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Found 89 with Last Name = 'lawandi' and Initial = 'j'
TargetProlyl endopeptidase(Sus scrofa)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50155838((S)-1-((S)-1-(4-phenylbutanoyl)pyrrolidine-2-carbo...)
Affinity DataKi:  0.0230nMAssay Description:Inhibition of pig POPMore data for this Ligand-Target Pair
TargetProlyl endopeptidase(Bos taurus)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50038879((S)-2-(2-Formyl-pyrrolidine-1-carbonyl)-pyrrolidin...)
Affinity DataKi:  0.210nMAssay Description:Inhibition of bovine brain POPMore data for this Ligand-Target Pair
TargetProlyl endopeptidase(Mus musculus)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50038879((S)-2-(2-Formyl-pyrrolidine-1-carbonyl)-pyrrolidin...)
Affinity DataKi:  0.350nMAssay Description:Inhibition of mouse brain POPMore data for this Ligand-Target Pair
TargetProlyl endopeptidase(Sus scrofa)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50170682((S)-1-((S)-1-(3-((S)-2-(cyclopentanecarbonyl)pyrro...)
Affinity DataKi:  0.360nMAssay Description:Inhibition of pig brain POPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Flavobacterium meningosepticum)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50038879((S)-2-(2-Formyl-pyrrolidine-1-carbonyl)-pyrrolidin...)
Affinity DataKi:  0.5nMAssay Description:Inhibition of Flavobacterium meningosepticum POPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Rattus norvegicus)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50038881(CHEMBL294803 | Y-29794 | [2-(8-Dimethylamino-octyl...)
Affinity DataKi:  0.950nMAssay Description:Inhibition of POP in rat brain homogenateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Rattus norvegicus)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50316818(((2S,3aS,7aS)-1-((1R,2R)-2-phenylcyclopropanecarbo...)
Affinity DataKi:  1.30nMAssay Description:inhibition of rat cortex POPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Homo sapiens (Human))
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50316818(((2S,3aS,7aS)-1-((1R,2R)-2-phenylcyclopropanecarbo...)
Affinity DataKi:  1.5nMAssay Description:Inhibition of human POPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Homo sapiens (Human))
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50200729((R)-1-(2-(2,5-dichlorobenzamido)acetyl)pyrrolidin-...)
Affinity DataKi:  2.20nMAssay Description:Inhibition of recombinant POPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Mus musculus)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50316840((R)-benzyl 2-((S)-2-formylpyrrolidine-1-carbonyl)i...)
Affinity DataKi:  2.40nMAssay Description:Inhibition of mouse brain POPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Mus musculus)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50279826((1S,2S)-2-((S)-2-Formyl-pyrrolidine-1-carbonyl)-cy...)
Affinity DataKi:  3nMAssay Description:Inhibition of mouse brain POPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Bos taurus)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50316839((S)-benzyl 2-((S)-2-formylpyrrolidine-1-carbonyl)-...)
Affinity DataKi:  3.40nMAssay Description:Inhibition of bovine brain POPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Rattus norvegicus)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50316819((S)-1-(4-(4-chlorobenzylamino)-4-oxobutanoyl)pyrro...)
Affinity DataKi:  12nMAssay Description:inhibition of rat cortex POPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase FAP(Homo sapiens (Human))
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50200730((R)-1-(2-acetamidoacetyl)pyrrolidin-2-ylboronic ac...)
Affinity DataKi:  23nMAssay Description:Inhibition of recombinant FAPalphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase FAP(Homo sapiens (Human))
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50200729((R)-1-(2-(2,5-dichlorobenzamido)acetyl)pyrrolidin-...)
Affinity DataKi:  29nMAssay Description:Inhibition of recombinant FAPalphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Mus musculus)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50316836((9H-fluoren-9-yl)methyl(S)-1-((S)-2-cyanopyrrolidi...)
Affinity DataKi:  33nMAssay Description:Inhibition of mouse brain POPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Bos taurus)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50316835((S)-benzyl 2-(thiazolidine-3-carbonyl)pyrrolidine-...)
Affinity DataKi:  39nMAssay Description:Inhibition of bovine brain POPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Homo sapiens (Human))
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50200730((R)-1-(2-acetamidoacetyl)pyrrolidin-2-ylboronic ac...)
Affinity DataKi:  211nMAssay Description:Inhibition of recombinant POPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50200730((R)-1-(2-acetamidoacetyl)pyrrolidin-2-ylboronic ac...)
Affinity DataKi:  377nMAssay Description:Inhibition of recombinant DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Bos taurus)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50316834((S)-2-(1-Oxo-1lambda*4*-thiazolidine-3-carbonyl)-p...)
Affinity DataKi:  1.61E+3nMAssay Description:Inhibition of bovine brain POPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Bos taurus)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50316820((S)-benzyl 2-(pyrrolidine-1-carbonyl)pyrrolidine-1...)
Affinity DataKi:  2.10E+3nMAssay Description:Inhibition of bovine brain POPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Sus scrofa)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50316825(2-(2,3-dihydro-1H-inden-2-yl)-1-((R)-4-((R)-4-(dim...)
Affinity DataKi:  2.90E+3nMAssay Description:Inhibition of pig POPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Bos taurus)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50316833((S)-benzyl 2-(oxazolidine-3-carbonyl)pyrrolidine-1...)
Affinity DataKi:  2.90E+3nMAssay Description:Inhibition of bovine brain POPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Homo sapiens (Human))
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50316828((S)-tert-butyl 3-methyl-1-(thiazolidin-3-yl)-1-thi...)
Affinity DataKi:  5.54E+3nMAssay Description:Inhibition of human placenta POPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50200729((R)-1-(2-(2,5-dichlorobenzamido)acetyl)pyrrolidin-...)
Affinity DataKi:  9.50E+3nMAssay Description:Inhibition of recombinant DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Bos taurus)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50316827((S)-benzyl 2-(2-(2-chloroacetyl)pyrrolidin-1-yl)-2...)
Affinity DataKi:  7.00E+4nMAssay Description:Inhibition of bovine brain POPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Rattus norvegicus)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50051495((S)-2-[(S)-2-(2-Hydroxy-acetyl)-pyrrolidine-1-carb...)
Affinity DataIC50:  0.830nMAssay Description:Inhibition of POP in rat brain homogenateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Sus scrofa)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50316821(CHEMBL1096175 | N-((S)-3-methyl-1-oxo-1-((S)-2-(pi...)
Affinity DataIC50:  1.05nMAssay Description:Inhibition of pig brain POPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Sus scrofa)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50316822(3-cyclohexyl-N-((S)-1-oxo-3-phenyl-1-((S)-2-(piper...)
Affinity DataIC50:  1.05nMAssay Description:Inhibition of pig brain POPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Rattus norvegicus)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50316823(((2S,3aS,7aS)-1-((1R,2R)-2-phenylcyclopropanecarbo...)
Affinity DataIC50:  1.20nMAssay Description:inhibition of rat cortex POPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Sus scrofa)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50193665(1-((2R,5S)-2-tert-butyl-5-(pyrrolidine-1-carbonyl)...)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of pig brain POPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Sus scrofa)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50051539((S)-4-phenyl-1-(2-(pyrrolidine-1-carbonyl)pyrrolid...)
Affinity DataIC50:  1.30nMAssay Description:Inhibition of pig brain POPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Sus scrofa)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50316817(4-phenyl-1-((S)-2-((S)-2-(5-phenylisoxazole-3-carb...)
Affinity DataIC50:  1.60nMAssay Description:Inhibition of pig POPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Rattus norvegicus)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50316829(CHEMBL1087103 | isoxazolidin-2-yl((2S,3aS,7aS)-1-(...)
Affinity DataIC50:  2nMAssay Description:inhibition of rat cortex POPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Sus scrofa)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50051539((S)-4-phenyl-1-(2-(pyrrolidine-1-carbonyl)pyrrolid...)
Affinity DataIC50:  2.20nMAssay Description:Inhibition of pig brain POPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Rattus norvegicus)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50316830(((2S,3aS,7aS)-2-(1H-pyrrole-1-carbonyl)octahydro-1...)
Affinity DataIC50:  2.30nMAssay Description:inhibition of rat cortex POPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Rattus norvegicus)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50316831((2,5-dihydro-1H-pyrrol-1-yl)((2S,3aS,7aS)-1-((1R,2...)
Affinity DataIC50:  2.40nMAssay Description:inhibition of rat cortex POPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Rattus norvegicus)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50316832((2,3-dihydro-1H-pyrrol-1-yl)((2S,3aS,7aS)-1-((1R,2...)
Affinity DataIC50:  2.70nMAssay Description:inhibition of rat cortex POPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Homo sapiens (Human))
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50312221(CHEMBL1079410 | N-Benzyloxycarbonylamino-L-alanine...)
Affinity DataIC50:  3nMAssay Description:Inhibition of prolyl oligopeptidase in human LN229 cell extracts assessed as blockade of Z-Gly-Pro-AMC substrate hydrolysis by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Bos taurus)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50316842((S)-1-((S)-3-methyl-2-(4-phenylbutanamido)butanoyl...)
Affinity DataIC50:  4.20nMAssay Description:Inhibition of bovine brain POPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Mus musculus)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50051539((S)-4-phenyl-1-(2-(pyrrolidine-1-carbonyl)pyrrolid...)
Affinity DataIC50:  4.70nMAssay Description:Inhibition of mouse brain POPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Homo sapiens (Human))
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50312221(CHEMBL1079410 | N-Benzyloxycarbonylamino-L-alanine...)
Affinity DataIC50:  5nMAssay Description:Inhibition of prolyl oligopeptidase in human LNZ308 cell extracts assessed as blockade of Z-Gly-Pro-AMC substrate hydrolysis by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Rattus norvegicus)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50316841(((S)-2-((1R,2R)-2-phenylcyclopropanecarbonyl)-2-az...)
Affinity DataIC50:  5nMAssay Description:inhibition of rat cortex POPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Sus scrofa)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50284127(4-Phenyl-1-{(S)-2-[(S)-2-(thiazole-2-carbonyl)-pyr...)
Affinity DataIC50:  5nMAssay Description:Inhibition of pig kidney POPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Homo sapiens (Human))
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50312221(CHEMBL1079410 | N-Benzyloxycarbonylamino-L-alanine...)
Affinity DataIC50:  7nMAssay Description:Inhibition of prolyl oligopeptidase in human HCEC cell extracts assessed as blockade of Z-Gly-Pro-AMC substrate hydrolysis by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Rattus norvegicus)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50051539((S)-4-phenyl-1-(2-(pyrrolidine-1-carbonyl)pyrrolid...)
Affinity DataIC50:  7.20nMAssay Description:Inhibition of rat brain POPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Sus scrofa)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50284126((S)-1-((S)-1-(4-phenylbutanoyl)pyrrolidine-2-carbo...)
Affinity DataIC50:  8.70nMAssay Description:Inhibition of pig kidney POPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Homo sapiens (Human))
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50312222(CHEMBL1079579 | N-Benzyloxycarbonylamino-glycine-2...)
Affinity DataIC50:  20nMAssay Description:Inhibition of prolyl oligopeptidase in human LN229 cell extracts assessed as blockade of Z-Gly-Pro-AMC substrate hydrolysis by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Homo sapiens (Human))
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50312222(CHEMBL1079579 | N-Benzyloxycarbonylamino-glycine-2...)
Affinity DataIC50:  20nMAssay Description:Inhibition of prolyl oligopeptidase in human LNZ308 cell extracts assessed as blockade of Z-Gly-Pro-AMC substrate hydrolysis by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Homo sapiens (Human))
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50312221(CHEMBL1079410 | N-Benzyloxycarbonylamino-L-alanine...)
Affinity DataIC50:  20nMAssay Description:Inhibition of prolyl oligopeptidase in intact human HCEC cells assessed as blockade of Z-Gly-Pro-AMC substrate hydrolysis by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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