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Found 107 with Last Name = 'haas' and Initial = 'ja'
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343301(2-((4-(4-Fluorophenyl)piperidin-1-yl)methyl)-1-met...)
Affinity DataKi:  24nMAssay Description:Displacement of [3H]spiperone from dopamine D2 receptor in rat corpus striatum by beta plate scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343305(2-((4-(4-Chloro-2-fluorophenyl)piperidin-1-yl)meth...)
Affinity DataKi:  91nMAssay Description:Displacement of [3H]spiperone from dopamine D2 receptor in rat corpus striatum by beta plate scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343299(2-((4-(2-Fluorophenyl)piperidin-1-yl)methyl)-1-met...)
Affinity DataKi:  93nMAssay Description:Displacement of [3H]spiperone from dopamine D2 receptor in rat corpus striatum by beta plate scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50277957((R)-3-((2',4'-difluorobiphenyl-4-yl)methyl)-5-meth...)
Affinity DataKi:  323nMAssay Description:Binding affinity to human 5HT2A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343317(1-methyl-2-(((1R,5S)-3-(4-(trifluoromethyl)phenyl)...)
Affinity DataKi:  355nMAssay Description:Displacement of [3H]spiperone from dopamine D2 receptor in rat corpus striatum by beta plate scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343308(1-Methyl-2-((4-(4-(trifluoromethyl)phenyl)piperidi...)
Affinity DataKi:  404nMAssay Description:Displacement of [3H]spiperone from dopamine D2 receptor in rat corpus striatum by beta plate scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343295(2-((4-(2-Methoxy-phenyl)piperidin-1-yl)methyl)-1-m...)
Affinity DataKi:  426nMAssay Description:Displacement of [3H]spiperone from dopamine D2 receptor in rat corpus striatum by beta plate scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343306(1-methyl-2-((4-(4-(trifluoromethyl)phenyl)piperidi...)
Affinity DataKi:  561nMAssay Description:Displacement of [3H]spiperone from dopamine D2 receptor in rat corpus striatum by beta plate scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343316(CHEMBL1774224 | cis-1-methyl-2-(((2R,4R)-2-methyl-...)
Affinity DataKi:  589nMAssay Description:Displacement of [3H]spiperone from dopamine D2 receptor in rat corpus striatum by beta plate scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343309(1-Methyl-2-((4-(4-(trifluoromethyl)phenyl)piperidi...)
Affinity DataKi:  671nMAssay Description:Displacement of [3H]spiperone from dopamine D2 receptor in rat corpus striatum by beta plate scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343314(2-((4-(2-Fluoro-4-(trifluoromethoxy)phenyl)piperid...)
Affinity DataKi:  1.18E+3nMAssay Description:Displacement of [3H]spiperone from dopamine D2 receptor in rat corpus striatum by beta plate scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343321(CHEMBL1774229 | cis-2-(((3R,4R)-4-(4-chloro-2-fluo...)
Affinity DataKi:  1.62E+3nMAssay Description:Displacement of [3H]spiperone from dopamine D2 receptor in rat corpus striatum by beta plate scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343313(2-((4-(2-Fluoro-4-(trifluoromethyl)phenyl)piperidi...)
Affinity DataKi:  1.78E+3nMAssay Description:Displacement of [3H]spiperone from dopamine D2 receptor in rat corpus striatum by beta plate scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50277955((R)-3-((3'-chloro-4'-fluorobiphenyl-4-yl)methyl)-5...)
Affinity DataKi:  2.10E+3nMAssay Description:Binding affinity to human 5HT2A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343312(2-((4-(2-Methoxy-4-(trifluoromethyl)phenyl)piperid...)
Affinity DataKi:  2.43E+3nMAssay Description:Displacement of [3H]spiperone from dopamine D2 receptor in rat corpus striatum by beta plate scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343318((S)-2-((3,3-dimethyl-4-(4-(trifluoromethyl)phenyl)...)
Affinity DataKi: >2.80E+3nMAssay Description:Displacement of [3H]spiperone from dopamine D2 receptor in rat corpus striatum by beta plate scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343319(CHEMBL1774227 | cis-1-methyl-2-(((3R,4R)-3-methyl-...)
Affinity DataKi: >2.80E+3nMAssay Description:Displacement of [3H]spiperone from dopamine D2 receptor in rat corpus striatum by beta plate scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343320(CHEMBL1774228 | cis-1-methyl-2-(((3S,4S)-3-methyl-...)
Affinity DataKi: >2.80E+3nMAssay Description:Displacement of [3H]spiperone from dopamine D2 receptor in rat corpus striatum by beta plate scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343319(CHEMBL1774227 | cis-1-methyl-2-(((3R,4R)-3-methyl-...)
Affinity DataKi: >2.80E+3nMAssay Description:Displacement of [3H]spiperone from dopamine D2 receptor in rat corpus striatum by beta plate scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50277956((R)-3-((2'-fluoro-4'-(trifluoromethoxy)biphenyl-4-...)
Affinity DataKi: >3.10E+3nMAssay Description:Binding affinity to human 5HT2A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50278007((R)-3-((6-(2-fluoro-4-(trifluoromethoxy)phenyl)pyr...)
Affinity DataKi: >3.10E+3nMAssay Description:Binding affinity to human 5HT2A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50278009((R)-3-((6-(3,4-difluorophenyl)pyridin-3-yl)methyl)...)
Affinity DataKi: >3.10E+3nMAssay Description:Binding affinity to human 5HT2A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50277846((5R)-3-(4-(1-cyclohexylethoxy)benzyl)-5-methyloxaz...)
Affinity DataKi: >3.20E+3nMAssay Description:Binding affinity to human 5HT2A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343327(CHEMBL1774235 | cis-2-(((3R,4R)-4-(2-fluoro-4-(tri...)
Affinity DataKi: >4.68E+3nMAssay Description:Displacement of [3H]spiperone from dopamine D2 receptor in rat corpus striatum by beta plate scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343323(CHEMBL1774231 | cis-2-(((3R,4R)-4-(2-methoxy-4-(tr...)
Affinity DataKi: >5.26E+3nMAssay Description:Displacement of [3H]spiperone from dopamine D2 receptor in rat corpus striatum by beta plate scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343325(CHEMBL1774233 | cis-2-(((3R,4R)-4-(2-fluoro-4-(tri...)
Affinity DataKi: >5.26E+3nMAssay Description:Displacement of [3H]spiperone from dopamine D2 receptor in rat corpus striatum by beta plate scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50277806((5S)-3-(4-(1-cyclohexylethoxy)benzyl)-5-methyloxaz...)
Affinity DataEC50:  22.1nMAssay Description:Agonist activity at mGluR2 (unknown origin) expressed in HEK cells by FLIPR assay in presence of glutamateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50277920((R)-3-((2'-ethoxybiphenyl-4-yl)methyl)-5-methyloxa...)
Affinity DataEC50:  26nMAssay Description:Agonist activity at mGluR2 (unknown origin) expressed in HEK cells by FLIPR assay in presence of glutamateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50277883((R)-3-((2'-chlorobiphenyl-4-yl)methyl)-5-methyloxa...)
Affinity DataEC50:  28nMAssay Description:Agonist activity at mGluR2 (unknown origin) expressed in HEK cells by FLIPR assay in presence of glutamateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50277955((R)-3-((3'-chloro-4'-fluorobiphenyl-4-yl)methyl)-5...)
Affinity DataEC50:  30nMAssay Description:Agonist activity at mGluR2 (unknown origin) expressed in HEK cells by FLIPR assay in presence of glutamateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50277956((R)-3-((2'-fluoro-4'-(trifluoromethoxy)biphenyl-4-...)
Affinity DataEC50:  32nMAssay Description:Agonist activity at mGluR2 (unknown origin) expressed in HEK cells by FLIPR assay in presence of glutamateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50277880((R)-3-((2'-fluorobiphenyl-4-yl)methyl)-5-methyloxa...)
Affinity DataEC50:  35nMAssay Description:Agonist activity at mGluR2 (unknown origin) expressed in HEK cells by FLIPR assay in presence of glutamateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50277917((R)-3-((2'-methoxybiphenyl-4-yl)methyl)-5-methylox...)
Affinity DataEC50:  41nMAssay Description:Agonist activity at mGluR2 (unknown origin) expressed in HEK cells by FLIPR assay in presence of glutamateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50277919((R)-3-((4'-methoxybiphenyl-4-yl)methyl)-5-methylox...)
Affinity DataEC50:  53nMAssay Description:Agonist activity at mGluR2 (unknown origin) expressed in HEK cells by FLIPR assay in presence of glutamateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50277957((R)-3-((2',4'-difluorobiphenyl-4-yl)methyl)-5-meth...)
Affinity DataEC50:  70nMAssay Description:Agonist activity at mGluR2 (unknown origin) expressed in HEK cells by FLIPR assay in presence of glutamateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50277771(3-(4-(1-cyclohexylethoxy)benzyl)-1,3-oxazinan-2-on...)
Affinity DataEC50:  75nMAssay Description:Agonist activity at mGluR2 (unknown origin) expressed in HEK cells by FLIPR assay in presence of glutamateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50277916((R)-3-((4'-chlorobiphenyl-4-yl)methyl)-5-methyloxa...)
Affinity DataEC50:  76nMAssay Description:Agonist activity at mGluR2 (unknown origin) expressed in HEK cells by FLIPR assay in presence of glutamateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50277882((R)-3-((4'-fluorobiphenyl-4-yl)methyl)-5-methyloxa...)
Affinity DataEC50:  84nMAssay Description:Agonist activity at mGluR2 (unknown origin) expressed in HEK cells by FLIPR assay in presence of glutamateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50277878((5R)-3-((6-(1-cyclohexylethoxy)pyridin-3-yl)methyl...)
Affinity DataEC50:  88nMAssay Description:Agonist activity at mGluR2 (unknown origin) expressed in HEK cells by FLIPR assay in presence of glutamateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50277953((R)-3-((4'-ethoxybiphenyl-4-yl)methyl)-5-methyloxa...)
Affinity DataEC50:  97nMAssay Description:Agonist activity at mGluR2 (unknown origin) expressed in HEK cells by FLIPR assay in presence of glutamateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50277770(3-(4-(cyclohexylmethoxy)benzyl)-1,3-oxazinan-2-one...)
Affinity DataEC50:  117nMAssay Description:Agonist activity at mGluR2 (unknown origin) expressed in HEK cells by FLIPR assay in presence of glutamateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50277805(3-(4-(cyclohexylmethoxy)benzyl)-5-methyloxazolidin...)
Affinity DataEC50:  15nMAssay Description:Agonist activity at mGluR2 (unknown origin) expressed in HEK cells by FLIPR assay in presence of glutamateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50278009((R)-3-((6-(3,4-difluorophenyl)pyridin-3-yl)methyl)...)
Affinity DataEC50:  3.40E+3nMAssay Description:Agonist activity at mGluR2 (unknown origin) expressed in HEK cells by FLIPR assay in presence of glutamateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50278006((R)-5-methyl-3-(4-(pyrimidin-5-yl)benzyl)oxazolidi...)
Affinity DataEC50:  4.38E+3nMAssay Description:Agonist activity at mGluR2 (unknown origin) expressed in HEK cells by FLIPR assay in presence of glutamateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50277958((R)-5-methyl-3-(4-(pyridin-4-yl)benzyl)oxazolidin-...)
Affinity DataEC50:  4.79E+3nMAssay Description:Agonist activity at mGluR2 (unknown origin) expressed in HEK cells by FLIPR assay in presence of glutamateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50278054((R)-3-((2'-((dimethylamino)methyl)biphenyl-4-yl)me...)
Affinity DataEC50:  6.36E+3nMAssay Description:Agonist activity at mGluR2 (unknown origin) expressed in HEK cells by FLIPR assay in presence of glutamateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50278005((R)-5-methyl-3-(4-(pyridin-3-yl)benzyl)oxazolidin-...)
Affinity DataEC50:  7.55E+3nMAssay Description:Agonist activity at mGluR2 (unknown origin) expressed in HEK cells by FLIPR assay in presence of glutamateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50277844(3-(4-(pyridin-3-ylmethoxy)benzyl)-1,3-oxazinan-2-o...)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at mGluR2 (unknown origin) expressed in HEK cells by FLIPR assay in presence of glutamateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50277845(5-methyl-3-(4-(tetrahydro-2H-pyran-4-yloxy)benzyl)...)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at mGluR2 (unknown origin) expressed in HEK cells by FLIPR assay in presence of glutamateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50277847((R)-3-(4-((cyclohexyl(methyl)amino)methyl)benzyl)-...)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at mGluR2 (unknown origin) expressed in HEK cells by FLIPR assay in presence of glutamateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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