BindingDB PrimarySearch_ki

Found 508 with Last Name = 'hurley' and Initial = 'td'

Aldehyde dehydrogenase, mitochondrial(Homo sapiens (Human))
Indiana University School Of Medicine

Curated by ChEMBL

PNG

BDBM50236899(CHEMBL4099822)

Ki: 19nMAssay Description:Competitive inhibition of full length recombinant human ALDH2 expressed in Escherichia coli assessed as reduction in dehydrogenase activity using pro...More data for this Ligand-Target Pair

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3D Structure (crystal)

Aldehyde dehydrogenase, mitochondrial(Homo sapiens (Human))
Indiana University School Of Medicine

Curated by ChEMBL

PNG

BDBM50236900(CHEMBL4072941)

Ki: 35nMAssay Description:In vitro for its ability to displace [3H]- spiperone from cloned human dopamine D2 short receptor expressed in CHO cellsMore data for this Ligand-Target Pair

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Retinal dehydrogenase 2(Homo sapiens (Human))
Indiana University School Of Medicine

Curated by ChEMBL

PNG

BDBM50459608(CHEBI:90441 | CHEMBL3276621)

Ki: 56nMAssay Description:Inhibition of human ALDH1A2More data for this Ligand-Target Pair

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3D Structure (crystal)

Aldehyde dehydrogenase, dimeric NADP-preferring(Homo sapiens (Human))
Indiana University School Of Medicine

Curated by ChEMBL

PNG

BDBM50447056(CHEMBL1378094 | US9320722, CB7 | US9328112, CB7)

Ki: 82nMAssay Description:Competitive inhibition of human ALDH3A1 using benzaldehyde as substrate by Lineweaver-Burk plot analysis in presence of 1.5 mM NADP+More data for this Ligand-Target Pair

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3D Structure (crystal)

Aldehyde dehydrogenase, mitochondrial(Homo sapiens (Human))
Indiana University School Of Medicine

Curated by ChEMBL

PNG

BDBM50236900(CHEMBL4072941)

Ki: 87nMAssay Description:Competitive inhibition of full length recombinant human ALDH2 expressed in Escherichia coli assessed as reduction in dehydrogenase activity using pro...More data for this Ligand-Target Pair

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Aldehyde dehydrogenase 1A1(Homo sapiens (Human))
Indiana University

Curated by ChEMBL

PNG

BDBM50076550(CHEMBL3416554)

Ki: 96nMAssay Description:Non-competitive tight inhibition of recombinant human ALDH1A1 using 1000 uM NAD+ as cofactor by Lineweaver-Burk plot analysis in presence of 100 to 8...More data for this Ligand-Target Pair

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3D Structure (crystal)

Aldehyde dehydrogenase, dimeric NADP-preferring(Homo sapiens (Human))
Indiana University School Of Medicine

Curated by ChEMBL

PNG

BDBM50447056(CHEMBL1378094 | US9320722, CB7 | US9328112, CB7)

Ki: 110nMAssay Description:Non-competitive inhibition of human ALDH3A1 using benzaldehyde as substrate by Lineweaver-Burk plot analysis in presence of 100 to 500 uM NADP+More data for this Ligand-Target Pair

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3D Structure (crystal)

Aldehyde dehydrogenase 1A1(Homo sapiens (Human))
Indiana University

Curated by ChEMBL

PNG

BDBM50236904(CHEMBL1335126)

Ki: 170nMAssay Description:Uncompetitive inhibition of full length recombinant human ALDH1A1 expressed in Escherichia coli BL21(DE3) using propionaldehyde as substrate in prese...More data for this Ligand-Target Pair

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3D Structure (crystal)

Aldehyde dehydrogenase, dimeric NADP-preferring(Homo sapiens (Human))
Indiana University School Of Medicine

Curated by ChEMBL

PNG

BDBM50447056(CHEMBL1378094 | US9320722, CB7 | US9328112, CB7)

Ki: 200nMAssay Description:Inhibition of human wild-type ALDH3A1-mediated benzaldehyde oxidationMore data for this Ligand-Target Pair

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3D Structure (crystal)

Aldehyde dehydrogenase, dimeric NADP-preferring(Homo sapiens (Human))
Indiana University School Of Medicine

Curated by ChEMBL

PNG

BDBM50447056(CHEMBL1378094 | US9320722, CB7 | US9328112, CB7)

Ki: 200nMpH: 7.5Assay Description:IC50 values were determined for CB29 and its analogs using propionaldehyde as the substrate for ALDH1A1 and ALDH2 or benzaldehyde as the substrate fo...More data for this Ligand-Target Pair

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3D Structure (crystal)

Aldehyde dehydrogenase, dimeric NADP-preferring(Homo sapiens (Human))
Indiana University School Of Medicine

Curated by ChEMBL

PNG

BDBM50447056(CHEMBL1378094 | US9320722, CB7 | US9328112, CB7)

Ki: 200nMpH: 7.5Assay Description:IC50 values were determined for CB29 and its analogs using propionaldehyde as the substrate for ALDH1A1 and ALDH2 or benzaldehyde as the substrate fo...More data for this Ligand-Target Pair

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3D Structure (crystal)

Aldehyde dehydrogenase 1A1(Homo sapiens (Human))
Indiana University

Curated by ChEMBL

PNG

BDBM50076741(CHEMBL3416562)

Ki: 230nMAssay Description:Competitive inhibition of recombinant human ALDH1A1 using 800 uM NAD+ as cofactor by Lineweaver-Burk plot analysis in presence of 100 to 800 uM aceta...More data for this Ligand-Target Pair

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3D Structure (crystal)

Aldehyde dehydrogenase 1A1(Homo sapiens (Human))
Indiana University

Curated by ChEMBL

PNG

BDBM50076740(CHEMBL1382328)

Ki: 240nMAssay Description:Competitive tight inhibition of recombinant human ALDH1A1 using 1000 uM NAD+ as cofactor by Lineweaver-Burk plot analysis in presence of 100 to 800 u...More data for this Ligand-Target Pair

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Aldehyde dehydrogenase family 1 member A3(Homo sapiens (Human))
Indiana University School Of Medicine

Curated by ChEMBL

PNG

BDBM50459608(CHEBI:90441 | CHEMBL3276621)

Ki: 261nMAssay Description:Inhibition of human ALDH1A3More data for this Ligand-Target Pair

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Aldehyde dehydrogenase 1A1(Homo sapiens (Human))
Indiana University

Curated by ChEMBL

PNG

BDBM50459608(CHEBI:90441 | CHEMBL3276621)

Ki: 285nMAssay Description:Inhibition of human ALDH1A1More data for this Ligand-Target Pair

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Aldehyde dehydrogenase 1A1(Homo sapiens (Human))
Indiana University

Curated by ChEMBL

PNG

BDBM50448790(CHEMBL3128208)

Ki: 290nMAssay Description:Noncompetitive/mixed type inhibition of human ALDH1A1 by Lineweaver-Burk plot analysis in presence of NAD+More data for this Ligand-Target Pair

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Aldehyde dehydrogenase, mitochondrial(Homo sapiens (Human))
Indiana University School Of Medicine

Curated by ChEMBL

PNG

BDBM50236901(CHEMBL4061563)

Ki: 310nMAssay Description:Displacement of [3H]spiperone from human Dopamine receptor D3 expressed in CHO cellsMore data for this Ligand-Target Pair

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Aldehyde dehydrogenase, dimeric NADP-preferring(Homo sapiens (Human))
Indiana University School Of Medicine

Curated by ChEMBL

PNG

BDBM50448790(CHEMBL3128208)

Ki: 380nMAssay Description:Inhibition of human ALDH3A1 using benzaldehyde as substrate by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair

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Aldehyde dehydrogenase 1A1(Homo sapiens (Human))
Indiana University

Curated by ChEMBL

PNG

BDBM50459601(CHEMBL4217738)

Ki: 380nMAssay Description:Non-competitive inhibition of human recombinant ALDH1A1 assessed as reduction of NAD(P)H formation using varying levels of NAD+More data for this Ligand-Target Pair

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Aldehyde dehydrogenase, dimeric NADP-preferring(Homo sapiens (Human))
Indiana University School Of Medicine

Curated by ChEMBL

PNG

BDBM50448790(CHEMBL3128208)

Ki: 500nMAssay Description:Inhibition of human ALDH3A1 by Lineweaver-Burk plot analysis in presence of NADP+More data for this Ligand-Target Pair

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Aldehyde dehydrogenase 1A1(Homo sapiens (Human))
Indiana University

Curated by ChEMBL

PNG

BDBM30972(8-[[4-(2-furoyl)piperazino]methyl]-7-isoamyl-1,3-d...)

Ki: 720nMAssay Description:Uncompetitive partial inhibition of recombinant human ALDH1A1 using 200 uM propionaldehyde as substrate by Lineweaver-Burk plot analysis in presence ...More data for this Ligand-Target Pair

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3D Structure (crystal)

Aldehyde dehydrogenase 1A1(Homo sapiens (Human))
Indiana University

Curated by ChEMBL

PNG

BDBM30972(8-[[4-(2-furoyl)piperazino]methyl]-7-isoamyl-1,3-d...)

Ki: 800nMAssay Description:Non-competitive partial inhibition of recombinant human ALDH1A1 using 800 uM NAD+ as cofactor by Lineweaver-Burk plot analysis in presence of 100 to ...More data for this Ligand-Target Pair

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3D Structure (crystal)

Aldehyde dehydrogenase 1A1(Homo sapiens (Human))
Indiana University

Curated by ChEMBL

PNG

BDBM50078833(4-Methyl-7-(diethylamino)coumarin | 7-(diethylamin...)

Ki: 870nMAssay Description:Non-competitive inhibition of full length recombinant human ALDH1A1 expressed in Escherichia coli BL21(DE3) assessed as reduction in dehydrogenase ac...More data for this Ligand-Target Pair

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3D Structure (crystal)

Aldehyde dehydrogenase 1A1(Homo sapiens (Human))
Indiana University

Curated by ChEMBL

PNG

BDBM50448790(CHEMBL3128208)

Ki: 900nMAssay Description:Competitive inhibition of human ALDH1A1 using propionaldehyde as substrate by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair

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Aldehyde dehydrogenase, mitochondrial(Homo sapiens (Human))
Indiana University School Of Medicine

Curated by ChEMBL

PNG

BDBM50448790(CHEMBL3128208)

Ki: 1.00E+3nMAssay Description:Inhibition of human ALDH2 using propionaldehyde as substrate by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair

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3D Structure (crystal)

Aldehyde dehydrogenase, mitochondrial(Homo sapiens (Human))
Indiana University School Of Medicine

Curated by ChEMBL

PNG

BDBM50236904(CHEMBL1335126)

Ki: 1.10E+3nMAssay Description:Competitive inhibition of full length recombinant human ALDH2 expressed in Escherichia coli assessed as reduction in dehydrogenase activity using pro...More data for this Ligand-Target Pair

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Aldehyde dehydrogenase, dimeric NADP-preferring(Homo sapiens (Human))
Indiana University School Of Medicine

Curated by ChEMBL

PNG

BDBM22794(1-benzyl-2,3-dihydro-1H-indole-2,3-dione | Isatin-...)

Ki: 1.20E+3nMAssay Description:Inhibition of human ALDH3A1 using benzaldehyde as substrate by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair

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Aldehyde dehydrogenase 1A1(Homo sapiens (Human))
Indiana University

Curated by ChEMBL

PNG

BDBM50078833(4-Methyl-7-(diethylamino)coumarin | 7-(diethylamin...)

Ki: 1.20E+3nMAssay Description:Non-competitive inhibition of full length recombinant human ALDH1A1 expressed in Escherichia coli BL21(DE3) assessed as reduction in dehydrogenase ac...More data for this Ligand-Target Pair

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3D Structure (crystal)

Glycogen [starch] synthase, muscle(Homo sapiens (Human))
Indiana University School Of Medicine

Curated by ChEMBL

PNG

BDBM50527393(CHEMBL4446895)

Ki: 1.31E+3nMAssay Description:Competitive inhibition of C-terminal 6His-tagged human GYS1 using UDPG as substrate in presence of G-6-P by 14C-glucose incorporation based Michaelis...More data for this Ligand-Target Pair

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Aldehyde dehydrogenase, mitochondrial(Homo sapiens (Human))
Indiana University School Of Medicine

Curated by ChEMBL

PNG

BDBM50448790(CHEMBL3128208)

Ki: 2.20E+3nMAssay Description:Inhibition of human ALDH2 by Lineweaver-Burk plot analysis in presence of NAD+More data for this Ligand-Target Pair

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3D Structure (crystal)

Aldehyde dehydrogenase, mitochondrial(Homo sapiens (Human))
Indiana University School Of Medicine

Curated by ChEMBL

PNG

BDBM50236910(CHEMBL4083412)

Ki: 2.40E+3nMAssay Description:Competitive inhibition of full length recombinant human ALDH2 expressed in Escherichia coli assessed as reduction in dehydrogenase activity using pro...More data for this Ligand-Target Pair

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Aldehyde dehydrogenase, dimeric NADP-preferring(Homo sapiens (Human))
Indiana University School Of Medicine

Curated by ChEMBL

PNG

BDBM22794(1-benzyl-2,3-dihydro-1H-indole-2,3-dione | Isatin-...)

Ki: 4.00E+3nMAssay Description:Inhibition of human ALDH3A1 by Lineweaver-Burk plot analysis in presence of NADP+More data for this Ligand-Target Pair

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Aldehyde dehydrogenase, dimeric NADP-preferring(Homo sapiens (Human))
Indiana University School Of Medicine

Curated by ChEMBL

PNG

BDBM109210(CB29)

Ki: 4.70E+3nM IC50: 1.60E+4nMAssay Description:To determine the IC50 values for CB29 and its analogues, propionaldehyde was used as the substrate for ALDH1A1 and ALDH2 and benzaldehyde was used as...More data for this Ligand-Target Pair

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3D Structure (crystal)

Aldehyde dehydrogenase, mitochondrial(Homo sapiens (Human))
Indiana University School Of Medicine

Curated by ChEMBL

PNG

BDBM50303403(2-(4-methyl-2-oxo-2H-chromen-7-yloxy)acetonitrile ...)

Ki: 5.60E+3nMAssay Description:Mixed-type non-competitive inhibition of full length recombinant human ALDH2 expressed in Escherichia coli assessed as reduction in dehydrogenase act...More data for this Ligand-Target Pair

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Aldehyde dehydrogenase 1A1(Homo sapiens (Human))
Indiana University

Curated by ChEMBL

PNG

BDBM50303403(2-(4-methyl-2-oxo-2H-chromen-7-yloxy)acetonitrile ...)

Ki: 6.90E+3nMAssay Description:Non-competitive inhibition of full length recombinant human ALDH1A1 expressed in Escherichia coli BL21(DE3) assessed as reduction in dehydrogenase ac...More data for this Ligand-Target Pair

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Aldehyde dehydrogenase, mitochondrial(Homo sapiens (Human))
Indiana University School Of Medicine

Curated by ChEMBL

PNG

BDBM22794(1-benzyl-2,3-dihydro-1H-indole-2,3-dione | Isatin-...)

Ki: 1.50E+4nMAssay Description:Competitive inhibition of human ALDH2 using propionaldehyde as substrate by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair

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3D Structure (crystal)

Aldehyde dehydrogenase, mitochondrial(Homo sapiens (Human))
Indiana University School Of Medicine

Curated by ChEMBL

PNG

BDBM22794(1-benzyl-2,3-dihydro-1H-indole-2,3-dione | Isatin-...)

Ki: 3.40E+4nMAssay Description:Noncompetitive/mixed type inhibition of human ALDH2 by Lineweaver-Burk plot analysis in presence of NAD+More data for this Ligand-Target Pair

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3D Structure (crystal)

Aldehyde dehydrogenase 1A1(Homo sapiens (Human))
Indiana University

Curated by ChEMBL

PNG

BDBM22794(1-benzyl-2,3-dihydro-1H-indole-2,3-dione | Isatin-...)

IC50: 20nMAssay Description:Inhibition of human ALDH1A1 using propionaldehyde as substrate preincubated for 2 mins followed by substrate addition by spectrophotometry in presenc...More data for this Ligand-Target Pair

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Retinal dehydrogenase 2(Homo sapiens (Human))
Indiana University School Of Medicine

Curated by ChEMBL

PNG

BDBM50567384(CHEMBL4849586)

IC50: 21nMAssay Description:Inhibition of human ALDH1A2 assessed as NADH formation using propionaldehyde as substrate by spectrophotometeryMore data for this Ligand-Target Pair

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Aldehyde dehydrogenase family 1 member A3(Homo sapiens (Human))
Indiana University School Of Medicine

Curated by ChEMBL

PNG

BDBM50567363(CHEMBL4876602)

IC50: 34nMAssay Description:Inhibition of human ALDH1A3 assessed as NADH formation using propionaldehyde as substrate by spectrophotometeryMore data for this Ligand-Target Pair

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Aldehyde dehydrogenase 1A1(Homo sapiens (Human))
Indiana University

Curated by ChEMBL

PNG

BDBM50448806(CHEMBL3128209)

IC50: 40nMAssay Description:Inhibition of human ALDH1A1 using propionaldehyde as substrate preincubated for 2 mins followed by substrate addition by spectrophotometry in presenc...More data for this Ligand-Target Pair

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Retinal dehydrogenase 2(Homo sapiens (Human))
Indiana University School Of Medicine

Curated by ChEMBL

PNG

BDBM50567363(CHEMBL4876602)

IC50: 40nMAssay Description:Inhibition of human ALDH1A2 assessed as NADH formation using propionaldehyde as substrate by spectrophotometeryMore data for this Ligand-Target Pair

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Aldehyde dehydrogenase family 1 member A3(Homo sapiens (Human))
Indiana University School Of Medicine

Curated by ChEMBL

PNG

BDBM50567386(CHEMBL4861872)

IC50: 50nMAssay Description:Inhibition of human ALDH1A3 assessed as NADH formation using propionaldehyde as substrate by spectrophotometeryMore data for this Ligand-Target Pair

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Aldehyde dehydrogenase 1A1(Homo sapiens (Human))
Indiana University

Curated by ChEMBL

PNG

BDBM47880(1-(3-phenylpropyl)indole-2,3-dione | 1-(3-phenylpr...)

IC50: 50nMAssay Description:Inhibition of human ALDH1A1 using propionaldehyde as substrate preincubated for 2 mins followed by substrate addition by spectrophotometry in presenc...More data for this Ligand-Target Pair

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Aldehyde dehydrogenase, mitochondrial(Homo sapiens (Human))
Indiana University School Of Medicine

Curated by ChEMBL

PNG

BDBM50448802(CHEMBL3128207)

IC50: 50nMAssay Description:Inhibition of human ALDH2 using propionaldehyde as substrate preincubated for 2 mins followed by substrate addition by spectrophotometry in presence ...More data for this Ligand-Target Pair

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Aldehyde dehydrogenase 1A1(Homo sapiens (Human))
Indiana University

Curated by ChEMBL

PNG

BDBM50076742(CHEBI:86194 | CHEMBL3416563)

IC50: 57nMAssay Description:Inhibition of recombinant human ALDH1A1 using propionaldehyde as substrate preincubated for 2 mins with NAD+ followed by substrate addition by UV-Vis...More data for this Ligand-Target Pair

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Aldehyde dehydrogenase 1A1(Homo sapiens (Human))
Indiana University

Curated by ChEMBL

PNG

BDBM50076742(CHEBI:86194 | CHEMBL3416563)

IC50: 57nMAssay Description:Inhibition of human ALDH1A1More data for this Ligand-Target Pair

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Retinal dehydrogenase 2(Homo sapiens (Human))
Indiana University School Of Medicine

Curated by ChEMBL

PNG

BDBM50567385(CHEMBL4846203)

IC50: 58nMAssay Description:Inhibition of human ALDH1A2 assessed as NADH formation using propionaldehyde as substrate by spectrophotometeryMore data for this Ligand-Target Pair

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Aldehyde dehydrogenase 1A1(Homo sapiens (Human))
Indiana University

Curated by ChEMBL

PNG

BDBM50133625(1-Benzyl-5-chloro-1H-indole-2,3-dione | CHEMBL3366...)

IC50: 60nMAssay Description:Inhibition of human ALDH1A1 using propionaldehyde as substrate preincubated for 2 mins followed by substrate addition by spectrophotometry in presenc...More data for this Ligand-Target Pair

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Aldehyde dehydrogenase family 1 member A3(Homo sapiens (Human))
Indiana University School Of Medicine

Curated by ChEMBL

PNG

BDBM50567382(CHEMBL4859904)

IC50: 60nMAssay Description:Inhibition of human ALDH1A3 assessed as NADH formation using propionaldehyde as substrate by spectrophotometeryMore data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

Details Article PubMed

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Targets 7▿
- Aldehyde dehydrogenase 1A1 155
- Aldehyde dehydrogenase, dimeric NADP-preferring 126
- Retinal dehydrogenase 2 71
- Aldehyde dehydrogenase family 1 member A3 70
- Aldehyde dehydrogenase, mitochondrial 55
- Aldehyde dehydrogenase X, mitochondrial 16
- Glycogen [starch] synthase, muscle 15
- ...
Publications 9▿
- Eur J Med Chem 211: (2021) 106
- J Med Chem 61: 8754-8773 (2018) 83
- US Patent US9320722 (2016) 81
- J Med Chem 57: 714-22 (2014) 70
- J Med Chem 60: 2439-2455 (2017) 59
- J Med Chem 58: 1964-75 (2015) 47
- J Med Chem 57: 449-61 (2014) 27
- Chembiochem 15: 701-712 (2014) 20
- J Med Chem 63: 3538-3551 (2020) 15
Institutions 4▿
- Indiana University School Of Medicine 254
- University Of Michigan 106
- Indiana University Research And Technology 81
- Indiana University 67
Affinity: 19 to 8.8E+5 nM▿
- Ki 37
- IC50 472
- Affinity ≤ nM
Xtal structures: 20
Docked structures: 0
Catalog Cmpds: 113