Compile Data Set for Download or QSAR
maximum 50k data
Found 76 with Last Name = 'gibbs' and Initial = 'ra'
TargetProtein-S-isoprenylcysteine O-methyltransferase(Saccharomyces cerevisiae)
Purdue University

Curated by ChEMBL
LigandPNGBDBM50174225(((2E,6E)-3,7,11-Trimethyl-dodeca-2,6,10-trienylsul...)
Affinity DataKi:  4.60E+3nMAssay Description:Inhibitory concentration against isoprenyl-cysteine carboxyl methyltransferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein-S-isoprenylcysteine O-methyltransferase(Saccharomyces cerevisiae)
Purdue University

Curated by ChEMBL
LigandPNGBDBM50174226(2-acetamido-3-[(2E,6E,10E)-3,7,11,15-tetramethylhe...)
Affinity DataKi:  1.32E+4nMAssay Description:Inhibitory concentration against isoprenyl-cysteine carboxyl methyltransferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein-S-isoprenylcysteine O-methyltransferase(Saccharomyces cerevisiae)
Purdue University

Curated by ChEMBL
LigandPNGBDBM50174224((R)-2-Acetylamino-3-[(2Z,6E)-7,11-dimethyl-3-(3-me...)
Affinity DataKi:  1.71E+4nMAssay Description:Inhibitory concentration against isoprenyl-cysteine carboxyl methyltransferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50476390(CHEMBL426360)
Affinity DataIC50:  13nMAssay Description:Inhibition of farnesyltransferase assessed as farnesylation of Dansyl-GCVLS peptideMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50476389(CHEMBL229376)
Affinity DataIC50:  16nMAssay Description:Inhibition of farnesyltransferase assessed as farnesylation of Dansyl-GCVLS peptideMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50090637((2Z,6E)-7,11-dimethyl-3-(prop-1-en-2-yl)dodeca-2,6...)
Affinity DataIC50:  18nMAssay Description:Inhibitory activity against recombinant mammalian protein Farnesyltransferase expressed in baculovirusMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50081229(10-(tert-butyl)-2,6-dimethyl-(6E,10Z)-2,6,10-dodec...)
Affinity DataIC50:  31nMAssay Description:Inhibitory activity against recombinant mammalian protein Farnesyltransferase expressed in baculovirusMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50081229(10-(tert-butyl)-2,6-dimethyl-(6E,10Z)-2,6,10-dodec...)
Affinity DataIC50:  31nMAssay Description:Inhibition of recombinant farnesyltransferase (mFTase) in scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50090639((2Z,6E)-7,11-dimethyl-3-(propan-2-yl)dodeca-2,6,10...)
Affinity DataIC50:  35nMAssay Description:Inhibitory activity against recombinant mammalian protein Farnesyltransferase expressed in baculovirusMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50100979(Phosphoric acid di-((2Z,6E,10E)-3,7,11,15-tetramet...)
Affinity DataIC50:  100nMAssay Description:Binding affinity to 5-HT3 serotonin receptor in NG 108-15 neuroblastoma glioma cells using [3H]-GR-65,630 radioligand.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50090636((2Z,6E)-3-(butan-2-yl)-7,11-dimethyldodeca-2,6,10-...)
Affinity DataIC50:  102nMAssay Description:Inhibitory activity against recombinant mammalian protein Farnesyltransferase expressed in baculovirusMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50081235(3-substituted farnesyl diphosphate analogue | 4-[(...)
Affinity DataIC50:  119nMAssay Description:Inhibitory activity against recombinant mammalian protein Farnesyltransferase expressed in baculovirusMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50081234(3-[(Z)-ethylidene]-7,11-dimethyl-(6E)-1,6,10-dodec...)
Affinity DataIC50:  173nMAssay Description:Inhibition of recombinant farnesyltransferase (mFTase) in scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50081234(3-[(Z)-ethylidene]-7,11-dimethyl-(6E)-1,6,10-dodec...)
Affinity DataIC50:  173nMAssay Description:Inhibitory activity against recombinant mammalian protein Farnesyltransferase expressed in baculovirusMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50081235(3-substituted farnesyl diphosphate analogue | 4-[(...)
Affinity DataIC50:  189nMAssay Description:Inhibition of recombinant farnesyltransferase (mFTase) in scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50081227(10-ethyl-2,6-dimethyl-(6E,10E)-2,6,10-dodecatriene...)
Affinity DataIC50:  215nMAssay Description:Inhibition of recombinant farnesyltransferase (mFTase) in scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50090642((2Z,6E)-7,11-dimethyl-3-(2-methylpropyl)dodeca-2,6...)
Affinity DataIC50:  290nMAssay Description:Inhibitory activity against recombinant mammalian protein Farnesyltransferase expressed in baculovirusMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50081226(1-[1-[(Z)-ethylidene]-5,9-dimethyl-(4E)-4,8-decadi...)
Affinity DataIC50:  299nMAssay Description:Inhibition of recombinant farnesyltransferase (mFTase) in scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50100978(Phosphoric acid di-((2E,6Z,10E)-3,7,11,15-tetramet...)
Affinity DataIC50:  340nMAssay Description:Binding affinity to 5-HT3 serotonin receptor in NG 108-15 neuroblastoma glioma cells using [3H]-GR-65,630 radioligand.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50081238(4-[(Z)-ethylidene]-8,12,16-trimethyl-(7E,11E)-1,7,...)
Affinity DataIC50:  453nMAssay Description:Inhibition of recombinant farnesyltransferase (mFTase) in scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50090638((2E,6E)-7,11-dimethyl-3-propyldodeca-2,6,10-trien-...)
Affinity DataIC50:  453nMAssay Description:Inhibitory activity against recombinant mammalian protein Farnesyltransferase expressed in baculovirusMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGhrelin O-acyltransferase(Homo sapiens (Human))
Purdue University

Curated by ChEMBL
LigandPNGBDBM50094876(CHEMBL3589129)
Affinity DataIC50:  700nMAssay Description:Inhibition of human GOAT octanoylation activity expressed in insect Sf9 cell membranes using GSSFLCAcDan as substrate after 1 hr by reverse phase HPL...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50081233(3-[(Z)-ethylidene]-7,11,15-trimethyl-(6E,10E)-1,6,...)
Affinity DataIC50:  715nMAssay Description:Inhibition of recombinant farnesyltransferase (mFTase) in scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein-S-isoprenylcysteine O-methyltransferase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50384449(CHEMBL2035530)
Affinity DataIC50:  800nMAssay Description:Inhibition of ICMT in cell free systemMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGhrelin O-acyltransferase(Homo sapiens (Human))
Purdue University

Curated by ChEMBL
LigandPNGBDBM50094875(CHEMBL3589130)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of human GOAT octanoylation activity expressed in insect Sf9 cell membranes using GSSFLCAcDan as substrate after 1 hr by reverse phase HPL...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50113055([4-((E)-4-(diphosphoxy)-2-methyl-but-2-enyloxymeth...)
Affinity DataIC50:  2.30E+3nMAssay Description:Inhibitory activity against mammalian protein-farnesyltransferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein-S-isoprenylcysteine O-methyltransferase(Saccharomyces cerevisiae)
Purdue University

Curated by ChEMBL
LigandPNGBDBM50174223(2-(3-Octyl-6-phenyl-indol-1-yl)-acetamide | CHEMBL...)
Affinity DataIC50:  2.40E+3nMAssay Description:Inhibitory concentration against isoprenyl-cysteine carboxyl methyltransferase; 0.2 - 2.4 uMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein-S-isoprenylcysteine O-methyltransferase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50363182(CHEMBL1946584)
Affinity DataIC50:  2.50E+3nMAssay Description:Inhibition of His-tagged human Icmt membrane protein over-expressed in Saccharomyces cerevisiae 2766 using [14C]-SAM and N-acetyl-S-farnesyl-l-cystei...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein-S-isoprenylcysteine O-methyltransferase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50384447(CHEMBL2035745)
Affinity DataIC50:  2.50E+3nMAssay Description:Inhibition of ICMT in cell free systemMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50081233(3-[(Z)-ethylidene]-7,11,15-trimethyl-(6E,10E)-1,6,...)
Affinity DataIC50:  3.05E+3nMAssay Description:Inhibition of recombinant Geranylgeranyl transferase type I in scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50081238(4-[(Z)-ethylidene]-8,12,16-trimethyl-(7E,11E)-1,7,...)
Affinity DataIC50:  3.38E+3nMAssay Description:Inhibition of recombinant Geranylgeranyl transferase type I in scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGhrelin O-acyltransferase(Homo sapiens (Human))
Purdue University

Curated by ChEMBL
LigandPNGBDBM50094874(CHEMBL3589131)
Affinity DataIC50:  3.80E+3nMAssay Description:Inhibition of human GOAT octanoylation activity expressed in insect Sf9 cell membranes using GSSFLCAcDan as substrate after 1 hr by reverse phase HPL...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50476391(CHEMBL447845)
Affinity DataIC50:  5.00E+3nMAssay Description:Inhibition of farnesyltransferase assessed as farnesylation of Dansyl-GCVLS peptideMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50113054((E)-3-Methyl-5-naphthalen-2-yl-pent-2-en-1-diphosp...)
Affinity DataIC50:  5.40E+3nMAssay Description:Inhibitory activity against mammalian protein-FarnesyltransferaseMore data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetGhrelin O-acyltransferase(Homo sapiens (Human))
Purdue University

Curated by ChEMBL
LigandPNGBDBM50094877(CHEMBL3589128)
Affinity DataIC50:  6.00E+3nMAssay Description:Inhibition of human GOAT octanoylation activity expressed in insect Sf9 cell membranes using GSSFLCAcDan as substrate after 1 hr by reverse phase HPL...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein-S-isoprenylcysteine O-methyltransferase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50363181(CHEMBL1946583)
Affinity DataIC50:  6.20E+3nMAssay Description:Inhibition of His-tagged human Icmt membrane protein over-expressed in Saccharomyces cerevisiae 2766 using [14C]-SAM and N-acetyl-S-farnesyl-l-cystei...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50090641((2Z,6E)-3-(2,2-dimethylpropyl)-7,11-dimethyldodeca...)
Affinity DataIC50:  6.60E+3nMAssay Description:Inhibitory activity against recombinant mammalian protein Farnesyltransferase expressed in baculovirusMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein-S-isoprenylcysteine O-methyltransferase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50363194(CHEMBL1946775)
Affinity DataIC50:  6.70E+3nMAssay Description:Inhibition of His-tagged human Icmt membrane protein over-expressed in Saccharomyces cerevisiae 2766 using [14C]-SAM and N-acetyl-S-farnesyl-l-cystei...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein-S-isoprenylcysteine O-methyltransferase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50363191(CHEMBL1946593)
Affinity DataIC50:  7.80E+3nMAssay Description:Inhibition of His-tagged human Icmt membrane protein over-expressed in Saccharomyces cerevisiae 2766 using [14C]-SAM and N-acetyl-S-farnesyl-l-cystei...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein-S-isoprenylcysteine O-methyltransferase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50342746(2-thienyl-sulfonamido-farnesylcysteine | CHEMBL177...)
Affinity DataIC50:  8.80E+3nMAssay Description:Inhibition of human ICMT incubated with N-Acetyl-S-farnesyl-L-cysteine substrate for 5 mins followed by addition of [14C]-SAM measured after 30 mins ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50090640(3-substituted farnesyl diphosphate analogue | {[(2...)
Affinity DataIC50:  1.01E+4nMAssay Description:Inhibitory activity against recombinant mammalian protein Farnesyltransferase expressed in baculovirusMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein-S-isoprenylcysteine O-methyltransferase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50342745((R)-2-(5-(dimethylamino)naphthalene-1-sulfonamido)...)
Affinity DataIC50:  1.16E+4nMAssay Description:Inhibition of human ICMT incubated with N-Acetyl-S-farnesyl-L-cysteine substrate for 5 mins followed by addition of [14C]-SAM measured after 30 mins ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein-S-isoprenylcysteine O-methyltransferase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50189242((R)-2-[(adamantane-1-carbonyl)-amino]-3-(3,7,11-tr...)
Affinity DataIC50:  1.24E+4nMAssay Description:Inhibition of human Icmt by methanol vapour diffusion assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein-S-isoprenylcysteine O-methyltransferase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50363189(CHEMBL1946591)
Affinity DataIC50:  1.34E+4nMAssay Description:Inhibition of His-tagged human Icmt membrane protein over-expressed in Saccharomyces cerevisiae 2766 using [14C]-SAM and N-acetyl-S-farnesyl-l-cystei...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein-S-isoprenylcysteine O-methyltransferase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50342747(3-nitrophenyl-sulfonamido-farnesylcysteine | CHEMB...)
Affinity DataIC50:  1.34E+4nMAssay Description:Inhibition of human ICMT incubated with N-Acetyl-S-farnesyl-L-cysteine substrate for 5 mins followed by addition of [14C]-SAM measured after 30 mins ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein-S-isoprenylcysteine O-methyltransferase(Saccharomyces cerevisiae)
Purdue University

Curated by ChEMBL
LigandPNGBDBM50174224((R)-2-Acetylamino-3-[(2Z,6E)-7,11-dimethyl-3-(3-me...)
Affinity DataIC50:  1.40E+4nMAssay Description:Inhibitory concentration against isoprenyl-cysteine carboxyl methyltransferase by Casey method; Range 7 - 14 uMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein-S-isoprenylcysteine O-methyltransferase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50189239((R)-2-(3,5-dinitrobenzamido)-3-(3,7,11-trimethyldo...)
Affinity DataIC50:  1.43E+4nMAssay Description:Inhibition of human Icmt by methanol vapour diffusion assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein-S-isoprenylcysteine O-methyltransferase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50363186(CHEMBL1946588)
Affinity DataIC50:  1.47E+4nMAssay Description:Inhibition of His-tagged human Icmt membrane protein over-expressed in Saccharomyces cerevisiae 2766 using [14C]-SAM and N-acetyl-S-farnesyl-l-cystei...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein-S-isoprenylcysteine O-methyltransferase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50342748(4-fluoro-phenyl-sulfonamido-farnesylcysteine | CHE...)
Affinity DataIC50:  1.55E+4nMAssay Description:Inhibition of human ICMT incubated with N-Acetyl-S-farnesyl-L-cysteine substrate for 5 mins followed by addition of [14C]-SAM measured after 30 mins ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein-S-isoprenylcysteine O-methyltransferase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50189241((R)-2-(4-nitrobenzamido)-3-(3,7,11-trimethyldodeca...)
Affinity DataIC50:  1.66E+4nMAssay Description:Inhibition of human Icmt by methanol vapour diffusion assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Displayed 1 to 50 (of 76 total ) | Next | Last >>
Jump to: