Affinity DataKi: 60nMAssay Description:The compound was tested for binding affinity against Cysteinyl leukotriene D4 receptor in guinea pig lung membraneMore data for this Ligand-Target Pair
Affinity DataKi: 2.80E+3nMAssay Description:Binding affinity towards Cysteinyl leukotriene D4 receptor antagonist in guinea pig lung membranesMore data for this Ligand-Target Pair
Affinity DataIC50: 2nMAssay Description:The compound was tested for inhibitory activity against Prostaglandin G/H synthase in human polymorphonuclear leukocytes[PMNS]More data for this Ligand-Target Pair
Affinity DataIC50: 4nMAssay Description:The compound was tested for inhibitory activity against Prostaglandin G/H synthase in mouse macrophageMore data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rattus norvegicus)
Wyeth-Ayerst Research
Curated by ChEMBL
Wyeth-Ayerst Research
Curated by ChEMBL
Affinity DataIC50: 5nMAssay Description:The compound was tested for inhibitory activity against 5-lipoxygenase translocation inhibitor in rat RBL-2H3 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 15nMAssay Description:In vitro inhibitory activity against human synovial fluid phospholipase A2 (HSF-PLA2) by monitoring hydrolysis of [3H]-arachidonic acid labeled E. co...More data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rattus norvegicus)
Wyeth-Ayerst Research
Curated by ChEMBL
Wyeth-Ayerst Research
Curated by ChEMBL
Affinity DataIC50: 19nMAssay Description:The compound was tested for inhibitory activity against 5-Lipoxygenase in rat RBL-1More data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Wyeth-Ayerst Research
Curated by ChEMBL
Wyeth-Ayerst Research
Curated by ChEMBL
Affinity DataIC50: 20nMAssay Description:The compound was tested for inhibitory activity against 5-lipoxygenase in human polymorphonuclear leukocytes[PMNS]More data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rattus norvegicus)
Wyeth-Ayerst Research
Curated by ChEMBL
Wyeth-Ayerst Research
Curated by ChEMBL
Affinity DataIC50: 47nMAssay Description:The compound was tested for inhibitory activity against 5-lipoxygenase translocation inhibitor in RBL-2H3 cellsMore data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Wyeth-Ayerst Research
Curated by ChEMBL
Wyeth-Ayerst Research
Curated by ChEMBL
Affinity DataIC50: 60nMAssay Description:The compound was tested for inhibitory activity against LT synthesis in human polymorphonuclear leukocytes[PMNS]More data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Wyeth-Ayerst Research
Curated by ChEMBL
Wyeth-Ayerst Research
Curated by ChEMBL
Affinity DataIC50: 100nMAssay Description:The compound was tested for inhibitory activity against 5-Lipoxygenase in human polymorphonuclear leukocytes[PMNS]More data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rattus norvegicus)
Wyeth-Ayerst Research
Curated by ChEMBL
Wyeth-Ayerst Research
Curated by ChEMBL
Affinity DataIC50: 100nMAssay Description:The compound was tested for inhibitory activity against 5-lipoxygenase in rat polymorphonuclear leukocytes[PMNS]More data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rattus norvegicus)
Wyeth-Ayerst Research
Curated by ChEMBL
Wyeth-Ayerst Research
Curated by ChEMBL
Affinity DataIC50: 130nMAssay Description:The compound was tested for inhibitory activity against 5-lipoxygenase in rat polymorphonuclear leukocytes[PMNS] (in vitro)More data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Wyeth-Ayerst Research
Curated by ChEMBL
Wyeth-Ayerst Research
Curated by ChEMBL
Affinity DataIC50: 140nMAssay Description:The compound was tested for inhibitory activity against 5-Lipoxygenase in human polymorphonuclear leukocytes[PMNS]More data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rattus norvegicus)
Wyeth-Ayerst Research
Curated by ChEMBL
Wyeth-Ayerst Research
Curated by ChEMBL
Affinity DataIC50: 150nMAssay Description:The compound was tested for inhibitory activity against 5-Lipoxygenase in rat RBL-1More data for this Ligand-Target Pair
Affinity DataIC50: 154nMAssay Description:Displacement of [3H](S)-5-chloro-N-(3-ethyl-1-hydroxypentan-2-yl)thiophene-2-sulfonamide from gamma secretase in human SH-SY5Y cells after 1 hrMore data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rattus norvegicus)
Wyeth-Ayerst Research
Curated by ChEMBL
Wyeth-Ayerst Research
Curated by ChEMBL
Affinity DataIC50: 160nMAssay Description:The compound was tested for inhibitory activity against 5-lipoxygenase in rat polymorphonuclear leukocytes[PMNS] (in vivo)More data for this Ligand-Target Pair
Affinity DataIC50: 200nMAssay Description:The compound was tested for inhibitory activity against 5-lipoxygenase in mouse macrophagesMore data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rattus norvegicus)
Wyeth-Ayerst Research
Curated by ChEMBL
Wyeth-Ayerst Research
Curated by ChEMBL
Affinity DataIC50: 230nMAssay Description:Inhibitory concentration of the compound to inhibit 5-lipoxygenase in the ratMore data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rattus norvegicus)
Wyeth-Ayerst Research
Curated by ChEMBL
Wyeth-Ayerst Research
Curated by ChEMBL
Affinity DataIC50: 300nMAssay Description:The compound was tested for inhibitory activity against 5-lipoxygenase in mouseMore data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Wyeth-Ayerst Research
Curated by ChEMBL
Wyeth-Ayerst Research
Curated by ChEMBL
Affinity DataIC50: 300nMAssay Description:Ability to inhibit 5-lipoxygenase in guinea pigMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Albert Ludwigs University Freiburg
Curated by ChEMBL
Albert Ludwigs University Freiburg
Curated by ChEMBL
Affinity DataIC50: 330nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged VEGFR2 (D807 to V1356 residues) expressed in sf9 cells using Poly(Glu,Tyr) 4:1 as substrate aft...More data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Wyeth-Ayerst Research
Curated by ChEMBL
Wyeth-Ayerst Research
Curated by ChEMBL
Affinity DataIC50: 350nMAssay Description:The compound was tested for inhibitory activity against 5-Lipoxygenase in human polymorphonuclear leukocytes[PMNS]More data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rattus norvegicus)
Wyeth-Ayerst Research
Curated by ChEMBL
Wyeth-Ayerst Research
Curated by ChEMBL
Affinity DataIC50: 400nMAssay Description:The compound was tested for inhibitory activity against 5-lipoxygenase in rat polymorphonuclear leukocytes[PMNS]More data for this Ligand-Target Pair
TargetAlcohol dehydrogenase 1A(Homo sapiens (Human))
Albert Ludwigs University Freiburg
Curated by ChEMBL
Albert Ludwigs University Freiburg
Curated by ChEMBL
Affinity DataIC50: 460nMAssay Description:Inhibition of ADH1 (unknown origin) preincubated for 2 hrs followed by substrate/NAD+ additionMore data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rattus norvegicus)
Wyeth-Ayerst Research
Curated by ChEMBL
Wyeth-Ayerst Research
Curated by ChEMBL
Affinity DataIC50: 500nMAssay Description:The compound was tested for inhibitory activity against 5-lipoxygenase in rat RBL-1More data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rattus norvegicus)
Wyeth-Ayerst Research
Curated by ChEMBL
Wyeth-Ayerst Research
Curated by ChEMBL
Affinity DataIC50: 500nMAssay Description:The compound was tested for inhibitory activity against 5-Lipoxygenase in rat RBL-1More data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rattus norvegicus)
Wyeth-Ayerst Research
Curated by ChEMBL
Wyeth-Ayerst Research
Curated by ChEMBL
Affinity DataIC50: 500nMAssay Description:The compound was tested for inhibitory activity against 5-Lipoxygenase in rat RBL-1More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Albert Ludwigs University Freiburg
Curated by ChEMBL
Albert Ludwigs University Freiburg
Curated by ChEMBL
Affinity DataIC50: 530nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged VEGFR2 (D807 to V1356 residues) expressed in sf9 cells using Poly(Glu,Tyr) 4:1 as substrate aft...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase ABL2(Homo sapiens (Human))
Albert Ludwigs University Freiburg
Curated by ChEMBL
Albert Ludwigs University Freiburg
Curated by ChEMBL
Affinity DataIC50: 540nMAssay Description:Inhibition of recombinant human N-terminal GST/His6-tagged ABL2 (M1 to P650 residues) expressed in sf9 cells using Poly(Glu,Tyr) 4:1 as substrate aft...More data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Wyeth-Ayerst Research
Curated by ChEMBL
Wyeth-Ayerst Research
Curated by ChEMBL
Affinity DataIC50: 600nMAssay Description:The compound was tested for inhibitory activity against 5-Lipoxygenase in guinea pig polymorphonuclear leukocytesMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase ABL2(Homo sapiens (Human))
Albert Ludwigs University Freiburg
Curated by ChEMBL
Albert Ludwigs University Freiburg
Curated by ChEMBL
Affinity DataIC50: 685nMAssay Description:Inhibition of recombinant human N-terminal GST/His6-tagged ABL2 (M1 to P650 residues) expressed in sf9 cells using Poly(Glu,Tyr) 4:1 as substrate aft...More data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Wyeth-Ayerst Research
Curated by ChEMBL
Wyeth-Ayerst Research
Curated by ChEMBL
Affinity DataIC50: 800nMAssay Description:The compound was tested for inhibitory activity against 5-lipoxygenase in human polymorphonuclear leukocytes[PMNS]More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 1(Homo sapiens (Human))
Albert Ludwigs University Freiburg
Curated by ChEMBL
Albert Ludwigs University Freiburg
Curated by ChEMBL
Affinity DataIC50: 1.28E+3nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged VEGFR1 (K784 to I1338 residues) expressed in sf9 cells using Poly(Glu,Tyr) 4:1 as substrate aft...More data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rattus norvegicus)
Wyeth-Ayerst Research
Curated by ChEMBL
Wyeth-Ayerst Research
Curated by ChEMBL
Affinity DataIC50: 1.40E+3nMAssay Description:Concentration that produces 50% inhibition of A-23,187-stimulated radiolabelled 5-HETE and TXB2 synthesis by PMN 5-lipoxygenase.More data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rattus norvegicus)
Wyeth-Ayerst Research
Curated by ChEMBL
Wyeth-Ayerst Research
Curated by ChEMBL
Affinity DataIC50: 1.40E+3nMAssay Description:The compound was tested for inhibitory activity against 5-Lipoxygenase receptor in rat polymorphonuclear leukocytes[PMNS]More data for this Ligand-Target Pair
Affinity DataIC50: 2.00E+3nMAssay Description:The compound was tested for inhibitory activity against Prostaglandin G/H synthase in rat polymorphonuclear leukocytes[PMNS]More data for this Ligand-Target Pair
Affinity DataIC50: >2.00E+3nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rattus norvegicus)
Wyeth-Ayerst Research
Curated by ChEMBL
Wyeth-Ayerst Research
Curated by ChEMBL
Affinity DataIC50: 2.00E+3nMAssay Description:The compound was tested for inhibitory activity against 5-lipoxygenase in rat polymorphonuclear leukocytes[PMNS]More data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rattus norvegicus)
Wyeth-Ayerst Research
Curated by ChEMBL
Wyeth-Ayerst Research
Curated by ChEMBL
Affinity DataIC50: 2.00E+3nMAssay Description:Concentration for 50% inhibition of A-23,187-stimulated radiolabelled 5-HETE and TXB2 synthesis by PMN 5-lipoxygenaseMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 1(Homo sapiens (Human))
Albert Ludwigs University Freiburg
Curated by ChEMBL
Albert Ludwigs University Freiburg
Curated by ChEMBL
Affinity DataIC50: 2.10E+3nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged VEGFR1 (K784 to I1338 residues) expressed in sf9 cells using Poly(Glu,Tyr) 4:1 as substrate aft...More data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Wyeth-Ayerst Research
Curated by ChEMBL
Wyeth-Ayerst Research
Curated by ChEMBL
Affinity DataIC50: 2.40E+3nMAssay Description:Ability to inhibit 5-lipoxygenase in guinea pigMore data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rattus norvegicus)
Wyeth-Ayerst Research
Curated by ChEMBL
Wyeth-Ayerst Research
Curated by ChEMBL
Affinity DataIC50: 2.50E+3nMAssay Description:The compound was tested for inhibitory activity against 5-lipoxygenase in rat polymorphonuclear leukocytes[PMNS]More data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Wyeth-Ayerst Research
Curated by ChEMBL
Wyeth-Ayerst Research
Curated by ChEMBL
Affinity DataIC50: 3.00E+3nMAssay Description:The compound was tested for inhibitory activity against 5-lipoxygenase in human polymorphonuclear leukocytes[PMNS]More data for this Ligand-Target Pair
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Albert Ludwigs University Freiburg
Curated by ChEMBL
Albert Ludwigs University Freiburg
Curated by ChEMBL
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of recombinant human N-terminal GST/His6-tagged c-KIT (T544 to V976 residues) expressed in sf9 cells using Poly(Glu,Tyr) 4:1 as substrate ...More data for this Ligand-Target Pair
Affinity DataIC50: 3.30E+3nMAssay Description:Inhibitory concentration to inhibit Prostaglandin G/H synthase in the ratMore data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rattus norvegicus)
Wyeth-Ayerst Research
Curated by ChEMBL
Wyeth-Ayerst Research
Curated by ChEMBL
Affinity DataIC50: 3.90E+3nMAssay Description:Concentration that produces 50% inhibition of A-23,187-stimulated radiolabelled 5-HETE and TXB2 synthesis by PMN 5-lipoxygenaseMore data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rattus norvegicus)
Wyeth-Ayerst Research
Curated by ChEMBL
Wyeth-Ayerst Research
Curated by ChEMBL
Affinity DataIC50: 3.90E+3nMAssay Description:The compound was tested for inhibitory activity against 5-Lipoxygenase in rat polymorphonuclear leukocytes[PMNS]More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 3(Homo sapiens (Human))
Albert Ludwigs University Freiburg
Curated by ChEMBL
Albert Ludwigs University Freiburg
Curated by ChEMBL
Affinity DataIC50: 4.20E+3nMAssay Description:Inhibition of recombinant human N-terminal GST/His6-tagged VEGFR3 (N799 to R1298 residues) expressed in sf9 cells using Poly(Glu,Tyr) 4:1 as substrat...More data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rattus norvegicus)
Wyeth-Ayerst Research
Curated by ChEMBL
Wyeth-Ayerst Research
Curated by ChEMBL
Affinity DataIC50: 4.60E+3nMAssay Description:Inhibitory concentration of the compound to inhibit 5-lipoxygenase in the ratMore data for this Ligand-Target Pair