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Found 950 with Last Name = 'ife' and Initial = 'rj'
TargetPlatelet-activating factor acetylhydrolase(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50117772(CHEMBL10921 | N-(2-Diethylamino-ethyl)-2-[2-(4-flu...)
Affinity DataKi:  0.0300nMAssay Description:Steady state and transient kinetics to a freely reversible, non-covalently bound, human recombinant Phospholipase A2 (rhLp-PLA2) was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 alpha(Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM8336(N-[5-(pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridazin-3-...)
Affinity DataKi:  0.0800nM ΔG°:  -57.1kJ/molepH: 7.0 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 10 uM ATP/ [gamma-33P] ATP. Aft...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 alpha(Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM8337(N-[5-(2,3-difluorophenyl)-1H-pyrazolo[3,4-c]pyrida...)
Affinity DataKi:  0.110nM ΔG°:  -56.3kJ/molepH: 7.0 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 10 uM ATP/ [gamma-33P] ATP. Aft...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-activating factor acetylhydrolase(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50125265(CHEMBL204021 | N-(2-Diethylamino-ethyl)-2-[2-(4-fl...)
Affinity DataKi:  0.110nMAssay Description:Inhibitory activity against recombinant human Lp-PLA2More data for this Ligand-Target Pair
TargetGlycogen synthase kinase-3 alpha(Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM8339(N-[5-(2,3-difluorophenyl)-1H-pyrazolo[3,4-c]pyrida...)
Affinity DataKi:  0.190nM ΔG°:  -54.9kJ/molepH: 7.0 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 10 uM ATP/ [gamma-33P] ATP. Aft...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50222900(CHEMBL267062)
Affinity DataKi:  0.407nMAssay Description:Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50217828(CHEMBL413707)
Affinity DataKi:  0.501nMAssay Description:Binding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50222781(CHEMBL9951)
Affinity DataKi:  0.562nMAssay Description:Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50217831(CHEMBL430706)
Affinity DataKi:  0.676nMAssay Description:Binding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50217829(CHEMBL115262)
Affinity DataKi:  0.708nMAssay Description:Binding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50217832(CHEMBL116292)
Affinity DataKi:  0.794nMAssay Description:Binding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50217835(CHEMBL114345)
Affinity DataKi:  0.832nMAssay Description:Binding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 alpha(Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM8338(N-[5-(2,3-difluorophenyl)-1H-pyrazolo[3,4-c]pyrida...)
Affinity DataKi:  0.950nM ΔG°:  -51.0kJ/molepH: 7.0 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 10 uM ATP/ [gamma-33P] ATP. Aft...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1B adrenergic receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50217831(CHEMBL430706)
Affinity DataKi:  1.30nMAssay Description:Binding affinity towards Alpha-1B adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50098551((R)-3-(2-(2-(4-methylpiperidin-1-yl)ethyl)pyrrolid...)
Affinity DataKi:  1.30nMAssay Description:Binding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50222900(CHEMBL267062)
Affinity DataKi:  1.70nMAssay Description:Binding affinity at human cloned 5-hydroxytryptamine 2A receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50222777(CHEMBL9616)
Affinity DataKi:  1.70nMAssay Description:Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50217825(CHEMBL323778)
Affinity DataKi:  1.80nMAssay Description:Binding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50130261(6-(2-{2-[4-(4-Chloro-phenoxy)-piperidin-1-yl]-ethy...)
Affinity DataKi:  2nMAssay Description:Compound was tested for its binding affinity in 5-hydroxytryptamine 7 receptor (using human cloned receptors in HEK 293 and [3H]5-CT as a radioligand...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50222899(CHEMBL9347)
Affinity DataKi:  2nMAssay Description:Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50125260(2-{2-[4-(5-Fluoro-2-oxo-2,3-dihydro-benzoimidazol-...)
Affinity DataKi:  2.20nMAssay Description:Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50130297(6-{(R)-2-[2-(4-Methyl-piperidin-1-yl)-ethyl]-pyrro...)
Affinity DataKi:  2.40nMAssay Description:Binding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50222780(CHEMBL275343)
Affinity DataKi:  2.5nMAssay Description:Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50222894(CHEMBL9952)
Affinity DataKi:  2.80nMAssay Description:Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1F(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50091438((E)-3-(3,4-Dichloro-phenyl)-N-{5-[4-(5-hydroxy-1H-...)
Affinity DataKi:  3.20nMAssay Description:Binding affinity for 5-hydroxytryptamine 1F receptor was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50222778(CHEMBL275451)
Affinity DataKi:  4.5nMAssay Description:Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM8337(N-[5-(2,3-difluorophenyl)-1H-pyrazolo[3,4-c]pyrida...)
Affinity DataKi:  5nM ΔG°:  -46.7kJ/molepH: 7.5 T: 2°CAssay Description:In vitro kinase assay using purified CDK2/Cyclin A was incubated at room temperature with substrate, and test compounds in the presence of 100 uM ATP...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM8336(N-[5-(pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridazin-3-...)
Affinity DataKi:  5nM ΔG°:  -46.7kJ/molepH: 7.5 T: 2°CAssay Description:In vitro kinase assay using purified CDK2/Cyclin A was incubated at room temperature with substrate, and test compounds in the presence of 100 uM ATP...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1E(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50091438((E)-3-(3,4-Dichloro-phenyl)-N-{5-[4-(5-hydroxy-1H-...)
Affinity DataKi:  6.30nMAssay Description:Binding affinity for 5-hydroxytryptamine 1E receptor was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50217833(CHEMBL331803)
Affinity DataKi:  6.30nMAssay Description:Binding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50217837(CHEMBL111922)
Affinity DataKi:  6.5nMAssay Description:Binding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50217827(CHEMBL112876)
Affinity DataKi:  6.5nMAssay Description:Binding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50222897(CHEMBL9446)
Affinity DataKi:  6.90nMAssay Description:Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50222781(CHEMBL9951)
Affinity DataKi:  6.90nMAssay Description:Binding affinity at human cloned 5-hydroxytryptamine 2A receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50096393(Benzo[b]thiophene-2-carboxylic acid [(S)-3-methyl-...)
Affinity DataKi:  7nMAssay Description:Inhibition of cathepsin KMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50091438((E)-3-(3,4-Dichloro-phenyl)-N-{5-[4-(5-hydroxy-1H-...)
Affinity DataKi:  7.90nMAssay Description:Binding affinity for Dopamine receptor D3 was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50222782(CHEMBL9770)
Affinity DataKi:  9.10nMAssay Description:Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50222893(CHEMBL9250)
Affinity DataKi:  9.30nMAssay Description:Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50096392((S)-2-[2-(3,4-Dimethoxy-phenyl)-acetylamino]-4-met...)
Affinity DataKi:  10nMAssay Description:Inhibition of cathepsin KMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50096392((S)-2-[2-(3,4-Dimethoxy-phenyl)-acetylamino]-4-met...)
Affinity DataKi:  10nMAssay Description:Inhibition of cathepsin KMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50222784(CHEMBL273872)
Affinity DataKi:  10nMAssay Description:Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50096383(Benzo[b]thiophene-2-carboxylic acid [(S)-3-methyl-...)
Affinity DataKi:  11nMAssay Description:Inhibition of cathepsin KMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50222779(CHEMBL269400)
Affinity DataKi:  11nMAssay Description:Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50222890(CHEMBL9840)
Affinity DataKi:  11nMAssay Description:Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50096383(Benzo[b]thiophene-2-carboxylic acid [(S)-3-methyl-...)
Affinity DataKi:  11nMAssay Description:Inhibitory activity against human cysteine protease, cathepsin K.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50222889(CHEMBL429202)
Affinity DataKi:  12nMAssay Description:Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1B(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50091438((E)-3-(3,4-Dichloro-phenyl)-N-{5-[4-(5-hydroxy-1H-...)
Affinity DataKi:  13nMAssay Description:Binding affinity for 5-hydroxytryptamine 1B receptor was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50096397(CHEMBL293694 | Naphthalene-2-carboxylic acid [(S)-...)
Affinity DataKi:  14nMAssay Description:Inhibition of cathepsin KMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50222896(CHEMBL275475)
Affinity DataKi:  14nMAssay Description:Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50096371(4-tert-Butyl-N-[(S)-3-methyl-1-(4-oxo-tetrahydro-f...)
Affinity DataKi:  15nMAssay Description:Inhibitory activity against human cysteine protease, cathepsin K.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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