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Found 595 with Last Name = 'kendall' and Initial = 'r'
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50146490(3-(S)-Benzo[1,3]dioxol-5-yl-3-({(R)-5-oxo-1-[3-(1,...)
Affinity DataKi:  0.100nMAssay Description:Binding affinity towards vitronectin receptor (AlphaV-beta3 integrin).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Amgen

LigandPNGBDBM17689(2-aminobenzimidazole, 14 | N-{4-chloro-3-[(4-methy...)
Affinity DataKi:  0.200nM ΔG°:  -54.8kJ/molepH: 7.5 T: 2°CAssay Description:The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50146492(3-Benzo[1,3]dioxol-5-yl-3-({1-[2-fluoro-5-(1,4,5,6...)
Affinity DataKi:  0.5nMAssay Description:Binding affinity towards vitronectin receptor (AlphaV-beta3 integrin).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Amgen

LigandPNGBDBM17705(2-aminobenzoxazole, 30 | N-{4-chloro-3-[(4-methylp...)
Affinity DataKi:  0.5nMAssay Description:The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Amgen

LigandPNGBDBM17703(2-aminobenzoxazole, 28 | N-(4-chloro-3-{[(2S)-1-me...)
Affinity DataKi:  0.5nMAssay Description:The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Amgen

LigandPNGBDBM17704(2-aminobenzoxazole, 29 | N-(4-chloro-3-{[(2S)-1-me...)
Affinity DataKi:  0.5nMAssay Description:The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50146497(3-Benzo[1,3]dioxol-5-yl-3-({5-oxo-1-[3-(1,4,5,6-te...)
Affinity DataKi:  0.700nMAssay Description:Affinity for alphaIIb-beta3 integrinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Amgen

LigandPNGBDBM17687(2-aminobenzimidazole, 12 | N-(3-{[(2R)-1-methylpyr...)
Affinity DataKi:  1nM ΔG°:  -50.9kJ/molepH: 7.5 T: 2°CAssay Description:The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50146493(3-({5-Oxo-1-[3-(1,4,5,6-tetrahydro-pyrimidin-2-yla...)
Affinity DataKi:  1.40nMAssay Description:Binding affinity towards vitronectin receptor (AlphaV-beta3 integrin).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Amgen

LigandPNGBDBM17709(2-aminobenzoxazole, 34 | N-(4-chloro-3-{[(2S)-1-me...)
Affinity DataKi:  1.60nMAssay Description:The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Amgen

LigandPNGBDBM17688(2-aminobenzimidazole, 13 | N-{4-chloro-3-[(4-methy...)
Affinity DataKi:  2nM ΔG°:  -49.2kJ/molepH: 7.5 T: 2°CAssay Description:The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Amgen

LigandPNGBDBM17710(2-aminobenzoxazole, 35 | N-{4-chloro-3-[(4-methylp...)
Affinity DataKi:  2nMAssay Description:The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Amgen

LigandPNGBDBM17713(2-aminobenzoxazole, 38 | 7-chloro-N-{4-chloro-3-[(...)
Affinity DataKi:  2nMAssay Description:The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Amgen

LigandPNGBDBM50222499(CHEMBL401153 | N-(3-chlorophenyl)-2-(pyridin-4-ylm...)
Affinity DataKi:  2nMAssay Description:Inhibition of phosphorylated-Kdr after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Amgen

LigandPNGBDBM17684(2-aminobenzimidazole, 9 | N-methyl-4-({2-[(3-{[(2R...)
Affinity DataKi:  2nM ΔG°:  -49.2kJ/molepH: 7.5 T: 2°CAssay Description:The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Amgen

LigandPNGBDBM50222500(CHEMBL250482 | N-(4-cyclohexylphenyl)-2-(pyridin-4...)
Affinity DataKi:  2nMAssay Description:Inhibition of phosphorylated-Kdr after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50146481(3-Benzo[1,3]dioxol-5-yl-3-({1-[3-(3-benzyl-ureido)...)
Affinity DataKi:  2.40nMAssay Description:Binding affinity towards vitronectin receptor (AlphaV-beta3 integrin).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Amgen

LigandPNGBDBM17697(2-aminobenzoxazole, 22 | 4-({2-[(4-chloro-3-{[(2S)...)
Affinity DataKi:  2.80nM ΔG°:  -48.3kJ/mole IC50:  4.60nMpH: 7.5 T: 2°CAssay Description:The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...More data for this Ligand-Target Pair
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50146488(3-{[1-(2-Fluoro-5-guanidino-phenyl)-5-oxo-pyrrolid...)
Affinity DataKi:  2.90nMAssay Description:Affinity for alphaIIb-beta3 integrinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Amgen

LigandPNGBDBM17701(2-aminobenzoxazole, 26 | 4-[(2-{[4-chloro-3-(piper...)
Affinity DataKi:  3nMAssay Description:The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Amgen

LigandPNGBDBM17702(2-aminobenzoxazole, 27 | 4-({2-[(4-chloro-3-{[(2S)...)
Affinity DataKi:  3nMAssay Description:The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Amgen

LigandPNGBDBM17711(2-aminobenzoxazole, 36 | 4-({2-[(4-chloro-3-{[(2S)...)
Affinity DataKi:  3nMAssay Description:The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Amgen

LigandPNGBDBM17691(2-aminobenzimidazole, 16 | N-{4-chloro-3-[(4-methy...)
Affinity DataKi:  3nM ΔG°:  -48.2kJ/molepH: 7.5 T: 2°CAssay Description:The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Amgen

LigandPNGBDBM17683(2-aminobenzimidazole, 8 | 4-{[2-({3-[2-(dimethylam...)
Affinity DataKi:  3nM ΔG°:  -48.2kJ/molepH: 7.5 T: 2°CAssay Description:The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Amgen

LigandPNGBDBM17706(2-aminobenzoxazole, 31 | N-{4-chloro-3-[(4-methylp...)
Affinity DataKi:  3.60nMAssay Description:The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Amgen

LigandPNGBDBM17682(2-aminobenzimidazole, 7 | 4-{[2-({4-chloro-3-[(4-m...)
Affinity DataKi:  3.90nM ΔG°:  -47.5kJ/molepH: 7.5 T: 2°CAssay Description:The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Amgen

LigandPNGBDBM17695(2-aminobenzoxazole, 20 | 4-{[2-({4-chloro-3-[(4-me...)
Affinity DataKi:  4nM ΔG°:  -47.5kJ/molepH: 7.5 T: 2°CAssay Description:The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Amgen

LigandPNGBDBM50222501(CHEMBL250684 | N-(4-chloro-3-(trifluoromethyl)phen...)
Affinity DataKi:  4nMAssay Description:Inhibition of phosphorylated-Kdr after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Amgen

LigandPNGBDBM17700(2-aminobenzoxazole, 25 | 4-[(2-{[4-chloro-3-(morph...)
Affinity DataKi:  4nMAssay Description:The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Amgen

LigandPNGBDBM17698(2-aminobenzoxazole, 23 | 4-{[2-({4-chloro-3-[2-(di...)
Affinity DataKi:  4nMAssay Description:The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Amgen

LigandPNGBDBM17699(2-aminobenzoxazole, 24 | 4-{[2-({4-chloro-3-[2-(di...)
Affinity DataKi:  5nMAssay Description:The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50146482(3-({1-[3-(4,5-Dihydro-1H-imidazol-2-ylamino)-pheny...)
Affinity DataKi:  5.10nMAssay Description:Affinity for alphaIIb-beta3 integrinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50146485(3-(R)-Benzo[1,3]dioxol-5-yl-3-({(R)-5-oxo-1-[3-(1,...)
Affinity DataKi:  7.30nMAssay Description:Binding affinity towards vitronectin receptor (AlphaV-beta3 integrin).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Amgen

LigandPNGBDBM17680(2-aminobenzimidazole, 5 | N-(4-chlorophenyl)-5-[(6...)
Affinity DataKi:  8nM ΔG°:  -45.7kJ/molepH: 7.5 T: 2°CAssay Description:The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Amgen

LigandPNGBDBM50222509(CHEMBL250228 | N-(4-chlorophenyl)-2-(pyridin-4-ylm...)
Affinity DataKi:  8nMAssay Description:Inhibition of unphosphorylated-Kdr after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Amgen

LigandPNGBDBM50222498(CHEMBL400512 | N-(3,5-bis(trifluoromethyl)phenyl)-...)
Affinity DataKi:  8nMAssay Description:Inhibition of phosphorylated-Kdr after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Amgen

LigandPNGBDBM50222512(2-(pyridin-4-ylmethylamino)-N-(4-(trifluoromethyl)...)
Affinity DataKi:  9nMAssay Description:Inhibition of phosphorylated-Kdr after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Amgen

LigandPNGBDBM17685(2-aminobenzimidazole, 10 | N-methyl-4-({2-[(3-{[(2...)
Affinity DataKi:  9nM ΔG°:  -45.5kJ/molepH: 7.5 T: 2°CAssay Description:The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Amgen

LigandPNGBDBM17678(2-aminobenzimidazole, 3 | 4-[(2-{[4-chloro-3-(trif...)
Affinity DataKi:  9nM ΔG°:  -45.5kJ/molepH: 7.5 T: 2°CAssay Description:The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Amgen

LigandPNGBDBM17694(2-aminobenzimidazole, 19 | 4-{[2-({4-chloro-3-[(4-...)
Affinity DataKi:  10nM ΔG°:  -45.2kJ/molepH: 7.5 T: 2°CAssay Description:The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Amgen

LigandPNGBDBM15019(CHEMBL385178 | N-(4-phenoxyphenyl)-2-[(pyridin-4-y...)
Affinity DataKi:  10nMAssay Description:Inhibition of phosphorylated-Kdr after 30 minsMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Amgen

LigandPNGBDBM17712(2-aminobenzoxazole, 37 | 4-{[7-chloro-2-({4-chloro...)
Affinity DataKi:  10nMAssay Description:The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50146495(3-({1-[3-(3-Benzyl-ureido)-phenyl]-5-oxo-pyrrolidi...)
Affinity DataKi:  10nMAssay Description:Affinity for alphaIIb-beta3 integrinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50146496((S)-3-({(R)-1-[3-(3-Benzyl-ureido)-phenyl]-5-oxo-p...)
Affinity DataKi:  10nMAssay Description:Affinity for alphaIIb-beta3 integrinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50146484(3-({1-[3-(3-Benzyl-ureido)-phenyl]-5-oxo-pyrrolidi...)
Affinity DataKi:  11nMAssay Description:Binding affinity towards vitronectin receptor (AlphaV-beta3 integrin).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Amgen

LigandPNGBDBM17696(2-aminobenzoxazole, 21 | 4-({2-[(4-chlorophenyl)am...)
Affinity DataKi:  12nM ΔG°:  -44.8kJ/molepH: 7.5 T: 2°CAssay Description:The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Amgen

LigandPNGBDBM50132151(CHEMBL101683 | N-(4-Chloro-phenyl)-2-[(pyridin-4-y...)
Affinity DataKi:  15nMAssay Description:Inhibition of phosphorylated-Kdr after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Amgen

LigandPNGBDBM50222513(CHEMBL248781 | N-(3,4-dichlorophenyl)-2-(pyridin-4...)
Affinity DataKi:  17nMAssay Description:Inhibition of phosphorylated-Kdr after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Amgen

LigandPNGBDBM17690(2-aminobenzimidazole, 15 | N-{4-chloro-3-[(4-methy...)
Affinity DataKi:  17nM ΔG°:  -43.9kJ/molepH: 7.5 T: 2°CAssay Description:The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50146489(3-{[1-(3-Guanidino-phenyl)-5-oxo-pyrrolidine-3-car...)
Affinity DataKi:  17nMAssay Description:Binding affinity towards vitronectin receptor (AlphaV-beta3 integrin).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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