Compile Data Set for Download or QSAR
maximum 50k data
Found 374 with Last Name = 'guzi' and Initial = 'tj'
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Blueprint Medicines

Curated by ChEMBL
LigandPNGBDBM50598680(CHEMBL5173517)
Affinity DataIC50:  0.100nMAssay Description:Inhibition of N-terminal GST tagged recombinant human EGFR L858R/T790M (669 to end residues) double mutant expressed in baculovirus infected Sf9 inse...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Blueprint Medicines

Curated by ChEMBL
LigandPNGBDBM50598682(CHEMBL5206444)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of N-terminal GST tagged recombinant human EGFR L858R/T790M (669 to end residues) double mutant expressed in baculovirus infected Sf9 inse...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Blueprint Medicines

Curated by ChEMBL
LigandPNGBDBM50598681(CHEMBL5200991)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of N-terminal GST tagged recombinant human EGFR L858R/T790M (669 to end residues) double mutant expressed in baculovirus infected Sf9 inse...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Blueprint Medicines

Curated by ChEMBL
LigandPNGBDBM50598673(CHEMBL5207390)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of N-terminal GST tagged recombinant human EGFR L858R/T790M (669 to end residues) double mutant expressed in baculovirus infected Sf9 inse...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Blueprint Medicines

Curated by ChEMBL
LigandPNGBDBM50598683(CHEMBL5196495)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of N-terminal GST tagged recombinant human EGFR L858R/T790M (669 to end residues) double mutant expressed in baculovirus infected Sf9 inse...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Blueprint Medicines

Curated by ChEMBL
LigandPNGBDBM50598668(CHEMBL5195164)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of N-terminal GST tagged recombinant human EGFR L858R/T790M (669 to end residues) double mutant expressed in baculovirus infected Sf9 inse...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Blueprint Medicines

Curated by ChEMBL
LigandPNGBDBM50598685(CHEMBL5208737)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of N-terminal GST tagged recombinant human EGFR L858R/T790M (669 to end residues) double mutant expressed in baculovirus infected Sf9 inse...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Blueprint Medicines

Curated by ChEMBL
LigandPNGBDBM50598686(BLU-945 | BLU945 | Blu-945)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of N-terminal GST tagged recombinant human EGFR L858R/T790M (669 to end residues) double mutant expressed in baculovirus infected Sf9 inse...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Blueprint Medicines

Curated by ChEMBL
LigandPNGBDBM50598684(CHEMBL5194722)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of N-terminal GST tagged recombinant human EGFR L858R/T790M (669 to end residues) double mutant expressed in baculovirus infected Sf9 inse...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Blueprint Medicines

Curated by ChEMBL
LigandPNGBDBM50598675(CHEMBL5185207)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of N-terminal GST tagged recombinant human EGFR L858R/T790M (669 to end residues) double mutant expressed in baculovirus infected Sf9 inse...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Blueprint Medicines

Curated by ChEMBL
LigandPNGBDBM50598686(BLU-945 | BLU945 | Blu-945)
Affinity DataIC50:  0.700nMAssay Description:Inhibition of N-terminal GST tagged recombinant human EGFR ex19del(746 to 750)/ T790M/C790S mutant (668 to end residues) expressed in baculovirus inf...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Blueprint Medicines

Curated by ChEMBL
LigandPNGBDBM50598687(CHEMBL5193016)
Affinity DataIC50:  0.700nMAssay Description:Inhibition of N-terminal GST tagged recombinant human EGFR L858R/T790M (669 to end residues) double mutant expressed in baculovirus infected Sf9 inse...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Blueprint Medicines

Curated by ChEMBL
LigandPNGBDBM50598686(BLU-945 | BLU945 | Blu-945)
Affinity DataIC50:  0.800nMAssay Description:Inhibition of N-terminal GST tagged recombinant human EGFR ex19del(746 to 750)/T790M mutant (668 to end residues) expressed in baculovirus infected S...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Blueprint Medicines

Curated by ChEMBL
LigandPNGBDBM50598679(CHEMBL5170376)
Affinity DataIC50:  0.900nMAssay Description:Inhibition of N-terminal GST tagged recombinant human EGFR L858R/T790M (669 to end residues) double mutant expressed in baculovirus infected Sf9 inse...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Blueprint Medicines

Curated by ChEMBL
LigandPNGBDBM50598678(CHEMBL5187021)
Affinity DataIC50:  1nMAssay Description:Inhibition of N-terminal GST tagged recombinant human EGFR L858R/T790M (669 to end residues) double mutant expressed in baculovirus infected Sf9 inse...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Blueprint Medicines

Curated by ChEMBL
LigandPNGBDBM50598683(CHEMBL5196495)
Affinity DataIC50:  1nMAssay Description:Inhibition of EGF stimulated EGFR L858R/T790M double mutant phosphorylation in human NCI-H1975 cells preincubated for 4 to 5 hrs followed by EGF stim...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Blueprint Medicines

Curated by ChEMBL
LigandPNGBDBM50598686(BLU-945 | BLU945 | Blu-945)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of EGF stimulated EGFR L858R/T790M double mutant phosphorylation in human NCI-H1975 cells preincubated for 4 to 5 hrs followed by EGF stim...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50442673(CHEMBL2442291)
Affinity DataIC50:  1.30nMAssay Description:Inhibition of Pim1 (unknown origin) using STK3 as substrate preincubated for 30 mins followed by substrate and ATP addition after 45 mins by HTRF ass...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50442690(CHEMBL2442296)
Affinity DataIC50:  1.5nMAssay Description:Inhibition of Pim1 (unknown origin) using STK3 as substrate preincubated for 30 mins followed by substrate and ATP addition after 45 mins by HTRF ass...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50442685(CHEMBL2442301)
Affinity DataIC50:  1.60nMAssay Description:Inhibition of Pim1 (unknown origin) using STK3 as substrate preincubated for 30 mins followed by substrate and ATP addition after 45 mins by HTRF ass...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Blueprint Medicines

Curated by ChEMBL
LigandPNGBDBM50598681(CHEMBL5200991)
Affinity DataIC50:  1.70nMAssay Description:Inhibition of EGF stimulated EGFR L858R/T790M double mutant phosphorylation in human NCI-H1975 cells preincubated for 4 to 5 hrs followed by EGF stim...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetSerine/threonine-protein kinase pim-3(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50442673(CHEMBL2442291)
Affinity DataIC50:  1.80nMAssay Description:Inhibition of Pim3 (unknown origin) using STK1 as substrate preincubated for 30 mins followed by substrate and ATP addition after 60 mins by HTRF ass...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Blueprint Medicines

Curated by ChEMBL
LigandPNGBDBM50598684(CHEMBL5194722)
Affinity DataIC50:  1.80nMAssay Description:Inhibition of EGF stimulated EGFR L858R/T790M double mutant phosphorylation in human NCI-H1975 cells preincubated for 4 to 5 hrs followed by EGF stim...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Blueprint Medicines

Curated by ChEMBL
LigandPNGBDBM50598674(CHEMBL5172587)
Affinity DataIC50:  1.80nMAssay Description:Inhibition of N-terminal GST tagged recombinant human EGFR L858R/T790M (669 to end residues) double mutant expressed in baculovirus infected Sf9 inse...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50442679(CHEMBL2442302)
Affinity DataIC50:  2nMAssay Description:Inhibition of Pim1 (unknown origin) using STK3 as substrate preincubated for 30 mins followed by substrate and ATP addition after 45 mins by HTRF ass...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Blueprint Medicines

Curated by ChEMBL
LigandPNGBDBM50598667(CHEMBL5208679)
Affinity DataIC50:  2.10nMAssay Description:Inhibition of N-terminal GST tagged recombinant human EGFR L858R/T790M (669 to end residues) double mutant expressed in baculovirus infected Sf9 inse...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Blueprint Medicines

Curated by ChEMBL
LigandPNGBDBM50598671(CHEMBL5182741)
Affinity DataIC50:  2.20nMAssay Description:Inhibition of N-terminal GST tagged recombinant human EGFR L858R/T790M (669 to end residues) double mutant expressed in baculovirus infected Sf9 inse...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Blueprint Medicines

Curated by ChEMBL
LigandPNGBDBM50598687(CHEMBL5193016)
Affinity DataIC50:  2.60nMAssay Description:Inhibition of EGF stimulated EGFR L858R/T790M double mutant phosphorylation in human NCI-H1975 cells preincubated for 4 to 5 hrs followed by EGF stim...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Blueprint Medicines

Curated by ChEMBL
LigandPNGBDBM50598682(CHEMBL5206444)
Affinity DataIC50:  2.70nMAssay Description:Inhibition of EGF stimulated EGFR L858R/T790M double mutant phosphorylation in human NCI-H1975 cells preincubated for 4 to 5 hrs followed by EGF stim...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50442692(CHEMBL2442317)
Affinity DataIC50:  2.90nMAssay Description:Inhibition of Pim1 (unknown origin) using STK3 as substrate preincubated for 30 mins followed by substrate and ATP addition after 45 mins by HTRF ass...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50334853(6-chloro-3-(1-methyl-1H-pyrazol-4-yl)-5-(piperidin...)
Affinity DataIC50:  3nMAssay Description:Inhibition of histidine-tagged recombinant CHK1 expressed in baculovirus expression system after 2 hrs by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM50223567(3-bromo-5-(2-chlorophenyl)-N-(pyridin-3-ylmethyl)p...)
Affinity DataIC50:  3nMpH: 8.0Assay Description:CDK2 kinase assays (either cyclin A or cyclin E-dependent) were performed in low protein binding 96-well plates (Corning Inc., Corning, N.Y.).More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50334855(6-iodo-3-(1-methyl-1H-pyrazol-4-yl)-5-(piperidin-3...)
Affinity DataIC50:  3nMAssay Description:Inhibition of histidine-tagged recombinant CHK1 expressed in baculovirus expression system after 2 hrs by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50334854(6-bromo-3-(1-methyl-1H-pyrazol-4-yl)-5-(piperidin-...)
Affinity DataIC50:  3nMAssay Description:Inhibition of histidine-tagged recombinant CHK1 expressed in baculovirus expression system after 2 hrs by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50442693(CHEMBL2442316)
Affinity DataIC50:  3.10nMAssay Description:Inhibition of Pim1 (unknown origin) using STK3 as substrate preincubated for 30 mins followed by substrate and ATP addition after 45 mins by HTRF ass...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Blueprint Medicines

Curated by ChEMBL
LigandPNGBDBM50598686(BLU-945 | BLU945 | Blu-945)
Affinity DataIC50:  3.20nMAssay Description:Inhibition of EGFR L858R/T790M/C797S triple mutant (unknown origin) expressed in mouse BaF3 cells assessed as inhibition of protein phosphorylationMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Blueprint Medicines

Curated by ChEMBL
LigandPNGBDBM50598676(CHEMBL5205583)
Affinity DataIC50:  3.40nMAssay Description:Inhibition of N-terminal GST tagged recombinant human EGFR L858R/T790M (669 to end residues) double mutant expressed in baculovirus infected Sf9 inse...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Blueprint Medicines

Curated by ChEMBL
LigandPNGBDBM50598672(CHEMBL5203267)
Affinity DataIC50:  3.60nMAssay Description:Inhibition of N-terminal GST tagged recombinant human EGFR L858R/T790M (669 to end residues) double mutant expressed in baculovirus infected Sf9 inse...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Blueprint Medicines

Curated by ChEMBL
LigandPNGBDBM50598685(CHEMBL5208737)
Affinity DataIC50:  3.80nMAssay Description:Inhibition of EGF stimulated EGFR L858R/T790M double mutant phosphorylation in human NCI-H1975 cells preincubated for 4 to 5 hrs followed by EGF stim...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50442681(CHEMBL2442290)
Affinity DataIC50:  4.5nMAssay Description:Inhibition of Pim1 (unknown origin) using STK3 as substrate preincubated for 30 mins followed by substrate and ATP addition after 45 mins by HTRF ass...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Blueprint Medicines

Curated by ChEMBL
LigandPNGBDBM50598680(CHEMBL5173517)
Affinity DataIC50:  4.80nMAssay Description:Inhibition of EGF stimulated EGFR L858R/T790M double mutant phosphorylation in human NCI-H1975 cells preincubated for 4 to 5 hrs followed by EGF stim...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50442686(CHEMBL2442300)
Affinity DataIC50:  5nMAssay Description:Inhibition of Pim1 (unknown origin) using STK3 as substrate preincubated for 30 mins followed by substrate and ATP addition after 45 mins by HTRF ass...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50334849(CHEMBL1643236 | Syn-5-((3-aminocyclohexyl)methyl)-...)
Affinity DataIC50:  5nMAssay Description:Inhibition of histidine-tagged recombinant CHK1 expressed in baculovirus expression system after 2 hrs by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50442687(CHEMBL2442299)
Affinity DataIC50:  5.10nMAssay Description:Inhibition of Pim1 (unknown origin) using STK3 as substrate preincubated for 30 mins followed by substrate and ATP addition after 45 mins by HTRF ass...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM105239(US8580782, 7)
Affinity DataIC50:  6nMpH: 8.0Assay Description:CDK2 kinase assays (either cyclin A or cyclin E-dependent) were performed in low protein binding 96-well plates (Corning Inc., Corning, N.Y.).More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50334876(6-bromo-3-(1-methyl-1H-pyrazol-4-yl)-5-(thiomorpho...)
Affinity DataIC50:  6nMAssay Description:Inhibition of histidine-tagged recombinant CHK1 expressed in baculovirus expression system after 2 hrs by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50442691(CHEMBL2442295)
Affinity DataIC50:  6.80nMAssay Description:Inhibition of Pim1 (unknown origin) using STK3 as substrate preincubated for 30 mins followed by substrate and ATP addition after 45 mins by HTRF ass...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50442698(CHEMBL2442287)
Affinity DataIC50:  7nMAssay Description:Inhibition of Pim1 (unknown origin) using STK3 as substrate preincubated for 30 mins followed by substrate and ATP addition after 45 mins by HTRF ass...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Blueprint Medicines

Curated by ChEMBL
LigandPNGBDBM50598668(CHEMBL5195164)
Affinity DataIC50:  7nMAssay Description:Inhibition of EGF stimulated EGFR L858R/T790M double mutant phosphorylation in human NCI-H1975 cells preincubated for 4 to 5 hrs followed by EGF stim...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Blueprint Medicines

Curated by ChEMBL
LigandPNGBDBM50598673(CHEMBL5207390)
Affinity DataIC50:  7nMAssay Description:Inhibition of EGF stimulated EGFR L858R/T790M double mutant phosphorylation in human NCI-H1975 cells preincubated for 4 to 5 hrs followed by EGF stim...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
Displayed 1 to 50 (of 374 total ) | Next | Last >>
Jump to: