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Found 1272 with Last Name = 'hazuda' and Initial = 'd'
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50088301((E)-N,N-dimethyl-N-(4-(2-p-tolyl-6,7-dihydro-5H-be...)
Affinity DataKi:  1.40nMAssay Description:Inhibitory activity of the compound against specific binding of [125I]-MIP-1 alpha to human CCR5 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50141931((R)-[(2S,3S)-3-[4-(5-Biphenyl-4-ylmethyl-2-ethyl-2...)
Affinity DataKi:  400nMAssay Description:Binding affinity against hERG Voltage-gated potassium channel subunit Kv11.1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50141911((R)-2-[(2S,3S)-3-{4-[5-(4-Cyano-benzyl)-2-ethyl-2H...)
Affinity DataKi:  1.00E+3nMAssay Description:Binding affinity against hERG Voltage-gated potassium channel subunit Kv11.1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50139111((4R,6S,7S)-7-[(S)-3-Carboxy-3-(3-methyl-butyrylami...)
Affinity DataKi:  1.70E+3nMAssay Description:Tested for inhibition of Beta-secretase 1 (BACE 1) expressed in insect cell using baculovirusMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50139112((S)-N-((1S,2S,4R)-1-Benzyl-2,6-dihydroxy-4-isobuty...)
Affinity DataKi:  1.90E+3nMAssay Description:Tested for inhibition of Beta-secretase 1 (BACE 1) expressed in insect cell using baculovirusMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50139109((S)-N-((1S,2S,4R)-6-Acetoxy-1-benzyl-2-hydroxy-4-i...)
Affinity DataKi:  1.90E+3nMAssay Description:Compound was tested for inhibition of human reninMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50141908((R)-2-[(2S,3S)-3-{4-[5-(4-tert-Butyl-benzyl)-2-eth...)
Affinity DataKi:  2.10E+3nMAssay Description:Binding affinity against hERG Voltage-gated potassium channel subunit Kv11.1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50139109((S)-N-((1S,2S,4R)-6-Acetoxy-1-benzyl-2-hydroxy-4-i...)
Affinity DataKi:  2.20E+3nMAssay Description:Compound was tested for inhibition of cathepsin DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50141905((R)-2-[(2S,3S)-3-[4-(5-Biphenyl-4-ylmethyl-2-ethyl...)
Affinity DataKi:  2.30E+3nMAssay Description:Binding affinity against hERG Voltage-gated potassium channel subunit Kv11.1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50139109((S)-N-((1S,2S,4R)-6-Acetoxy-1-benzyl-2-hydroxy-4-i...)
Affinity DataKi:  2.70E+3nMAssay Description:Tested for inhibition of Beta-secretase 1 (BACE 1) expressed in insect cell using baculovirusMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50141978((2R,4S)-2-[(2S,3S)-3-[4-(5-Biphenyl-4-ylmethyl-2-e...)
Affinity DataKi:  3.00E+3nMAssay Description:Binding affinity against hERG Voltage-gated potassium channel subunit Kv11.1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50141935((2R,4R)-2-[(2S,3S)-3-{4-[5-(4-Cyclobutoxy-benzyl)-...)
Affinity DataKi:  3.40E+3nMAssay Description:Binding affinity against hERG Voltage-gated potassium channel subunit Kv11.1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50141951((R)-2-[(2S,3S)-3-{4-[5-(4-Cyclobutoxy-benzyl)-2-et...)
Affinity DataKi:  3.50E+3nMAssay Description:Binding affinity against hERG Voltage-gated potassium channel subunit Kv11.1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50141913((2R,4S)-2-[(2S,3S)-3-(4-{2-Ethyl-5-[4-(2,2,2-trifl...)
Affinity DataKi:  3.80E+3nMAssay Description:Binding affinity against hERG Voltage-gated potassium channel subunit Kv11.1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50141941((2R,4R)-2-[(2S,3S)-3-{4-[5-(4-tert-Butoxy-benzyl)-...)
Affinity DataKi:  5.60E+3nMAssay Description:Binding affinity against hERG Voltage-gated potassium channel subunit Kv11.1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50141906((2R,4S)-2-[(2S,3S)-3-{4-[5-(4-Cyclobutoxy-benzyl)-...)
Affinity DataKi:  5.70E+3nMAssay Description:Binding affinity against hERG Voltage-gated potassium channel subunit Kv11.1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50141973(2-[3-{4-[2-Ethyl-5-(4-trifluoromethoxy-benzyl)-2H-...)
Affinity DataKi:  6.00E+3nMAssay Description:Binding affinity against hERG Voltage-gated potassium channel subunit Kv11.1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50141910((2R,4S)-2-[(2S,3S)-3-{4-[2-Ethyl-5-(4-isopropyl-be...)
Affinity DataKi:  8.10E+3nMAssay Description:Binding affinity against hERG Voltage-gated potassium channel subunit Kv11.1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50141979((R)-2-[(2S,3S)-3-{4-[2-Ethyl-5-(4-isopropoxy-benzy...)
Affinity DataKi:  9.60E+3nMAssay Description:Binding affinity against hERG Voltage-gated potassium channel subunit Kv11.1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50141883((R)-2-((3S,4S)-3-((4-(3-benzyl-1-ethyl-1H-pyrazol-...)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity against hERG Voltage-gated potassium channel subunit Kv11.1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50141984((2R,4S)-2-[(2S,3S)-3-{4-[5-(4-Cyano-benzyl)-2-ethy...)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity against hERG Voltage-gated potassium channel subunit Kv11.1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50139112((S)-N-((1S,2S,4R)-1-Benzyl-2,6-dihydroxy-4-isobuty...)
Affinity DataKi:  1.09E+4nMAssay Description:Compound was tested for inhibition of human reninMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50141972((R)-2-[(2S,3S)-3-{4-[5-(3,4-Dimethoxy-benzyl)-2-et...)
Affinity DataKi:  1.10E+4nMAssay Description:Binding affinity against hERG Voltage-gated potassium channel subunit Kv11.1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50139112((S)-N-((1S,2S,4R)-1-Benzyl-2,6-dihydroxy-4-isobuty...)
Affinity DataKi:  1.25E+4nMAssay Description:Compound was tested for inhibition of cathepsin DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50141874((R)-2-((3S,4S)-3-((4-(3-benzyl-1-ethyl-1H-pyrazol-...)
Affinity DataKi:  1.40E+4nMAssay Description:Binding affinity against hERG Voltage-gated potassium channel subunit Kv11.1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50141945((2R,4S)-2-[(2S,3S)-3-{4-[5-(4-Ethoxy-benzyl)-2-eth...)
Affinity DataKi:  1.60E+4nMAssay Description:Binding affinity against hERG Voltage-gated potassium channel subunit Kv11.1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50141914((2R,4S)-2-[(2S,3S)-3-{4-[5-(3,4-Dimethoxy-benzyl)-...)
Affinity DataKi:  2.20E+4nMAssay Description:Binding affinity against hERG Voltage-gated potassium channel subunit Kv11.1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50139110((S)-N-((1S,2S,4R)-1-Benzyl-2-hydroxy-4-isobutylcar...)
Affinity DataKi:  2.44E+4nMAssay Description:Compound was tested for inhibition of human reninMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50139110((S)-N-((1S,2S,4R)-1-Benzyl-2-hydroxy-4-isobutylcar...)
Affinity DataKi:  2.80E+4nMAssay Description:Compound was tested for inhibition of cathepsin DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50141875((2R,3S)-2-[(2S,3S)-3-[4-(5-Benzyl-2-ethyl-2H-pyraz...)
Affinity DataKi:  3.00E+4nMAssay Description:Binding affinity against hERG Voltage-gated potassium channel subunit Kv11.1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50141887((2R,4R)-2-[(2S,3S)-3-{4-[5-(3,4-Dimethoxy-benzyl)-...)
Affinity DataKi:  3.70E+4nMAssay Description:Binding affinity against hERG Voltage-gated potassium channel subunit Kv11.1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50139110((S)-N-((1S,2S,4R)-1-Benzyl-2-hydroxy-4-isobutylcar...)
Affinity DataKi:  6.95E+4nMAssay Description:Tested for inhibition of Beta-secretase 1 (BACE 1) expressed in insect cell using baculovirusMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50139111((4R,6S,7S)-7-[(S)-3-Carboxy-3-(3-methyl-butyrylami...)
Affinity DataKi:  7.36E+4nMAssay Description:Compound was tested for inhibition of human reninMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50139111((4R,6S,7S)-7-[(S)-3-Carboxy-3-(3-methyl-butyrylami...)
Affinity DataKi:  7.97E+4nMAssay Description:Compound was tested for inhibition of cathepsin DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50121838((R)-3-cyclopropyl-2-((3S,4S)-3-((4-(3,3-difluoro-3...)
Affinity DataIC50:  0.0600nMAssay Description:Ability to displace [125I]- labeled MIP-1alpha from CCR5 receptor expressed on CHO cell membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50105510(Allyl-{1-[(S)-4-(benzenesulfonyl-methyl-amino)-3-m...)
Affinity DataIC50:  0.100nMAssay Description:Inhibitory concentration, binding towards C-C chemokine receptor type 5 using [125I]-MIP-1 alpha as radioligand expressed on CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50105517(Allyl-[1-((3S,4S)-1-benzyl-4-phenyl-pyrrolidin-3-y...)
Affinity DataIC50:  0.100nMAssay Description:Inhibitory concentration, binding towards C-C chemokine receptor type 5 using [125I]-MIP-1 alpha as radioligand expressed on CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50119338((R)-3-Cyclobutyl-2-{(3S,4S)-3-phenyl-4-[4-(3-pheny...)
Affinity DataIC50:  0.100nMAssay Description:Ability to displace [125I]- labeled MIP-1alpha from CCR5 receptor expressed on CHO cell membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50121836((R)-3-Cyclobutyl-2-((S)-3-(3-fluoro-phenyl)-4-{4-[...)
Affinity DataIC50:  0.100nMAssay Description:Ability to displace [125I]- labeled MIP-1alpha from CCR5 receptor expressed on CHO cell membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50119338((R)-3-Cyclobutyl-2-{(3S,4S)-3-phenyl-4-[4-(3-pheny...)
Affinity DataIC50:  0.100nMAssay Description:Displacement of [125I]-MIP-1 alpha from human C-C chemokine receptor type 5 expressed on CHO cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50119341((R)-3-cyclopropyl-2-((3S,4S)-3-phenyl-4-((4-(3-phe...)
Affinity DataIC50:  0.100nMAssay Description:In vitro binding affinity at CCR5 receptor in the presence of [125I]-MIP-1 alpha.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50119349((R)-2-cyclobutyl-2-((3S,4S)-3-phenyl-4-((4-(3-phen...)
Affinity DataIC50:  0.100nMAssay Description:In vitro binding affinity at CCR5 receptor in the presence of [125I]-MIP-1 alpha.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50119338((R)-3-Cyclobutyl-2-{(3S,4S)-3-phenyl-4-[4-(3-pheny...)
Affinity DataIC50:  0.100nMAssay Description:In vitro binding affinity at CCR5 receptor in the presence of [125I]-MIP-1 alpha.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50119336(2-cyclohexyl-2-{3-phenyl-4-[4-(3-phenylpropyl)hexa...)
Affinity DataIC50:  0.100nMAssay Description:In vitro binding affinity at CCR5 receptor in the presence of [125I]-MIP-1 alpha.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50110088(4N-allyl-4N-[4-nitrobenzyloxycarboyl]-1-[4'-phenyl...)
Affinity DataIC50:  0.130nMAssay Description:Ability to displace [125I]-labeled MIP-1alpha from the C-C chemokine receptor type 5 expressed on CHO cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50119336(2-cyclohexyl-2-{3-phenyl-4-[4-(3-phenylpropyl)hexa...)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of human CX3C chemokine receptor 5 from GP120-membrane-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50105503(Allyl-[1-((3S,4S)-1-benzoyl-4-phenyl-pyrrolidin-3-...)
Affinity DataIC50:  0.200nMAssay Description:Inhibitory concentration, binding towards C-C chemokine receptor type 5 using [125I]-MIP-1 alpha as radioligand expressed on CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50105521(Allyl-[1-((3S,4S)-1-cyclopentanecarbonyl-4-phenyl-...)
Affinity DataIC50:  0.200nMAssay Description:Inhibitory concentration, binding towards C-C chemokine receptor type 5 using [125I]-MIP-1 alpha as radioligand expressed on CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50121828((R)-3-Cyclobutyl-2-((S)-3-(3-fluoro-phenyl)-4-{4-[...)
Affinity DataIC50:  0.200nMAssay Description:Ability to displace [125I]- labeled MIP-1alpha from CCR5 receptor expressed on CHO cell membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50121833((R)-3-cyclobutyl-2-((3S,4S)-3-((4-(3,3-difluoro-3-...)
Affinity DataIC50:  0.200nMAssay Description:Ability to displace [125I]- labeled MIP-1alpha from CCR5 receptor expressed on CHO cell membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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