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Found 1055 with Last Name = 'gilbert' and Initial = 'ih'
TargetDihydrofolate reductase(Homo sapiens (Human))
Cardiff University

Curated by ChEMBL
LigandPNGBDBM18050(2-[(4-{[(2,4-diaminopteridin-6-yl)methyl](methyl)a...)
Affinity DataKi:  0.0380nMAssay Description:Inhibitory activity against Trypanosoma cruzi dihydrofolate reductaseMore data for this Ligand-Target Pair
TargetDihydrofolate reductase(Homo sapiens (Human))
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50077798(2-{4-[(3-Carboxy-propyl)-(2,4-diamino-pteridin-6-y...)
Affinity DataKi:  0.107nMAssay Description:Inhibitory activity against Trypanosoma cruzi dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50077796(2-{4-[(4-Carboxy-butyl)-(2,4-diamino-pteridin-6-yl...)
Affinity DataKi:  0.131nMAssay Description:Inhibitory activity against Trypanosoma cruzi dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
Cardiff University

Curated by ChEMBL
LigandPNGBDBM18050(2-[(4-{[(2,4-diaminopteridin-6-yl)methyl](methyl)a...)
Affinity DataKi:  0.179nMAssay Description:Inhibitory activity against dihydrofolate reductase in humansMore data for this Ligand-Target Pair
TargetDihydrofolate reductase(Homo sapiens (Human))
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50077799(2-{4-[(5-Carboxy-pentyl)-(2,4-diamino-pteridin-6-y...)
Affinity DataKi:  0.183nMAssay Description:Inhibitory activity against Trypanosoma cruzi dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPurine nucleoside phosphorylase(Plasmodium falciparum)
Instituto De ParasitologíA Y Biomedicina LóPez-Neyra

Curated by ChEMBL
LigandPNGBDBM50195587(1,4-DIDEOXY-4-AZA-1-(S)-(9-DEAZAHYPOXANTHIN-9-YL)-...)
Affinity DataKi:  0.860nMAssay Description:Inhibition of Plasmodium falciparum PNP expressed in Escherichia coli BL21(DE3) cells by spectrophotometryMore data for this Ligand-Target Pair
TargetUridine phosphorylase 1(Homo sapiens (Human))
Instituto De ParasitologíA Y Biomedicina LóPez-Neyra

Curated by ChEMBL
LigandPNGBDBM50330391(5-(3-(benzyloxy)benzyl)-1-((2-hydroxyethoxy)methyl...)
Affinity DataKi:  1.10nMAssay Description:Inhibition of human uridine phosphorylaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPurine nucleoside phosphorylase(Plasmodium falciparum)
Instituto De ParasitologíA Y Biomedicina LóPez-Neyra

Curated by ChEMBL
LigandPNGBDBM50330391(5-(3-(benzyloxy)benzyl)-1-((2-hydroxyethoxy)methyl...)
Affinity DataKi:  1.10nMAssay Description:Inhibition of Plasmodium falciparum PNP expressed in Escherichia coli BL21(DE3) cells by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50077796(2-{4-[(4-Carboxy-butyl)-(2,4-diamino-pteridin-6-yl...)
Affinity DataKi:  1.5nMAssay Description:Inhibitory activity against dihydrofolate reductase in humansMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50077799(2-{4-[(5-Carboxy-pentyl)-(2,4-diamino-pteridin-6-y...)
Affinity DataKi:  1.60nMAssay Description:Inhibitory activity against Trypanosoma cruzi dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50077798(2-{4-[(3-Carboxy-propyl)-(2,4-diamino-pteridin-6-y...)
Affinity DataKi:  2nMAssay Description:Inhibitory activity against dihydrofolate reductase in humansMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPurine nucleoside phosphorylase(Plasmodium falciparum)
Instituto De ParasitologíA Y Biomedicina LóPez-Neyra

Curated by ChEMBL
LigandPNGBDBM50330390(5'-methylthio-immucillin-H | CHEMBL1275659)
Affinity DataKi:  2.70nMAssay Description:Inhibition of Plasmodium falciparum PNP expressed in Escherichia coli BL21(DE3) cells by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50081905(5-(3-Butoxy-benzyl)-pyrimidine-2,4-diamine | CHEMB...)
Affinity DataKi:  3.60nMAssay Description:Inhibition of recombinant Dihydrofolate reductase from humans.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50081918(5-(4-Propoxy-benzyl)-pyrimidine-2,4-diamine | CHEM...)
Affinity DataKi:  6.40nMAssay Description:Inhibition of recombinant Dihydrofolate reductase from humans.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPteridine reductase(Trypanosoma brucei brucei)
University Of Dundee

LigandPNGBDBM31801(2-aminobenzimidazole deriv., 12)
Affinity DataKi:  7nM ΔG°:  -46.2kJ/molepH: 6.0 T: 2°CAssay Description:TbPTR1 activity was measured in 96-well microtiter plates via reduction of cytochrome c (cytc) as a result of the enzymatic production of tetrahydrob...More data for this Ligand-Target Pair
TargetDihydrofolate reductase(Homo sapiens (Human))
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50081916(5-(3-Pentyloxy-benzyl)-pyrimidine-2,4-diamine | CH...)
Affinity DataKi:  7.10nMAssay Description:Inhibition of recombinant Dihydrofolate reductase from humans.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50081907(5-(3-Ethoxy-benzyl)-pyrimidine-2,4-diamine | CHEMB...)
Affinity DataKi:  8.60nMAssay Description:Inhibition of recombinant Dihydrofolate reductase from humans.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50081922(5-(3-Isopropoxy-benzyl)-pyrimidine-2,4-diamine | C...)
Affinity DataKi:  8.80nMAssay Description:Inhibition of recombinant Dihydrofolate reductase from humans.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50081908(5-(3-Methoxy-benzyl)-pyrimidine-2,4-diamine | CHEM...)
Affinity DataKi:  9.60nMAssay Description:Inhibition of recombinant Dihydrofolate reductase from humans.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50081917(5-(3-Hexyloxy-benzyl)-pyrimidine-2,4-diamine | CHE...)
Affinity DataKi:  9.80nMAssay Description:Inhibition of recombinant Dihydrofolate reductase from humans.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50081921(5-(4-Ethoxy-benzyl)-pyrimidine-2,4-diamine | CHEMB...)
Affinity DataKi:  9.80nMAssay Description:Inhibition of recombinant Dihydrofolate reductase from humans.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target6-phosphogluconate dehydrogenase, decarboxylating(Homo sapiens (Human))
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50148767(2,3-dihydroxy-4-(hydroxyamino)-4-oxobutyl dihydrog...)
Affinity DataKi:  10nMAssay Description:Inhibition constant against 6-phosphogluconate dehydrogenase of Trypanosoma brucei expressed in Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
Cardiff University

Curated by ChEMBL
LigandPNGBDBM18069(5-[(3,4,5-trimethoxyphenyl)methyl]pyrimidine-2,4-d...)
Affinity DataKi:  10nMAssay Description:Inhibition of recombinant Dihydrofolate reductase from humans.More data for this Ligand-Target Pair
TargetDihydrofolate reductase(Homo sapiens (Human))
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50081920(5-(3-Propoxy-benzyl)-pyrimidine-2,4-diamine | CHEM...)
Affinity DataKi:  10.5nMAssay Description:Inhibition of recombinant Dihydrofolate reductase from humans.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50081909(5-(3-(benzyloxy)benzyl)pyrimidine-2,4-diamine | 5-...)
Affinity DataKi:  11nMAssay Description:Inhibition of recombinant Dihydrofolate reductase from humans.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
Cardiff University

Curated by ChEMBL
LigandPNGBDBM18512(5-(4-chlorophenyl)-6-ethylpyrimidine-2,4-diamine |...)
Affinity DataKi:  11nMAssay Description:Inhibition of recombinant Dihydrofolate reductase from humans.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetDihydrofolate reductase(Homo sapiens (Human))
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50081915(5-[3-(Tetrahydro-pyran-2-yloxy)-benzyl]-pyrimidine...)
Affinity DataKi:  13nMAssay Description:Inhibition of recombinant Dihydrofolate reductase from humans.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50077794(2-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-(3-ethoxyc...)
Affinity DataKi:  14nMAssay Description:Inhibitory activity against Trypanosoma cruzi dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50081906(6-Ethyl-5-(3-heptyloxy-benzyl)-pyrimidine-2,4-diam...)
Affinity DataKi:  19nMAssay Description:Inhibition of recombinant Dihydrofolate reductase from humans.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50081922(5-(3-Isopropoxy-benzyl)-pyrimidine-2,4-diamine | C...)
Affinity DataKi:  23nMAssay Description:Inhibition of recombinant Dihydrofolate reductase from Trypanosoma cruzi.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50081910(5-(3-Octyloxy-benzyl)-pyrimidine-2,4-diamine | CHE...)
Affinity DataKi:  24nMAssay Description:Inhibition of recombinant Dihydrofolate reductase from humans.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target6-phosphogluconate dehydrogenase, decarboxylating(Homo sapiens (Human))
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50148780(((4R,5R)-5-(hydroxycarbamoyl)-2,2-dimethyl-1,3-dio...)
Affinity DataKi:  35nMAssay Description:Inhibition constant against 6-phosphogluconate dehydrogenase of Trypanosoma brucei expressed in Escherichia coliMore data for this Ligand-Target Pair
TargetDihydrofolate reductase(Homo sapiens (Human))
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50081911(5-(3-Nonyloxy-benzyl)-pyrimidine-2,4-diamine | CHE...)
Affinity DataKi:  36nMAssay Description:Inhibition of recombinant Dihydrofolate reductase from humans.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50077797(2-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-(4-ethoxyc...)
Affinity DataKi:  46nMAssay Description:Inhibitory activity against Trypanosoma cruzi dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPteridine reductase(Trypanosoma brucei brucei)
University Of Dundee

LigandPNGBDBM31800(2-aminobenzimidazole deriv., 11)
Affinity DataKi:  47nM ΔG°:  -41.5kJ/molepH: 6.0 T: 2°CAssay Description:TbPTR1 activity was measured in 96-well microtiter plates via reduction of cytochrome c (cytc) as a result of the enzymatic production of tetrahydrob...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50081906(6-Ethyl-5-(3-heptyloxy-benzyl)-pyrimidine-2,4-diam...)
Affinity DataKi:  48nMAssay Description:Inhibition of recombinant Dihydrofolate reductase from Leishmania major.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50081913(5-(3-Decyloxy-benzyl)-pyrimidine-2,4-diamine | CHE...)
Affinity DataKi:  52nMAssay Description:Inhibition of recombinant Dihydrofolate reductase from humans.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50077795(2-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-(5-ethoxyc...)
Affinity DataKi:  56nMAssay Description:Inhibitory activity against Trypanosoma cruzi dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene synthase(Trypanosoma cruzi)
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50052351(3-Biphenyl-4-yl-1-aza-bicyclo[2.2.2]octan-3-ol | 3...)
Affinity DataKi:  62nMAssay Description:Inhibition of Trypanosoma cruzi squalene synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50081909(5-(3-(benzyloxy)benzyl)pyrimidine-2,4-diamine | 5-...)
Affinity DataKi:  65nMAssay Description:Inhibition of recombinant Dihydrofolate reductase from Leishmania major.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50081912(5-(3-Heptyloxy-benzyl)-6-methyl-pyrimidine-2,4-dia...)
Affinity DataKi:  75nMAssay Description:Inhibition of recombinant Dihydrofolate reductase from humans.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target6-phosphogluconate dehydrogenase, decarboxylating(Homo sapiens (Human))
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50148765(1-(hydroxyamino)-1-oxo-4-(phosphonooxy)butane-2,3-...)
Affinity DataKi:  80nMAssay Description:Inhibition constant against 6-phosphogluconate dehydrogenase of Trypanosoma brucei expressed in Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50081915(5-[3-(Tetrahydro-pyran-2-yloxy)-benzyl]-pyrimidine...)
Affinity DataKi:  93nMAssay Description:Inhibition of recombinant Dihydrofolate reductase from Leishmania major.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50081910(5-(3-Octyloxy-benzyl)-pyrimidine-2,4-diamine | CHE...)
Affinity DataKi:  97nMAssay Description:Inhibition of recombinant Dihydrofolate reductase from Leishmania major.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
Cardiff University

Curated by ChEMBL
LigandPNGBDBM18512(5-(4-chlorophenyl)-6-ethylpyrimidine-2,4-diamine |...)
Affinity DataKi:  98nMAssay Description:Inhibition of recombinant Dihydrofolate reductase from Trypanosoma cruzi.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetDihydrofolate reductase(Homo sapiens (Human))
Cardiff University

Curated by ChEMBL
LigandPNGBDBM18512(5-(4-chlorophenyl)-6-ethylpyrimidine-2,4-diamine |...)
Affinity DataKi:  120nMAssay Description:Inhibition of recombinant Dihydrofolate reductase from humans.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetDihydrofolate reductase(Homo sapiens (Human))
Cardiff University

Curated by ChEMBL
LigandPNGBDBM18069(5-[(3,4,5-trimethoxyphenyl)methyl]pyrimidine-2,4-d...)
Affinity DataKi:  120nMAssay Description:Inhibition of recombinant Dihydrofolate reductase from Leishmania major.More data for this Ligand-Target Pair
Target6-phosphogluconate dehydrogenase, decarboxylating(Homo sapiens (Human))
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50148790((2R,3R)-2,3-Dihydroxy-4-phosphonooxy-butyric acid ...)
Affinity DataKi:  130nMAssay Description:Inhibition constant against 6-phosphogluconate dehydrogenase of Trypanosoma brucei expressed in Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50081920(5-(3-Propoxy-benzyl)-pyrimidine-2,4-diamine | CHEM...)
Affinity DataKi:  130nMAssay Description:Inhibition of recombinant Dihydrofolate reductase from Leishmania major.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50081921(5-(4-Ethoxy-benzyl)-pyrimidine-2,4-diamine | CHEMB...)
Affinity DataKi:  130nMAssay Description:Inhibition of recombinant Dihydrofolate reductase from Leishmania major.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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