 96-well microtiter plates via reduction of cytochrome c (cytc) as a result of the enzymatic production of tetrahydrob...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndochitinase(Saccharomyces cerevisiae)
University Of Dundee

Curated by ChEMBL
LigandPNGBDBM50331851(Allosamidin | CHEMBL1230997)
Affinity DataKi:  610nMAssay Description:Inhibition of Saccharomyces cerevisiae CTS1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrypanothione reductase(Trypanosoma brucei brucei)
University Of Dundee

Curated by ChEMBL
LigandPNGBDBM50354279(CHEMBL1836603)
Affinity DataKi:  1.46E+3nMAssay Description:Mixed type inhibition of recombinant trypanothione reductase from Trypanosoma brucei brucei S427 by Lineweaver burk methodMore data for this Ligand-Target Pair
TargetTrypanothione reductase(Trypanosoma brucei brucei)
University Of Dundee

Curated by ChEMBL
LigandPNGBDBM50354268(CHEMBL1836570)
Affinity DataKi:  1.78E+3nMAssay Description:Mixed type inhibition of recombinant trypanothione reductase from Trypanosoma brucei brucei S427 by Lineweaver burk methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrypanothione reductase(Trypanosoma brucei brucei)
University Of Dundee

Curated by ChEMBL
LigandPNGBDBM50354257(CHEMBL1836559)
Affinity DataKi:  2.27E+3nMAssay Description:Mixed type inhibition of recombinant trypanothione reductase from Trypanosoma brucei brucei S427 by Lineweaver burk methodMore data for this Ligand-Target Pair
TargetEndochitinase(Saccharomyces cerevisiae)
University Of Dundee

Curated by ChEMBL
LigandPNGBDBM39302(CHEMBL228792 | MLS000101228 | N-(2-furanylmethyl)-...)
Affinity DataKi:  3.20E+3nMAssay Description:Inhibition of Saccharomyces cerevisiae CTS1More data for this Ligand-Target Pair
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
Teijin Pharma

Curated by ChEMBL
LigandPNGBDBM50395262(CHEMBL2163999)
Affinity DataKi:  6.00E+3nMAssay Description:Competitive inhibition of MAPKAP-K2 using KKLNRTLSVA as substrate and [33P]-gamma-ATP by Lineweaver-Burke plot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPteridine reductase(Trypanosoma brucei brucei)
University Of Dundee

LigandPNGBDBM31795(2-aminobenzimidazole deriv., 6)
Affinity DataKi:  9.80E+3nM ΔG°:  -28.4kJ/molepH: 6.0 T: 2°CAssay Description:TbPTR1 activity was measured in 96-well microtiter plates via reduction of cytochrome c (cytc) as a result of the enzymatic production of tetrahydrob...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPteridine reductase(Trypanosoma brucei brucei)
University Of Dundee

LigandPNGBDBM31794(2-aminobenzimidazole deriv., 4 | 5-Chloro-1H-benzo...)
Affinity DataKi:  1.06E+4nM ΔG°:  -28.2kJ/molepH: 6.0 T: 2°CAssay Description:TbPTR1 activity was measured in 96-well microtiter plates via reduction of cytochrome c (cytc) as a result of the enzymatic production of tetrahydrob...More data for this Ligand-Target Pair
TargetEndochitinase(Saccharomyces cerevisiae)
University Of Dundee

Curated by ChEMBL
LigandPNGBDBM10880(AZA | AZA2 | AZM acetazolamide | Acerazolamide, AA...)
Affinity DataKi:  2.10E+4nMAssay Description:Inhibition of Saccharomyces cerevisiae CTS1More data for this Ligand-Target Pair
TargetPteridine reductase(Trypanosoma brucei brucei)
University Of Dundee

LigandPNGBDBM31791(2-aminobenzothiazole deriv., 2)
Affinity DataKi:  2.11E+4nM ΔG°:  -26.5kJ/molepH: 6.0 T: 2°CAssay Description:TbPTR1 activity was measured in 96-well microtiter plates via reduction of cytochrome c (cytc) as a result of the enzymatic production of tetrahydrob...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPteridine reductase(Trypanosoma brucei brucei)
University Of Dundee

LigandPNGBDBM31797(2-aminobenzimidazole deriv., 8)
Affinity DataKi:  2.39E+4nM ΔG°:  -26.2kJ/molepH: 6.0 T: 2°CAssay Description:TbPTR1 activity was measured in 96-well microtiter plates via reduction of cytochrome c (cytc) as a result of the enzymatic production of tetrahydrob...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPteridine reductase(Trypanosoma brucei brucei)
University Of Dundee

LigandPNGBDBM31793(2-aminobenzothiazole deriv., 3)
Affinity DataKi:  1.41E+5nM ΔG°:  -21.8kJ/molepH: 6.0 T: 2°CAssay Description:TbPTR1 activity was measured in 96-well microtiter plates via reduction of cytochrome c (cytc) as a result of the enzymatic production of tetrahydrob...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPteridine reductase(Trypanosoma brucei brucei)
University Of Dundee

LigandPNGBDBM31796(2-aminobenzimidazole deriv., 7)
Affinity DataKi: >2.00E+5nM ΔG°: >-21.0kJ/molepH: 6.0 T: 2°CAssay Description:TbPTR1 activity was measured in 96-well microtiter plates via reduction of cytochrome c (cytc) as a result of the enzymatic production of tetrahydrob...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPteridine reductase(Trypanosoma brucei brucei)
University Of Dundee

LigandPNGBDBM7960(1H-1,3-benzodiazol-2-amine | 2-Aminobenzimidazole ...)
Affinity DataKi:  2.88E+5nM ΔG°:  -20.1kJ/molepH: 6.0 T: 2°CAssay Description:TbPTR1 activity was measured in 96-well microtiter plates via reduction of cytochrome c (cytc) as a result of the enzymatic production of tetrahydrob...More data for this Ligand-Target Pair
TargetEndochitinase(Saccharomyces cerevisiae)
University Of Dundee

Curated by ChEMBL
LigandPNGBDBM50331852(8-CHLORO-1,3-DIMETHYL-3,7-DIHYDRO-1H-PURINE-2,6-DI...)
Affinity DataKi:  3.40E+5nMAssay Description:Inhibition of Saccharomyces cerevisiae CTS1More data for this Ligand-Target Pair
TargetGlycylpeptide N-tetradecanoyltransferase(Leishmania major)
University Of Dundee

Curated by ChEMBL
LigandPNGBDBM50364113(CHEMBL1230468)
Affinity DataIC50:  2nMAssay Description:Inhibition of Leishmania major N-myristoyltransferase using [3H]myristoyl-CoA and GCGGSKVKPQPPQAK(biotin)-amide as substrate preincubated for 5 mins ...More data for this Ligand-Target Pair
TargetGlycylpeptide N-tetradecanoyltransferase 1(Homo sapiens (Human))
University Of Dundee

Curated by ChEMBL
LigandPNGBDBM50364113(CHEMBL1230468)
Affinity DataIC50:  3nMAssay Description:Inhibition of human N-myristoyltransferase 1 assessed as transfer of [3H]-myristic acid to a biotinylated substrate peptide (GCGGSKVKPQPPQAK(biotin)-...More data for this Ligand-Target Pair
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
Teijin Pharma

Curated by ChEMBL
LigandPNGBDBM50395284(CHEMBL2163996)
Affinity DataIC50:  3nMAssay Description:Inhibition of CDK2 after 60 mins using [33P]-gamma-ATP by liquid scintillation counterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycylpeptide N-tetradecanoyltransferase 2(Homo sapiens (Human))
University Of Dundee

Curated by ChEMBL
LigandPNGBDBM50364113(CHEMBL1230468)
Affinity DataIC50:  3nMAssay Description:Inhibition of human N-myristoyltransferase 2 assessed as transfer of [3H]-myristic acid to a biotinylated substrate peptide (GCGGSKVKPQPPQAK(biotin)-...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycylpeptide N-tetradecanoyltransferase 1(Homo sapiens (Human))
University Of Dundee

Curated by ChEMBL
LigandPNGBDBM50364113(CHEMBL1230468)
Affinity DataIC50:  3nMAssay Description:Inhibition of human N-myristoyltransferase 1 using [3H]myristoyl-CoA and GCGGSKVKPQPPQAK(biotin)-amide as substrate preincubated for 5 mins prior sub...More data for this Ligand-Target Pair
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
Teijin Pharma

Curated by ChEMBL
LigandPNGBDBM50395283(CHEMBL2163995)
Affinity DataIC50:  3.40nMAssay Description:Inhibition of CDK2 after 60 mins using [33P]-gamma-ATP by liquid scintillation counterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycylpeptide N-tetradecanoyltransferase 1(Homo sapiens (Human))
University Of Dundee

Curated by ChEMBL
LigandPNGBDBM50033418(CHEMBL3357685)
Affinity DataIC50:  4nMAssay Description:Inhibition of human N-myristoyltransferase 1 assessed as transfer of [3H]-myristic acid to a biotinylated substrate peptide (GCGGSKVKPQPPQAK(biotin)-...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
Teijin Pharma

Curated by ChEMBL
LigandPNGBDBM50395285(CHEMBL2163997)
Affinity DataIC50:  4nMAssay Description:Inhibition of CDK2 after 60 mins using [33P]-gamma-ATP by liquid scintillation counterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycylpeptide N-tetradecanoyltransferase 1(Homo sapiens (Human))
University Of Dundee

Curated by ChEMBL
LigandPNGBDBM50033480(CHEMBL3357697)
Affinity DataIC50:  4nMAssay Description:Inhibition of human N-myristoyltransferase 1 assessed as transfer of [3H]-myristic acid to a biotinylated substrate peptide (GCGGSKVKPQPPQAK(biotin)-...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycylpeptide N-tetradecanoyltransferase 1(Homo sapiens (Human))
University Of Dundee

Curated by ChEMBL
LigandPNGBDBM50033485(CHEMBL3357702)
Affinity DataIC50:  4nMAssay Description:Inhibition of human N-myristoyltransferase 1 assessed as transfer of [3H]-myristic acid to a biotinylated substrate peptide (GCGGSKVKPQPPQAK(biotin)-...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycylpeptide N-tetradecanoyltransferase 1(Homo sapiens (Human))
University Of Dundee

Curated by ChEMBL
LigandPNGBDBM50033616(CHEMBL3358119)
Affinity DataIC50:  4nMAssay Description:Inhibition of human N-myristoyltransferase 1 assessed as transfer of [3H]-myristic acid to a biotinylated substrate peptide (GCGGSKVKPQPPQAK(biotin)-...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycylpeptide N-tetradecanoyltransferase 1(Homo sapiens (Human))
University Of Dundee

Curated by ChEMBL
LigandPNGBDBM50364113(CHEMBL1230468)
Affinity DataIC50:  4nMAssay Description:Inhibition of human NMT1 using [3H]-myristoyl-coA/biotinylated CAP5.5 as substrate after 15 mins by scintillation/luminescence counting methodMore data for this Ligand-Target Pair
TargetGlycogen synthase kinase-3(Homo sapiens (Human))
University Of Dundee

Curated by ChEMBL
LigandPNGBDBM50025648(CHEMBL3335149)
Affinity DataIC50: <5nMAssay Description:Inhibition of human GSK3 using biotinylated GSP2 substrate by flashplate assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3(Homo sapiens (Human))
University Of Dundee

Curated by ChEMBL
LigandPNGBDBM50025649(CHEMBL3335150)
Affinity DataIC50: <5nMAssay Description:Inhibition of human GSK3 using biotinylated GSP2 substrate by flashplate assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3(Homo sapiens (Human))
University Of Dundee

Curated by ChEMBL
LigandPNGBDBM50025650(CHEMBL3335151)
Affinity DataIC50: <5nMAssay Description:Inhibition of human GSK3 using biotinylated GSP2 substrate by flashplate assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3(Homo sapiens (Human))
University Of Dundee

Curated by ChEMBL
LigandPNGBDBM50025652(CHEMBL3335153)
Affinity DataIC50: <5nMAssay Description:Inhibition of human GSK3 using biotinylated GSP2 substrate by flashplate assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3(Homo sapiens (Human))
University Of Dundee

Curated by ChEMBL
LigandPNGBDBM50025653(CHEMBL3335154)
Affinity DataIC50:  5nMAssay Description:Inhibition of human GSK3 using biotinylated GSP2 substrate by flashplate assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycylpeptide N-tetradecanoyltransferase 1(Homo sapiens (Human))
University Of Dundee

Curated by ChEMBL
LigandPNGBDBM50033617(CHEMBL3358120)
Affinity DataIC50:  5nMAssay Description:Inhibition of human NMT1 using [3H]-myristoyl-coA/biotinylated CAP5.5 as substrate after 15 mins by scintillation/luminescence counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
Teijin Pharma

Curated by ChEMBL
LigandPNGBDBM50395272(CHEMBL1231206)
Affinity DataIC50:  5nMAssay Description:Binding affinity to recombinant MAPKAP-K2 using KKKALSRQLSVAA as substrate after 4 mins by surface plasmon resonance spectroscopic analysisMore data for this Ligand-Target Pair
TargetGlycylpeptide N-tetradecanoyltransferase 1(Homo sapiens (Human))
University Of Dundee

Curated by ChEMBL
LigandPNGBDBM50033482(CHEMBL3357699)
Affinity DataIC50:  5nMAssay Description:Inhibition of human N-myristoyltransferase 1 assessed as transfer of [3H]-myristic acid to a biotinylated substrate peptide (GCGGSKVKPQPPQAK(biotin)-...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycylpeptide N-tetradecanoyltransferase 1(Homo sapiens (Human))
University Of Dundee

Curated by ChEMBL
LigandPNGBDBM50033617(CHEMBL3358120)
Affinity DataIC50:  5nMAssay Description:Inhibition of human N-myristoyltransferase 1 assessed as transfer of [3H]-myristic acid to a biotinylated substrate peptide (GCGGSKVKPQPPQAK(biotin)-...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycylpeptide N-tetradecanoyltransferase 1(Homo sapiens (Human))
University Of Dundee

Curated by ChEMBL
LigandPNGBDBM50033618(CHEMBL3358121)
Affinity DataIC50:  5nMAssay Description:Inhibition of human N-myristoyltransferase 1 assessed as transfer of [3H]-myristic acid to a biotinylated substrate peptide (GCGGSKVKPQPPQAK(biotin)-...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3(Homo sapiens (Human))
University Of Dundee

Curated by ChEMBL
LigandPNGBDBM50025628(CHEMBL3335124)
Affinity DataIC50: <5nMAssay Description:Inhibition of human GSK3 using biotinylated GSP2 substrate by flashplate assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3(Homo sapiens (Human))
University Of Dundee

Curated by ChEMBL
LigandPNGBDBM50025634(CHEMBL3335125)
Affinity DataIC50: <5nMAssay Description:Inhibition of human GSK3 using biotinylated GSP2 substrate by flashplate assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3(Homo sapiens (Human))
University Of Dundee

Curated by ChEMBL
LigandPNGBDBM50025640(CHEMBL3335141)
Affinity DataIC50: <5nMAssay Description:Inhibition of human GSK3 using biotinylated GSP2 substrate by flashplate assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3(Homo sapiens (Human))
University Of Dundee

Curated by ChEMBL
LigandPNGBDBM50025642(CHEMBL3335143)
Affinity DataIC50: <5nMAssay Description:Inhibition of human GSK3 using biotinylated GSP2 substrate by flashplate assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3(Homo sapiens (Human))
University Of Dundee

Curated by ChEMBL
LigandPNGBDBM50025643(CHEMBL3335144)
Affinity DataIC50: <5nMAssay Description:Inhibition of human GSK3 using biotinylated GSP2 substrate by flashplate assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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